Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6A3_LEIDO

TriTrypDb:

LdBPK_081190.1 , LdCL_080017200 , LdCL_080017900 , LdCL_080018600 , LDHU3_08.1620 , LDHU3_08.1710

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6A3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	81	83	PF00082	0.512
CLV_PCSK_KEX2_1	90	92	PF00082	0.480
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.512
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.480
CLV_PCSK_SKI1_1	41	45	PF00082	0.433
CLV_PCSK_SKI1_1	52	56	PF00082	0.413
CLV_PCSK_SKI1_1	71	75	PF00082	0.635
DOC_USP7_MATH_1	94	98	PF00917	0.616
DOC_USP7_UBL2_3	81	85	PF12436	0.598
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_FHA_2	54	60	PF00498	0.387
LIG_LIR_Nem_3	56	60	PF02991	0.375
LIG_SH2_STAP1	83	87	PF00017	0.518
MOD_CK2_1	53	59	PF00069	0.396
MOD_GSK3_1	81	88	PF00069	0.499
MOD_PKA_1	81	87	PF00069	0.599
MOD_PKA_2	81	87	PF00069	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBJ7	Leptomonas seymouri	84%	97%
A0A0S4IPN5	Bodo saltans	64%	100%
A0A1X0NF37	Trypanosomatidae	75%	98%
A0A3R7MKU3	Trypanosoma rangeli	78%	98%
A4HC44	Leishmania braziliensis	89%	100%
C9ZPG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	98%
E9AG90	Leishmania infantum	100%	100%
E9AMJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4QI39	Leishmania major	99%	100%