Cilia- and flagella-associated protein 299

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4464), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6D9_LEIDO

TriTrypDb:

LdBPK_090830.1 , LdCL_090013700 , LDHU3_09.0980

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A0A3S5H6D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6D9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.515
CLV_C14_Caspase3-7	67	71	PF00656	0.487
CLV_NRD_NRD_1	105	107	PF00675	0.260
CLV_NRD_NRD_1	222	224	PF00675	0.235
CLV_NRD_NRD_1	260	262	PF00675	0.224
CLV_NRD_NRD_1	72	74	PF00675	0.315
CLV_PCSK_KEX2_1	104	106	PF00082	0.249
CLV_PCSK_KEX2_1	130	132	PF00082	0.243
CLV_PCSK_KEX2_1	183	185	PF00082	0.250
CLV_PCSK_KEX2_1	220	222	PF00082	0.235
CLV_PCSK_KEX2_1	260	262	PF00082	0.224
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.287
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.264
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.259
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.235
CLV_PCSK_SKI1_1	139	143	PF00082	0.275
CLV_PCSK_SKI1_1	178	182	PF00082	0.249
CLV_PCSK_SKI1_1	42	46	PF00082	0.274
CLV_PCSK_SKI1_1	83	87	PF00082	0.249
CLV_Separin_Metazoa	133	137	PF03568	0.419
DOC_CYCLIN_RxL_1	175	185	PF00134	0.503
DOC_MAPK_gen_1	136	146	PF00069	0.427
DOC_MAPK_gen_1	218	228	PF00069	0.435
DOC_USP7_MATH_1	182	186	PF00917	0.487
DOC_USP7_MATH_2	235	241	PF00917	0.539
DOC_USP7_UBL2_3	175	179	PF12436	0.495
DOC_USP7_UBL2_3	220	224	PF12436	0.435
DOC_WW_Pin1_4	119	124	PF00397	0.487
DOC_WW_Pin1_4	19	24	PF00397	0.688
DOC_WW_Pin1_4	199	204	PF00397	0.515
DOC_WW_Pin1_4	229	234	PF00397	0.431
LIG_14-3-3_CanoR_1	164	173	PF00244	0.433
LIG_14-3-3_CanoR_1	29	33	PF00244	0.722
LIG_APCC_ABBAyCdc20_2	223	229	PF00400	0.515
LIG_BRCT_BRCA1_1	166	170	PF00533	0.494
LIG_BRCT_BRCA1_1	201	205	PF00533	0.435
LIG_Clathr_ClatBox_1	63	67	PF01394	0.515
LIG_FHA_1	135	141	PF00498	0.515
LIG_FHA_1	192	198	PF00498	0.435
LIG_FHA_1	20	26	PF00498	0.543
LIG_FHA_1	202	208	PF00498	0.435
LIG_FHA_1	98	104	PF00498	0.529
LIG_FHA_2	47	53	PF00498	0.466
LIG_FHA_2	57	63	PF00498	0.414
LIG_KLC1_Yacidic_2	62	67	PF13176	0.487
LIG_LIR_Gen_1	202	213	PF02991	0.424
LIG_LIR_Nem_3	156	161	PF02991	0.435
LIG_LIR_Nem_3	167	173	PF02991	0.435
LIG_LIR_Nem_3	202	208	PF02991	0.424
LIG_LIR_Nem_3	46	50	PF02991	0.427
LIG_Pex14_1	11	15	PF04695	0.513
LIG_Pex14_2	170	174	PF04695	0.435
LIG_SH2_GRB2like	189	192	PF00017	0.433
LIG_SH2_NCK_1	255	259	PF00017	0.441
LIG_SH2_SRC	255	258	PF00017	0.435
