Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6E7_LEIDO

TriTrypDb:

LdBPK_091400.1 , LdCL_090020400 , LDHU3_09.1650

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H6E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.739
CLV_NRD_NRD_1	457	459	PF00675	0.466
CLV_NRD_NRD_1	590	592	PF00675	0.782
CLV_PCSK_SKI1_1	209	213	PF00082	0.730
DEG_APCC_DBOX_1	45	53	PF00400	0.503
DOC_CKS1_1	198	203	PF01111	0.567
DOC_MAPK_gen_1	306	314	PF00069	0.435
DOC_MAPK_gen_1	343	352	PF00069	0.415
DOC_MAPK_gen_1	523	531	PF00069	0.669
DOC_MAPK_MEF2A_6	306	314	PF00069	0.423
DOC_MAPK_MEF2A_6	346	354	PF00069	0.404
DOC_MAPK_MEF2A_6	523	531	PF00069	0.669
DOC_MAPK_MEF2A_6	58	67	PF00069	0.562
DOC_MAPK_NFAT4_5	58	66	PF00069	0.448
DOC_PP1_RVXF_1	317	324	PF00149	0.480
DOC_PP2B_LxvP_1	330	333	PF13499	0.513
DOC_PP2B_LxvP_1	350	353	PF13499	0.445
DOC_PP2B_PxIxI_1	118	124	PF00149	0.428
DOC_PP4_FxxP_1	178	181	PF00568	0.545
DOC_PP4_FxxP_1	454	457	PF00568	0.566
DOC_USP7_MATH_1	241	245	PF00917	0.435
DOC_USP7_MATH_1	381	385	PF00917	0.544
DOC_USP7_MATH_1	557	561	PF00917	0.401
DOC_USP7_MATH_1	80	84	PF00917	0.505
DOC_USP7_MATH_1	86	90	PF00917	0.547
DOC_USP7_MATH_1	99	103	PF00917	0.464
DOC_USP7_UBL2_3	461	465	PF12436	0.719
DOC_USP7_UBL2_3	592	596	PF12436	0.515
DOC_WW_Pin1_4	177	182	PF00397	0.540
DOC_WW_Pin1_4	184	189	PF00397	0.538
DOC_WW_Pin1_4	197	202	PF00397	0.390
DOC_WW_Pin1_4	228	233	PF00397	0.534
DOC_WW_Pin1_4	30	35	PF00397	0.663
DOC_WW_Pin1_4	36	41	PF00397	0.521
DOC_WW_Pin1_4	422	427	PF00397	0.552
DOC_WW_Pin1_4	453	458	PF00397	0.647
LIG_14-3-3_CanoR_1	132	140	PF00244	0.516
LIG_14-3-3_CanoR_1	196	201	PF00244	0.543
LIG_14-3-3_CanoR_1	48	53	PF00244	0.593
LIG_14-3-3_CanoR_1	526	532	PF00244	0.601
LIG_BRCT_BRCA1_1	448	452	PF00533	0.411
LIG_FHA_1	11	17	PF00498	0.586
LIG_FHA_1	111	117	PF00498	0.567
LIG_FHA_1	151	157	PF00498	0.535
LIG_FHA_1	347	353	PF00498	0.370
LIG_FHA_1	438	444	PF00498	0.325
LIG_FHA_1	469	475	PF00498	0.682
LIG_FHA_1	489	495	PF00498	0.534
LIG_FHA_1	551	557	PF00498	0.375
LIG_FHA_1	73	79	PF00498	0.536
LIG_FHA_2	256	262	PF00498	0.442
LIG_LIR_Apic_2	543	547	PF02991	0.746
LIG_LIR_Gen_1	21	32	PF02991	0.613
LIG_LIR_Gen_1	261	267	PF02991	0.457
LIG_LIR_Gen_1	355	366	PF02991	0.395
LIG_LIR_Gen_1	409	420	PF02991	0.481
LIG_LIR_Gen_1	530	538	PF02991	0.654
LIG_LIR_Gen_1	549	559	PF02991	0.546
LIG_LIR_Nem_3	21	27	PF02991	0.591
LIG_LIR_Nem_3	261	265	PF02991	0.456
LIG_LIR_Nem_3	292	297	PF02991	0.399
LIG_LIR_Nem_3	355	361	PF02991	0.415
LIG_LIR_Nem_3	409	415	PF02991	0.541
LIG_LIR_Nem_3	518	524	PF02991	0.675
LIG_LIR_Nem_3	530	534	PF02991	0.586
LIG_LIR_Nem_3	549	555	PF02991	0.546
LIG_PCNA_yPIPBox_3	124	138	PF02747	0.485
LIG_Pex14_1	356	360	PF04695	0.376
LIG_Pex14_2	448	452	PF04695	0.408
LIG_SH2_CRK	358	362	PF00017	0.432
LIG_SH2_CRK	544	548	PF00017	0.737
LIG_SH2_CRK	552	556	PF00017	0.345
LIG_SH2_GRB2like	297	300	PF00017	0.441
LIG_SH2_NCK_1	257	261	PF00017	0.514
LIG_SH2_PTP2	262	265	PF00017	0.526
LIG_SH2_PTP2	508	511	PF00017	0.614
LIG_SH2_SRC	508	511	PF00017	0.614
LIG_SH2_STAP1	242	246	PF00017	0.506
LIG_SH2_STAP1	55	59	PF00017	0.572
LIG_SH2_STAP1	552	556	PF00017	0.375
LIG_SH2_STAP1	581	585	PF00017	0.484
LIG_SH2_STAT3	574	577	PF00017	0.476
LIG_SH2_STAT5	257	260	PF00017	0.508
LIG_SH2_STAT5	262	265	PF00017	0.436
LIG_SH2_STAT5	276	279	PF00017	0.334
LIG_SH2_STAT5	297	300	PF00017	0.498
LIG_SH2_STAT5	303	306	PF00017	0.488
LIG_SH2_STAT5	340	343	PF00017	0.473
LIG_SH2_STAT5	414	417	PF00017	0.550
LIG_SH2_STAT5	435	438	PF00017	0.481
LIG_SH2_STAT5	478	481	PF00017	0.638
LIG_SH2_STAT5	508	511	PF00017	0.597
LIG_SH2_STAT5	552	555	PF00017	0.411
LIG_SH2_STAT5	574	577	PF00017	0.476
LIG_SH3_1	544	550	PF00018	0.732
LIG_SH3_3	195	201	PF00018	0.548
LIG_SH3_3	221	227	PF00018	0.564
LIG_SH3_3	34	40	PF00018	0.541
LIG_SH3_3	375	381	PF00018	0.553
LIG_SH3_3	423	429	PF00018	0.460
LIG_SH3_3	544	550	PF00018	0.752
LIG_Sin3_3	15	22	PF02671	0.523
LIG_Sin3_3	7	14	PF02671	0.595
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.478
LIG_SUMO_SIM_par_1	15	21	PF11976	0.570
LIG_SUMO_SIM_par_1	489	496	PF11976	0.668
LIG_TYR_ITIM	519	524	PF00017	0.658
MOD_CDC14_SPxK_1	456	459	PF00782	0.734
MOD_CDK_SPK_2	453	458	PF00069	0.559
MOD_CDK_SPxK_1	453	459	PF00069	0.557
MOD_CDK_SPxxK_3	197	204	PF00069	0.471
MOD_CK1_1	126	132	PF00069	0.556
MOD_CK1_1	23	29	PF00069	0.564
MOD_CK1_1	234	240	PF00069	0.429
MOD_CK1_1	253	259	PF00069	0.341
MOD_CK1_1	370	376	PF00069	0.508
MOD_CK1_1	39	45	PF00069	0.541
MOD_CK1_1	403	409	PF00069	0.489
MOD_CK1_1	422	428	PF00069	0.569
MOD_CK1_1	437	443	PF00069	0.315
MOD_CK1_1	486	492	PF00069	0.697
MOD_CK1_1	73	79	PF00069	0.609
MOD_CK1_1	94	100	PF00069	0.498
MOD_CK2_1	255	261	PF00069	0.441
MOD_CK2_1	263	269	PF00069	0.462
MOD_CK2_1	275	281	PF00069	0.282
MOD_GlcNHglycan	101	104	PF01048	0.744
MOD_GlcNHglycan	134	137	PF01048	0.682
MOD_GlcNHglycan	236	239	PF01048	0.697
MOD_GlcNHglycan	392	395	PF01048	0.752
MOD_GlcNHglycan	421	424	PF01048	0.754
MOD_GlcNHglycan	436	439	PF01048	0.620
MOD_GlcNHglycan	443	446	PF01048	0.418
MOD_GlcNHglycan	448	451	PF01048	0.429
MOD_GlcNHglycan	559	562	PF01048	0.338
MOD_GlcNHglycan	93	96	PF01048	0.738
MOD_GSK3_1	122	129	PF00069	0.514
MOD_GSK3_1	132	139	PF00069	0.523
MOD_GSK3_1	196	203	PF00069	0.515
MOD_GSK3_1	32	39	PF00069	0.581
MOD_GSK3_1	406	413	PF00069	0.571
MOD_GSK3_1	437	444	PF00069	0.319
MOD_GSK3_1	453	460	PF00069	0.529
MOD_GSK3_1	484	491	PF00069	0.641
MOD_N-GLC_1	253	258	PF02516	0.678
MOD_N-GLC_1	298	303	PF02516	0.721
MOD_N-GLC_1	346	351	PF02516	0.579
MOD_N-GLC_1	400	405	PF02516	0.690
MOD_NEK2_1	18	23	PF00069	0.572
MOD_NEK2_1	212	217	PF00069	0.602
MOD_NEK2_1	283	288	PF00069	0.484
MOD_NEK2_1	304	309	PF00069	0.479
MOD_NEK2_1	321	326	PF00069	0.360
MOD_NEK2_1	367	372	PF00069	0.476
MOD_NEK2_1	392	397	PF00069	0.500
MOD_NEK2_1	434	439	PF00069	0.485
MOD_NEK2_1	452	457	PF00069	0.543
MOD_NEK2_1	492	497	PF00069	0.659
MOD_PIKK_1	110	116	PF00454	0.508
MOD_PIKK_1	222	228	PF00454	0.597
MOD_PIKK_1	32	38	PF00454	0.411
MOD_PIKK_1	321	327	PF00454	0.395
MOD_PIKK_1	80	86	PF00454	0.475
MOD_PK_1	470	476	PF00069	0.646
MOD_PKA_2	250	256	PF00069	0.513
MOD_PKA_2	457	463	PF00069	0.725
MOD_PKB_1	46	54	PF00069	0.590
MOD_Plk_1	253	259	PF00069	0.504
MOD_Plk_1	298	304	PF00069	0.518
MOD_Plk_1	403	409	PF00069	0.518
MOD_Plk_1	492	498	PF00069	0.686
MOD_Plk_1	86	92	PF00069	0.502
MOD_Plk_4	126	132	PF00069	0.505
MOD_Plk_4	139	145	PF00069	0.402
MOD_Plk_4	219	225	PF00069	0.561
MOD_Plk_4	293	299	PF00069	0.425
MOD_Plk_4	367	373	PF00069	0.509
MOD_Plk_4	470	476	PF00069	0.646
MOD_Plk_4	515	521	PF00069	0.705
MOD_Plk_4	550	556	PF00069	0.375
MOD_ProDKin_1	177	183	PF00069	0.540
MOD_ProDKin_1	184	190	PF00069	0.540
MOD_ProDKin_1	197	203	PF00069	0.388
MOD_ProDKin_1	228	234	PF00069	0.528
MOD_ProDKin_1	30	36	PF00069	0.666
MOD_ProDKin_1	422	428	PF00069	0.552
MOD_ProDKin_1	453	459	PF00069	0.645
MOD_SUMO_for_1	158	161	PF00179	0.505
MOD_SUMO_for_1	469	472	PF00179	0.671
MOD_SUMO_rev_2	311	321	PF00179	0.503
MOD_SUMO_rev_2	72	81	PF00179	0.496
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.544
TRG_ENDOCYTIC_2	262	265	PF00928	0.453
TRG_ENDOCYTIC_2	358	361	PF00928	0.425
TRG_ENDOCYTIC_2	402	405	PF00928	0.505
TRG_ENDOCYTIC_2	508	511	PF00928	0.614
TRG_ENDOCYTIC_2	521	524	PF00928	0.533
TRG_ENDOCYTIC_2	552	555	PF00928	0.411
TRG_ENDOCYTIC_2	573	576	PF00928	0.472
TRG_ER_diArg_1	306	309	PF00400	0.443
TRG_ER_diArg_1	46	49	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG0	Leptomonas seymouri	38%	100%
A4H5W1	Leishmania braziliensis	64%	100%
A4HU56	Leishmania infantum	100%	100%
E9AMY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QHP2	Leishmania major	89%	100%