LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H6F1_LEIDO
TriTrypDb:
LdBPK_091640.1 , LdCL_090022800 , LDHU3_09.1910
Length:
181

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S5H6F1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6F1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.486
CLV_NRD_NRD_1 87 89 PF00675 0.424
CLV_PCSK_KEX2_1 86 88 PF00082 0.431
CLV_PCSK_SKI1_1 68 72 PF00082 0.424
CLV_PCSK_SKI1_1 87 91 PF00082 0.321
CLV_PCSK_SKI1_1 95 99 PF00082 0.420
DOC_MAPK_gen_1 126 135 PF00069 0.592
DOC_MAPK_MEF2A_6 128 137 PF00069 0.487
DOC_MAPK_RevD_3 109 124 PF00069 0.684
DOC_PP4_FxxP_1 122 125 PF00568 0.653
DOC_USP7_MATH_1 12 16 PF00917 0.772
DOC_USP7_MATH_1 157 161 PF00917 0.467
DOC_WW_Pin1_4 19 24 PF00397 0.716
DOC_WW_Pin1_4 39 44 PF00397 0.527
LIG_14-3-3_CanoR_1 95 103 PF00244 0.622
LIG_BRCT_BRCA1_1 133 137 PF00533 0.408
LIG_FHA_1 43 49 PF00498 0.670
LIG_LIR_Gen_1 117 125 PF02991 0.691
LIG_LIR_LC3C_4 31 34 PF02991 0.671
LIG_LIR_Nem_3 117 122 PF02991 0.682
LIG_LYPXL_L_2 61 70 PF13949 0.653
LIG_NRP_CendR_1 180 181 PF00754 0.720
LIG_Pex14_2 137 141 PF04695 0.401
LIG_SH2_SRC 19 22 PF00017 0.755
LIG_SH2_STAT3 158 161 PF00017 0.436
LIG_SH2_STAT5 73 76 PF00017 0.614
LIG_SH3_3 143 149 PF00018 0.444
LIG_SH3_3 37 43 PF00018 0.697
LIG_SUMO_SIM_anti_2 44 50 PF11976 0.669
MOD_CK1_1 42 48 PF00069 0.726
MOD_CK2_1 19 25 PF00069 0.663
MOD_CK2_1 3 9 PF00069 0.727
MOD_GlcNHglycan 116 119 PF01048 0.440
MOD_GlcNHglycan 34 37 PF01048 0.470
MOD_GSK3_1 19 26 PF00069 0.655
MOD_GSK3_1 3 10 PF00069 0.745
MOD_NEK2_1 1 6 PF00069 0.707
MOD_NEK2_1 32 37 PF00069 0.662
MOD_NMyristoyl 1 7 PF02799 0.744
MOD_PIKK_1 157 163 PF00454 0.381
MOD_ProDKin_1 19 25 PF00069 0.713
MOD_ProDKin_1 39 45 PF00069 0.525
MOD_SUMO_rev_2 64 70 PF00179 0.661
TRG_DiLeu_BaEn_1 44 49 PF01217 0.669
TRG_ER_diArg_1 125 128 PF00400 0.652
TRG_ER_diArg_1 86 88 PF00400 0.732
TRG_NLS_MonoCore_2 122 127 PF00514 0.713
TRG_Pf-PMV_PEXEL_1 88 92 PF00026 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JHE9 Bodo saltans 61% 100%
A0A1X0NID1 Trypanosomatidae 63% 96%
A0A3R7KNE8 Trypanosoma rangeli 61% 96%
A4H5Y2 Leishmania braziliensis 82% 100%
A4HU78 Leishmania infantum 99% 100%
D0A9R0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 73%
E9AN08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QHM0 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS