PITH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6E4_LEIDO

TriTrypDb:

LdBPK_091200.1 , LdCL_090018400 , LDHU3_09.1430

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0030992	intraciliary transport particle B	2	11
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1

Expansion

Sequence features

A0A3S5H6E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6E4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	25	27	PF00675	0.721
CLV_NRD_NRD_1	39	41	PF00675	0.614
CLV_NRD_NRD_1	51	53	PF00675	0.565
CLV_PCSK_KEX2_1	24	26	PF00082	0.721
CLV_PCSK_KEX2_1	39	41	PF00082	0.607
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.716
CLV_PCSK_PC7_1	35	41	PF00082	0.709
CLV_PCSK_SKI1_1	124	128	PF00082	0.568
CLV_PCSK_SKI1_1	52	56	PF00082	0.680
CLV_PCSK_SKI1_1	62	66	PF00082	0.487
DEG_APCC_DBOX_1	38	46	PF00400	0.707
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DOC_MAPK_gen_1	112	120	PF00069	0.604
DOC_MAPK_gen_1	187	196	PF00069	0.494
DOC_MAPK_MEF2A_6	112	120	PF00069	0.604
DOC_MAPK_MEF2A_6	187	196	PF00069	0.516
DOC_PP1_RVXF_1	185	192	PF00149	0.609
DOC_PP1_RVXF_1	60	66	PF00149	0.673
DOC_PP4_FxxP_1	15	18	PF00568	0.642
DOC_USP7_MATH_1	148	152	PF00917	0.725
DOC_USP7_MATH_1	58	62	PF00917	0.698
DOC_WW_Pin1_4	132	137	PF00397	0.641
DOC_WW_Pin1_4	5	10	PF00397	0.671
LIG_14-3-3_CanoR_1	107	116	PF00244	0.597
LIG_BIR_III_4	210	214	PF00653	0.608
LIG_BRCT_BRCA1_1	60	64	PF00533	0.546
LIG_FHA_1	175	181	PF00498	0.691
LIG_FHA_1	87	93	PF00498	0.579
LIG_FHA_2	135	141	PF00498	0.589
LIG_FHA_2	36	42	PF00498	0.712
LIG_LIR_Apic_2	13	18	PF02991	0.635
LIG_LIR_Gen_1	137	147	PF02991	0.564
LIG_LIR_Gen_1	188	197	PF02991	0.519
LIG_LIR_Gen_1	198	207	PF02991	0.440
LIG_LIR_Gen_1	66	77	PF02991	0.539
LIG_LIR_Nem_3	188	194	PF02991	0.523
LIG_LIR_Nem_3	198	203	PF02991	0.451
LIG_LIR_Nem_3	61	67	PF02991	0.536
LIG_Pex14_2	65	69	PF04695	0.662
LIG_SH2_STAP1	200	204	PF00017	0.540
LIG_SH2_STAP1	207	211	PF00017	0.536
LIG_SH3_3	15	21	PF00018	0.719
LIG_SH3_3	167	173	PF00018	0.735
LIG_TRFH_1	178	182	PF08558	0.709
LIG_WRC_WIRS_1	69	74	PF05994	0.521
MOD_CK1_1	114	120	PF00069	0.546
MOD_CK1_1	157	163	PF00069	0.787
MOD_CK1_1	198	204	PF00069	0.516
MOD_CK2_1	134	140	PF00069	0.612
MOD_CK2_1	222	228	PF00069	0.677
MOD_GlcNHglycan	109	112	PF01048	0.521
MOD_GlcNHglycan	159	162	PF01048	0.779
MOD_GlcNHglycan	197	200	PF01048	0.482
MOD_GlcNHglycan	5	8	PF01048	0.644
MOD_GSK3_1	1	8	PF00069	0.695
MOD_GSK3_1	103	110	PF00069	0.538
MOD_GSK3_1	148	155	PF00069	0.628
MOD_GSK3_1	29	36	PF00069	0.743
MOD_GSK3_1	82	89	PF00069	0.600
MOD_NEK2_1	1	6	PF00069	0.696
MOD_NEK2_1	56	61	PF00069	0.765
MOD_NEK2_1	91	96	PF00069	0.537
MOD_PIKK_1	213	219	PF00454	0.611
MOD_PIKK_1	30	36	PF00454	0.742
MOD_PKA_2	148	154	PF00069	0.659
MOD_PKA_2	192	198	PF00069	0.571
MOD_PKA_2	29	35	PF00069	0.688
MOD_Plk_1	143	149	PF00069	0.617
MOD_Plk_4	192	198	PF00069	0.536
MOD_Plk_4	87	93	PF00069	0.583
MOD_ProDKin_1	132	138	PF00069	0.643
MOD_ProDKin_1	5	11	PF00069	0.674
MOD_SUMO_rev_2	117	126	PF00179	0.560
TRG_ENDOCYTIC_2	200	203	PF00928	0.554
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A8	Leptomonas seymouri	74%	100%
A0A1X0NHU5	Trypanosomatidae	43%	100%
A0A3S5ISF4	Trypanosoma rangeli	43%	100%
A4H5U2	Leishmania braziliensis	85%	100%
A4HU36	Leishmania infantum	100%	100%
D0A9L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	93%
Q4QHR1	Leishmania major	86%	99%
V5AY45	Trypanosoma cruzi	45%	100%