LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
serine/threonine protein phosphatase, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H6D4_LEIDO
TriTrypDb:
LdBPK_090520.1 , LdCL_090010300 , LDHU3_09.0650
Length:
652

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

A0A3S5H6D4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6D4

Function

Biological processes
TermNameLevelCount
GO:0000724 double-strand break repair via homologous recombination 7 1
GO:0000725 recombinational repair 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006302 double-strand break repair 6 1
GO:0006310 DNA recombination 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 16
GO:0004721 phosphoprotein phosphatase activity 3 16
GO:0004722 protein serine/threonine phosphatase activity 4 16
GO:0016787 hydrolase activity 2 16
GO:0016788 hydrolase activity, acting on ester bonds 3 16
GO:0016791 phosphatase activity 5 16
GO:0017018 myosin phosphatase activity 5 16
GO:0042578 phosphoric ester hydrolase activity 4 16
GO:0140096 catalytic activity, acting on a protein 2 16
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 141 145 PF00656 0.655
CLV_C14_Caspase3-7 190 194 PF00656 0.720
CLV_C14_Caspase3-7 588 592 PF00656 0.409
CLV_NRD_NRD_1 260 262 PF00675 0.609
CLV_NRD_NRD_1 37 39 PF00675 0.711
CLV_NRD_NRD_1 77 79 PF00675 0.624
CLV_PCSK_KEX2_1 260 262 PF00082 0.611
CLV_PCSK_KEX2_1 37 39 PF00082 0.677
CLV_PCSK_KEX2_1 77 79 PF00082 0.581
CLV_PCSK_SKI1_1 261 265 PF00082 0.622
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P5U5 Leptomonas seymouri 73% 96%
A0A0S4IYE4 Bodo saltans 55% 100%
A0A0S4J323 Bodo saltans 27% 100%
A0A1X0NPA5 Trypanosomatidae 57% 100%
A0A3Q8I8M6 Leishmania donovani 33% 100%
A0A3R7NXP6 Trypanosoma rangeli 56% 100%
A4H5M4 Leishmania braziliensis 85% 99%
A4HTW1 Leishmania infantum 100% 100%
A4HVT0 Leishmania infantum 33% 100%
D0A9C5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS