RNA-binding protein 5-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 5-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H6A8_LEIDO

TriTrypDb:

LdBPK_090100.1 , LdCL_090005900 , LDHU3_09.0130

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H6A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6A8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.568
CLV_NRD_NRD_1	94	96	PF00675	0.702
CLV_PCSK_KEX2_1	94	96	PF00082	0.702
CLV_PCSK_PC7_1	90	96	PF00082	0.429
DEG_SIAH_1	162	170	PF03145	0.588
DOC_CKS1_1	108	113	PF01111	0.633
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.634
DOC_USP7_MATH_1	157	161	PF00917	0.749
DOC_USP7_MATH_1	171	175	PF00917	0.557
DOC_USP7_MATH_1	54	58	PF00917	0.538
DOC_USP7_MATH_1	98	102	PF00917	0.606
DOC_WW_Pin1_4	107	112	PF00397	0.691
DOC_WW_Pin1_4	114	119	PF00397	0.658
DOC_WW_Pin1_4	159	164	PF00397	0.673
DOC_WW_Pin1_4	175	180	PF00397	0.738
DOC_WW_Pin1_4	38	43	PF00397	0.513
LIG_14-3-3_CanoR_1	170	180	PF00244	0.720
LIG_14-3-3_CanoR_1	45	52	PF00244	0.513
LIG_14-3-3_CanoR_1	53	63	PF00244	0.513
LIG_APCC_ABBA_1	65	70	PF00400	0.513
LIG_BRCT_BRCA1_1	100	104	PF00533	0.633
LIG_BRCT_BRCA1_2	100	106	PF00533	0.607
LIG_FHA_1	123	129	PF00498	0.585
LIG_FHA_2	130	136	PF00498	0.586
LIG_LIR_Gen_1	101	112	PF02991	0.612
LIG_LIR_Gen_1	161	172	PF02991	0.554
LIG_LIR_Gen_1	205	215	PF02991	0.589
LIG_LIR_Nem_3	101	107	PF02991	0.600
LIG_LIR_Nem_3	161	167	PF02991	0.559
LIG_LIR_Nem_3	185	189	PF02991	0.658
LIG_LIR_Nem_3	205	210	PF02991	0.434
LIG_LIR_Nem_3	38	43	PF02991	0.560
LIG_LIR_Nem_3	60	66	PF02991	0.510
LIG_MAD2	106	114	PF02301	0.627
LIG_PDZ_Class_2	240	245	PF00595	0.489
LIG_PTB_Apo_2	180	187	PF02174	0.693
LIG_PTB_Phospho_1	180	186	PF10480	0.694
LIG_SH2_CRK	164	168	PF00017	0.575
LIG_SH2_CRK	186	190	PF00017	0.630
LIG_SH2_CRK	43	47	PF00017	0.472
LIG_SH2_CRK	63	67	PF00017	0.499
LIG_SH2_NCK_1	131	135	PF00017	0.564
LIG_SH2_NCK_1	164	168	PF00017	0.616
LIG_SH2_PTP2	227	230	PF00017	0.557
LIG_SH2_SRC	164	167	PF00017	0.626
LIG_SH2_STAP1	143	147	PF00017	0.668
LIG_SH2_STAP1	164	168	PF00017	0.611
LIG_SH2_STAT3	155	158	PF00017	0.599
LIG_SH2_STAT5	131	134	PF00017	0.597
LIG_SH2_STAT5	206	209	PF00017	0.634
LIG_SH2_STAT5	227	230	PF00017	0.557
LIG_SH2_STAT5	23	26	PF00017	0.552
LIG_SH3_1	131	137	PF00018	0.514
LIG_SH3_3	108	114	PF00018	0.739
LIG_SH3_3	131	137	PF00018	0.565
LIG_SH3_3	186	192	PF00018	0.602
LIG_SH3_3	226	232	PF00018	0.738
MOD_CDK_SPxxK_3	38	45	PF00069	0.513
MOD_CK1_1	116	122	PF00069	0.639
MOD_CK1_1	124	130	PF00069	0.725
MOD_CK1_1	57	63	PF00069	0.513
MOD_CK2_1	69	75	PF00069	0.520
MOD_GlcNHglycan	143	146	PF01048	0.664
MOD_GlcNHglycan	47	50	PF01048	0.311
MOD_GlcNHglycan	72	75	PF01048	0.284
MOD_GSK3_1	113	120	PF00069	0.792
MOD_GSK3_1	12	19	PF00069	0.620
MOD_GSK3_1	171	178	PF00069	0.673
MOD_GSK3_1	205	212	PF00069	0.658
MOD_GSK3_1	23	30	PF00069	0.576
MOD_GSK3_1	98	105	PF00069	0.674
MOD_N-GLC_1	122	127	PF02516	0.765
MOD_NEK2_1	102	107	PF00069	0.615
MOD_NEK2_1	129	134	PF00069	0.724
MOD_NEK2_1	16	21	PF00069	0.568
MOD_PIKK_1	117	123	PF00454	0.728
MOD_Plk_1	12	18	PF00069	0.652
MOD_Plk_1	98	104	PF00069	0.604
MOD_Plk_4	124	130	PF00069	0.578
MOD_Plk_4	202	208	PF00069	0.612
MOD_ProDKin_1	107	113	PF00069	0.694
MOD_ProDKin_1	114	120	PF00069	0.660
MOD_ProDKin_1	159	165	PF00069	0.676
MOD_ProDKin_1	175	181	PF00069	0.740
MOD_ProDKin_1	38	44	PF00069	0.513
TRG_ENDOCYTIC_2	164	167	PF00928	0.567
TRG_ENDOCYTIC_2	186	189	PF00928	0.572
TRG_ENDOCYTIC_2	227	230	PF00928	0.606
TRG_ENDOCYTIC_2	43	46	PF00928	0.472
TRG_ENDOCYTIC_2	63	66	PF00928	0.499
TRG_ER_diArg_1	93	95	PF00400	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P379	Leptomonas seymouri	44%	100%
A0A3S7WQG5	Leishmania donovani	31%	82%
A4H5I5	Leishmania braziliensis	81%	100%
A4H5I6	Leishmania braziliensis	31%	82%
A4HTS6	Leishmania infantum	100%	100%
A4HTS7	Leishmania infantum	32%	100%
E9AMK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QI27	Leishmania major	93%	100%