Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 3

Species:

Leishmania donovani

UniProt:

A0A3S5H6D5_LEIDO

TriTrypDb:

LdBPK_090570.1 , LdCL_090010800 , LDHU3_09.0700

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H6D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6D5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0071889	14-3-3 protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.693
CLV_NRD_NRD_1	265	267	PF00675	0.532
CLV_NRD_NRD_1	410	412	PF00675	0.449
CLV_NRD_NRD_1	463	465	PF00675	0.522
CLV_NRD_NRD_1	696	698	PF00675	0.546
CLV_NRD_NRD_1	715	717	PF00675	0.463
CLV_NRD_NRD_1	754	756	PF00675	0.691
CLV_PCSK_KEX2_1	214	216	PF00082	0.440
CLV_PCSK_KEX2_1	239	241	PF00082	0.460
CLV_PCSK_KEX2_1	410	412	PF00082	0.449
CLV_PCSK_KEX2_1	463	465	PF00082	0.522
CLV_PCSK_KEX2_1	616	618	PF00082	0.564
CLV_PCSK_KEX2_1	696	698	PF00082	0.527
CLV_PCSK_KEX2_1	715	717	PF00082	0.676
CLV_PCSK_KEX2_1	754	756	PF00082	0.691
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.440
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.460
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.564
CLV_PCSK_SKI1_1	112	116	PF00082	0.553
CLV_PCSK_SKI1_1	229	233	PF00082	0.469
CLV_PCSK_SKI1_1	342	346	PF00082	0.446
CLV_PCSK_SKI1_1	400	404	PF00082	0.550
CLV_PCSK_SKI1_1	451	455	PF00082	0.371
CLV_PCSK_SKI1_1	466	470	PF00082	0.440
CLV_PCSK_SKI1_1	542	546	PF00082	0.454
CLV_PCSK_SKI1_1	58	62	PF00082	0.392
CLV_PCSK_SKI1_1	631	635	PF00082	0.666
CLV_PCSK_SKI1_1	71	75	PF00082	0.444
DOC_CKS1_1	725	730	PF01111	0.468
DOC_CYCLIN_yCln2_LP_2	725	731	PF00134	0.486
DOC_MAPK_gen_1	239	247	PF00069	0.497
DOC_MAPK_gen_1	436	444	PF00069	0.346
DOC_MAPK_HePTP_8	526	538	PF00069	0.437
DOC_MAPK_MEF2A_6	436	444	PF00069	0.446
DOC_MAPK_MEF2A_6	529	538	PF00069	0.435
DOC_PP4_FxxP_1	384	387	PF00568	0.576
DOC_USP7_MATH_1	387	391	PF00917	0.577
DOC_USP7_MATH_1	543	547	PF00917	0.521
DOC_USP7_MATH_1	562	566	PF00917	0.561
DOC_USP7_MATH_1	644	648	PF00917	0.754
DOC_USP7_MATH_1	709	713	PF00917	0.568
DOC_USP7_MATH_1	753	757	PF00917	0.773
DOC_USP7_UBL2_3	183	187	PF12436	0.661
DOC_USP7_UBL2_3	529	533	PF12436	0.502
DOC_WW_Pin1_4	417	422	PF00397	0.384
DOC_WW_Pin1_4	626	631	PF00397	0.734
DOC_WW_Pin1_4	640	645	PF00397	0.653
DOC_WW_Pin1_4	647	652	PF00397	0.690
DOC_WW_Pin1_4	674	679	PF00397	0.734
DOC_WW_Pin1_4	724	729	PF00397	0.482
LIG_14-3-3_CanoR_1	158	164	PF00244	0.559
LIG_14-3-3_CanoR_1	259	264	PF00244	0.456
LIG_14-3-3_CanoR_1	484	490	PF00244	0.526
LIG_14-3-3_CanoR_1	542	548	PF00244	0.457
LIG_14-3-3_CanoR_1	625	630	PF00244	0.648
LIG_14-3-3_CanoR_1	645	653	PF00244	0.797
LIG_14-3-3_CanoR_1	696	700	PF00244	0.712
LIG_14-3-3_CanoR_1	763	768	PF00244	0.747
LIG_14-3-3_CanoR_1	92	101	PF00244	0.467
LIG_Actin_WH2_2	44	60	PF00022	0.425
LIG_APCC_ABBA_1	729	734	PF00400	0.432
LIG_APCC_ABBAyCdc20_2	248	254	PF00400	0.384
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_2	743	747	PF00653	0.644
LIG_EVH1_2	548	552	PF00568	0.403
LIG_FHA_1	151	157	PF00498	0.480
LIG_FHA_1	357	363	PF00498	0.476
LIG_FHA_1	435	441	PF00498	0.551
LIG_FHA_1	46	52	PF00498	0.540
LIG_FHA_1	762	768	PF00498	0.745
LIG_FHA_2	160	166	PF00498	0.610
LIG_FHA_2	189	195	PF00498	0.610
LIG_FHA_2	374	380	PF00498	0.494
LIG_FHA_2	499	505	PF00498	0.424
LIG_HCF-1_HBM_1	289	292	PF13415	0.423
LIG_IBAR_NPY_1	567	569	PF08397	0.566
LIG_LIR_Apic_2	698	702	PF02991	0.754
LIG_LIR_Gen_1	217	226	PF02991	0.550
LIG_LIR_Gen_1	242	252	PF02991	0.438
LIG_LIR_Gen_1	321	327	PF02991	0.575
LIG_LIR_Gen_1	515	526	PF02991	0.475
LIG_LIR_Gen_1	572	578	PF02991	0.670
LIG_LIR_Nem_3	242	247	PF02991	0.440
LIG_LIR_Nem_3	250	255	PF02991	0.414
LIG_LIR_Nem_3	308	314	PF02991	0.480
LIG_LIR_Nem_3	349	355	PF02991	0.417
LIG_LIR_Nem_3	379	384	PF02991	0.483
LIG_LIR_Nem_3	490	496	PF02991	0.529
LIG_LIR_Nem_3	514	520	PF02991	0.486
LIG_LIR_Nem_3	572	576	PF02991	0.614
LIG_Pex14_2	350	354	PF04695	0.369
LIG_PTB_Apo_2	246	253	PF02174	0.494
LIG_PTB_Apo_2	698	705	PF02174	0.488
LIG_PTB_Phospho_1	698	704	PF10480	0.485
LIG_REV1ctd_RIR_1	91	101	PF16727	0.395
LIG_SH2_CRK	301	305	PF00017	0.459
LIG_SH2_GRB2like	314	317	PF00017	0.502
LIG_SH2_GRB2like	489	492	PF00017	0.546
LIG_SH2_NCK_1	573	577	PF00017	0.620
LIG_SH2_SRC	314	317	PF00017	0.503
LIG_SH2_SRC	392	395	PF00017	0.519
LIG_SH2_SRC	573	576	PF00017	0.642
LIG_SH2_STAP1	489	493	PF00017	0.548
LIG_SH2_STAT3	189	192	PF00017	0.687
LIG_SH2_STAT3	489	492	PF00017	0.546
LIG_SH2_STAT3	527	530	PF00017	0.549
LIG_SH2_STAT5	168	171	PF00017	0.624
LIG_SH2_STAT5	189	192	PF00017	0.687
LIG_SH2_STAT5	292	295	PF00017	0.562
LIG_SH2_STAT5	314	317	PF00017	0.370
LIG_SH2_STAT5	392	395	PF00017	0.519
LIG_SH2_STAT5	505	508	PF00017	0.462
LIG_SH2_STAT5	518	521	PF00017	0.474
LIG_SH2_STAT5	551	554	PF00017	0.418
LIG_SH2_STAT5	704	707	PF00017	0.630
LIG_SH2_STAT5	83	86	PF00017	0.447
LIG_SH3_3	531	537	PF00018	0.557
LIG_SH3_3	672	678	PF00018	0.605
LIG_SH3_3	681	687	PF00018	0.566
LIG_Sin3_3	479	486	PF02671	0.387
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.391
LIG_SUMO_SIM_par_1	452	457	PF11976	0.443
LIG_TRAF2_1	162	165	PF00917	0.578
LIG_TRAF2_1	231	234	PF00917	0.450
LIG_TRAF2_1	472	475	PF00917	0.473
LIG_TRAF2_1	669	672	PF00917	0.634
LIG_UBA3_1	180	187	PF00899	0.711
LIG_WW_1	548	551	PF00397	0.411
LIG_WW_3	547	551	PF00397	0.421
MOD_CDK_SPK_2	626	631	PF00069	0.734
MOD_CDK_SPK_2	640	645	PF00069	0.653
MOD_CK1_1	150	156	PF00069	0.460
MOD_CK1_1	170	176	PF00069	0.504
MOD_CK1_1	262	268	PF00069	0.602
MOD_CK1_1	356	362	PF00069	0.456
MOD_CK1_1	395	401	PF00069	0.463
MOD_CK1_1	41	47	PF00069	0.597
MOD_CK1_1	420	426	PF00069	0.408
MOD_CK1_1	485	491	PF00069	0.521
MOD_CK1_1	561	567	PF00069	0.688
MOD_CK1_1	647	653	PF00069	0.741
MOD_CK1_1	748	754	PF00069	0.680
MOD_CK1_1	761	767	PF00069	0.662
MOD_CK2_1	159	165	PF00069	0.533
MOD_CK2_1	170	176	PF00069	0.552
MOD_CK2_1	188	194	PF00069	0.555
MOD_CK2_1	30	36	PF00069	0.523
MOD_CK2_1	373	379	PF00069	0.522
MOD_CK2_1	456	462	PF00069	0.493
MOD_CK2_1	498	504	PF00069	0.393
MOD_CK2_1	601	607	PF00069	0.523
MOD_GlcNHglycan	1	4	PF01048	0.700
MOD_GlcNHglycan	149	152	PF01048	0.464
MOD_GlcNHglycan	484	487	PF01048	0.532
MOD_GlcNHglycan	560	563	PF01048	0.565
MOD_GlcNHglycan	747	750	PF01048	0.680
MOD_GlcNHglycan	751	754	PF01048	0.645
MOD_GSK3_1	136	143	PF00069	0.559
MOD_GSK3_1	166	173	PF00069	0.591
MOD_GSK3_1	394	401	PF00069	0.577
MOD_GSK3_1	41	48	PF00069	0.593
MOD_GSK3_1	558	565	PF00069	0.618
MOD_GSK3_1	640	647	PF00069	0.676
MOD_GSK3_1	7	14	PF00069	0.514
MOD_GSK3_1	745	752	PF00069	0.620
MOD_GSK3_1	759	766	PF00069	0.655
MOD_LATS_1	202	208	PF00433	0.488
MOD_N-GLC_1	398	403	PF02516	0.506
MOD_N-GLC_1	457	462	PF02516	0.514
MOD_NEK2_1	136	141	PF00069	0.547
MOD_NEK2_1	147	152	PF00069	0.468
MOD_NEK2_1	327	332	PF00069	0.517
MOD_NEK2_1	39	44	PF00069	0.573
MOD_NEK2_1	454	459	PF00069	0.522
MOD_NEK2_1	593	598	PF00069	0.584
MOD_NEK2_1	612	617	PF00069	0.448
MOD_NEK2_1	633	638	PF00069	0.706
MOD_PIKK_1	140	146	PF00454	0.625
MOD_PIKK_1	188	194	PF00454	0.610
MOD_PIKK_1	204	210	PF00454	0.511
MOD_PIKK_1	92	98	PF00454	0.556
MOD_PK_1	763	769	PF00069	0.736
MOD_PKA_2	634	640	PF00069	0.648
MOD_PKA_2	644	650	PF00069	0.706
MOD_PKA_2	695	701	PF00069	0.682
MOD_PKA_2	709	715	PF00069	0.533
MOD_PKA_2	753	759	PF00069	0.700
MOD_PKB_1	90	98	PF00069	0.466
MOD_Plk_1	279	285	PF00069	0.532
MOD_Plk_1	398	404	PF00069	0.457
MOD_Plk_4	136	142	PF00069	0.569
MOD_Plk_4	185	191	PF00069	0.704
MOD_Plk_4	21	27	PF00069	0.464
MOD_Plk_4	7	13	PF00069	0.539
MOD_ProDKin_1	417	423	PF00069	0.384
MOD_ProDKin_1	626	632	PF00069	0.732
MOD_ProDKin_1	640	646	PF00069	0.650
MOD_ProDKin_1	647	653	PF00069	0.684
MOD_ProDKin_1	674	680	PF00069	0.731
MOD_ProDKin_1	724	730	PF00069	0.483
MOD_SUMO_rev_2	379	384	PF00179	0.479
TRG_DiLeu_BaEn_1	127	132	PF01217	0.450
TRG_DiLeu_BaEn_1	450	455	PF01217	0.382
TRG_DiLeu_BaEn_4	109	115	PF01217	0.552
TRG_DiLeu_BaEn_4	671	677	PF01217	0.614
TRG_ENDOCYTIC_2	160	163	PF00928	0.516
TRG_ENDOCYTIC_2	218	221	PF00928	0.550
TRG_ENDOCYTIC_2	314	317	PF00928	0.371
TRG_ENDOCYTIC_2	352	355	PF00928	0.349
TRG_ENDOCYTIC_2	381	384	PF00928	0.477
TRG_ENDOCYTIC_2	493	496	PF00928	0.512
TRG_ENDOCYTIC_2	517	520	PF00928	0.473
TRG_ENDOCYTIC_2	551	554	PF00928	0.396
TRG_ENDOCYTIC_2	573	576	PF00928	0.621
TRG_ENDOCYTIC_2	704	707	PF00928	0.628
TRG_ER_diArg_1	463	466	PF00400	0.528
TRG_ER_diArg_1	707	710	PF00400	0.640
TRG_ER_diArg_1	714	716	PF00400	0.683
TRG_ER_diArg_1	90	93	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D7	Leptomonas seymouri	79%	100%
A0A1X0NMP1	Trypanosomatidae	56%	96%
A0A3R7MX09	Trypanosoma rangeli	56%	97%
A4H5M9	Leishmania braziliensis	90%	100%
A4HTW6	Leishmania infantum	100%	100%
D0A9D0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	96%
E9AMQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QHX2	Leishmania major	97%	100%
V5BSM8	Trypanosoma cruzi	55%	96%