LeishMANIAdb
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Ring finger domain/RING-H2 zinc finger containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ring finger domain/RING-H2 zinc finger containing protein, putative
Gene product:
Ring finger domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H6C5_LEIDO
TriTrypDb:
LdBPK_090320.1 * , LdCL_090008900 , LDHU3_09.0490
Length:
875

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6C5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6C5

Function

Biological processes
TermNameLevelCount
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 1
GO:0004842 ubiquitin-protein transferase activity 4 1
GO:0005488 binding 1 4
GO:0008270 zinc ion binding 6 4
GO:0016740 transferase activity 2 1
GO:0019787 ubiquitin-like protein transferase activity 3 1
GO:0043167 ion binding 2 4
GO:0043169 cation binding 3 4
GO:0046872 metal ion binding 4 4
GO:0046914 transition metal ion binding 5 4
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 212 216 PF00656 0.746
CLV_C14_Caspase3-7 526 530 PF00656 0.688
CLV_C14_Caspase3-7 664 668 PF00656 0.702
CLV_C14_Caspase3-7 88 92 PF00656 0.748
CLV_MEL_PAP_1 769 775 PF00089 0.582
CLV_NRD_NRD_1 210 212 PF00675 0.715
CLV_NRD_NRD_1 401 403 PF00675 0.773
CLV_NRD_NRD_1 424 426 PF00675 0.847
CLV_NRD_NRD_1 548 550 PF00675 0.624
CLV_NRD_NRD_1 865 867 PF00675 0.667
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Homologs

ProteinTaxonomySequence identityCoverage
A4H5K9 Leishmania braziliensis 55% 94%
A4HTU8 Leishmania infantum 100% 100%
E9AMN5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
Q4QHZ0 Leishmania major 85% 97%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS