LeishMANIAdb
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Variant-specific surface protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Variant-specific surface protein
Gene product:
hypothetical protein
Species:
Leishmania donovani
UniProt:
A0A3S5H6E3_LEIDO
TriTrypDb:
LdCL_090016800 , LDHU3_09.1290
Length:
89

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 0
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S5H6E3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6E3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 7 11 PF00082 0.535
DEG_SPOP_SBC_1 39 43 PF00917 0.292
DOC_MAPK_MEF2A_6 7 15 PF00069 0.322
DOC_WW_Pin1_4 23 28 PF00397 0.539
LIG_BIR_II_1 1 5 PF00653 0.368
LIG_FHA_1 80 86 PF00498 0.195
LIG_PDZ_Class_2 84 89 PF00595 0.248
LIG_PTB_Apo_2 46 53 PF02174 0.280
LIG_PTB_Phospho_1 46 52 PF10480 0.278
LIG_SUMO_SIM_par_1 14 20 PF11976 0.403
MOD_GSK3_1 23 30 PF00069 0.572
MOD_NEK2_1 1 6 PF00069 0.454
MOD_PIKK_1 40 46 PF00454 0.314
MOD_ProDKin_1 23 29 PF00069 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E9 Leptomonas seymouri 39% 86%
A0A0N1II34 Leptomonas seymouri 39% 100%
A4H445 Leishmania braziliensis 53% 71%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS