SRP40_C-inal_domain_containing_protein_putative/P fam:PF05022

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SRP40, C-terminal domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6F2_LEIDO

TriTrypDb:

LdBPK_100080.1 , LdCL_100006000 , LDHU3_10.0160

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Phosphorylation

Promastigote: 101, 103, 67

Expansion

Sequence features

A0A3S5H6F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6F2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.730
CLV_NRD_NRD_1	183	185	PF00675	0.348
CLV_NRD_NRD_1	24	26	PF00675	0.580
CLV_NRD_NRD_1	93	95	PF00675	0.616
CLV_PCSK_KEX2_1	170	172	PF00082	0.731
CLV_PCSK_KEX2_1	183	185	PF00082	0.344
CLV_PCSK_SKI1_1	78	82	PF00082	0.709
CLV_Separin_Metazoa	217	221	PF03568	0.351
DEG_SPOP_SBC_1	80	84	PF00917	0.819
DOC_MAPK_gen_1	204	212	PF00069	0.324
DOC_PP1_RVXF_1	190	196	PF00149	0.305
DOC_USP7_MATH_1	139	143	PF00917	0.666
DOC_USP7_MATH_1	80	84	PF00917	0.785
DOC_USP7_UBL2_3	115	119	PF12436	0.662
DOC_USP7_UBL2_3	224	228	PF12436	0.314
DOC_USP7_UBL2_3	230	234	PF12436	0.369
DOC_WW_Pin1_4	113	118	PF00397	0.617
DOC_WW_Pin1_4	169	174	PF00397	0.629
DOC_WW_Pin1_4	34	39	PF00397	0.523
DOC_WW_Pin1_4	54	59	PF00397	0.520
DOC_WW_Pin1_4	81	86	PF00397	0.677
LIG_14-3-3_CanoR_1	52	58	PF00244	0.536
LIG_APCC_ABBAyCdc20_2	124	130	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_CtBP_PxDLS_1	241	247	PF00389	0.313
LIG_FHA_2	161	167	PF00498	0.611
LIG_LIR_Nem_3	179	185	PF02991	0.593
LIG_SH2_STAT3	51	54	PF00017	0.542
LIG_SH2_STAT5	12	15	PF00017	0.479
LIG_SH3_3	105	111	PF00018	0.643
LIG_SxIP_EBH_1	81	94	PF03271	0.663
LIG_TRAF2_1	43	46	PF00917	0.453
LIG_WW_1	117	120	PF00397	0.524
MOD_CDK_SPxK_1	113	119	PF00069	0.535
MOD_CDK_SPxxK_3	34	41	PF00069	0.527
MOD_CDK_SPxxK_3	83	90	PF00069	0.645
MOD_CK1_1	129	135	PF00069	0.790
MOD_CK1_1	142	148	PF00069	0.692
MOD_CK1_1	76	82	PF00069	0.737
MOD_CK1_1	83	89	PF00069	0.576
MOD_CK2_1	100	106	PF00069	0.660
MOD_CK2_1	128	134	PF00069	0.733
MOD_CK2_1	160	166	PF00069	0.721
MOD_CK2_1	40	46	PF00069	0.473
MOD_Cter_Amidation	39	42	PF01082	0.537
MOD_GlcNHglycan	142	145	PF01048	0.809
MOD_GSK3_1	100	107	PF00069	0.714
MOD_GSK3_1	76	83	PF00069	0.671
MOD_N-GLC_1	140	145	PF02516	0.622
MOD_NEK2_1	218	223	PF00069	0.417
MOD_PIKK_1	73	79	PF00454	0.581
MOD_PKA_2	73	79	PF00069	0.636
MOD_Plk_1	104	110	PF00069	0.608
MOD_Plk_1	242	248	PF00069	0.351
MOD_Plk_2-3	100	106	PF00069	0.635
MOD_ProDKin_1	113	119	PF00069	0.614
MOD_ProDKin_1	169	175	PF00069	0.623
MOD_ProDKin_1	34	40	PF00069	0.516
MOD_ProDKin_1	54	60	PF00069	0.529
MOD_ProDKin_1	81	87	PF00069	0.675
TRG_ER_diArg_1	182	184	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8F0	Bodo saltans	41%	100%
A0A1X0NQ23	Trypanosomatidae	49%	100%
A4H5Z2	Leishmania braziliensis	74%	98%
A4HUB7	Leishmania infantum	100%	100%
E9AN16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QHL0	Leishmania major	90%	100%