Plus-3 domain/Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6D0_LEIDO

TriTrypDb:

LdBPK_090480.1 , LdCL_090009900 , LDHU3_09.0610

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6D0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.653
CLV_C14_Caspase3-7	333	337	PF00656	0.569
CLV_NRD_NRD_1	201	203	PF00675	0.651
CLV_NRD_NRD_1	233	235	PF00675	0.612
CLV_NRD_NRD_1	366	368	PF00675	0.483
CLV_PCSK_FUR_1	199	203	PF00082	0.609
CLV_PCSK_KEX2_1	14	16	PF00082	0.360
CLV_PCSK_KEX2_1	201	203	PF00082	0.651
CLV_PCSK_KEX2_1	233	235	PF00082	0.672
CLV_PCSK_KEX2_1	366	368	PF00082	0.485
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.360
CLV_PCSK_SKI1_1	136	140	PF00082	0.454
CLV_PCSK_SKI1_1	319	323	PF00082	0.732
CLV_PCSK_SKI1_1	350	354	PF00082	0.620
CLV_PCSK_SKI1_1	42	46	PF00082	0.300
DEG_APCC_DBOX_1	114	122	PF00400	0.329
DEG_COP1_1	124	132	PF00400	0.468
DEG_Nend_Nbox_1	1	3	PF02207	0.518
DEG_SPOP_SBC_1	342	346	PF00917	0.665
DOC_CYCLIN_RxL_1	39	49	PF00134	0.300
DOC_CYCLIN_yCln2_LP_2	213	216	PF00134	0.667
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.376
DOC_MAPK_MEF2A_6	122	129	PF00069	0.466
DOC_PP2B_LxvP_1	127	130	PF13499	0.451
DOC_PP2B_LxvP_1	213	216	PF13499	0.667
DOC_PP2B_LxvP_1	443	446	PF13499	0.300
DOC_PP2B_LxvP_1	45	48	PF13499	0.360
DOC_PP2B_LxvP_1	85	88	PF13499	0.300
DOC_PP4_FxxP_1	322	325	PF00568	0.551
DOC_USP7_MATH_1	158	162	PF00917	0.624
DOC_USP7_MATH_1	16	20	PF00917	0.450
DOC_USP7_MATH_1	206	210	PF00917	0.631
DOC_USP7_MATH_1	251	255	PF00917	0.648
DOC_USP7_MATH_1	257	261	PF00917	0.643
DOC_USP7_MATH_1	301	305	PF00917	0.650
DOC_USP7_MATH_1	309	313	PF00917	0.626
DOC_USP7_MATH_1	332	336	PF00917	0.643
DOC_USP7_MATH_1	343	347	PF00917	0.704
LIG_14-3-3_CanoR_1	20	27	PF00244	0.384
LIG_14-3-3_CanoR_1	201	206	PF00244	0.605
LIG_14-3-3_CanoR_1	233	240	PF00244	0.667
LIG_14-3-3_CanoR_1	350	355	PF00244	0.620
LIG_14-3-3_CanoR_1	58	68	PF00244	0.376
LIG_BIR_III_4	386	390	PF00653	0.479
LIG_BRCT_BRCA1_1	6	10	PF00533	0.445
LIG_FHA_1	124	130	PF00498	0.468
LIG_FHA_1	137	143	PF00498	0.490
LIG_FHA_1	209	215	PF00498	0.747
LIG_FHA_1	427	433	PF00498	0.360
LIG_FHA_1	448	454	PF00498	0.336
LIG_FHA_1	76	82	PF00498	0.344
LIG_FHA_2	47	53	PF00498	0.481
LIG_FHA_2	61	67	PF00498	0.223
LIG_Integrin_isoDGR_2	165	167	PF01839	0.627
LIG_LIR_Apic_2	320	325	PF02991	0.561
LIG_LIR_Gen_1	116	125	PF02991	0.419
LIG_LIR_Gen_1	79	90	PF02991	0.300
LIG_LIR_Nem_3	66	71	PF02991	0.307
LIG_LIR_Nem_3	79	85	PF02991	0.382
LIG_PDZ_Class_3	462	467	PF00595	0.525
LIG_SH2_NCK_1	306	310	PF00017	0.689
LIG_SH2_STAT5	306	309	PF00017	0.816
LIG_SH2_STAT5	405	408	PF00017	0.455
LIG_SH2_STAT5	54	57	PF00017	0.300
LIG_SH2_STAT5	82	85	PF00017	0.300
LIG_SH3_3	174	180	PF00018	0.648
LIG_SH3_3	378	384	PF00018	0.483
LIG_SH3_3	443	449	PF00018	0.489
LIG_SUMO_SIM_anti_2	429	434	PF11976	0.360
LIG_TRAF2_1	312	315	PF00917	0.606
LIG_WRC_WIRS_1	302	307	PF05994	0.540
MOD_CK1_1	105	111	PF00069	0.351
MOD_CK1_1	154	160	PF00069	0.621
MOD_CK1_1	161	167	PF00069	0.657
MOD_CK1_1	19	25	PF00069	0.416
MOD_CK1_1	208	214	PF00069	0.697
MOD_CK1_1	253	259	PF00069	0.664
MOD_CK1_1	304	310	PF00069	0.633
MOD_CK1_1	346	352	PF00069	0.651
MOD_CK1_1	447	453	PF00069	0.350
MOD_CK1_1	69	75	PF00069	0.360
MOD_CK2_1	105	111	PF00069	0.351
MOD_CK2_1	293	299	PF00069	0.725
MOD_CK2_1	309	315	PF00069	0.616
MOD_CK2_1	356	362	PF00069	0.543
MOD_CK2_1	46	52	PF00069	0.483
MOD_CK2_1	60	66	PF00069	0.225
MOD_GlcNHglycan	156	159	PF01048	0.668
MOD_GlcNHglycan	172	176	PF01048	0.575
MOD_GlcNHglycan	192	195	PF01048	0.642
MOD_GlcNHglycan	226	229	PF01048	0.706
MOD_GlcNHglycan	235	238	PF01048	0.631
MOD_GlcNHglycan	243	247	PF01048	0.573
MOD_GlcNHglycan	252	256	PF01048	0.612
MOD_GlcNHglycan	68	71	PF01048	0.360
MOD_GSK3_1	100	107	PF00069	0.300
MOD_GSK3_1	145	152	PF00069	0.642
MOD_GSK3_1	154	161	PF00069	0.573
MOD_GSK3_1	201	208	PF00069	0.668
MOD_GSK3_1	253	260	PF00069	0.727
MOD_GSK3_1	289	296	PF00069	0.744
MOD_GSK3_1	342	349	PF00069	0.679
MOD_GSK3_1	66	73	PF00069	0.392
MOD_N-GLC_1	105	110	PF02516	0.360
MOD_N-GLC_1	158	163	PF02516	0.697
MOD_N-GLC_1	30	35	PF02516	0.328
MOD_NEK2_1	205	210	PF00069	0.680
MOD_NEK2_1	232	237	PF00069	0.681
MOD_NEK2_1	341	346	PF00069	0.668
MOD_NEK2_2	301	306	PF00069	0.592
MOD_OFUCOSY	441	448	PF10250	0.374
MOD_PIKK_1	206	212	PF00454	0.697
MOD_PIKK_1	309	315	PF00454	0.633
MOD_PKA_1	201	207	PF00069	0.650
MOD_PKA_1	233	239	PF00069	0.666
MOD_PKA_2	19	25	PF00069	0.360
MOD_PKA_2	201	207	PF00069	0.606
MOD_PKA_2	232	238	PF00069	0.734
MOD_PKB_1	149	157	PF00069	0.612
MOD_PKB_1	199	207	PF00069	0.611
MOD_Plk_1	105	111	PF00069	0.360
MOD_Plk_1	30	36	PF00069	0.328
MOD_Plk_1	4	10	PF00069	0.461
MOD_Plk_4	208	214	PF00069	0.631
MOD_Plk_4	272	278	PF00069	0.699
MOD_Plk_4	301	307	PF00069	0.620
MOD_Plk_4	343	349	PF00069	0.665
MOD_Plk_4	426	432	PF00069	0.300
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.509
TRG_ENDOCYTIC_2	68	71	PF00928	0.307
TRG_ENDOCYTIC_2	82	85	PF00928	0.300
TRG_ER_diArg_1	199	202	PF00400	0.649
TRG_ER_diArg_1	232	234	PF00400	0.612
TRG_ER_diArg_1	366	369	PF00400	0.548
TRG_ER_diArg_1	394	397	PF00400	0.534
TRG_ER_FFAT_2	299	310	PF00635	0.541
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I698	Leptomonas seymouri	62%	97%
A4H5L9	Leishmania braziliensis	75%	98%
A4HTV7	Leishmania infantum	100%	100%
E9AMP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHY1	Leishmania major	95%	100%
V5BIH0	Trypanosoma cruzi	38%	100%