Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6A4_LEIDO

TriTrypDb:

LdBPK_090030.1 , LdCL_090005200 , LDHU3_09.0040

Length:

107

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H6A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	69	71	PF00675	0.604
CLV_PCSK_FUR_1	67	71	PF00082	0.608
CLV_PCSK_KEX2_1	69	71	PF00082	0.604
CLV_PCSK_PC7_1	65	71	PF00082	0.609
DOC_PP2B_LxvP_1	9	12	PF13499	0.585
LIG_14-3-3_CanoR_1	26	34	PF00244	0.463
LIG_14-3-3_CanoR_1	48	56	PF00244	0.495
LIG_Actin_WH2_2	32	50	PF00022	0.446
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_EH_1	60	64	PF12763	0.413
LIG_FHA_1	4	10	PF00498	0.609
LIG_FHA_2	99	105	PF00498	0.402
LIG_LIR_Apic_2	55	59	PF02991	0.406
LIG_LIR_Gen_1	60	71	PF02991	0.411
LIG_LIR_Nem_3	50	56	PF02991	0.407
LIG_LIR_Nem_3	60	66	PF02991	0.411
LIG_LIR_Nem_3	95	100	PF02991	0.384
LIG_Pex14_2	76	80	PF04695	0.424
LIG_SH2_STAT5	100	103	PF00017	0.394
LIG_SH2_STAT5	53	56	PF00017	0.406
LIG_SH3_1	56	62	PF00018	0.405
LIG_SH3_3	56	62	PF00018	0.405
LIG_SH3_3	9	15	PF00018	0.586
LIG_TYR_ITIM	42	47	PF00017	0.446
MOD_CK1_1	3	9	PF00069	0.623
MOD_CK2_1	98	104	PF00069	0.398
MOD_N-GLC_1	17	22	PF02516	0.426
MOD_NEK2_1	16	21	PF00069	0.629
MOD_NEK2_1	25	30	PF00069	0.552
MOD_NEK2_1	47	52	PF00069	0.391
MOD_PKA_2	25	31	PF00069	0.463
MOD_PKA_2	47	53	PF00069	0.484
MOD_Plk_1	17	23	PF00069	0.597
TRG_ENDOCYTIC_2	44	47	PF00928	0.340
TRG_ER_diArg_1	66	69	PF00400	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8M9	Bodo saltans	65%	100%
A0A1X0NMV9	Trypanosomatidae	84%	100%
A0A422NE39	Trypanosoma rangeli	85%	100%
A4H5H8	Leishmania braziliensis	99%	100%
A4HTR9	Leishmania infantum	100%	100%
D0A978	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	67%
E9AMK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5B330	Trypanosoma cruzi	84%	100%