EF-hand domain pair family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar pocket cytoskeletal protein bilbo1

Species:

Leishmania donovani

UniProt:

A0A3S5H6A9_LEIDO

TriTrypDb:

LdBPK_090120.1 , LdCL_090006100 , LDHU3_09.0170

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6A9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.761
CLV_C14_Caspase3-7	292	296	PF00656	0.698
CLV_C14_Caspase3-7	375	379	PF00656	0.521
CLV_C14_Caspase3-7	45	49	PF00656	0.663
CLV_C14_Caspase3-7	473	477	PF00656	0.736
CLV_C14_Caspase3-7	543	547	PF00656	0.520
CLV_NRD_NRD_1	152	154	PF00675	0.724
CLV_NRD_NRD_1	261	263	PF00675	0.532
CLV_NRD_NRD_1	324	326	PF00675	0.658
CLV_NRD_NRD_1	352	354	PF00675	0.528
CLV_NRD_NRD_1	368	370	PF00675	0.579
CLV_NRD_NRD_1	474	476	PF00675	0.506
CLV_NRD_NRD_1	521	523	PF00675	0.545
CLV_PCSK_KEX2_1	152	154	PF00082	0.724
CLV_PCSK_KEX2_1	368	370	PF00082	0.586
CLV_PCSK_KEX2_1	395	397	PF00082	0.604
CLV_PCSK_KEX2_1	474	476	PF00082	0.507
CLV_PCSK_KEX2_1	521	523	PF00082	0.627
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.606
CLV_PCSK_SKI1_1	179	183	PF00082	0.369
CLV_PCSK_SKI1_1	508	512	PF00082	0.570
DEG_APCC_DBOX_1	23	31	PF00400	0.594
DEG_APCC_DBOX_1	352	360	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.472
DEG_SCF_FBW7_1	121	128	PF00400	0.811
DEG_SPOP_SBC_1	131	135	PF00917	0.749
DOC_CYCLIN_yClb1_LxF_4	12	17	PF00134	0.566
DOC_PP1_RVXF_1	12	18	PF00149	0.456
DOC_PP1_RVXF_1	177	183	PF00149	0.361
DOC_USP7_MATH_1	119	123	PF00917	0.746
DOC_USP7_MATH_1	125	129	PF00917	0.656
DOC_USP7_MATH_1	130	134	PF00917	0.688
DOC_USP7_MATH_1	157	161	PF00917	0.724
DOC_USP7_MATH_1	272	276	PF00917	0.619
DOC_USP7_MATH_1	282	286	PF00917	0.547
DOC_USP7_MATH_1	360	364	PF00917	0.576
DOC_USP7_MATH_1	372	376	PF00917	0.565
DOC_USP7_MATH_1	571	575	PF00917	0.665
DOC_USP7_UBL2_3	350	354	PF12436	0.656
DOC_USP7_UBL2_3	488	492	PF12436	0.464
DOC_USP7_UBL2_3	96	100	PF12436	0.609
DOC_WW_Pin1_4	121	126	PF00397	0.805
DOC_WW_Pin1_4	170	175	PF00397	0.698
LIG_14-3-3_CanoR_1	129	138	PF00244	0.806
LIG_14-3-3_CanoR_1	152	156	PF00244	0.684
LIG_14-3-3_CanoR_1	228	237	PF00244	0.432
LIG_14-3-3_CanoR_1	32	38	PF00244	0.620
LIG_APCC_ABBA_1	60	65	PF00400	0.472
LIG_APCC_ABBAyCdc20_2	59	65	PF00400	0.438
LIG_BIR_III_2	171	175	PF00653	0.642
LIG_BRCT_BRCA1_1	251	255	PF00533	0.437
LIG_FHA_1	110	116	PF00498	0.817
LIG_FHA_1	160	166	PF00498	0.797
LIG_FHA_1	188	194	PF00498	0.398
LIG_FHA_1	243	249	PF00498	0.400
LIG_FHA_1	52	58	PF00498	0.529
LIG_FHA_2	211	217	PF00498	0.390
LIG_FHA_2	230	236	PF00498	0.429
LIG_FHA_2	43	49	PF00498	0.537
LIG_FHA_2	526	532	PF00498	0.581
LIG_LIR_Gen_1	230	238	PF02991	0.361
LIG_LIR_Gen_1	68	74	PF02991	0.548
LIG_LIR_Gen_1	80	90	PF02991	0.429
LIG_LIR_Nem_3	230	234	PF02991	0.361
LIG_LIR_Nem_3	235	240	PF02991	0.416
LIG_LIR_Nem_3	68	73	PF02991	0.544
LIG_LIR_Nem_3	80	85	PF02991	0.427
LIG_LYPXL_S_1	240	244	PF13949	0.437
LIG_LYPXL_yS_3	241	244	PF13949	0.417
LIG_Pex14_2	17	21	PF04695	0.441
LIG_Pex14_2	198	202	PF04695	0.432
LIG_RPA_C_Fungi	481	493	PF08784	0.593
LIG_SH2_CRK	82	86	PF00017	0.486
LIG_SH2_STAT3	86	89	PF00017	0.422
LIG_SH2_STAT5	141	144	PF00017	0.770
LIG_SH2_STAT5	231	234	PF00017	0.554
LIG_SH2_STAT5	249	252	PF00017	0.453
LIG_SH2_STAT5	562	565	PF00017	0.685
LIG_SH2_STAT5	82	85	PF00017	0.472
LIG_SH3_3	19	25	PF00018	0.478
LIG_SH3_3	87	93	PF00018	0.524
LIG_SH3_3	98	104	PF00018	0.577
LIG_Sin3_3	370	377	PF02671	0.678
LIG_SUMO_SIM_par_1	190	197	PF11976	0.420
LIG_TRAF2_1	173	176	PF00917	0.535
LIG_TRAF2_1	26	29	PF00917	0.491
MOD_CDK_SPxxK_3	170	177	PF00069	0.675
MOD_CK1_1	210	216	PF00069	0.388
MOD_CK1_1	23	29	PF00069	0.563
MOD_CK1_1	275	281	PF00069	0.608
MOD_CK1_1	36	42	PF00069	0.502
MOD_CK1_1	557	563	PF00069	0.543
MOD_CK2_1	170	176	PF00069	0.589
MOD_CK2_1	227	233	PF00069	0.379
MOD_CK2_1	23	29	PF00069	0.512
MOD_CK2_1	264	270	PF00069	0.578
MOD_CK2_1	525	531	PF00069	0.516
MOD_GlcNHglycan	117	120	PF01048	0.773
MOD_GlcNHglycan	125	128	PF01048	0.777
MOD_GlcNHglycan	210	213	PF01048	0.418
MOD_GlcNHglycan	297	300	PF01048	0.589
MOD_GlcNHglycan	35	38	PF01048	0.562
MOD_GlcNHglycan	458	461	PF01048	0.539
MOD_GSK3_1	103	110	PF00069	0.649
MOD_GSK3_1	115	122	PF00069	0.754
MOD_GSK3_1	139	146	PF00069	0.753
MOD_GSK3_1	147	154	PF00069	0.710
MOD_GSK3_1	33	40	PF00069	0.564
MOD_GSK3_1	51	58	PF00069	0.623
MOD_GSK3_1	550	557	PF00069	0.542
MOD_GSK3_1	569	576	PF00069	0.588
MOD_NEK2_1	115	120	PF00069	0.882
MOD_NEK2_1	151	156	PF00069	0.896
MOD_NEK2_1	207	212	PF00069	0.417
MOD_NEK2_1	55	60	PF00069	0.620
MOD_NEK2_2	51	56	PF00069	0.629
MOD_PIKK_1	525	531	PF00454	0.516
MOD_PIKK_1	95	101	PF00454	0.593
MOD_PKA_2	151	157	PF00069	0.704
MOD_PKA_2	227	233	PF00069	0.432
MOD_PKA_2	23	29	PF00069	0.529
MOD_PKA_2	31	37	PF00069	0.557
MOD_PKA_2	360	366	PF00069	0.610
MOD_PKA_2	544	550	PF00069	0.526
MOD_Plk_1	275	281	PF00069	0.653
MOD_Plk_1	28	34	PF00069	0.518
MOD_Plk_1	530	536	PF00069	0.639
MOD_Plk_2-3	264	270	PF00069	0.466
MOD_ProDKin_1	121	127	PF00069	0.805
MOD_ProDKin_1	170	176	PF00069	0.693
MOD_SUMO_for_1	434	437	PF00179	0.651
MOD_SUMO_rev_2	171	178	PF00179	0.513
MOD_SUMO_rev_2	183	190	PF00179	0.348
MOD_SUMO_rev_2	375	384	PF00179	0.584
MOD_SUMO_rev_2	392	397	PF00179	0.614
MOD_SUMO_rev_2	546	556	PF00179	0.538
MOD_SUMO_rev_2	64	68	PF00179	0.556
TRG_ENDOCYTIC_2	231	234	PF00928	0.441
TRG_ENDOCYTIC_2	241	244	PF00928	0.439
TRG_ENDOCYTIC_2	82	85	PF00928	0.488
TRG_ER_diArg_1	151	153	PF00400	0.754
TRG_ER_diArg_1	521	524	PF00400	0.629
TRG_ER_diArg_1	539	542	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II86	Leptomonas seymouri	83%	99%
A0A0S4JFD7	Bodo saltans	33%	95%
A0A0S4JWH7	Bodo saltans	51%	98%
A0A0S4KKB4	Bodo saltans	23%	85%
A0A1X0NMV7	Trypanosomatidae	58%	98%
A0A3S7X1F4	Leishmania donovani	23%	100%
A0A422NE50	Trypanosoma rangeli	56%	100%
A4H5I7	Leishmania braziliensis	92%	100%
A4HGH2	Leishmania braziliensis	25%	98%
A4HTS8	Leishmania infantum	100%	100%
A4I3K4	Leishmania infantum	23%	99%
D0A836	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A989	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E9AML1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AZU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q8E1	Leishmania major	24%	100%
Q4QI25	Leishmania major	99%	100%
V5DJB6	Trypanosoma cruzi	57%	90%