Zeta toxin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zeta toxin, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6D7_LEIDO

TriTrypDb:

LdBPK_090700.1 , LdCL_090012100 , LDHU3_09.0840

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6D7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	327	329	PF00675	0.510
CLV_NRD_NRD_1	477	479	PF00675	0.690
CLV_NRD_NRD_1	480	482	PF00675	0.716
CLV_NRD_NRD_1	601	603	PF00675	0.674
CLV_NRD_NRD_1	93	95	PF00675	0.417
CLV_PCSK_FUR_1	475	479	PF00082	0.633
CLV_PCSK_KEX2_1	327	329	PF00082	0.531
CLV_PCSK_KEX2_1	346	348	PF00082	0.443
CLV_PCSK_KEX2_1	477	479	PF00082	0.696
CLV_PCSK_KEX2_1	480	482	PF00082	0.723
CLV_PCSK_KEX2_1	601	603	PF00082	0.674
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.443
CLV_PCSK_PC7_1	323	329	PF00082	0.500
CLV_PCSK_SKI1_1	249	253	PF00082	0.606
CLV_PCSK_SKI1_1	425	429	PF00082	0.529
CLV_PCSK_SKI1_1	481	485	PF00082	0.618
CLV_PCSK_SKI1_1	555	559	PF00082	0.711
CLV_PCSK_SKI1_1	602	606	PF00082	0.664
CLV_PCSK_SKI1_1	76	80	PF00082	0.576
CLV_PCSK_SKI1_1	81	85	PF00082	0.536
DEG_APCC_DBOX_1	75	83	PF00400	0.599
DEG_COP1_1	9	18	PF00400	0.754
DEG_SCF_FBW7_1	127	134	PF00400	0.784
DEG_SPOP_SBC_1	529	533	PF00917	0.670
DOC_CKS1_1	15	20	PF01111	0.732
DOC_CYCLIN_RxL_1	552	559	PF00134	0.739
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.682
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.672
DOC_MAPK_DCC_7	137	147	PF00069	0.669
DOC_MAPK_gen_1	327	333	PF00069	0.466
DOC_MAPK_gen_1	346	352	PF00069	0.454
DOC_MAPK_gen_1	543	552	PF00069	0.761
DOC_MAPK_MEF2A_6	137	145	PF00069	0.678
DOC_MAPK_MEF2A_6	211	218	PF00069	0.524
DOC_MAPK_MEF2A_6	354	362	PF00069	0.412
DOC_MAPK_RevD_3	312	328	PF00069	0.479
DOC_MAPK_RevD_3	331	347	PF00069	0.448
DOC_PP2B_LxvP_1	115	118	PF13499	0.616
DOC_PP2B_LxvP_1	139	142	PF13499	0.670
DOC_PP2B_LxvP_1	169	172	PF13499	0.503
DOC_PP2B_LxvP_1	237	240	PF13499	0.513
DOC_PP4_FxxP_1	132	135	PF00568	0.698
DOC_USP7_MATH_1	206	210	PF00917	0.620
DOC_USP7_MATH_1	224	228	PF00917	0.216
DOC_USP7_MATH_1	528	532	PF00917	0.744
DOC_USP7_MATH_1	607	611	PF00917	0.686
DOC_WW_Pin1_4	123	128	PF00397	0.686
DOC_WW_Pin1_4	131	136	PF00397	0.653
DOC_WW_Pin1_4	3	8	PF00397	0.758
DOC_WW_Pin1_4	45	50	PF00397	0.766
DOC_WW_Pin1_4	524	529	PF00397	0.751
DOC_WW_Pin1_4	9	14	PF00397	0.684
LIG_14-3-3_CanoR_1	200	204	PF00244	0.395
LIG_14-3-3_CanoR_1	379	384	PF00244	0.620
LIG_14-3-3_CanoR_1	389	395	PF00244	0.524
LIG_14-3-3_CanoR_1	40	49	PF00244	0.690
LIG_14-3-3_CanoR_1	493	499	PF00244	0.634
LIG_14-3-3_CanoR_1	543	552	PF00244	0.659
