Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6D6_LEIDO

TriTrypDb:

LdBPK_090630.1 , LdCL_090011400 , LDHU3_09.0770

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 75

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 28, no: 6
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	35
GO:0042995	cell projection	2	35
GO:0043226	organelle	2	35
GO:0043227	membrane-bounded organelle	3	35
GO:0110165	cellular anatomical entity	1	35
GO:0120025	plasma membrane bounded cell projection	3	35
GO:0016020	membrane	2	10

Expansion

Sequence features

A0A3S5H6D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.385
CLV_PCSK_KEX2_1	6	8	PF00082	0.385
CLV_PCSK_SKI1_1	219	223	PF00082	0.462
CLV_PCSK_SKI1_1	29	33	PF00082	0.593
DEG_APCC_DBOX_1	167	175	PF00400	0.237
DEG_MDM2_SWIB_1	118	125	PF02201	0.281
DOC_CYCLIN_RxL_1	126	136	PF00134	0.221
DOC_MAPK_gen_1	126	133	PF00069	0.312
DOC_PP1_RVXF_1	127	134	PF00149	0.237
DOC_USP7_MATH_1	148	152	PF00917	0.354
DOC_USP7_MATH_1	162	166	PF00917	0.386
DOC_USP7_MATH_1	228	232	PF00917	0.328
DOC_USP7_MATH_1	249	253	PF00917	0.372
DOC_USP7_MATH_1	35	39	PF00917	0.281
DOC_USP7_MATH_1	67	71	PF00917	0.309
DOC_WW_Pin1_4	209	214	PF00397	0.257
LIG_14-3-3_CanoR_1	150	156	PF00244	0.254
LIG_14-3-3_CanoR_1	168	172	PF00244	0.267
LIG_14-3-3_CanoR_1	219	229	PF00244	0.257
LIG_14-3-3_CanoR_1	29	39	PF00244	0.407
LIG_14-3-3_CanoR_1	6	11	PF00244	0.391
LIG_Actin_WH2_2	145	160	PF00022	0.229
LIG_Actin_WH2_2	170	187	PF00022	0.299
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BRCT_BRCA1_1	222	226	PF00533	0.294
LIG_deltaCOP1_diTrp_1	61	66	PF00928	0.267
LIG_DLG_GKlike_1	6	13	PF00625	0.385
LIG_FHA_1	152	158	PF00498	0.391
LIG_FHA_1	220	226	PF00498	0.293
LIG_FHA_1	272	278	PF00498	0.262
LIG_FHA_1	76	82	PF00498	0.376
LIG_FHA_1	85	91	PF00498	0.384
LIG_FHA_2	108	114	PF00498	0.412
LIG_FHA_2	57	63	PF00498	0.280
LIG_GBD_Chelix_1	269	277	PF00786	0.290
LIG_LIR_Gen_1	145	152	PF02991	0.364
LIG_LIR_Gen_1	223	234	PF02991	0.485
LIG_LIR_Nem_3	121	125	PF02991	0.294
LIG_LIR_Nem_3	136	142	PF02991	0.321
LIG_LIR_Nem_3	65	69	PF02991	0.295
LIG_PDZ_Class_2	280	285	PF00595	0.553
LIG_Pex14_2	118	122	PF04695	0.288
LIG_Pex14_2	43	47	PF04695	0.272
LIG_PTB_Apo_2	80	87	PF02174	0.246
LIG_RPA_C_Fungi	1	13	PF08784	0.333
LIG_SH2_PTP2	19	22	PF00017	0.180
LIG_SH2_STAT5	19	22	PF00017	0.180
LIG_SH2_STAT5	194	197	PF00017	0.292
LIG_SH2_STAT5	68	71	PF00017	0.399
LIG_SH3_3	230	236	PF00018	0.657
LIG_SH3_3	46	52	PF00018	0.255
LIG_SUMO_SIM_anti_2	74	82	PF11976	0.266
LIG_SUMO_SIM_par_1	268	274	PF11976	0.256
LIG_SUMO_SIM_par_1	77	82	PF11976	0.255
LIG_TRAF2_2	255	260	PF00917	0.420
LIG_TYR_ITIM	17	22	PF00017	0.180
LIG_WRC_WIRS_1	44	49	PF05994	0.254
LIG_WW_1	255	258	PF00397	0.412
MOD_CK1_1	151	157	PF00069	0.365
MOD_CK1_1	212	218	PF00069	0.413
MOD_CK1_1	56	62	PF00069	0.576
MOD_CK2_1	86	92	PF00069	0.465
MOD_CMANNOS	63	66	PF00535	0.265
MOD_GlcNHglycan	160	163	PF01048	0.436
MOD_GlcNHglycan	222	225	PF01048	0.294
MOD_GlcNHglycan	230	233	PF01048	0.422
MOD_GlcNHglycan	98	101	PF01048	0.490
MOD_GSK3_1	138	145	PF00069	0.376
MOD_GSK3_1	158	165	PF00069	0.553
MOD_GSK3_1	184	191	PF00069	0.384
MOD_GSK3_1	215	222	PF00069	0.410
MOD_GSK3_1	43	50	PF00069	0.357
MOD_N-GLC_1	131	136	PF02516	0.357
MOD_N-GLC_1	158	163	PF02516	0.438
MOD_N-GLC_1	199	204	PF02516	0.500
MOD_N-GLC_1	75	80	PF02516	0.321
MOD_N-GLC_2	207	209	PF02516	0.344
MOD_NEK2_1	118	123	PF00069	0.396
MOD_NEK2_1	131	136	PF00069	0.316
MOD_NEK2_1	138	143	PF00069	0.380
MOD_NEK2_1	157	162	PF00069	0.485
MOD_NEK2_1	184	189	PF00069	0.395
MOD_NEK2_1	43	48	PF00069	0.276
MOD_NEK2_1	86	91	PF00069	0.386
MOD_OFUCOSY	64	71	PF10250	0.437
MOD_PKA_1	6	12	PF00069	0.200
MOD_PKA_2	167	173	PF00069	0.293
MOD_PKA_2	184	190	PF00069	0.326
MOD_PKA_2	6	12	PF00069	0.279
MOD_Plk_1	105	111	PF00069	0.391
MOD_Plk_1	199	205	PF00069	0.482
MOD_Plk_1	75	81	PF00069	0.256
MOD_Plk_4	151	157	PF00069	0.326
MOD_Plk_4	199	205	PF00069	0.506
MOD_Plk_4	212	218	PF00069	0.414
MOD_Plk_4	271	277	PF00069	0.277
MOD_Plk_4	53	59	PF00069	0.338
MOD_ProDKin_1	209	215	PF00069	0.288
TRG_ENDOCYTIC_2	19	22	PF00928	0.288
TRG_ER_diArg_1	6	8	PF00400	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E6	Leptomonas seymouri	28%	100%
A0A0N0P2L4	Leptomonas seymouri	27%	96%
A0A0N0P4M2	Leptomonas seymouri	35%	100%
A0A1X0NKN8	Trypanosomatidae	32%	99%
A0A3Q8I9A6	Leishmania donovani	31%	100%
A0A3Q8I9D0	Leishmania donovani	34%	100%
A0A3Q8IIJ9	Leishmania donovani	26%	100%
A0A3S7WP69	Leishmania donovani	29%	100%
A0A3S7WPB2	Leishmania donovani	29%	100%
A0A3S7X4J4	Leishmania donovani	26%	94%
A4H4D2	Leishmania braziliensis	30%	100%
A4H4G6	Leishmania braziliensis	28%	100%
A4H5P0	Leishmania braziliensis	70%	100%
A4HJC8	Leishmania braziliensis	24%	100%
A4HSL2	Leishmania infantum	30%	100%
A4HTX9	Leishmania infantum	99%	100%
A4HVB0	Leishmania infantum	25%	71%
A4I6S4	Leishmania infantum	26%	100%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ACQ0	Leishmania major	29%	100%
E9AG65	Leishmania infantum	28%	100%
E9AGG5	Leishmania infantum	30%	100%
E9AGH0	Leishmania infantum	29%	100%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	68%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q25331	Leishmania major	32%	74%
Q4Q6B6	Leishmania major	27%	100%
Q4Q6B7	Leishmania major	27%	100%
Q4QGJ4	Leishmania major	32%	74%
Q4QGJ7	Leishmania major	32%	76%
Q4QGK6	Leishmania major	32%	74%
Q4QGL4	Leishmania major	30%	72%
Q4QHW6	Leishmania major	92%	100%
Q4QJB2	Leishmania major	29%	100%
Q8GT95	Oryza sativa subsp. japonica	27%	86%