Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6F0_LEIDO

TriTrypDb:

LdBPK_091610.1 , LdCL_090022500 , LDHU3_09.1880

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A0A3S5H6F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6F0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	30	32	PF00675	0.422
CLV_NRD_NRD_1	48	50	PF00675	0.511
CLV_PCSK_KEX2_1	30	32	PF00082	0.389
CLV_PCSK_KEX2_1	48	50	PF00082	0.416
CLV_PCSK_SKI1_1	208	212	PF00082	0.518
CLV_PCSK_SKI1_1	299	303	PF00082	0.501
CLV_PCSK_SKI1_1	48	52	PF00082	0.427
CLV_PCSK_SKI1_1	8	12	PF00082	0.678
DEG_SCF_FBW7_1	283	288	PF00400	0.493
DOC_ANK_TNKS_1	220	227	PF00023	0.429
DOC_CDC14_PxL_1	89	97	PF14671	0.358
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.508
DOC_MAPK_gen_1	208	217	PF00069	0.512
DOC_MAPK_MEF2A_6	11	19	PF00069	0.559
DOC_MAPK_MEF2A_6	90	97	PF00069	0.509
DOC_PP2B_LxvP_1	134	137	PF13499	0.398
DOC_PP2B_PxIxI_1	14	20	PF00149	0.615
DOC_USP7_MATH_1	10	14	PF00917	0.692
DOC_USP7_MATH_1	323	327	PF00917	0.546
DOC_USP7_UBL2_3	331	335	PF12436	0.565
DOC_USP7_UBL2_3	4	8	PF12436	0.659
DOC_WW_Pin1_4	281	286	PF00397	0.436
LIG_14-3-3_CanoR_1	154	160	PF00244	0.429
LIG_14-3-3_CanoR_1	299	305	PF00244	0.535
LIG_Actin_WH2_2	260	276	PF00022	0.455
LIG_Actin_WH2_2	80	98	PF00022	0.403
LIG_APCC_ABBA_1	70	75	PF00400	0.415
LIG_EH_1	126	130	PF12763	0.398
LIG_FHA_1	158	164	PF00498	0.339
LIG_FHA_1	252	258	PF00498	0.522
LIG_FHA_1	286	292	PF00498	0.444
LIG_FHA_1	301	307	PF00498	0.314
LIG_FHA_1	308	314	PF00498	0.466
LIG_LIR_Nem_3	118	123	PF02991	0.526
LIG_LIR_Nem_3	165	169	PF02991	0.309
LIG_LIR_Nem_3	191	197	PF02991	0.324
LIG_LIR_Nem_3	41	46	PF02991	0.494
LIG_LYPXL_yS_3	92	95	PF13949	0.331
LIG_PCNA_yPIPBox_3	154	163	PF02747	0.429
LIG_SH2_CRK	120	124	PF00017	0.560
LIG_SH2_CRK	194	198	PF00017	0.343
LIG_SH2_CRK	315	319	PF00017	0.513
LIG_SH2_STAT5	148	151	PF00017	0.478
LIG_SH2_STAT5	152	155	PF00017	0.492
LIG_SH2_STAT5	194	197	PF00017	0.343
LIG_SH2_STAT5	204	207	PF00017	0.343
LIG_SH3_3	39	45	PF00018	0.517
LIG_SH3_3	63	69	PF00018	0.438
LIG_SUMO_SIM_anti_2	107	115	PF11976	0.410
LIG_SUMO_SIM_anti_2	212	219	PF11976	0.456
LIG_SUMO_SIM_par_1	107	115	PF11976	0.379
LIG_SUMO_SIM_par_1	160	165	PF11976	0.235
LIG_SUMO_SIM_par_1	259	265	PF11976	0.467
LIG_SUMO_SIM_par_1	317	322	PF11976	0.422
LIG_TYR_ITIM	192	197	PF00017	0.324
LIG_TYR_ITIM	313	318	PF00017	0.535
MOD_CK1_1	185	191	PF00069	0.429
MOD_CK1_1	213	219	PF00069	0.415
MOD_CK1_1	307	313	PF00069	0.548
MOD_CK2_1	238	244	PF00069	0.502
MOD_CK2_1	283	289	PF00069	0.524
MOD_Cter_Amidation	328	331	PF01082	0.608
MOD_Cter_Amidation	333	336	PF01082	0.665
MOD_Cter_Amidation	5	8	PF01082	0.659
MOD_GlcNHglycan	12	15	PF01048	0.677
MOD_GlcNHglycan	285	288	PF01048	0.531
MOD_GlcNHglycan	321	324	PF01048	0.512
MOD_GSK3_1	182	189	PF00069	0.415
MOD_GSK3_1	279	286	PF00069	0.456
MOD_GSK3_1	291	298	PF00069	0.388
MOD_GSK3_1	300	307	PF00069	0.496
MOD_GSK3_1	319	326	PF00069	0.389
MOD_N-GLC_1	155	160	PF02516	0.324
MOD_N-GLC_1	183	188	PF02516	0.309
MOD_N-GLC_1	213	218	PF02516	0.429
MOD_N-GLC_2	279	281	PF02516	0.406
MOD_NEK2_1	248	253	PF00069	0.389
MOD_NEK2_1	291	296	PF00069	0.407
MOD_PIKK_1	115	121	PF00454	0.494
MOD_PIKK_1	323	329	PF00454	0.515
MOD_PKA_2	304	310	PF00069	0.533
MOD_Plk_1	155	161	PF00069	0.324
MOD_Plk_1	183	189	PF00069	0.324
MOD_Plk_1	213	219	PF00069	0.398
MOD_Plk_1	52	58	PF00069	0.425
MOD_Plk_4	148	154	PF00069	0.466
MOD_Plk_4	158	164	PF00069	0.418
MOD_Plk_4	213	219	PF00069	0.456
MOD_ProDKin_1	281	287	PF00069	0.429
MOD_SUMO_for_1	50	53	PF00179	0.414
MOD_SUMO_rev_2	75	84	PF00179	0.382
TRG_ENDOCYTIC_2	120	123	PF00928	0.484
TRG_ENDOCYTIC_2	194	197	PF00928	0.324
TRG_ENDOCYTIC_2	315	318	PF00928	0.459
TRG_ENDOCYTIC_2	92	95	PF00928	0.366
TRG_ER_diArg_1	29	31	PF00400	0.422
TRG_ER_diArg_1	48	50	PF00400	0.472
TRG_ER_diLys_1	333	338	PF00400	0.681
TRG_NLS_MonoCore_2	329	334	PF00514	0.550
TRG_NLS_MonoExtC_3	330	335	PF00514	0.535
TRG_NLS_MonoExtN_4	330	336	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA8	Leptomonas seymouri	71%	100%
A0A0S4JEI1	Bodo saltans	38%	90%
A0A1X0NI28	Trypanosomatidae	46%	100%
A0A1X0P364	Trypanosomatidae	25%	79%
A0A3R7N0J2	Trypanosoma rangeli	45%	100%
A0JPI9	Rattus norvegicus	21%	71%
A4H5X9	Leishmania braziliensis	86%	100%
A4HU75	Leishmania infantum	100%	100%
D0A9Q7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AN05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	71%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	85%
P10775	Sus scrofa	27%	74%
P29315	Rattus norvegicus	27%	74%
Q0VAA2	Homo sapiens	20%	69%
Q4QHM3	Leishmania major	95%	100%
Q91VI7	Mus musculus	29%	74%
V5BDE5	Trypanosoma cruzi	45%	98%