LIG_14-3-3_CanoR_1	601	605	PF00244	0.699
LIG_14-3-3_CanoR_1	92	101	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BRCT_BRCA1_1	128	132	PF00533	0.671
LIG_BRCT_BRCA1_1	590	594	PF00533	0.668
LIG_FAT_LD_1	317	325	PF03623	0.450
LIG_FHA_1	114	120	PF00498	0.601
LIG_FHA_1	243	249	PF00498	0.411
LIG_FHA_1	457	463	PF00498	0.608
LIG_FHA_2	275	281	PF00498	0.617
LIG_FHA_2	419	425	PF00498	0.607
LIG_FHA_2	431	437	PF00498	0.490
LIG_HP1_1	118	122	PF01393	0.657
LIG_LIR_Apic_2	129	135	PF02991	0.702
LIG_LIR_Gen_1	199	206	PF02991	0.486
LIG_LIR_Gen_1	424	435	PF02991	0.511
LIG_LIR_Gen_1	437	448	PF02991	0.524
LIG_LIR_Nem_3	199	204	PF02991	0.488
LIG_LIR_Nem_3	260	266	PF02991	0.522
LIG_LIR_Nem_3	29	34	PF02991	0.614
LIG_LIR_Nem_3	393	397	PF02991	0.472
LIG_LIR_Nem_3	424	430	PF02991	0.527
LIG_LIR_Nem_3	437	443	PF02991	0.516
LIG_LIR_Nem_3	72	77	PF02991	0.531
LIG_NRBOX	100	106	PF00104	0.509
LIG_NRBOX	320	326	PF00104	0.500
LIG_OCRL_FandH_1	426	438	PF00620	0.522
LIG_Pex14_2	263	267	PF04695	0.508
LIG_RPA_C_Fungi	384	396	PF08784	0.435
LIG_RPA_C_Plants	384	395	PF08784	0.540
LIG_SH2_CRK	440	444	PF00017	0.528
LIG_SH2_NCK_1	109	113	PF00017	0.597
LIG_SH2_STAP1	109	113	PF00017	0.636
LIG_SH2_STAT3	306	309	PF00017	0.459
LIG_SH2_STAT5	109	112	PF00017	0.660
LIG_SH2_STAT5	167	170	PF00017	0.521
LIG_SH2_STAT5	342	345	PF00017	0.458
LIG_SH2_STAT5	390	393	PF00017	0.522
LIG_SH3_3	10	16	PF00018	0.810
LIG_SH3_3	138	144	PF00018	0.678
LIG_SH3_3	359	365	PF00018	0.450
LIG_SH3_3	513	519	PF00018	0.707
LIG_SH3_3	629	635	PF00018	0.716
LIG_SUMO_SIM_par_1	116	123	PF11976	0.669
LIG_SUMO_SIM_par_1	143	149	PF11976	0.657
LIG_SUMO_SIM_par_1	412	419	PF11976	0.501
LIG_WRC_WIRS_1	391	396	PF05994	0.503
MOD_CDC14_SPxK_1	134	137	PF00782	0.609
MOD_CDK_SPxK_1	127	133	PF00069	0.713
MOD_CK1_1	126	132	PF00069	0.652
MOD_CK1_1	199	205	PF00069	0.396
MOD_CK1_1	244	250	PF00069	0.478
MOD_CK1_1	45	51	PF00069	0.769
MOD_CK1_1	491	497	PF00069	0.707
MOD_CK1_1	531	537	PF00069	0.703
MOD_CK1_1	566	572	PF00069	0.731
MOD_CK1_1	6	12	PF00069	0.756
MOD_CK1_1	72	78	PF00069	0.575
MOD_CK2_1	20	26	PF00069	0.689
MOD_CK2_1	266	272	PF00069	0.483
MOD_CK2_1	293	299	PF00069	0.585
MOD_CK2_1	366	372	PF00069	0.604
MOD_CK2_1	430	436	PF00069	0.593
MOD_CK2_1	47	53	PF00069	0.794
MOD_GlcNHglycan	105	108	PF01048	0.524
MOD_GlcNHglycan	154	157	PF01048	0.634
MOD_GlcNHglycan	208	211	PF01048	0.474
MOD_GlcNHglycan	221	224	PF01048	0.323
MOD_GlcNHglycan	283	286	PF01048	0.701
MOD_GlcNHglycan	288	291	PF01048	0.715
MOD_GlcNHglycan	295	298	PF01048	0.613
MOD_GlcNHglycan	481	484	PF01048	0.764
