Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6C2_LEIDO

TriTrypDb:

LdBPK_090240.1 , LdCL_090008100 , LDHU3_09.0410

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.820
CLV_C14_Caspase3-7	60	64	PF00656	0.584
CLV_C14_Caspase3-7	603	607	PF00656	0.746
CLV_C14_Caspase3-7	662	666	PF00656	0.749
CLV_NRD_NRD_1	122	124	PF00675	0.506
CLV_NRD_NRD_1	186	188	PF00675	0.530
CLV_NRD_NRD_1	189	191	PF00675	0.531
CLV_NRD_NRD_1	204	206	PF00675	0.518
CLV_NRD_NRD_1	295	297	PF00675	0.617
CLV_NRD_NRD_1	320	322	PF00675	0.551
CLV_NRD_NRD_1	348	350	PF00675	0.645
CLV_NRD_NRD_1	731	733	PF00675	0.489
CLV_NRD_NRD_1	750	752	PF00675	0.599
CLV_PCSK_FUR_1	187	191	PF00082	0.539
CLV_PCSK_KEX2_1	122	124	PF00082	0.505
CLV_PCSK_KEX2_1	185	187	PF00082	0.531
CLV_PCSK_KEX2_1	189	191	PF00082	0.531
CLV_PCSK_KEX2_1	204	206	PF00082	0.518
CLV_PCSK_KEX2_1	320	322	PF00082	0.551
CLV_PCSK_KEX2_1	348	350	PF00082	0.645
CLV_PCSK_KEX2_1	731	733	PF00082	0.559
CLV_PCSK_KEX2_1	750	752	PF00082	0.599
CLV_PCSK_PC7_1	182	188	PF00082	0.538
CLV_PCSK_SKI1_1	104	108	PF00082	0.466
CLV_PCSK_SKI1_1	297	301	PF00082	0.617
CLV_PCSK_SKI1_1	349	353	PF00082	0.576
DEG_APCC_DBOX_1	295	303	PF00400	0.758
DEG_Nend_Nbox_1	1	3	PF02207	0.346
DEG_SCF_FBW7_1	487	493	PF00400	0.774
DOC_CKS1_1	199	204	PF01111	0.725
DOC_CKS1_1	487	492	PF01111	0.773
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.688
DOC_MAPK_gen_1	296	304	PF00069	0.816
DOC_MAPK_gen_1	317	326	PF00069	0.773
DOC_MAPK_gen_1	770	780	PF00069	0.798
DOC_MAPK_MEF2A_6	296	304	PF00069	0.746
DOC_MAPK_MEF2A_6	317	326	PF00069	0.843
DOC_MAPK_MEF2A_6	721	730	PF00069	0.638
DOC_MAPK_MEF2A_6	773	782	PF00069	0.733
DOC_PP1_RVXF_1	566	572	PF00149	0.672
DOC_PP2B_LxvP_1	24	27	PF13499	0.692
DOC_PP2B_LxvP_1	292	295	PF13499	0.753
DOC_PP2B_LxvP_1	393	396	PF13499	0.734
DOC_PP2B_LxvP_1	551	554	PF13499	0.699
DOC_PP2B_LxvP_1	75	78	PF13499	0.770
DOC_PP4_FxxP_1	522	525	PF00568	0.679
DOC_PP4_MxPP_1	485	488	PF00568	0.801
DOC_SPAK_OSR1_1	532	536	PF12202	0.772
DOC_USP7_MATH_1	333	337	PF00917	0.800
DOC_USP7_MATH_1	37	41	PF00917	0.798
DOC_USP7_MATH_1	414	418	PF00917	0.761
DOC_USP7_MATH_1	490	494	PF00917	0.792
DOC_USP7_MATH_1	503	507	PF00917	0.618
DOC_USP7_MATH_1	51	55	PF00917	0.646
DOC_USP7_MATH_1	511	515	PF00917	0.696
DOC_USP7_MATH_1	602	606	PF00917	0.740
DOC_USP7_MATH_1	615	619	PF00917	0.653
DOC_USP7_MATH_1	710	714	PF00917	0.806
DOC_WW_Pin1_4	111	116	PF00397	0.702
DOC_WW_Pin1_4	198	203	PF00397	0.724
DOC_WW_Pin1_4	274	279	PF00397	0.825
DOC_WW_Pin1_4	336	341	PF00397	0.840
DOC_WW_Pin1_4	355	360	PF00397	0.822
DOC_WW_Pin1_4	486	491	PF00397	0.805
DOC_WW_Pin1_4	493	498	PF00397	0.745
DOC_WW_Pin1_4	505	510	PF00397	0.679
LIG_14-3-3_CanoR_1	158	167	PF00244	0.760
LIG_14-3-3_CanoR_1	282	291	PF00244	0.819
LIG_14-3-3_CanoR_1	321	327	PF00244	0.760
LIG_14-3-3_CanoR_1	384	394	PF00244	0.777
LIG_14-3-3_CanoR_1	512	519	PF00244	0.675
LIG_14-3-3_CanoR_1	568	572	PF00244	0.686
LIG_14-3-3_CanoR_1	773	779	PF00244	0.705
LIG_14-3-3_CanoR_1	89	94	PF00244	0.728
LIG_Actin_WH2_2	304	319	PF00022	0.764
LIG_BIR_III_4	332	336	PF00653	0.856
LIG_BRCT_BRCA1_1	513	517	PF00533	0.736
LIG_DCNL_PONY_1	1	4	PF03556	0.346
LIG_EH1_1	208	216	PF00400	0.746
LIG_eIF4E_1	394	400	PF01652	0.689
LIG_eIF4E_1	71	77	PF01652	0.707
LIG_FHA_1	232	238	PF00498	0.675
LIG_FHA_1	410	416	PF00498	0.748
LIG_FHA_1	570	576	PF00498	0.658
LIG_FHA_1	588	594	PF00498	0.667
LIG_FHA_1	773	779	PF00498	0.699
LIG_FHA_1	86	92	PF00498	0.748
LIG_FHA_1	96	102	PF00498	0.669
LIG_FHA_2	313	319	PF00498	0.704
LIG_FHA_2	58	64	PF00498	0.761
LIG_LIR_Gen_1	207	218	PF02991	0.672
LIG_LIR_Gen_1	22	30	PF02991	0.510
LIG_LIR_Gen_1	88	94	PF02991	0.661
LIG_LIR_Nem_3	207	213	PF02991	0.680
LIG_LIR_Nem_3	22	26	PF02991	0.486
LIG_LIR_Nem_3	736	742	PF02991	0.712
LIG_LIR_Nem_3	88	93	PF02991	0.666
LIG_LYPXL_yS_3	739	742	PF13949	0.714
LIG_MYND_1	677	681	PF01753	0.740
LIG_NRBOX	1	7	PF00104	0.346
LIG_PCNA_yPIPBox_3	719	732	PF02747	0.685
LIG_Pex14_1	127	131	PF04695	0.744
LIG_PTAP_UEV_1	588	593	PF05743	0.765
LIG_SH2_CRK	71	75	PF00017	0.771
LIG_SH2_CRK	84	88	PF00017	0.606
LIG_SH2_GRB2like	252	255	PF00017	0.733
LIG_SH2_NCK_1	671	675	PF00017	0.780
LIG_SH2_NCK_1	84	88	PF00017	0.718
LIG_SH2_PTP2	90	93	PF00017	0.663
LIG_SH2_SRC	394	397	PF00017	0.661
LIG_SH2_STAP1	131	135	PF00017	0.811
LIG_SH2_STAP1	252	256	PF00017	0.702
LIG_SH2_STAT3	528	531	PF00017	0.685
LIG_SH2_STAT5	129	132	PF00017	0.762
LIG_SH2_STAT5	20	23	PF00017	0.513
LIG_SH2_STAT5	650	653	PF00017	0.749
LIG_SH2_STAT5	84	87	PF00017	0.671
LIG_SH2_STAT5	90	93	PF00017	0.679
LIG_SH3_2	199	204	PF14604	0.704
LIG_SH3_2	677	682	PF14604	0.748
LIG_SH3_3	132	138	PF00018	0.655
LIG_SH3_3	196	202	PF00018	0.709
LIG_SH3_3	273	279	PF00018	0.668
LIG_SH3_3	292	298	PF00018	0.750
LIG_SH3_3	316	322	PF00018	0.764
LIG_SH3_3	460	466	PF00018	0.701
LIG_SH3_3	484	490	PF00018	0.794
LIG_SH3_3	586	592	PF00018	0.693
LIG_SH3_3	674	680	PF00018	0.718
LIG_SH3_5	436	440	PF00018	0.754
LIG_Sin3_3	594	601	PF02671	0.666
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.700
LIG_SUMO_SIM_anti_2	724	729	PF11976	0.678
LIG_SUMO_SIM_par_1	303	309	PF11976	0.809
LIG_SUMO_SIM_par_1	471	476	PF11976	0.736
LIG_TYR_ITIM	101	106	PF00017	0.669
LIG_TYR_ITIM	737	742	PF00017	0.701
LIG_UBA3_1	733	741	PF00899	0.720
LIG_WRC_WIRS_1	20	25	PF05994	0.299
LIG_WW_2	677	680	PF00397	0.728
LIG_WW_3	679	683	PF00397	0.753
MOD_CDK_SPK_2	111	116	PF00069	0.702
MOD_CDK_SPxK_1	198	204	PF00069	0.726
MOD_CDK_SPxK_1	336	342	PF00069	0.774
MOD_CDK_SPxK_1	493	499	PF00069	0.774
MOD_CDK_SPxxK_3	198	205	PF00069	0.798
MOD_CDK_SPxxK_3	341	348	PF00069	0.700
MOD_CDK_SPxxK_3	505	512	PF00069	0.652
MOD_CK1_1	166	172	PF00069	0.739
MOD_CK1_1	177	183	PF00069	0.772
MOD_CK1_1	284	290	PF00069	0.782
MOD_CK1_1	331	337	PF00069	0.831
MOD_CK1_1	35	41	PF00069	0.674
MOD_CK1_1	375	381	PF00069	0.773
MOD_CK1_1	398	404	PF00069	0.754
MOD_CK1_1	416	422	PF00069	0.748
MOD_CK1_1	493	499	PF00069	0.771
MOD_CK1_1	587	593	PF00069	0.765
MOD_CK1_1	605	611	PF00069	0.645
MOD_CK1_1	687	693	PF00069	0.837
MOD_CK1_1	700	706	PF00069	0.669
MOD_CK2_1	111	117	PF00069	0.705
MOD_CK2_1	610	616	PF00069	0.752
MOD_CK2_1	89	95	PF00069	0.677
MOD_DYRK1A_RPxSP_1	486	490	PF00069	0.772
MOD_GlcNHglycan	138	141	PF01048	0.617
MOD_GlcNHglycan	148	151	PF01048	0.532
MOD_GlcNHglycan	160	163	PF01048	0.607
MOD_GlcNHglycan	168	171	PF01048	0.506
MOD_GlcNHglycan	206	209	PF01048	0.559
MOD_GlcNHglycan	271	274	PF01048	0.583
MOD_GlcNHglycan	286	289	PF01048	0.653
MOD_GlcNHglycan	308	311	PF01048	0.605
MOD_GlcNHglycan	332	336	PF01048	0.589
MOD_GlcNHglycan	363	366	PF01048	0.645
MOD_GlcNHglycan	39	42	PF01048	0.623
MOD_GlcNHglycan	424	427	PF01048	0.631
MOD_GlcNHglycan	45	48	PF01048	0.540
MOD_GlcNHglycan	455	458	PF01048	0.517
MOD_GlcNHglycan	501	504	PF01048	0.589
MOD_GlcNHglycan	505	508	PF01048	0.486
MOD_GlcNHglycan	513	516	PF01048	0.429
MOD_GlcNHglycan	53	56	PF01048	0.447
MOD_GlcNHglycan	608	611	PF01048	0.562
MOD_GlcNHglycan	634	637	PF01048	0.611
MOD_GlcNHglycan	682	685	PF01048	0.631
MOD_GlcNHglycan	687	690	PF01048	0.632
MOD_GlcNHglycan	699	702	PF01048	0.486
MOD_GlcNHglycan	708	711	PF01048	0.543
MOD_GlcNHglycan	752	755	PF01048	0.603
MOD_GSK3_1	153	160	PF00069	0.801
MOD_GSK3_1	165	172	PF00069	0.729
MOD_GSK3_1	174	181	PF00069	0.779
MOD_GSK3_1	33	40	PF00069	0.755
MOD_GSK3_1	374	381	PF00069	0.808
MOD_GSK3_1	394	401	PF00069	0.777
MOD_GSK3_1	405	412	PF00069	0.718
MOD_GSK3_1	413	420	PF00069	0.692
MOD_GSK3_1	422	429	PF00069	0.768
MOD_GSK3_1	486	493	PF00069	0.748
MOD_GSK3_1	499	506	PF00069	0.664
MOD_GSK3_1	601	608	PF00069	0.788
MOD_GSK3_1	640	647	PF00069	0.687
MOD_GSK3_1	680	687	PF00069	0.727
MOD_GSK3_1	706	713	PF00069	0.753
MOD_GSK3_1	85	92	PF00069	0.675
MOD_N-GLC_1	375	380	PF02516	0.590
MOD_N-GLC_1	493	498	PF02516	0.546
MOD_N-GLC_1	690	695	PF02516	0.579
MOD_NEK2_1	178	183	PF00069	0.748
MOD_NEK2_1	312	317	PF00069	0.700
MOD_NEK2_1	399	404	PF00069	0.741
MOD_NEK2_1	646	651	PF00069	0.698
MOD_NEK2_1	685	690	PF00069	0.838
MOD_NEK2_1	733	738	PF00069	0.672
MOD_NEK2_1	769	774	PF00069	0.757
MOD_NEK2_1	8	13	PF00069	0.411
MOD_NEK2_1	83	88	PF00069	0.691
MOD_NEK2_2	224	229	PF00069	0.655
MOD_PIKK_1	282	288	PF00454	0.825
MOD_PIKK_1	648	654	PF00454	0.747
MOD_PKA_1	204	210	PF00069	0.775
MOD_PKA_1	750	756	PF00069	0.805
MOD_PKA_2	153	159	PF00069	0.755
MOD_PKA_2	181	187	PF00069	0.738
MOD_PKA_2	204	210	PF00069	0.759
MOD_PKA_2	281	287	PF00069	0.853
MOD_PKA_2	420	426	PF00069	0.732
MOD_PKA_2	511	517	PF00069	0.664
MOD_PKA_2	567	573	PF00069	0.688
MOD_PKA_2	667	673	PF00069	0.840
MOD_PKA_2	750	756	PF00069	0.795
MOD_PKA_2	769	775	PF00069	0.556
MOD_Plk_1	375	381	PF00069	0.796
MOD_Plk_1	584	590	PF00069	0.698
MOD_Plk_1	654	660	PF00069	0.758
MOD_Plk_1	690	696	PF00069	0.779
MOD_Plk_1	94	100	PF00069	0.741
MOD_Plk_2-3	471	477	PF00069	0.738
MOD_Plk_4	395	401	PF00069	0.780
MOD_Plk_4	654	660	PF00069	0.706
MOD_ProDKin_1	111	117	PF00069	0.705
MOD_ProDKin_1	198	204	PF00069	0.726
MOD_ProDKin_1	274	280	PF00069	0.826
MOD_ProDKin_1	336	342	PF00069	0.841
MOD_ProDKin_1	355	361	PF00069	0.822
MOD_ProDKin_1	486	492	PF00069	0.806
MOD_ProDKin_1	493	499	PF00069	0.746
MOD_ProDKin_1	505	511	PF00069	0.678
MOD_SUMO_for_1	228	231	PF00179	0.667
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.820
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.745
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.692
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.797
TRG_DiLeu_BaLyEn_6	729	734	PF01217	0.676
TRG_ENDOCYTIC_2	103	106	PF00928	0.671
TRG_ENDOCYTIC_2	20	23	PF00928	0.513
TRG_ENDOCYTIC_2	576	579	PF00928	0.677
TRG_ENDOCYTIC_2	71	74	PF00928	0.772
TRG_ENDOCYTIC_2	739	742	PF00928	0.711
TRG_ENDOCYTIC_2	84	87	PF00928	0.596
TRG_ENDOCYTIC_2	90	93	PF00928	0.545
TRG_ER_diArg_1	122	125	PF00400	0.704
TRG_ER_diArg_1	185	187	PF00400	0.740
TRG_ER_diArg_1	188	190	PF00400	0.744
TRG_ER_diArg_1	203	205	PF00400	0.703
TRG_ER_diArg_1	256	259	PF00400	0.657
TRG_ER_diArg_1	319	321	PF00400	0.749
TRG_ER_diArg_1	730	732	PF00400	0.751
TRG_ER_diArg_1	750	752	PF00400	0.799
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	731	735	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK26	Leptomonas seymouri	43%	94%
A4H5K2	Leishmania braziliensis	69%	96%
A4HTU0	Leishmania infantum	99%	100%
E9AMM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QHZ8	Leishmania major	91%	100%