Ef-hand protein 5, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ef-hand protein 5, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6E1_LEIDO

TriTrypDb:

LdBPK_090960.1 , LdCL_090015000 , LDHU3_09.1110

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6E1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.669
CLV_PCSK_KEX2_1	15	17	PF00082	0.666
CLV_PCSK_KEX2_1	20	22	PF00082	0.629
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.703
CLV_PCSK_PC7_1	16	22	PF00082	0.599
CLV_PCSK_SKI1_1	119	123	PF00082	0.491
CLV_PCSK_SKI1_1	136	140	PF00082	0.461
CLV_PCSK_SKI1_1	33	37	PF00082	0.660
CLV_PCSK_SKI1_1	49	53	PF00082	0.582
CLV_PCSK_SKI1_1	63	67	PF00082	0.405
DEG_APCC_KENBOX_2	55	59	PF00400	0.371
DOC_MAPK_gen_1	135	143	PF00069	0.601
DOC_MAPK_MEF2A_6	174	183	PF00069	0.505
DOC_USP7_MATH_1	161	165	PF00917	0.598
DOC_USP7_MATH_1	7	11	PF00917	0.636
DOC_USP7_UBL2_3	63	67	PF12436	0.460
DOC_WW_Pin1_4	5	10	PF00397	0.694
LIG_14-3-3_CanoR_1	119	125	PF00244	0.644
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_FHA_1	105	111	PF00498	0.437
LIG_FHA_1	128	134	PF00498	0.467
LIG_FHA_1	92	98	PF00498	0.501
LIG_FHA_2	161	167	PF00498	0.673
LIG_FHA_2	74	80	PF00498	0.493
LIG_LIR_Gen_1	120	126	PF02991	0.658
LIG_LIR_Gen_1	171	180	PF02991	0.431
LIG_LIR_Gen_1	98	106	PF02991	0.468
LIG_LIR_Nem_3	120	125	PF02991	0.479
LIG_LIR_Nem_3	171	175	PF02991	0.444
LIG_LIR_Nem_3	46	51	PF02991	0.518
LIG_LIR_Nem_3	64	69	PF02991	0.466
LIG_LIR_Nem_3	98	102	PF02991	0.465
LIG_NRBOX	178	184	PF00104	0.459
LIG_Pex14_2	138	142	PF04695	0.480
LIG_SH2_CRK	172	176	PF00017	0.514
LIG_SH2_CRK	48	52	PF00017	0.579
LIG_SUMO_SIM_anti_2	155	166	PF11976	0.539
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.455
LIG_TRAF2_1	114	117	PF00917	0.532
LIG_TRAF2_1	150	153	PF00917	0.465
LIG_TRAF2_1	163	166	PF00917	0.457
LIG_TRAF2_1	76	79	PF00917	0.460
LIG_TYR_ITIM	170	175	PF00017	0.529
LIG_UBA3_1	103	108	PF00899	0.595
MOD_CK1_1	120	126	PF00069	0.492
MOD_CK1_1	25	31	PF00069	0.613
MOD_CK2_1	111	117	PF00069	0.515
MOD_CK2_1	141	147	PF00069	0.489
MOD_CK2_1	160	166	PF00069	0.421
MOD_CK2_1	73	79	PF00069	0.459
MOD_GlcNHglycan	119	122	PF01048	0.495
MOD_GlcNHglycan	144	147	PF01048	0.693
MOD_GlcNHglycan	149	152	PF01048	0.485
MOD_GlcNHglycan	24	27	PF01048	0.650
MOD_GlcNHglycan	28	31	PF01048	0.594
MOD_GlcNHglycan	38	41	PF01048	0.380
MOD_GlcNHglycan	52	55	PF01048	0.567
MOD_GSK3_1	120	127	PF00069	0.477
MOD_GSK3_1	142	149	PF00069	0.597
MOD_GSK3_1	22	29	PF00069	0.568
MOD_GSK3_1	5	12	PF00069	0.646
MOD_N-GLC_1	127	132	PF02516	0.577
MOD_N-GLC_1	36	41	PF02516	0.544
MOD_NEK2_1	141	146	PF00069	0.479
MOD_NEK2_1	36	41	PF00069	0.544
MOD_PIKK_1	9	15	PF00454	0.670
MOD_Plk_1	111	117	PF00069	0.548
MOD_Plk_1	91	97	PF00069	0.617
MOD_Plk_2-3	111	117	PF00069	0.658
MOD_ProDKin_1	5	11	PF00069	0.697
MOD_SUMO_rev_2	109	115	PF00179	0.599
TRG_DiLeu_BaEn_1	101	106	PF01217	0.536
TRG_DiLeu_BaEn_1	153	158	PF01217	0.505
TRG_DiLeu_BaEn_1	178	183	PF01217	0.455
TRG_DiLeu_BaEn_1	80	85	PF01217	0.567
TRG_DiLeu_BaEn_2	97	103	PF01217	0.594
TRG_DiLeu_BaEn_4	155	161	PF01217	0.623
TRG_ENDOCYTIC_2	172	175	PF00928	0.442
TRG_ENDOCYTIC_2	48	51	PF00928	0.611
TRG_ER_diArg_1	19	21	PF00400	0.605
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	27%	100%
A0A0N0P2H6	Leptomonas seymouri	74%	100%
A0A0S4IS38	Bodo saltans	27%	100%
A0A0S4IXG9	Bodo saltans	25%	100%
A0A0S4J1R1	Bodo saltans	35%	100%
A0A0S4J7U6	Bodo saltans	27%	100%
A0A0S4JFC8	Bodo saltans	27%	100%
A0A1X0NEW2	Trypanosomatidae	30%	97%
A0A1X0NMM5	Trypanosomatidae	27%	100%
A0A1X0NN63	Trypanosomatidae	48%	96%
A0A1X0P607	Trypanosomatidae	23%	100%
A0A3R7LX73	Trypanosoma rangeli	45%	92%
A0A422N447	Trypanosoma rangeli	25%	100%
A0A422N5Z1	Trypanosoma rangeli	30%	98%
A2WN93	Oryza sativa subsp. indica	27%	100%
A2WNH1	Oryza sativa subsp. indica	25%	100%
A2Y609	Oryza sativa subsp. indica	28%	100%
A4H5R8	Leishmania braziliensis	81%	100%
A4H5R9	Leishmania braziliensis	27%	100%
A4HU12	Leishmania infantum	99%	100%
A4HU13	Leishmania infantum	27%	100%
B1PSN3	Leishmania donovani	27%	100%
D0A9H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	95%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AMU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O02367	Ciona intestinalis	27%	100%
O23320	Arabidopsis thaliana	26%	100%
O82018	Mougeotia scalaris	27%	100%
O82659	Arabidopsis thaliana	28%	100%
O96081	Halocynthia roretzi	27%	100%
O96102	Physarum polycephalum	27%	100%
O97341	Suberites domuncula	27%	100%
P02588	Gallus gallus	28%	100%
P02589	Pelophylax lessonae	31%	100%
P02591	Oryctolagus cuniculus	25%	100%
P02595	Patinopecten sp.	27%	100%
P02597	Gallus gallus	26%	100%
P02599	Dictyostelium discoideum	26%	100%
P04352	Chlamydomonas reinhardtii	28%	100%
P04353	Spinacia oleracea	27%	100%
P04464	Triticum aestivum	27%	100%
P05434	Chlamydomonas reinhardtii	28%	100%
P05936	Coturnix japonica	26%	100%
P09860	Gallus gallus	27%	100%
P0DH95	Arabidopsis thaliana	28%	100%
P0DH96	Arabidopsis thaliana	28%	100%
P0DH97	Arabidopsis thaliana	27%	100%
P0DH98	Arabidopsis thaliana	27%	100%
P10246	Meleagris gallopavo	28%	100%
P11118	Euglena gracilis	29%	100%
P17928	Medicago sativa	27%	100%
P18061	Trypanosoma cruzi	27%	100%
P19123	Mus musculus	25%	100%
P25027	Trypanosoma brucei brucei	42%	97%
P27482	Homo sapiens	24%	100%
P41040	Zea mays	27%	100%
P41045	Leishmania tarentolae	88%	100%
P41048	Trypanosoma cruzi	45%	89%
P41049	Trypanosoma cruzi	44%	89%
P41210	Atriplex nummularia	26%	100%
P53440	Naegleria gruberi	26%	100%
P59220	Arabidopsis thaliana	26%	100%
P62162	Hordeum vulgare	27%	100%
P62163	Glycine max	27%	100%
P62184	Renilla reniformis	27%	100%
P62199	Petunia hybrida	26%	100%
P62200	Daucus carota	26%	100%
P62201	Lilium longiflorum	26%	100%
P62202	Bryonia dioica	26%	100%
P63315	Bos taurus	25%	100%
P63316	Homo sapiens	25%	100%
P63317	Sus scrofa	25%	100%
P69097	Trypanosoma brucei brucei	27%	100%
P69098	Trypanosoma brucei gambiense	27%	100%
P81660	Anguilla anguilla	33%	100%
P93087	Capsicum annuum	25%	100%
P93171	Helianthus annuus	26%	100%
Q03509	Arabidopsis thaliana	27%	100%
Q06827	Scherffelia dubia	28%	100%
Q0JNL7	Oryza sativa subsp. japonica	26%	100%
Q0JNS6	Oryza sativa subsp. japonica	27%	100%
Q2R1Z5	Oryza sativa subsp. japonica	24%	100%
Q2TBN3	Bos taurus	28%	100%
Q338P8	Oryza sativa subsp. japonica	26%	97%
Q4QHT2	Leishmania major	27%	100%
Q4QHT4	Leishmania major	98%	100%
Q5U206	Rattus norvegicus	26%	100%
Q682T9	Arabidopsis thaliana	27%	100%
Q6F332	Oryza sativa subsp. japonica	28%	100%
Q7DMN9	Solanum tuberosum	25%	100%
Q7F0J0	Oryza sativa subsp. japonica	28%	100%
Q7Y052	Euphorbia characias	26%	100%
Q84MN0	Oryza sativa subsp. japonica	28%	100%
Q95NI4	Halichondria okadai	28%	100%
Q9CQ46	Mus musculus	27%	100%
Q9D6P8	Mus musculus	25%	100%
Q9R1K9	Mus musculus	27%	100%
V5DQ66	Trypanosoma cruzi	30%	98%