LeishMANIAdb
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CHASE domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CHASE domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H6C4_LEIDO
TriTrypDb:
LdBPK_090290.1 , LdCL_090008600 , LDHU3_09.0460
Length:
850

Annotations

LeishMANIAdb annotations

Appears to be an enzyme-linked receptor, putatively a receptor nucleotide cyclase (cAMP synthase).. Expanded on the Leishmaniid lineage. The first helical segment is very similar to a signal peptide.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A0A3S5H6C4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6C4

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006163 purine nucleotide metabolic process 5 7
GO:0006164 purine nucleotide biosynthetic process 6 7
GO:0006171 cAMP biosynthetic process 8 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006753 nucleoside phosphate metabolic process 4 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009058 biosynthetic process 2 7
GO:0009117 nucleotide metabolic process 5 7
GO:0009150 purine ribonucleotide metabolic process 6 7
GO:0009152 purine ribonucleotide biosynthetic process 7 7
GO:0009165 nucleotide biosynthetic process 6 7
GO:0009187 cyclic nucleotide metabolic process 6 7
GO:0009190 cyclic nucleotide biosynthetic process 7 7
GO:0009259 ribonucleotide metabolic process 5 7
GO:0009260 ribonucleotide biosynthetic process 6 7
GO:0009987 cellular process 1 7
GO:0018130 heterocycle biosynthetic process 4 7
GO:0019438 aromatic compound biosynthetic process 4 7
GO:0019637 organophosphate metabolic process 3 7
GO:0019693 ribose phosphate metabolic process 4 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0034654 nucleobase-containing compound biosynthetic process 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044271 cellular nitrogen compound biosynthetic process 4 7
GO:0044281 small molecule metabolic process 2 7
GO:0046058 cAMP metabolic process 7 7
GO:0046390 ribose phosphate biosynthetic process 5 7
GO:0046483 heterocycle metabolic process 3 7
GO:0052652 cyclic purine nucleotide metabolic process 6 7
GO:0055086 nucleobase-containing small molecule metabolic process 3 7
GO:0071704 organic substance metabolic process 2 7
GO:0072521 purine-containing compound metabolic process 4 7
GO:0072522 purine-containing compound biosynthetic process 5 7
GO:0090407 organophosphate biosynthetic process 4 7
GO:1901135 carbohydrate derivative metabolic process 3 7
GO:1901137 carbohydrate derivative biosynthetic process 4 7
GO:1901293 nucleoside phosphate biosynthetic process 5 7
GO:1901360 organic cyclic compound metabolic process 3 7
GO:1901362 organic cyclic compound biosynthetic process 4 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:1901566 organonitrogen compound biosynthetic process 4 7
GO:1901576 organic substance biosynthetic process 3 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 647 651 PF00656 0.510
CLV_NRD_NRD_1 128 130 PF00675 0.569
CLV_NRD_NRD_1 205 207 PF00675 0.538
CLV_NRD_NRD_1 24 26 PF00675 0.255
CLV_NRD_NRD_1 562 564 PF00675 0.454
CLV_NRD_NRD_1 598 600 PF00675 0.516
CLV_NRD_NRD_1 786 788 PF00675 0.593
CLV_PCSK_KEX2_1 128 130 PF00082 0.573
CLV_PCSK_KEX2_1 205 207 PF00082 0.536
CLV_PCSK_KEX2_1 24 26 PF00082 0.255
CLV_PCSK_KEX2_1 249 251 PF00082 0.666
CLV_PCSK_KEX2_1 562 564 PF00082 0.455
CLV_PCSK_KEX2_1 598 600 PF00082 0.516
CLV_PCSK_KEX2_1 786 788 PF00082 0.593
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.664
CLV_PCSK_PC7_1 20 26 PF00082 0.304
CLV_PCSK_SKI1_1 151 155 PF00082 0.572
CLV_PCSK_SKI1_1 441 445 PF00082 0.380
CLV_PCSK_SKI1_1 449 453 PF00082 0.351
CLV_PCSK_SKI1_1 541 545 PF00082 0.513
CLV_PCSK_SKI1_1 599 603 PF00082 0.308
CLV_PCSK_SKI1_1 638 642 PF00082 0.654
CLV_PCSK_SKI1_1 725 729 PF00082 0.651
CLV_PCSK_SKI1_1 741 745 PF00082 0.468
CLV_PCSK_SKI1_1 770 774 PF00082 0.540
CLV_PCSK_SKI1_1 787 791 PF00082 0.622
DEG_APCC_DBOX_1 12 20 PF00400 0.675
DEG_APCC_DBOX_1 724 732 PF00400 0.420
DEG_SCF_FBW7_1 172 177 PF00400 0.324
DEG_SPOP_SBC_1 407 411 PF00917 0.556
DEG_SPOP_SBC_1 566 570 PF00917 0.626
DOC_CYCLIN_yCln2_LP_2 727 733 PF00134 0.370
DOC_CYCLIN_yCln2_LP_2 772 778 PF00134 0.378
DOC_MAPK_DCC_7 13 21 PF00069 0.588
DOC_MAPK_gen_1 13 21 PF00069 0.624
DOC_MAPK_gen_1 24 32 PF00069 0.462
DOC_MAPK_gen_1 516 523 PF00069 0.543
DOC_MAPK_MEF2A_6 13 21 PF00069 0.591
DOC_MAPK_MEF2A_6 734 742 PF00069 0.440
DOC_MAPK_MEF2A_6 754 762 PF00069 0.343
DOC_PP1_RVXF_1 739 745 PF00149 0.374
DOC_PP1_RVXF_1 768 774 PF00149 0.391
DOC_PP1_RVXF_1 815 822 PF00149 0.333
DOC_PP2B_LxvP_1 104 107 PF13499 0.327
DOC_PP2B_LxvP_1 776 779 PF13499 0.385
DOC_PP2B_LxvP_1 99 102 PF13499 0.312
DOC_PP4_FxxP_1 147 150 PF00568 0.316
DOC_PP4_FxxP_1 489 492 PF00568 0.535
DOC_PP4_FxxP_1 792 795 PF00568 0.342
DOC_USP7_MATH_1 188 192 PF00917 0.324
DOC_USP7_MATH_1 242 246 PF00917 0.303
DOC_USP7_MATH_1 490 494 PF00917 0.604
DOC_USP7_MATH_1 566 570 PF00917 0.772
DOC_USP7_MATH_1 573 577 PF00917 0.811
DOC_USP7_MATH_1 622 626 PF00917 0.564
DOC_USP7_MATH_1 649 653 PF00917 0.528
DOC_USP7_MATH_1 663 667 PF00917 0.638
DOC_USP7_MATH_1 695 699 PF00917 0.536
DOC_USP7_MATH_2 573 579 PF00917 0.663
DOC_WW_Pin1_4 146 151 PF00397 0.368
DOC_WW_Pin1_4 170 175 PF00397 0.380
DOC_WW_Pin1_4 291 296 PF00397 0.462
DOC_WW_Pin1_4 310 315 PF00397 0.404
DOC_WW_Pin1_4 42 47 PF00397 0.337
DOC_WW_Pin1_4 547 552 PF00397 0.724
DOC_WW_Pin1_4 641 646 PF00397 0.564
DOC_WW_Pin1_4 682 687 PF00397 0.554
DOC_WW_Pin1_4 832 837 PF00397 0.534
LIG_14-3-3_CanoR_1 128 134 PF00244 0.499
LIG_14-3-3_CanoR_1 190 196 PF00244 0.397
LIG_14-3-3_CanoR_1 211 215 PF00244 0.466
LIG_14-3-3_CanoR_1 286 292 PF00244 0.408
LIG_14-3-3_CanoR_1 525 530 PF00244 0.696
LIG_14-3-3_CanoR_1 565 574 PF00244 0.629
LIG_14-3-3_CanoR_1 786 795 PF00244 0.422
LIG_14-3-3_CanoR_1 815 820 PF00244 0.364
LIG_14-3-3_CterR_2 847 850 PF00244 0.429
LIG_Actin_WH2_2 498 513 PF00022 0.625
LIG_APCC_ABBA_1 256 261 PF00400 0.302
LIG_BRCT_BRCA1_1 695 699 PF00533 0.413
LIG_BRCT_BRCA1_1 714 718 PF00533 0.431
LIG_BRCT_BRCA1_1 817 821 PF00533 0.366
LIG_EH_1 238 242 PF12763 0.404
LIG_EH1_1 92 100 PF00400 0.264
LIG_FHA_1 129 135 PF00498 0.365
LIG_FHA_1 190 196 PF00498 0.391
LIG_FHA_1 260 266 PF00498 0.430
LIG_FHA_1 381 387 PF00498 0.611
LIG_FHA_1 408 414 PF00498 0.544
LIG_FHA_1 542 548 PF00498 0.745
LIG_FHA_1 556 562 PF00498 0.782
LIG_FHA_1 581 587 PF00498 0.667
LIG_FHA_1 706 712 PF00498 0.502
LIG_FHA_1 722 728 PF00498 0.363
LIG_FHA_1 748 754 PF00498 0.429
LIG_FHA_2 116 122 PF00498 0.319
LIG_FHA_2 171 177 PF00498 0.387
LIG_FHA_2 210 216 PF00498 0.367
LIG_FHA_2 425 431 PF00498 0.612
LIG_FHA_2 494 500 PF00498 0.605
LIG_FHA_2 591 597 PF00498 0.726
LIG_FHA_2 671 677 PF00498 0.563
LIG_LIR_Apic_2 790 795 PF02991 0.420
LIG_LIR_Gen_1 118 127 PF02991 0.369
LIG_LIR_Gen_1 173 183 PF02991 0.457
LIG_LIR_Gen_1 283 291 PF02991 0.375
LIG_LIR_Gen_1 745 753 PF02991 0.366
LIG_LIR_Nem_3 118 123 PF02991 0.343
LIG_LIR_Nem_3 173 178 PF02991 0.448
LIG_LIR_Nem_3 221 225 PF02991 0.355
LIG_LIR_Nem_3 23 29 PF02991 0.481
LIG_LIR_Nem_3 283 287 PF02991 0.423
LIG_LIR_Nem_3 60 66 PF02991 0.315
LIG_LIR_Nem_3 745 749 PF02991 0.365
LIG_LIR_Nem_3 752 758 PF02991 0.345
LIG_LIR_Nem_3 767 772 PF02991 0.366
LIG_MAD2 10 18 PF02301 0.612
LIG_MYND_1 14 18 PF01753 0.609
LIG_NRBOX 324 330 PF00104 0.291
LIG_NRBOX 590 596 PF00104 0.691
LIG_NRP_CendR_1 847 850 PF00754 0.629
LIG_PCNA_PIPBox_1 796 805 PF02747 0.392
LIG_Pex14_1 223 227 PF04695 0.252
LIG_Pex14_2 40 44 PF04695 0.322
LIG_SH2_CRK 746 750 PF00017 0.400
LIG_SH2_CRK 76 80 PF00017 0.310
LIG_SH2_CRK 769 773 PF00017 0.399
LIG_SH2_CRK 842 846 PF00017 0.422
LIG_SH2_NCK_1 214 218 PF00017 0.340
LIG_SH2_NCK_1 346 350 PF00017 0.593
LIG_SH2_NCK_1 66 70 PF00017 0.403
LIG_SH2_PTP2 185 188 PF00017 0.305
LIG_SH2_PTP2 26 29 PF00017 0.360
LIG_SH2_SRC 546 549 PF00017 0.622
LIG_SH2_SRC 755 758 PF00017 0.385
LIG_SH2_STAP1 346 350 PF00017 0.593
LIG_SH2_STAP1 454 458 PF00017 0.564
LIG_SH2_STAP1 57 61 PF00017 0.369
LIG_SH2_STAT3 400 403 PF00017 0.611
LIG_SH2_STAT5 185 188 PF00017 0.305
LIG_SH2_STAT5 254 257 PF00017 0.318
LIG_SH2_STAT5 26 29 PF00017 0.408
LIG_SH2_STAT5 412 415 PF00017 0.562
LIG_SH2_STAT5 546 549 PF00017 0.747
LIG_SH2_STAT5 63 66 PF00017 0.435
LIG_SH2_STAT5 764 767 PF00017 0.316
LIG_SH2_STAT5 93 96 PF00017 0.349
LIG_SH3_3 292 298 PF00018 0.414
LIG_SH3_3 545 551 PF00018 0.701
LIG_SH3_3 639 645 PF00018 0.528
LIG_SH3_3 685 691 PF00018 0.499
LIG_SH3_3 727 733 PF00018 0.372
LIG_SH3_3 8 14 PF00018 0.669
LIG_SH3_3 820 826 PF00018 0.409
LIG_SUMO_SIM_anti_2 45 51 PF11976 0.291
LIG_SUMO_SIM_par_1 316 323 PF11976 0.336
LIG_SUMO_SIM_par_1 77 82 PF11976 0.360
LIG_TRAF2_1 427 430 PF00917 0.603
LIG_TYR_ITIM 753 758 PF00017 0.369
LIG_UBA3_1 47 55 PF00899 0.458
LIG_WRC_WIRS_1 219 224 PF05994 0.365
MOD_CDK_SPK_2 146 151 PF00069 0.264
MOD_CK1_1 213 219 PF00069 0.506
MOD_CK1_1 310 316 PF00069 0.419
MOD_CK1_1 411 417 PF00069 0.580
MOD_CK1_1 493 499 PF00069 0.586
MOD_CK1_1 512 518 PF00069 0.685
MOD_CK1_1 550 556 PF00069 0.713
MOD_CK1_1 577 583 PF00069 0.714
MOD_CK1_1 615 621 PF00069 0.584
MOD_CK1_1 644 650 PF00069 0.557
MOD_CK1_1 666 672 PF00069 0.487
MOD_CK1_1 682 688 PF00069 0.541
MOD_CK1_1 693 699 PF00069 0.520
MOD_CK2_1 170 176 PF00069 0.417
MOD_CK2_1 209 215 PF00069 0.313
MOD_CK2_1 423 429 PF00069 0.577
MOD_CK2_1 493 499 PF00069 0.608
MOD_CK2_1 575 581 PF00069 0.679
MOD_CK2_1 670 676 PF00069 0.498
MOD_GlcNHglycan 104 107 PF01048 0.581
MOD_GlcNHglycan 179 182 PF01048 0.649
MOD_GlcNHglycan 215 218 PF01048 0.651
MOD_GlcNHglycan 232 235 PF01048 0.446
MOD_GlcNHglycan 261 265 PF01048 0.580
MOD_GlcNHglycan 325 328 PF01048 0.379
MOD_GlcNHglycan 541 544 PF01048 0.514
MOD_GlcNHglycan 617 620 PF01048 0.722
MOD_GlcNHglycan 624 627 PF01048 0.725
MOD_GlcNHglycan 646 649 PF01048 0.843
MOD_GlcNHglycan 652 655 PF01048 0.804
MOD_GlcNHglycan 665 668 PF01048 0.735
MOD_GlcNHglycan 681 684 PF01048 0.768
MOD_GSK3_1 170 177 PF00069 0.376
MOD_GSK3_1 209 216 PF00069 0.511
MOD_GSK3_1 260 267 PF00069 0.398
MOD_GSK3_1 287 294 PF00069 0.364
MOD_GSK3_1 319 326 PF00069 0.369
MOD_GSK3_1 407 414 PF00069 0.590
MOD_GSK3_1 465 472 PF00069 0.622
MOD_GSK3_1 547 554 PF00069 0.767
MOD_GSK3_1 573 580 PF00069 0.782
MOD_GSK3_1 590 597 PF00069 0.651
MOD_GSK3_1 658 665 PF00069 0.586
MOD_GSK3_1 666 673 PF00069 0.549
MOD_GSK3_1 690 697 PF00069 0.504
MOD_GSK3_1 701 708 PF00069 0.540
MOD_N-GLC_1 102 107 PF02516 0.617
MOD_N-GLC_1 115 120 PF02516 0.580
MOD_N-GLC_1 129 134 PF02516 0.508
MOD_N-GLC_1 151 156 PF02516 0.689
MOD_N-GLC_1 209 214 PF02516 0.583
MOD_N-GLC_1 230 235 PF02516 0.562
MOD_N-GLC_1 259 264 PF02516 0.598
MOD_N-GLC_1 310 315 PF02516 0.602
MOD_NEK2_1 225 230 PF00069 0.317
MOD_NEK2_1 241 246 PF00069 0.385
MOD_NEK2_1 269 274 PF00069 0.421
MOD_NEK2_1 287 292 PF00069 0.240
MOD_NEK2_1 299 304 PF00069 0.324
MOD_NEK2_1 340 345 PF00069 0.563
MOD_NEK2_1 408 413 PF00069 0.584
MOD_NEK2_1 423 428 PF00069 0.616
MOD_NEK2_1 469 474 PF00069 0.670
MOD_NEK2_1 594 599 PF00069 0.707
MOD_NEK2_1 681 686 PF00069 0.577
MOD_NEK2_1 765 770 PF00069 0.387
MOD_NEK2_1 84 89 PF00069 0.341
MOD_NEK2_2 254 259 PF00069 0.283
MOD_PIKK_1 276 282 PF00454 0.459
MOD_PIKK_1 580 586 PF00454 0.731
MOD_PIKK_1 84 90 PF00454 0.304
MOD_PKA_1 128 134 PF00069 0.298
MOD_PKA_2 128 134 PF00069 0.336
MOD_PKA_2 157 163 PF00069 0.365
MOD_PKA_2 189 195 PF00069 0.465
MOD_PKA_2 210 216 PF00069 0.471
MOD_PKB_1 563 571 PF00069 0.629
MOD_Plk_1 129 135 PF00069 0.366
MOD_Plk_1 209 215 PF00069 0.368
MOD_Plk_1 53 59 PF00069 0.308
MOD_Plk_1 64 70 PF00069 0.442
MOD_Plk_2-3 575 581 PF00069 0.641
MOD_Plk_2-3 670 676 PF00069 0.474
MOD_Plk_4 129 135 PF00069 0.394
MOD_Plk_4 174 180 PF00069 0.401
MOD_Plk_4 320 326 PF00069 0.300
MOD_Plk_4 408 414 PF00069 0.537
MOD_Plk_4 490 496 PF00069 0.597
MOD_Plk_4 541 547 PF00069 0.756
MOD_ProDKin_1 146 152 PF00069 0.370
MOD_ProDKin_1 170 176 PF00069 0.380
MOD_ProDKin_1 291 297 PF00069 0.461
MOD_ProDKin_1 310 316 PF00069 0.402
MOD_ProDKin_1 42 48 PF00069 0.337
MOD_ProDKin_1 547 553 PF00069 0.722
MOD_ProDKin_1 641 647 PF00069 0.564
MOD_ProDKin_1 682 688 PF00069 0.553
MOD_ProDKin_1 832 838 PF00069 0.533
TRG_DiLeu_BaEn_1 447 452 PF01217 0.620
TRG_DiLeu_BaEn_1 676 681 PF01217 0.441
TRG_DiLeu_BaEn_1 757 762 PF01217 0.378
TRG_DiLeu_BaEn_4 369 375 PF01217 0.626
TRG_DiLeu_BaLyEn_6 43 48 PF01217 0.322
TRG_DiLeu_BaLyEn_6 446 451 PF01217 0.624
TRG_DiLeu_BaLyEn_6 727 732 PF01217 0.395
TRG_ENDOCYTIC_2 145 148 PF00928 0.403
TRG_ENDOCYTIC_2 26 29 PF00928 0.360
TRG_ENDOCYTIC_2 746 749 PF00928 0.360
TRG_ENDOCYTIC_2 755 758 PF00928 0.317
TRG_ENDOCYTIC_2 76 79 PF00928 0.315
TRG_ENDOCYTIC_2 769 772 PF00928 0.360
TRG_ENDOCYTIC_2 842 845 PF00928 0.435
TRG_ER_diArg_1 12 15 PF00400 0.660
TRG_ER_diArg_1 127 129 PF00400 0.322
TRG_ER_diArg_1 204 206 PF00400 0.336
TRG_ER_diArg_1 24 26 PF00400 0.557
TRG_ER_diArg_1 303 306 PF00400 0.400
TRG_ER_diArg_1 524 527 PF00400 0.691
TRG_ER_diArg_1 561 563 PF00400 0.637
TRG_ER_diArg_1 598 600 PF00400 0.716
TRG_ER_diArg_1 785 787 PF00400 0.391
TRG_Pf-PMV_PEXEL_1 725 729 PF00026 0.707

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C6 Leptomonas seymouri 50% 99%
A0A3R7NB09 Trypanosoma rangeli 32% 96%
A0A3S7WQJ6 Leishmania donovani 50% 92%
A4H5K6 Leishmania braziliensis 41% 98%
A4H5K7 Leishmania braziliensis 69% 100%
A4HTU4 Leishmania infantum 50% 100%
A4HTU5 Leishmania infantum 99% 100%
D0A9A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 99%
E9AMN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AMN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QHZ3 Leishmania major 89% 99%
Q4QHZ4 Leishmania major 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS