Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6B0_LEIDO

TriTrypDb:

LdBPK_090140.1 , LdCL_090006300 , LDHU3_09.0190

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.612
CLV_NRD_NRD_1	119	121	PF00675	0.629
CLV_NRD_NRD_1	136	138	PF00675	0.467
CLV_NRD_NRD_1	189	191	PF00675	0.558
CLV_NRD_NRD_1	192	194	PF00675	0.533
CLV_NRD_NRD_1	214	216	PF00675	0.620
CLV_NRD_NRD_1	25	27	PF00675	0.491
CLV_NRD_NRD_1	277	279	PF00675	0.499
CLV_NRD_NRD_1	304	306	PF00675	0.571
CLV_NRD_NRD_1	324	326	PF00675	0.515
CLV_NRD_NRD_1	331	333	PF00675	0.479
CLV_NRD_NRD_1	421	423	PF00675	0.494
CLV_NRD_NRD_1	426	428	PF00675	0.489
CLV_NRD_NRD_1	440	442	PF00675	0.465
CLV_NRD_NRD_1	532	534	PF00675	0.475
CLV_NRD_NRD_1	581	583	PF00675	0.814
CLV_NRD_NRD_1	596	598	PF00675	0.665
CLV_NRD_NRD_1	688	690	PF00675	0.651
CLV_NRD_NRD_1	96	98	PF00675	0.556
CLV_PCSK_FUR_1	117	121	PF00082	0.566
CLV_PCSK_FUR_1	190	194	PF00082	0.612
CLV_PCSK_KEX2_1	119	121	PF00082	0.648
CLV_PCSK_KEX2_1	136	138	PF00082	0.438
CLV_PCSK_KEX2_1	189	191	PF00082	0.532
CLV_PCSK_KEX2_1	192	194	PF00082	0.512
CLV_PCSK_KEX2_1	214	216	PF00082	0.620
CLV_PCSK_KEX2_1	25	27	PF00082	0.491
CLV_PCSK_KEX2_1	277	279	PF00082	0.506
CLV_PCSK_KEX2_1	324	326	PF00082	0.509
CLV_PCSK_KEX2_1	330	332	PF00082	0.460
CLV_PCSK_KEX2_1	426	428	PF00082	0.507
CLV_PCSK_KEX2_1	439	441	PF00082	0.464
CLV_PCSK_KEX2_1	532	534	PF00082	0.477
CLV_PCSK_KEX2_1	581	583	PF00082	0.814
CLV_PCSK_KEX2_1	596	598	PF00082	0.665
CLV_PCSK_KEX2_1	95	97	PF00082	0.523
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.521
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.530
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.541
CLV_PCSK_PC7_1	422	428	PF00082	0.582
CLV_PCSK_SKI1_1	369	373	PF00082	0.679
CLV_PCSK_SKI1_1	417	421	PF00082	0.428
CLV_PCSK_SKI1_1	471	475	PF00082	0.587
CLV_PCSK_SKI1_1	82	86	PF00082	0.595
CLV_Separin_Metazoa	32	36	PF03568	0.446
DEG_APCC_DBOX_1	148	156	PF00400	0.549
DEG_APCC_DBOX_1	486	494	PF00400	0.463
DEG_COP1_1	622	632	PF00400	0.725
DEG_ODPH_VHL_1	247	260	PF01847	0.477
DEG_SCF_FBW7_1	383	390	PF00400	0.528
DEG_SPOP_SBC_1	203	207	PF00917	0.560
DEG_SPOP_SBC_1	584	588	PF00917	0.609
DEG_SPOP_SBC_1	611	615	PF00917	0.713
DOC_CYCLIN_RxL_1	329	337	PF00134	0.620
DOC_CYCLIN_RxL_1	76	89	PF00134	0.591
DOC_MAPK_gen_1	170	180	PF00069	0.649
DOC_MAPK_gen_1	25	33	PF00069	0.526
DOC_MAPK_gen_1	303	312	PF00069	0.652
DOC_MAPK_gen_1	330	336	PF00069	0.620
DOC_MAPK_gen_1	426	435	PF00069	0.491
DOC_MAPK_JIP1_4	306	312	PF00069	0.579
DOC_MAPK_MEF2A_6	173	182	PF00069	0.572
DOC_PP1_RVXF_1	224	230	PF00149	0.558
DOC_PP1_RVXF_1	415	422	PF00149	0.439
DOC_PP4_FxxP_1	508	511	PF00568	0.591
DOC_USP7_MATH_1	115	119	PF00917	0.591
DOC_USP7_MATH_1	202	206	PF00917	0.637
DOC_USP7_MATH_1	222	226	PF00917	0.627
DOC_USP7_MATH_1	457	461	PF00917	0.714
DOC_USP7_MATH_1	50	54	PF00917	0.561
DOC_USP7_MATH_1	552	556	PF00917	0.627
DOC_USP7_MATH_1	584	588	PF00917	0.808
DOC_USP7_MATH_1	612	616	PF00917	0.608
DOC_USP7_MATH_1	65	69	PF00917	0.700
DOC_USP7_MATH_1	668	672	PF00917	0.787
DOC_USP7_MATH_1	701	705	PF00917	0.655
DOC_USP7_UBL2_3	365	369	PF12436	0.693
DOC_WW_Pin1_4	105	110	PF00397	0.698
DOC_WW_Pin1_4	214	219	PF00397	0.592
DOC_WW_Pin1_4	343	348	PF00397	0.567
DOC_WW_Pin1_4	383	388	PF00397	0.591
DOC_WW_Pin1_4	559	564	PF00397	0.710
DOC_WW_Pin1_4	632	637	PF00397	0.682
DOC_WW_Pin1_4	652	657	PF00397	0.503
LIG_14-3-3_CanoR_1	173	179	PF00244	0.698
LIG_14-3-3_CanoR_1	271	279	PF00244	0.494
LIG_14-3-3_CanoR_1	296	304	PF00244	0.625
LIG_14-3-3_CanoR_1	411	419	PF00244	0.509
LIG_14-3-3_CanoR_1	5	13	PF00244	0.657
LIG_14-3-3_CanoR_1	566	571	PF00244	0.676
LIG_14-3-3_CanoR_1	623	630	PF00244	0.659
LIG_14-3-3_CanoR_1	66	75	PF00244	0.687
LIG_14-3-3_CanoR_1	681	688	PF00244	0.690
LIG_APCC_ABBA_1	500	505	PF00400	0.645
LIG_APCC_ABBA_1	52	57	PF00400	0.489
LIG_APCC_ABBAyCdc20_2	250	256	PF00400	0.544
LIG_APCC_Cbox_2	480	486	PF00515	0.452
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BIR_III_2	514	518	PF00653	0.582
LIG_BRCT_BRCA1_1	682	686	PF00533	0.502
LIG_FHA_1	384	390	PF00498	0.685
LIG_FHA_1	552	558	PF00498	0.670
LIG_FHA_1	649	655	PF00498	0.721
LIG_FHA_2	119	125	PF00498	0.649
LIG_FHA_2	492	498	PF00498	0.607
LIG_FHA_2	586	592	PF00498	0.755
LIG_Integrin_RGD_1	512	514	PF01839	0.490
LIG_LIR_Apic_2	302	307	PF02991	0.651
LIG_LIR_Apic_2	505	511	PF02991	0.566
LIG_LIR_Apic_2	539	544	PF02991	0.518
LIG_LIR_Apic_2	558	563	PF02991	0.541
LIG_LIR_Apic_2	604	610	PF02991	0.735
LIG_LIR_Apic_2	635	641	PF02991	0.529
LIG_LIR_Apic_2	687	691	PF02991	0.616
LIG_LIR_Gen_1	18	27	PF02991	0.557
LIG_LIR_Gen_1	460	470	PF02991	0.607
LIG_LIR_Gen_1	619	629	PF02991	0.661
LIG_LIR_Nem_3	18	22	PF02991	0.561
LIG_LIR_Nem_3	619	624	PF02991	0.665
LIG_PDZ_Class_1	706	711	PF00595	0.533
LIG_Pex14_1	542	546	PF04695	0.668
LIG_Pex14_2	603	607	PF04695	0.734
LIG_RPA_C_Fungi	115	127	PF08784	0.511
LIG_RPA_C_Fungi	137	149	PF08784	0.423
LIG_SH2_CRK	304	308	PF00017	0.721
LIG_SH2_CRK	694	698	PF00017	0.639
LIG_SH2_NCK_1	546	550	PF00017	0.613
LIG_SH2_PTP2	638	641	PF00017	0.498
LIG_SH2_STAP1	223	227	PF00017	0.496
LIG_SH2_STAP1	254	258	PF00017	0.579
LIG_SH2_STAP1	55	59	PF00017	0.533
LIG_SH2_STAP1	650	654	PF00017	0.603
LIG_SH2_STAT5	19	22	PF00017	0.559
LIG_SH2_STAT5	261	264	PF00017	0.698
LIG_SH2_STAT5	463	466	PF00017	0.613
LIG_SH2_STAT5	638	641	PF00017	0.692
LIG_SH2_STAT5	650	653	PF00017	0.603
LIG_SH3_1	638	644	PF00018	0.515
LIG_SH3_3	103	109	PF00018	0.654
LIG_SH3_3	44	50	PF00018	0.500
LIG_SH3_3	461	467	PF00018	0.671
LIG_SH3_3	503	509	PF00018	0.609
LIG_SH3_3	638	644	PF00018	0.648
LIG_SH3_3	653	659	PF00018	0.580
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.529
LIG_SUMO_SIM_par_1	650	655	PF11976	0.600
LIG_TRAF2_1	494	497	PF00917	0.498
LIG_TRAF2_1	625	628	PF00917	0.608
LIG_TRAF2_1	90	93	PF00917	0.595
LIG_TYR_ITIM	17	22	PF00017	0.560
LIG_TYR_ITIM	692	697	PF00017	0.637
LIG_WRC_WIRS_1	261	266	PF05994	0.523
MOD_CDK_SPxxK_3	343	350	PF00069	0.550
MOD_CDK_SPxxK_3	559	566	PF00069	0.777
MOD_CK1_1	118	124	PF00069	0.603
MOD_CK1_1	153	159	PF00069	0.616
MOD_CK1_1	205	211	PF00069	0.572
MOD_CK1_1	269	275	PF00069	0.531
MOD_CK1_1	311	317	PF00069	0.642
MOD_CK1_1	320	326	PF00069	0.452
MOD_CK1_1	346	352	PF00069	0.628
MOD_CK1_1	390	396	PF00069	0.551
MOD_CK1_1	491	497	PF00069	0.484
MOD_CK1_1	555	561	PF00069	0.620
MOD_CK1_1	562	568	PF00069	0.671
MOD_CK1_1	569	575	PF00069	0.738
MOD_CK1_1	580	586	PF00069	0.789
MOD_CK1_1	587	593	PF00069	0.555
MOD_CK1_1	619	625	PF00069	0.656
MOD_CK1_1	631	637	PF00069	0.606
MOD_CK1_1	680	686	PF00069	0.694
MOD_CK2_1	222	228	PF00069	0.555
MOD_CK2_1	491	497	PF00069	0.516
MOD_CK2_1	585	591	PF00069	0.771
MOD_CK2_1	622	628	PF00069	0.713
MOD_Cter_Amidation	23	26	PF01082	0.542
MOD_GlcNHglycan	155	158	PF01048	0.680
MOD_GlcNHglycan	207	210	PF01048	0.649
MOD_GlcNHglycan	211	214	PF01048	0.671
MOD_GlcNHglycan	220	223	PF01048	0.502
MOD_GlcNHglycan	268	271	PF01048	0.533
MOD_GlcNHglycan	372	375	PF01048	0.696
MOD_GlcNHglycan	401	404	PF01048	0.587
MOD_GlcNHglycan	406	409	PF01048	0.616
MOD_GlcNHglycan	460	463	PF01048	0.669
MOD_GlcNHglycan	577	580	PF01048	0.776
MOD_GlcNHglycan	582	585	PF01048	0.807
MOD_GlcNHglycan	630	633	PF01048	0.684
MOD_GlcNHglycan	656	659	PF01048	0.601
MOD_GlcNHglycan	682	685	PF01048	0.692
MOD_GlcNHglycan	697	700	PF01048	0.673
MOD_GlcNHglycan	708	711	PF01048	0.670
MOD_GSK3_1	105	112	PF00069	0.659
MOD_GSK3_1	174	181	PF00069	0.521
MOD_GSK3_1	204	211	PF00069	0.561
MOD_GSK3_1	214	221	PF00069	0.587
MOD_GSK3_1	266	273	PF00069	0.505
MOD_GSK3_1	295	302	PF00069	0.655
MOD_GSK3_1	370	377	PF00069	0.718
MOD_GSK3_1	379	386	PF00069	0.543
MOD_GSK3_1	551	558	PF00069	0.706
MOD_GSK3_1	562	569	PF00069	0.641
MOD_GSK3_1	573	580	PF00069	0.647
MOD_GSK3_1	583	590	PF00069	0.810
MOD_GSK3_1	610	617	PF00069	0.659
MOD_GSK3_1	628	635	PF00069	0.475
MOD_GSK3_1	648	655	PF00069	0.635
MOD_GSK3_1	680	687	PF00069	0.618
MOD_GSK3_1	695	702	PF00069	0.587
MOD_GSK3_1	7	14	PF00069	0.596
MOD_N-GLC_1	50	55	PF02516	0.434
MOD_NEK2_1	260	265	PF00069	0.598
MOD_NEK2_1	295	300	PF00069	0.706
MOD_NEK2_1	404	409	PF00069	0.569
MOD_NEK2_1	616	621	PF00069	0.697
MOD_NEK2_2	308	313	PF00069	0.553
MOD_NEK2_2	445	450	PF00069	0.612
MOD_NEK2_2	50	55	PF00069	0.525
MOD_PIKK_1	566	572	PF00454	0.768
MOD_PIKK_1	622	628	PF00454	0.666
MOD_PKA_2	118	124	PF00069	0.691
MOD_PKA_2	159	165	PF00069	0.560
MOD_PKA_2	270	276	PF00069	0.538
MOD_PKA_2	295	301	PF00069	0.641
MOD_PKA_2	374	380	PF00069	0.646
MOD_PKA_2	399	405	PF00069	0.531
MOD_PKA_2	410	416	PF00069	0.475
MOD_PKA_2	458	464	PF00069	0.652
MOD_PKA_2	552	558	PF00069	0.612
MOD_PKA_2	580	586	PF00069	0.806
MOD_PKA_2	622	628	PF00069	0.728
MOD_PKA_2	65	71	PF00069	0.568
MOD_PKA_2	662	668	PF00069	0.774
MOD_PKA_2	680	686	PF00069	0.690
MOD_PKB_1	559	567	PF00069	0.599
MOD_PKB_1	693	701	PF00069	0.590
MOD_Plk_1	178	184	PF00069	0.620
MOD_Plk_1	445	451	PF00069	0.556
MOD_Plk_1	491	497	PF00069	0.482
MOD_Plk_1	50	56	PF00069	0.496
MOD_Plk_4	308	314	PF00069	0.679
MOD_Plk_4	50	56	PF00069	0.522
MOD_Plk_4	643	649	PF00069	0.666
MOD_ProDKin_1	105	111	PF00069	0.694
MOD_ProDKin_1	214	220	PF00069	0.587
MOD_ProDKin_1	343	349	PF00069	0.565
MOD_ProDKin_1	383	389	PF00069	0.581
MOD_ProDKin_1	559	565	PF00069	0.711
MOD_ProDKin_1	632	638	PF00069	0.684
MOD_ProDKin_1	652	658	PF00069	0.503
TRG_DiLeu_BaEn_1	29	34	PF01217	0.447
TRG_DiLeu_BaEn_1	415	420	PF01217	0.509
TRG_DiLeu_BaEn_4	430	436	PF01217	0.523
TRG_ENDOCYTIC_2	19	22	PF00928	0.575
TRG_ENDOCYTIC_2	261	264	PF00928	0.618
TRG_ENDOCYTIC_2	463	466	PF00928	0.613
TRG_ENDOCYTIC_2	694	697	PF00928	0.639
TRG_ER_diArg_1	117	120	PF00400	0.669
TRG_ER_diArg_1	136	139	PF00400	0.505
TRG_ER_diArg_1	189	192	PF00400	0.565
TRG_ER_diArg_1	214	216	PF00400	0.634
TRG_ER_diArg_1	25	27	PF00400	0.485
TRG_ER_diArg_1	277	279	PF00400	0.648
TRG_ER_diArg_1	324	326	PF00400	0.621
TRG_ER_diArg_1	330	332	PF00400	0.622
TRG_ER_diArg_1	397	400	PF00400	0.523
TRG_ER_diArg_1	439	441	PF00400	0.572
TRG_ER_diArg_1	532	535	PF00400	0.506
TRG_NLS_Bipartite_1	81	99	PF00514	0.534
TRG_NLS_MonoExtN_4	365	372	PF00514	0.588
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI3	Leptomonas seymouri	55%	97%
A0A0S4JTQ5	Bodo saltans	30%	94%
A0A1X0NN57	Trypanosomatidae	35%	100%
A0A3R7NK16	Trypanosoma rangeli	37%	100%
A4H5I9	Leishmania braziliensis	74%	98%
A4HTT0	Leishmania infantum	99%	100%
D0A991	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ALI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AML3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QI23	Leishmania major	93%	100%
V5BSF1	Trypanosoma cruzi	37%	100%