NRDE_protein_putative/Pfam:PF05742

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NRDE protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6B6_LEIDO

TriTrypDb:

LdBPK_090220.1 , LdCL_090007300 , LDHU3_09.0300

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.450
CLV_C14_Caspase3-7	285	289	PF00656	0.294
CLV_NRD_NRD_1	233	235	PF00675	0.287
CLV_NRD_NRD_1	465	467	PF00675	0.217
CLV_NRD_NRD_1	47	49	PF00675	0.190
CLV_NRD_NRD_1	70	72	PF00675	0.225
CLV_PCSK_KEX2_1	233	235	PF00082	0.287
CLV_PCSK_KEX2_1	47	49	PF00082	0.190
CLV_PCSK_KEX2_1	70	72	PF00082	0.225
CLV_PCSK_SKI1_1	155	159	PF00082	0.430
CLV_PCSK_SKI1_1	172	176	PF00082	0.291
CLV_PCSK_SKI1_1	356	360	PF00082	0.401
DEG_Nend_UBRbox_4	1	3	PF02207	0.197
DEG_SPOP_SBC_1	319	323	PF00917	0.404
DOC_PP1_RVXF_1	464	471	PF00149	0.286
DOC_PP2B_LxvP_1	215	218	PF13499	0.364
DOC_PP2B_PxIxI_1	14	20	PF00149	0.274
DOC_PP4_FxxP_1	349	352	PF00568	0.284
DOC_PP4_FxxP_1	421	424	PF00568	0.257
DOC_SPAK_OSR1_1	62	66	PF12202	0.192
DOC_USP7_MATH_1	142	146	PF00917	0.469
DOC_USP7_MATH_1	148	152	PF00917	0.621
DOC_USP7_MATH_1	197	201	PF00917	0.581
DOC_USP7_MATH_1	239	243	PF00917	0.563
DOC_USP7_MATH_1	443	447	PF00917	0.377
DOC_USP7_MATH_1	473	477	PF00917	0.510
DOC_USP7_MATH_1	49	53	PF00917	0.194
DOC_WW_Pin1_4	184	189	PF00397	0.485
DOC_WW_Pin1_4	324	329	PF00397	0.508
DOC_WW_Pin1_4	69	74	PF00397	0.225
LIG_14-3-3_CanoR_1	155	160	PF00244	0.280
LIG_14-3-3_CanoR_1	265	273	PF00244	0.320
LIG_14-3-3_CanoR_1	346	350	PF00244	0.264
LIG_14-3-3_CanoR_1	466	471	PF00244	0.427
LIG_Actin_WH2_2	480	497	PF00022	0.262
LIG_BRCT_BRCA1_1	400	404	PF00533	0.308
LIG_BRCT_BRCA1_1	417	421	PF00533	0.197
LIG_BRCT_BRCA1_1	59	63	PF00533	0.225
LIG_DLG_GKlike_1	466	474	PF00625	0.253
LIG_eIF4E_1	221	227	PF01652	0.345
LIG_FHA_1	121	127	PF00498	0.333
LIG_FHA_1	154	160	PF00498	0.307
LIG_FHA_1	175	181	PF00498	0.291
LIG_FHA_1	28	34	PF00498	0.192
LIG_FHA_1	294	300	PF00498	0.347
LIG_FHA_1	302	308	PF00498	0.523
LIG_FHA_1	321	327	PF00498	0.562
LIG_FHA_1	37	43	PF00498	0.192
LIG_FHA_1	456	462	PF00498	0.265
LIG_FHA_1	472	478	PF00498	0.354
LIG_FHA_2	138	144	PF00498	0.586
LIG_FHA_2	190	196	PF00498	0.629
LIG_FHA_2	379	385	PF00498	0.298
LIG_LIR_Apic_2	158	164	PF02991	0.398
LIG_LIR_Apic_2	348	352	PF02991	0.265
LIG_LIR_Apic_2	418	424	PF02991	0.250
LIG_LIR_Nem_3	12	17	PF02991	0.193
LIG_LIR_Nem_3	52	56	PF02991	0.192
LIG_LIR_Nem_3	60	66	PF02991	0.192
LIG_Pex14_2	421	425	PF04695	0.489
LIG_SH2_CRK	161	165	PF00017	0.340
LIG_SH2_CRK	485	489	PF00017	0.247
LIG_SH2_NCK_1	161	165	PF00017	0.416
LIG_SH2_SRC	161	164	PF00017	0.417
LIG_SH2_STAT3	428	431	PF00017	0.211
LIG_SH2_STAT5	261	264	PF00017	0.293
LIG_SH2_STAT5	266	269	PF00017	0.387
LIG_SH2_STAT5	286	289	PF00017	0.335
LIG_SH2_STAT5	388	391	PF00017	0.466
LIG_SH2_STAT5	415	418	PF00017	0.277
LIG_SH3_1	70	76	PF00018	0.274
LIG_SH3_3	270	276	PF00018	0.384
LIG_SH3_3	307	313	PF00018	0.360
LIG_SH3_3	475	481	PF00018	0.319
LIG_SH3_3	70	76	PF00018	0.204
LIG_SUMO_SIM_par_1	434	439	PF11976	0.236
LIG_TYR_ITIM	483	488	PF00017	0.229
LIG_WW_1	218	221	PF00397	0.413
MOD_CK1_1	249	255	PF00069	0.484
MOD_CK1_1	321	327	PF00069	0.479
MOD_CK1_1	446	452	PF00069	0.577
MOD_CK1_1	453	459	PF00069	0.335
MOD_CK2_1	137	143	PF00069	0.583
MOD_CK2_1	189	195	PF00069	0.510
MOD_CK2_1	378	384	PF00069	0.382
MOD_GlcNHglycan	248	251	PF01048	0.498
MOD_GlcNHglycan	252	255	PF01048	0.463
MOD_GlcNHglycan	323	326	PF01048	0.642
MOD_GlcNHglycan	359	362	PF01048	0.436
MOD_GlcNHglycan	391	394	PF01048	0.430
MOD_GlcNHglycan	453	456	PF01048	0.391
MOD_GlcNHglycan	496	499	PF01048	0.587
MOD_GlcNHglycan	59	62	PF01048	0.225
MOD_GlcNHglycan	79	82	PF01048	0.404
MOD_GSK3_1	126	133	PF00069	0.351
MOD_GSK3_1	246	253	PF00069	0.665
MOD_GSK3_1	260	267	PF00069	0.329
MOD_GSK3_1	27	34	PF00069	0.190
MOD_GSK3_1	320	327	PF00069	0.526
MOD_GSK3_1	329	336	PF00069	0.391
MOD_GSK3_1	427	434	PF00069	0.239
MOD_GSK3_1	446	453	PF00069	0.423
MOD_LATS_1	244	250	PF00433	0.500
MOD_N-GLC_1	250	255	PF02516	0.474
MOD_NEK2_1	174	179	PF00069	0.429
MOD_NEK2_1	189	194	PF00069	0.484
MOD_NEK2_1	260	265	PF00069	0.287
MOD_NEK2_1	282	287	PF00069	0.280
MOD_NEK2_1	35	40	PF00069	0.198
MOD_NEK2_1	354	359	PF00069	0.517
MOD_NEK2_1	389	394	PF00069	0.394
MOD_NEK2_1	416	421	PF00069	0.287
MOD_NEK2_1	77	82	PF00069	0.513
MOD_PIKK_1	427	433	PF00454	0.238
MOD_PIKK_1	471	477	PF00454	0.332
MOD_PKA_1	466	472	PF00069	0.237
MOD_PKA_2	264	270	PF00069	0.328
MOD_PKA_2	27	33	PF00069	0.203
MOD_PKA_2	345	351	PF00069	0.253
MOD_PKA_2	494	500	PF00069	0.368
MOD_Plk_1	197	203	PF00069	0.491
MOD_Plk_1	354	360	PF00069	0.341
MOD_Plk_1	398	404	PF00069	0.331
MOD_Plk_2-3	345	351	PF00069	0.302
MOD_Plk_4	121	127	PF00069	0.288
MOD_Plk_4	130	136	PF00069	0.424
MOD_Plk_4	282	288	PF00069	0.294
MOD_Plk_4	416	422	PF00069	0.285
MOD_Plk_4	431	437	PF00069	0.203
MOD_Plk_4	456	462	PF00069	0.272
MOD_Plk_4	473	479	PF00069	0.287
MOD_Plk_4	49	55	PF00069	0.192
MOD_ProDKin_1	184	190	PF00069	0.489
MOD_ProDKin_1	324	330	PF00069	0.504
MOD_ProDKin_1	69	75	PF00069	0.225
MOD_SUMO_for_1	352	355	PF00179	0.303
TRG_DiLeu_BaEn_2	11	17	PF01217	0.274
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.379
TRG_ENDOCYTIC_2	221	224	PF00928	0.294
TRG_ENDOCYTIC_2	485	488	PF00928	0.237
TRG_ER_diArg_1	232	234	PF00400	0.269
TRG_NES_CRM1_1	24	36	PF08389	0.265
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R3	Leptomonas seymouri	46%	100%
A0A1X0NNG0	Trypanosomatidae	33%	100%
A0A3R7K8K9	Trypanosoma rangeli	32%	100%
A4HTT8	Leishmania infantum	100%	100%
E9AML9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4QI06	Leishmania major	92%	100%
V5BMV9	Trypanosoma cruzi	31%	100%