Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6E0_LEIDO

TriTrypDb:

LdBPK_090910.1 , LdCL_090014500 , LDHU3_09.1060

Length:

106

Annotations

LeishMANIAdb annotations

A very small protein, that could also possibly be organellar (mitochondrial). A transit peptide cannot be excluded in the sequence.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

A0A3S5H6E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6E0

Function

Biological processes
Term	Name	Level	Count
GO:0008535	respiratory chain complex IV assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0017004	cytochrome complex assembly	6	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.455
CLV_NRD_NRD_1	27	29	PF00675	0.401
CLV_NRD_NRD_1	54	56	PF00675	0.589
CLV_PCSK_FUR_1	52	56	PF00082	0.630
CLV_PCSK_KEX2_1	22	24	PF00082	0.425
CLV_PCSK_KEX2_1	27	29	PF00082	0.387
CLV_PCSK_KEX2_1	54	56	PF00082	0.589
CLV_PCSK_KEX2_1	6	8	PF00082	0.520
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.479
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.520
CLV_PCSK_PC7_1	23	29	PF00082	0.457
DEG_Nend_UBRbox_3	1	3	PF02207	0.687
DOC_MAPK_gen_1	67	75	PF00069	0.455
DOC_PP2B_LxvP_1	75	78	PF13499	0.512
LIG_14-3-3_CanoR_1	14	21	PF00244	0.676
LIG_14-3-3_CanoR_1	23	31	PF00244	0.642
LIG_APCC_ABBA_1	44	49	PF00400	0.525
LIG_FHA_1	14	20	PF00498	0.678
LIG_LIR_Gen_1	85	91	PF02991	0.464
LIG_LIR_LC3C_4	26	31	PF02991	0.626
LIG_LIR_Nem_3	85	90	PF02991	0.476
LIG_RPA_C_Fungi	23	35	PF08784	0.415
LIG_SH2_CRK	41	45	PF00017	0.410
LIG_SH2_NCK_1	41	45	PF00017	0.386
LIG_SH2_STAP1	41	45	PF00017	0.386
LIG_SH2_STAT5	4	7	PF00017	0.615
LIG_SH2_STAT5	45	48	PF00017	0.517
LIG_SH2_STAT5	8	11	PF00017	0.570
MOD_GlcNHglycan	41	44	PF01048	0.451
MOD_PK_1	55	61	PF00069	0.501
MOD_PKA_1	22	28	PF00069	0.637
MOD_PKA_2	13	19	PF00069	0.688
MOD_PKA_2	22	28	PF00069	0.637
TRG_ENDOCYTIC_2	41	44	PF00928	0.357
TRG_ENDOCYTIC_2	87	90	PF00928	0.597
TRG_ER_diArg_1	27	29	PF00400	0.540
TRG_ER_diArg_1	52	55	PF00400	0.545
TRG_ER_diArg_1	68	71	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P760	Leptomonas seymouri	66%	100%
A0A0S4IM31	Bodo saltans	41%	85%
A4H5R7	Leishmania braziliensis	81%	100%
A4HU07	Leishmania infantum	100%	100%
D0A9H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AMT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QHT8	Leishmania major	93%	100%