Autophagy protein Atg8 ubiquitin like family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATG8/AUT7/APG8/PAZ2, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6B2_LEIDO

TriTrypDb:

LdBPK_090180.1 , LdCL_090006700 , LdCL_090006900 , LDHU3_09.0230 , LDHU3_09.0240 , LDHU3_09.0260

Length:

134

Annotations

Annotations by Jardim et al.

Autophagy, Autophagy-related ATG8C.1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 47
NetGPI	no	yes: 0, no: 47

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	47
GO:0110165	cellular anatomical entity	1	47

Expansion

Sequence features

A0A3S5H6B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6B2

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009987	cellular process	1	26
GO:0044237	cellular metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0061919	process utilizing autophagic mechanism	2	14
GO:0006950	response to stress	2	14
GO:0006995	cellular response to nitrogen starvation	5	14
GO:0007154	cell communication	2	14
GO:0009267	cellular response to starvation	4	14
GO:0009605	response to external stimulus	2	14
GO:0009991	response to extracellular stimulus	3	14
GO:0031667	response to nutrient levels	4	14
GO:0031668	cellular response to extracellular stimulus	3	14
GO:0031669	cellular response to nutrient levels	4	14
GO:0033554	cellular response to stress	3	14
GO:0042594	response to starvation	3	14
GO:0043562	cellular response to nitrogen levels	5	14
GO:0050896	response to stimulus	1	14
GO:0051716	cellular response to stimulus	2	14
GO:0071496	cellular response to external stimulus	3	14

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.373
CLV_PCSK_KEX2_1	93	95	PF00082	0.589
CLV_PCSK_SKI1_1	13	17	PF00082	0.525
DEG_SCF_FBW7_1	114	120	PF00400	0.509
DOC_CKS1_1	114	119	PF01111	0.637
DOC_CKS1_1	6	11	PF01111	0.421
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.414
DOC_MAPK_gen_1	67	74	PF00069	0.509
DOC_MAPK_JIP1_4	68	74	PF00069	0.434
DOC_MAPK_MEF2A_6	21	30	PF00069	0.565
DOC_MAPK_MEF2A_6	67	74	PF00069	0.415
DOC_USP7_MATH_1	117	121	PF00917	0.684
DOC_USP7_MATH_1	75	79	PF00917	0.490
DOC_WW_Pin1_4	113	118	PF00397	0.664
DOC_WW_Pin1_4	5	10	PF00397	0.444
DOC_WW_Pin1_4	77	82	PF00397	0.536
LIG_Actin_WH2_2	7	23	PF00022	0.435
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_FHA_2	125	131	PF00498	0.425
LIG_FHA_2	6	12	PF00498	0.448
LIG_FHA_2	82	88	PF00498	0.592
LIG_PDZ_Class_2	129	134	PF00595	0.590
LIG_SH2_STAT5	101	104	PF00017	0.421
LIG_SH2_STAT5	4	7	PF00017	0.548
LIG_SH3_3	111	117	PF00018	0.681
LIG_SUMO_SIM_par_1	26	32	PF11976	0.530
LIG_SUMO_SIM_par_1	68	73	PF11976	0.544
MOD_CK2_1	5	11	PF00069	0.446
MOD_CK2_1	81	87	PF00069	0.432
MOD_GlcNHglycan	1	4	PF01048	0.615
MOD_GlcNHglycan	42	45	PF01048	0.548
MOD_GlcNHglycan	81	84	PF01048	0.475
MOD_GSK3_1	113	120	PF00069	0.570
MOD_GSK3_1	75	82	PF00069	0.521
MOD_OFUCOSY	115	121	PF10250	0.529
MOD_PKA_2	46	52	PF00069	0.514
MOD_Plk_1	47	53	PF00069	0.521
MOD_ProDKin_1	113	119	PF00069	0.664
MOD_ProDKin_1	5	11	PF00069	0.446
MOD_ProDKin_1	77	83	PF00069	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR42	Leptomonas seymouri	43%	100%
A0A0N1P9V5	Leptomonas seymouri	46%	100%
A0A0N1PAQ9	Leptomonas seymouri	40%	67%
A0A1X0P492	Trypanosomatidae	38%	95%
A0A1X0P5E7	Trypanosomatidae	40%	96%
A0A381MAT2	Leishmania infantum	100%	100%
A0A381MBG2	Leishmania infantum	98%	100%
A0A381MCF0	Leishmania infantum	99%	100%
A0A381MFR9	Leishmania infantum	50%	100%
A0A3Q8IB99	Leishmania donovani	49%	98%
A0A3Q8IK22	Leishmania donovani	40%	100%
A0A3S5H6B3	Leishmania donovani	98%	100%
A0A3S5H761	Leishmania donovani	48%	100%
A0A3S5H762	Leishmania donovani	48%	100%
A0A3S7WQH8	Leishmania donovani	99%	100%
A0A3S7WQJ1	Leishmania donovani	100%	100%
A0A3S7WVM4	Leishmania donovani	50%	100%
A4H5J2	Leishmania braziliensis	88%	100%
A4H5J3	Leishmania braziliensis	87%	100%
A4HA39	Leishmania braziliensis	39%	100%
A4HA42	Leishmania braziliensis	47%	98%
A4HA43	Leishmania braziliensis	47%	98%
A4HTT6	Leishmania infantum	100%	100%
A4HYA4	Leishmania infantum	48%	100%
A4HYA5	Leishmania infantum	49%	100%
E9AGS4	Leishmania infantum	39%	100%
E9AML6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AS34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AS37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AS38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AS40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AS41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
Q4QDC5	Leishmania major	51%	98%
Q4QDC8	Leishmania major	51%	100%
Q4QDD0	Leishmania major	49%	98%
Q4QDD1	Leishmania major	39%	100%
Q4QDD3	Leishmania major	50%	99%
Q4QDD4	Leishmania major	40%	100%
Q4QDD6	Leishmania major	49%	99%
Q4QI08	Leishmania major	98%	100%
Q4QI09	Leishmania major	96%	100%
Q4QI11	Leishmania major	98%	100%
Q4QI13	Leishmania major	94%	100%
Q4QI15	Leishmania major	95%	100%
Q4QI18	Leishmania major	98%	100%
Q4QI19	Leishmania major	96%	100%