MOD_GlcNHglycan	49	52	PF01048	0.723
MOD_GlcNHglycan	496	499	PF01048	0.809
MOD_GlcNHglycan	545	548	PF01048	0.767
MOD_GlcNHglycan	581	584	PF01048	0.691
MOD_GSK3_1	103	110	PF00069	0.542
MOD_GSK3_1	123	130	PF00069	0.653
MOD_GSK3_1	172	179	PF00069	0.553
MOD_GSK3_1	224	231	PF00069	0.352
MOD_GSK3_1	41	48	PF00069	0.682
MOD_GSK3_1	430	437	PF00069	0.506
MOD_GSK3_1	481	488	PF00069	0.738
MOD_GSK3_1	524	531	PF00069	0.815
MOD_GSK3_1	574	581	PF00069	0.723
MOD_GSK3_1	633	640	PF00069	0.686
MOD_N-GLC_1	123	128	PF02516	0.523
MOD_N-GLC_1	159	164	PF02516	0.559
MOD_N-GLC_1	286	291	PF02516	0.571
MOD_N-GLC_1	488	493	PF02516	0.742
MOD_NEK2_1	1	6	PF00069	0.784
MOD_NEK2_1	151	156	PF00069	0.565
MOD_NEK2_1	232	237	PF00069	0.411
MOD_NEK2_1	266	271	PF00069	0.459
MOD_NEK2_1	350	355	PF00069	0.573
MOD_NEK2_1	416	421	PF00069	0.499
MOD_NEK2_1	423	428	PF00069	0.535
MOD_NEK2_1	430	435	PF00069	0.488
MOD_NEK2_1	461	466	PF00069	0.532
MOD_NEK2_1	614	619	PF00069	0.780
MOD_NEK2_2	390	395	PF00069	0.577
MOD_PIKK_1	159	165	PF00454	0.727
MOD_PIKK_1	232	238	PF00454	0.411
MOD_PK_1	327	333	PF00069	0.466
MOD_PKA_1	327	333	PF00069	0.466
MOD_PKA_2	199	205	PF00069	0.396
MOD_PKA_2	327	333	PF00069	0.441
MOD_PKA_2	479	485	PF00069	0.674
MOD_PKA_2	566	572	PF00069	0.731
MOD_PKA_2	600	606	PF00069	0.760
MOD_PKA_2	93	99	PF00069	0.608
MOD_PKB_1	377	385	PF00069	0.601
MOD_Plk_1	423	429	PF00069	0.519
MOD_Plk_4	228	234	PF00069	0.436
MOD_Plk_4	26	32	PF00069	0.541
MOD_Plk_4	327	333	PF00069	0.466
MOD_Plk_4	430	436	PF00069	0.522
MOD_Plk_4	574	580	PF00069	0.811
MOD_Plk_4	633	639	PF00069	0.806
MOD_ProDKin_1	123	129	PF00069	0.695
MOD_ProDKin_1	131	137	PF00069	0.641
MOD_ProDKin_1	14	20	PF00069	0.598
MOD_ProDKin_1	3	9	PF00069	0.759
MOD_ProDKin_1	45	51	PF00069	0.769
MOD_ProDKin_1	524	530	PF00069	0.753
MOD_SUMO_rev_2	482	488	PF00179	0.566
TRG_DiLeu_BaEn_1	334	339	PF01217	0.443
TRG_DiLeu_BaEn_1	633	638	PF01217	0.810
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.476
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.596
TRG_ENDOCYTIC_2	440	443	PF00928	0.560
TRG_ER_diArg_1	252	255	PF00400	0.522
TRG_ER_diArg_1	376	379	PF00400	0.561
TRG_ER_diArg_1	474	477	PF00400	0.657
TRG_ER_diArg_1	478	481	PF00400	0.694
TRG_ER_diArg_1	542	545	PF00400	0.793
TRG_ER_diArg_1	600	602	PF00400	0.731
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I622	Leptomonas seymouri	47%	96%
A4H5P6	Leishmania braziliensis	78%	100%
A4HTY6	Leishmania infantum	99%	100%
E9AMR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QHV9	Leishmania major	90%	97%