Tetratricopeptide repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 8 protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6D1_LEIDO

TriTrypDb:

LdBPK_090490.1 , LdCL_090010000 , LDHU3_09.0620

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0030669	clathrin-coated endocytic vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0097730	non-motile cilium	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S5H6D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6D1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.524
CLV_NRD_NRD_1	403	405	PF00675	0.363
CLV_NRD_NRD_1	497	499	PF00675	0.504
CLV_NRD_NRD_1	504	506	PF00675	0.484
CLV_PCSK_KEX2_1	403	405	PF00082	0.363
CLV_PCSK_KEX2_1	497	499	PF00082	0.548
CLV_PCSK_KEX2_1	504	506	PF00082	0.501
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.485
CLV_PCSK_SKI1_1	113	117	PF00082	0.587
CLV_PCSK_SKI1_1	128	132	PF00082	0.536
CLV_PCSK_SKI1_1	169	173	PF00082	0.377
CLV_PCSK_SKI1_1	180	184	PF00082	0.504
CLV_PCSK_SKI1_1	246	250	PF00082	0.437
CLV_PCSK_SKI1_1	262	266	PF00082	0.282
CLV_PCSK_SKI1_1	403	407	PF00082	0.369
CLV_PCSK_SKI1_1	504	508	PF00082	0.508
DEG_Nend_UBRbox_2	1	3	PF02207	0.431
DEG_SPOP_SBC_1	184	188	PF00917	0.422
DEG_SPOP_SBC_1	272	276	PF00917	0.467
DOC_ANK_TNKS_1	103	110	PF00023	0.706
DOC_CYCLIN_RxL_1	498	509	PF00134	0.516
DOC_MAPK_gen_1	167	174	PF00069	0.415
DOC_MAPK_gen_1	246	256	PF00069	0.429
DOC_MAPK_gen_1	400	410	PF00069	0.376
DOC_MAPK_gen_1	560	568	PF00069	0.526
DOC_MAPK_MEF2A_6	167	174	PF00069	0.415
DOC_MAPK_MEF2A_6	392	399	PF00069	0.404
DOC_PP2B_LxvP_1	217	220	PF13499	0.720
DOC_PP2B_LxvP_1	512	515	PF13499	0.537
DOC_PP4_FxxP_1	269	272	PF00568	0.579
DOC_USP7_MATH_1	191	195	PF00917	0.746
DOC_USP7_MATH_1	224	228	PF00917	0.664
DOC_USP7_MATH_1	283	287	PF00917	0.702
DOC_USP7_MATH_1	39	43	PF00917	0.575
DOC_USP7_MATH_1	47	51	PF00917	0.485
DOC_USP7_MATH_1	83	87	PF00917	0.605
DOC_USP7_UBL2_3	318	322	PF12436	0.315
DOC_USP7_UBL2_3	497	501	PF12436	0.565
DOC_WW_Pin1_4	268	273	PF00397	0.404
LIG_14-3-3_CanoR_1	434	442	PF00244	0.440
LIG_14-3-3_CanoR_1	46	52	PF00244	0.530
LIG_14-3-3_CanoR_1	73	83	PF00244	0.620
LIG_Actin_WH2_2	115	130	PF00022	0.659
LIG_Actin_WH2_2	167	182	PF00022	0.521
LIG_Actin_WH2_2	250	267	PF00022	0.477
LIG_Actin_WH2_2	37	54	PF00022	0.643
LIG_BRCT_BRCA1_1	3	7	PF00533	0.534
LIG_Clathr_ClatBox_1	161	165	PF01394	0.389
LIG_deltaCOP1_diTrp_1	240	243	PF00928	0.407
LIG_eIF4E_1	263	269	PF01652	0.461
LIG_FHA_1	122	128	PF00498	0.514
LIG_FHA_1	174	180	PF00498	0.488
LIG_FHA_1	185	191	PF00498	0.686
LIG_FHA_1	221	227	PF00498	0.558
LIG_FHA_1	308	314	PF00498	0.490
LIG_FHA_1	410	416	PF00498	0.361
LIG_FHA_1	507	513	PF00498	0.479
LIG_FHA_1	516	522	PF00498	0.409
LIG_FHA_2	326	332	PF00498	0.341
LIG_FHA_2	360	366	PF00498	0.470
LIG_FHA_2	480	486	PF00498	0.509
LIG_GBD_Chelix_1	153	161	PF00786	0.368
LIG_LIR_Gen_1	116	127	PF02991	0.594
LIG_LIR_Gen_1	365	373	PF02991	0.431
LIG_LIR_Gen_1	413	424	PF02991	0.331
LIG_LIR_Gen_1	535	545	PF02991	0.415
LIG_LIR_Gen_1	563	568	PF02991	0.505
LIG_LIR_Nem_3	116	122	PF02991	0.616
LIG_LIR_Nem_3	159	163	PF02991	0.425
LIG_LIR_Nem_3	362	367	PF02991	0.410
LIG_LIR_Nem_3	451	456	PF02991	0.296
LIG_LIR_Nem_3	535	541	PF02991	0.388
LIG_LIR_Nem_3	563	568	PF02991	0.505
LIG_PDZ_Class_2	563	568	PF00595	0.539
LIG_PTAP_UEV_1	192	197	PF05743	0.649
LIG_PTB_Apo_2	462	469	PF02174	0.415
LIG_SH2_CRK	367	371	PF00017	0.387
LIG_SH2_CRK	402	406	PF00017	0.352
LIG_SH2_CRK	538	542	PF00017	0.392
LIG_SH2_CRK	90	94	PF00017	0.663
LIG_SH2_NCK_1	19	23	PF00017	0.611
LIG_SH2_NCK_1	90	94	PF00017	0.722
LIG_SH2_SRC	163	166	PF00017	0.433
LIG_SH2_SRC	19	22	PF00017	0.605
LIG_SH2_STAP1	333	337	PF00017	0.420
LIG_SH2_STAP1	425	429	PF00017	0.367
LIG_SH2_STAT3	425	428	PF00017	0.373
LIG_SH2_STAT5	160	163	PF00017	0.372
LIG_SH2_STAT5	263	266	PF00017	0.463
LIG_SH2_STAT5	320	323	PF00017	0.420
LIG_SH2_STAT5	425	428	PF00017	0.494
LIG_SH3_3	178	184	PF00018	0.575
LIG_SH3_3	190	196	PF00018	0.636
LIG_SH3_3	546	552	PF00018	0.416
LIG_SxIP_EBH_1	183	196	PF03271	0.429
LIG_TRAF2_1	228	231	PF00917	0.627
LIG_TYR_ITIM	536	541	PF00017	0.446
LIG_WRC_WIRS_1	424	429	PF05994	0.495
LIG_WRC_WIRS_1	526	531	PF05994	0.432
MOD_CK1_1	102	108	PF00069	0.682
MOD_CK1_1	126	132	PF00069	0.572
MOD_CK1_1	271	277	PF00069	0.666
MOD_CK2_1	325	331	PF00069	0.325
MOD_CK2_1	373	379	PF00069	0.382
MOD_CK2_1	479	485	PF00069	0.499
MOD_Cter_Amidation	502	505	PF01082	0.507
MOD_GlcNHglycan	104	107	PF01048	0.645
MOD_GlcNHglycan	187	190	PF01048	0.708
MOD_GlcNHglycan	193	196	PF01048	0.694
MOD_GlcNHglycan	226	229	PF01048	0.607
MOD_GlcNHglycan	293	297	PF01048	0.665
MOD_GlcNHglycan	477	480	PF01048	0.369
MOD_GlcNHglycan	76	79	PF01048	0.692
MOD_GSK3_1	220	227	PF00069	0.648
MOD_GSK3_1	268	275	PF00069	0.608
MOD_GSK3_1	325	332	PF00069	0.432
MOD_GSK3_1	410	417	PF00069	0.495
MOD_GSK3_1	475	482	PF00069	0.435
MOD_GSK3_1	521	528	PF00069	0.431
MOD_N-GLC_1	308	313	PF02516	0.518
MOD_N-GLC_1	47	52	PF02516	0.622
MOD_NEK2_1	1	6	PF00069	0.517
MOD_NEK2_1	373	378	PF00069	0.399
MOD_NEK2_1	429	434	PF00069	0.354
MOD_NEK2_1	506	511	PF00069	0.444
MOD_NEK2_1	521	526	PF00069	0.407
MOD_NEK2_1	534	539	PF00069	0.483
MOD_NEK2_1	7	12	PF00069	0.398
MOD_NEK2_1	74	79	PF00069	0.686
MOD_NEK2_2	123	128	PF00069	0.634
MOD_NEK2_2	47	52	PF00069	0.634
MOD_PIKK_1	444	450	PF00454	0.522
MOD_PK_1	99	105	PF00069	0.734
MOD_Plk_1	1	7	PF00069	0.531
MOD_Plk_1	308	314	PF00069	0.516
MOD_Plk_1	429	435	PF00069	0.454
MOD_Plk_1	47	53	PF00069	0.641
MOD_Plk_1	534	540	PF00069	0.470
MOD_Plk_4	1	7	PF00069	0.544
MOD_Plk_4	14	20	PF00069	0.428
MOD_Plk_4	308	314	PF00069	0.516
MOD_ProDKin_1	268	274	PF00069	0.417
MOD_SUMO_rev_2	159	168	PF00179	0.483
TRG_DiLeu_BaEn_2	2	8	PF01217	0.475
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.368
TRG_DiLeu_BaLyEn_6	502	507	PF01217	0.497
TRG_ENDOCYTIC_2	320	323	PF00928	0.384
TRG_ENDOCYTIC_2	367	370	PF00928	0.419
TRG_ENDOCYTIC_2	402	405	PF00928	0.354
TRG_ENDOCYTIC_2	538	541	PF00928	0.368
TRG_ER_diArg_1	402	404	PF00400	0.363
TRG_ER_diArg_1	504	506	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	543	548	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM3	Leptomonas seymouri	71%	85%
A0A0S4IWH2	Bodo saltans	37%	100%
A0A1X0NMP5	Trypanosomatidae	45%	94%
A0A422NV89	Trypanosoma rangeli	44%	100%
A4H5M0	Leishmania braziliensis	88%	100%
A4HTV8	Leishmania infantum	100%	100%
D0A9C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q23049	Caenorhabditis elegans	29%	100%
Q4QHY0	Leishmania major	94%	100%
Q8TAM2	Homo sapiens	33%	100%
Q8VD72	Mus musculus	31%	100%
V5DJG5	Trypanosoma cruzi	43%	89%