LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
serine/threonine protein phosphatase, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H6D4_LEIDO
TriTrypDb:
LdBPK_090520.1 , LdCL_090010300 , LDHU3_09.0650
Length:
652

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3S5H6D4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6D4

Function

Biological processes
Term Name Level Count
GO:0000724 double-strand break repair via homologous recombination 7 1
GO:0000725 recombinational repair 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006302 double-strand break repair 6 1
GO:0006310 DNA recombination 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0004721 phosphoprotein phosphatase activity 3 16
GO:0004722 protein serine/threonine phosphatase activity 4 16
GO:0016787 hydrolase activity 2 16
GO:0016788 hydrolase activity, acting on ester bonds 3 16
GO:0016791 phosphatase activity 5 16
GO:0017018 myosin phosphatase activity 5 16
GO:0042578 phosphoric ester hydrolase activity 4 16
GO:0140096 catalytic activity, acting on a protein 2 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 141 145 PF00656 0.655
CLV_C14_Caspase3-7 190 194 PF00656 0.720
CLV_C14_Caspase3-7 588 592 PF00656 0.409
CLV_NRD_NRD_1 260 262 PF00675 0.609
CLV_NRD_NRD_1 37 39 PF00675 0.711
CLV_NRD_NRD_1 77 79 PF00675 0.624
CLV_PCSK_KEX2_1 260 262 PF00082 0.611
CLV_PCSK_KEX2_1 37 39 PF00082 0.677
CLV_PCSK_KEX2_1 77 79 PF00082 0.581
CLV_PCSK_SKI1_1 261 265 PF00082 0.622
CLV_PCSK_SKI1_1 342 346 PF00082 0.395
CLV_PCSK_SKI1_1 369 373 PF00082 0.377
CLV_PCSK_SKI1_1 390 394 PF00082 0.331
CLV_PCSK_SKI1_1 421 425 PF00082 0.287
CLV_PCSK_SKI1_1 600 604 PF00082 0.346
DOC_CYCLIN_RxL_1 10 23 PF00134 0.511
DOC_CYCLIN_yClb3_PxF_3 104 110 PF00134 0.510
DOC_PP1_RVXF_1 259 266 PF00149 0.645
DOC_PP2B_LxvP_1 125 128 PF13499 0.627
DOC_PP4_FxxP_1 516 519 PF00568 0.317
DOC_SPAK_OSR1_1 165 169 PF12202 0.650
DOC_USP7_MATH_1 128 132 PF00917 0.583
DOC_USP7_MATH_1 148 152 PF00917 0.451
DOC_USP7_MATH_1 181 185 PF00917 0.684
DOC_USP7_MATH_1 243 247 PF00917 0.652
DOC_USP7_MATH_1 298 302 PF00917 0.445
DOC_USP7_MATH_1 60 64 PF00917 0.703
DOC_USP7_MATH_2 541 547 PF00917 0.343
DOC_WW_Pin1_4 144 149 PF00397 0.585
DOC_WW_Pin1_4 179 184 PF00397 0.689
DOC_WW_Pin1_4 193 198 PF00397 0.619
DOC_WW_Pin1_4 294 299 PF00397 0.527
DOC_WW_Pin1_4 320 325 PF00397 0.457
DOC_WW_Pin1_4 353 358 PF00397 0.353