LIG_SH2_STAP1	50	54	PF00017	0.442
LIG_SH2_STAT3	53	56	PF00017	0.435
LIG_SH2_STAT5	149	152	PF00017	0.454
LIG_SH2_STAT5	158	161	PF00017	0.410
LIG_SH2_STAT5	173	176	PF00017	0.433
LIG_SH2_STAT5	249	252	PF00017	0.424
LIG_SH2_STAT5	53	56	PF00017	0.435
LIG_SH2_STAT5	65	68	PF00017	0.435
LIG_SH3_3	227	233	PF00018	0.449
LIG_SH3_5	245	249	PF00018	0.539
LIG_TRAF2_1	151	154	PF00917	0.483
LIG_TYR_ITIM	253	258	PF00017	0.515
LIG_UBA3_1	124	130	PF00899	0.466
MOD_CK1_1	185	191	PF00069	0.470
MOD_CK1_1	201	207	PF00069	0.344
MOD_CK2_1	148	154	PF00069	0.483
MOD_CK2_1	231	237	PF00069	0.539
MOD_CK2_1	45	51	PF00069	0.429
MOD_CK2_1	84	90	PF00069	0.435
MOD_GlcNHglycan	107	110	PF01048	0.285
MOD_GlcNHglycan	113	116	PF01048	0.243
MOD_GlcNHglycan	150	153	PF01048	0.254
MOD_GlcNHglycan	154	158	PF01048	0.237
MOD_GlcNHglycan	210	213	PF01048	0.186
MOD_GSK3_1	119	126	PF00069	0.476
MOD_GSK3_1	15	22	PF00069	0.686
MOD_N-GLC_1	199	204	PF02516	0.235
MOD_N-GLC_1	237	242	PF02516	0.254
MOD_NEK2_1	134	139	PF00069	0.487
MOD_NEK2_1	198	203	PF00069	0.447
MOD_NEK2_1	208	213	PF00069	0.522
MOD_NEK2_1	45	50	PF00069	0.435
MOD_NEK2_1	97	102	PF00069	0.515
MOD_PIKK_1	15	21	PF00454	0.524
MOD_PKA_1	105	111	PF00069	0.487
MOD_PKA_2	105	111	PF00069	0.515
MOD_PKA_2	28	34	PF00069	0.617
MOD_Plk_1	153	159	PF00069	0.449
MOD_Plk_1	185	191	PF00069	0.435
MOD_Plk_1	45	51	PF00069	0.461
MOD_Plk_2-3	46	52	PF00069	0.432
MOD_Plk_4	139	145	PF00069	0.429
MOD_Plk_4	185	191	PF00069	0.435
MOD_Plk_4	193	199	PF00069	0.435
MOD_Plk_4	21	27	PF00069	0.547
MOD_ProDKin_1	119	125	PF00069	0.487
MOD_ProDKin_1	19	25	PF00069	0.692
MOD_ProDKin_1	199	205	PF00069	0.515
MOD_ProDKin_1	229	235	PF00069	0.431
MOD_SUMO_for_1	129	132	PF00179	0.466
MOD_SUMO_for_1	174	177	PF00179	0.452
MOD_SUMO_rev_2	171	181	PF00179	0.515
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.437
TRG_ENDOCYTIC_2	255	258	PF00928	0.461
TRG_ER_diArg_1	163	166	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.249

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0T4	Leptomonas seymouri	91%	100%
A0A0S4IMY7	Bodo saltans	68%	100%
A0A1X0NN64	Trypanosomatidae	66%	100%
A0A422N781	Trypanosoma rangeli	70%	100%
A2AVJ0	Danio rerio	47%	100%
A4H5Q9	Leishmania braziliensis	92%	100%
A4HTZ9	Leishmania infantum	100%	100%
D0A9G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AMS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q2YDG2	Bos taurus	50%	100%
Q4QHU6	Leishmania major	97%	100%
Q5PQ44	Xenopus laevis	52%	100%
Q6V702	Homo sapiens	49%	100%
Q810M1	Mus musculus	49%	100%