DOC_WW_Pin1_4 384 389 PF00397 0.317
DOC_WW_Pin1_4 40 45 PF00397 0.753
DOC_WW_Pin1_4 520 525 PF00397 0.371
LIG_14-3-3_CanoR_1 29 35 PF00244 0.635
LIG_14-3-3_CanoR_1 38 44 PF00244 0.652
LIG_14-3-3_CanoR_1 465 473 PF00244 0.343
LIG_14-3-3_CanoR_1 50 58 PF00244 0.516
LIG_Actin_WH2_2 371 387 PF00022 0.317
LIG_AP2alpha_1 368 372 PF02296 0.317
LIG_AP2alpha_1 573 577 PF02296 0.428
LIG_BIR_II_1 1 5 PF00653 0.591
LIG_BIR_III_2 180 184 PF00653 0.644
LIG_BRCT_BRCA1_1 466 470 PF00533 0.296
LIG_BRCT_BRCA1_1 505 509 PF00533 0.428
LIG_deltaCOP1_diTrp_1 460 470 PF00928 0.298
LIG_EH1_1 372 380 PF00400 0.377
LIG_eIF4E_1 373 379 PF01652 0.298
LIG_FHA_1 145 151 PF00498 0.617
LIG_FHA_1 156 162 PF00498 0.606
LIG_FHA_1 279 285 PF00498 0.623
LIG_FHA_1 311 317 PF00498 0.512
LIG_FHA_1 474 480 PF00498 0.317
LIG_FHA_1 558 564 PF00498 0.418
LIG_FHA_2 219 225 PF00498 0.678
LIG_FHA_2 43 49 PF00498 0.636
LIG_FHA_2 59 65 PF00498 0.574
LIG_FHA_2 634 640 PF00498 0.597
LIG_FHA_2 82 88 PF00498 0.618
LIG_LIR_Apic_2 513 519 PF02991 0.318
LIG_LIR_Apic_2 535 541 PF02991 0.283
LIG_LIR_Gen_1 380 388 PF02991 0.312
LIG_LIR_Gen_1 467 477 PF02991 0.327
LIG_LIR_Nem_3 380 384 PF02991 0.368
LIG_LIR_Nem_3 467 473 PF02991 0.327
LIG_LIR_Nem_3 513 518 PF02991 0.335
LIG_NRP_CendR_1 651 652 PF00754 0.752
LIG_OCRL_FandH_1 360 372 PF00620 0.298
LIG_Pex14_2 285 289 PF04695 0.575
LIG_Pex14_2 368 372 PF04695 0.317
LIG_Pex14_2 573 577 PF04695 0.397
LIG_Pex14_2 579 583 PF04695 0.348
LIG_PTAP_UEV_1 104 109 PF05743 0.551
LIG_PTB_Apo_2 283 290 PF02174 0.623
LIG_PTB_Apo_2 301 308 PF02174 0.308
LIG_PTB_Apo_2 440 447 PF02174 0.428
LIG_PTB_Phospho_1 301 307 PF10480 0.444
LIG_SH2_CRK 307 311 PF00017 0.387
LIG_SH2_CRK 529 533 PF00017 0.428
LIG_SH2_STAT3 137 140 PF00017 0.594
LIG_SH2_STAT5 154 157 PF00017 0.791
LIG_SH2_STAT5 309 312 PF00017 0.356
LIG_SH2_STAT5 359 362 PF00017 0.311
LIG_SH2_STAT5 373 376 PF00017 0.377
LIG_SH2_STAT5 386 389 PF00017 0.328
LIG_SH2_STAT5 397 400 PF00017 0.322
LIG_SH2_STAT5 410 413 PF00017 0.329
LIG_SH2_STAT5 484 487 PF00017 0.413
LIG_SH2_STAT5 581 584 PF00017 0.296
LIG_SH2_STAT5 610 613 PF00017 0.450
LIG_SH2_STAT5 642 645 PF00017 0.629
LIG_SH3_3 102 108 PF00018 0.648
LIG_SH3_3 194 200 PF00018 0.755
LIG_SH3_3 228 234 PF00018 0.559
LIG_SH3_3 351 357 PF00018 0.506
LIG_SH3_3 413 419 PF00018 0.324
LIG_SH3_3 504 510 PF00018 0.398
LIG_SUMO_SIM_anti_2 115 120 PF11976 0.452
LIG_SUMO_SIM_anti_2 404 409 PF11976 0.331
LIG_SUMO_SIM_par_1 115 120 PF11976 0.547
LIG_SUMO_SIM_par_1 15 23 PF11976 0.533
LIG_SUMO_SIM_par_1 618 624 PF11976 0.357
LIG_TRAF2_1 585 588 PF00917 0.298
LIG_TRAF2_1 636 639 PF00917 0.641
LIG_TRAF2_1 9 12 PF00917 0.582
LIG_UBA3_1 334 342 PF00899 0.473
LIG_UBA3_1 411 415 PF00899 0.328
LIG_WRC_WIRS_1 311 316 PF05994 0.500
LIG_WRC_WIRS_1 378 383 PF05994 0.298
LIG_WRC_WIRS_1 512 517 PF05994 0.317
MOD_CDC14_SPxK_1 196 199 PF00782 0.657
MOD_CDK_SPxK_1 193 199 PF00069 0.660
MOD_CDK_SPxK_1 384 390 PF00069 0.317
MOD_CDK_SPxxK_3 520 527 PF00069 0.343
MOD_CK1_1 106 112 PF00069 0.606
MOD_CK1_1 160 166 PF00069 0.635
MOD_CK1_1 167 173 PF00069 0.599
MOD_CK1_1 22 28 PF00069 0.685
MOD_CK1_1 297 303 PF00069 0.512
MOD_CK1_1 353 359 PF00069 0.400
MOD_CK1_1 42 48 PF00069 0.833
MOD_CK1_1 51 57 PF00069 0.736
MOD_CK1_1 63 69 PF00069 0.664
MOD_CK1_1 81 87 PF00069 0.624
MOD_CK2_1 222 228 PF00069 0.726
MOD_CK2_1 6 12 PF00069 0.597
MOD_CK2_1 633 639 PF00069 0.653
MOD_CK2_1 81 87 PF00069 0.756
MOD_GlcNHglycan 101 104 PF01048 0.511
MOD_GlcNHglycan 105 108 PF01048 0.611
MOD_GlcNHglycan 171 174 PF01048 0.693
MOD_GlcNHglycan 201 204 PF01048 0.635
MOD_GlcNHglycan 207 210 PF01048 0.667
MOD_GlcNHglycan 23 27 PF01048 0.542
MOD_GlcNHglycan 237 240 PF01048 0.772
MOD_GlcNHglycan 434 437 PF01048 0.298
MOD_GlcNHglycan 438 441 PF01048 0.298
MOD_GlcNHglycan 466 469 PF01048 0.478
MOD_GlcNHglycan 493 496 PF01048 0.377
MOD_GlcNHglycan 54 57 PF01048 0.754
MOD_GlcNHglycan 597 600 PF01048 0.418
MOD_GlcNHglycan 607 610 PF01048 0.391
MOD_GlcNHglycan 64 68 PF01048 0.641
MOD_GlcNHglycan 74 77 PF01048 0.474
MOD_GlcNHglycan 90 93 PF01048 0.678
MOD_GlcNHglycan 97 100 PF01048 0.608
MOD_GSK3_1 106 113 PF00069 0.504
MOD_GSK3_1 123 130 PF00069 0.535
MOD_GSK3_1 144 151 PF00069 0.661
MOD_GSK3_1 160 167 PF00069 0.519
MOD_GSK3_1 189 196 PF00069 0.735
MOD_GSK3_1 218 225 PF00069 0.771
MOD_GSK3_1 294 301 PF00069 0.497
MOD_GSK3_1 432 439 PF00069 0.354
MOD_GSK3_1 48 55 PF00069 0.833
MOD_GSK3_1 600 607 PF00069 0.330
MOD_GSK3_1 78 85 PF00069 0.667
MOD_GSK3_1 95 102 PF00069 0.632
MOD_N-GLC_1 222 227 PF02516 0.746
MOD_N-GLC_1 442 447 PF02516 0.428
MOD_N-GLC_1 520 525 PF02516 0.406
MOD_N-GLC_1 543 548 PF02516 0.428
MOD_N-GLC_1 78 83 PF02516 0.767
MOD_N-GLC_2 318 320 PF02516 0.407
MOD_N-GLC_2 336 338 PF02516 0.477
MOD_NEK2_1 110 115 PF00069 0.605
MOD_NEK2_1 133 138 PF00069 0.621
MOD_NEK2_1 155 160 PF00069 0.639
MOD_NEK2_1 191 196 PF00069 0.632
MOD_NEK2_1 330 335 PF00069 0.385
MOD_NEK2_1 564 569 PF00069 0.306
MOD_NEK2_1 593 598 PF00069 0.392
MOD_NEK2_1 605 610 PF00069 0.356
MOD_NEK2_2 410 415 PF00069 0.397
MOD_NEK2_2 442 447 PF00069 0.317
MOD_PIKK_1 160 166 PF00454 0.717
MOD_PIKK_1 42 48 PF00454 0.741
MOD_PK_1 350 356 PF00069 0.408
MOD_PKA_2 155 161 PF00069 0.639
MOD_PKA_2 164 170 PF00069 0.541
MOD_PKA_2 198 204 PF00069 0.722
MOD_PKA_2 205 211 PF00069 0.538
MOD_PKA_2 464 470 PF00069 0.343
MOD_PKA_2 491 497 PF00069 0.377
MOD_PKA_2 51 57 PF00069 0.836
MOD_PKA_2 557 563 PF00069 0.343
MOD_PKA_2 95 101 PF00069 0.684
MOD_PKB_1 50 58 PF00069 0.641
MOD_Plk_1 110 116 PF00069 0.541
MOD_Plk_1 133 139 PF00069 0.590
MOD_Plk_1 22 28 PF00069 0.530
MOD_Plk_1 267 273 PF00069 0.627
MOD_Plk_1 401 407 PF00069 0.298
MOD_Plk_1 429 435 PF00069 0.298
MOD_Plk_1 442 448 PF00069 0.298
MOD_Plk_2-3 543 549 PF00069 0.349
MOD_Plk_4 112 118 PF00069 0.533
MOD_Plk_4 128 134 PF00069 0.437
MOD_Plk_4 429 435 PF00069 0.320
MOD_Plk_4 511 517 PF00069 0.327
MOD_ProDKin_1 144 150 PF00069 0.587
MOD_ProDKin_1 179 185 PF00069 0.690
MOD_ProDKin_1 193 199 PF00069 0.621
MOD_ProDKin_1 294 300 PF00069 0.513
MOD_ProDKin_1 320 326 PF00069 0.457
MOD_ProDKin_1 353 359 PF00069 0.349
MOD_ProDKin_1 384 390 PF00069 0.317
MOD_ProDKin_1 40 46 PF00069 0.755
MOD_ProDKin_1 520 526 PF00069 0.371
MOD_SUMO_rev_2 339 344 PF00179 0.419
TRG_DiLeu_BaEn_3 339 345 PF01217 0.410
TRG_DiLeu_BaLyEn_6 625 630 PF01217 0.369
TRG_ENDOCYTIC_2 307 310 PF00928 0.392
TRG_ENDOCYTIC_2 529 532 PF00928 0.377
TRG_ER_diArg_1 259 261 PF00400 0.619
TRG_ER_diArg_1 49 52 PF00400 0.696
TRG_Pf-PMV_PEXEL_1 16 21 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 267 272 PF00026 0.547

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5U5 Leptomonas seymouri 73% 96%
A0A0S4IYE4 Bodo saltans 55% 100%
A0A0S4J323 Bodo saltans 27% 100%
A0A1X0NPA5 Trypanosomatidae 57% 100%
A0A3Q8I8M6 Leishmania donovani 33% 100%
A0A3R7NXP6 Trypanosoma rangeli 56% 100%
A4H5M4 Leishmania braziliensis 85% 99%
A4HTW1 Leishmania infantum 100% 100%
A4HVT0 Leishmania infantum 33% 100%
D0A9C5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AMP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9APH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
Q4QG03 Leishmania major 33% 100%
Q4QHX7 Leishmania major 97% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS