Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H6A2_LEIDO

TriTrypDb:

LdBPK_081160.1 , LdCL_080017800 , LdCL_080018500 , LDHU3_08.1700

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H6A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.567
CLV_C14_Caspase3-7	219	223	PF00656	0.712
CLV_NRD_NRD_1	277	279	PF00675	0.543
CLV_NRD_NRD_1	337	339	PF00675	0.569
CLV_NRD_NRD_1	494	496	PF00675	0.694
CLV_PCSK_KEX2_1	277	279	PF00082	0.543
CLV_PCSK_KEX2_1	337	339	PF00082	0.609
CLV_PCSK_KEX2_1	493	495	PF00082	0.771
CLV_PCSK_PC7_1	490	496	PF00082	0.767
CLV_PCSK_SKI1_1	260	264	PF00082	0.582
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SPOP_SBC_1	415	419	PF00917	0.754
DOC_CYCLIN_yCln2_LP_2	36	39	PF00134	0.525
DOC_PP2B_LxvP_1	36	39	PF13499	0.525
DOC_PP4_FxxP_1	42	45	PF00568	0.629
DOC_USP7_MATH_1	223	227	PF00917	0.709
DOC_USP7_MATH_1	287	291	PF00917	0.692
DOC_USP7_MATH_1	328	332	PF00917	0.659
DOC_USP7_MATH_1	356	360	PF00917	0.612
DOC_USP7_MATH_1	481	485	PF00917	0.724
DOC_USP7_MATH_1	83	87	PF00917	0.781
DOC_USP7_MATH_1	97	101	PF00917	0.533
DOC_WW_Pin1_4	105	110	PF00397	0.753
DOC_WW_Pin1_4	149	154	PF00397	0.717
DOC_WW_Pin1_4	206	211	PF00397	0.712
DOC_WW_Pin1_4	289	294	PF00397	0.686
DOC_WW_Pin1_4	427	432	PF00397	0.634
LIG_14-3-3_CanoR_1	337	341	PF00244	0.614
LIG_14-3-3_CanoR_1	396	402	PF00244	0.616
LIG_14-3-3_CanoR_1	406	414	PF00244	0.604
LIG_14-3-3_CanoR_1	73	77	PF00244	0.772
LIG_Actin_WH2_2	127	143	PF00022	0.741
LIG_BIR_III_2	411	415	PF00653	0.786
LIG_BIR_III_4	327	331	PF00653	0.611
LIG_BIR_III_4	51	55	PF00653	0.617
LIG_BIR_III_4	96	100	PF00653	0.685
LIG_Clathr_ClatBox_1	361	365	PF01394	0.711
LIG_EVH1_2	38	42	PF00568	0.681
LIG_FHA_1	126	132	PF00498	0.761
LIG_FHA_2	144	150	PF00498	0.741
LIG_FHA_2	405	411	PF00498	0.539
LIG_FHA_2	457	463	PF00498	0.830
LIG_GBD_Chelix_1	393	401	PF00786	0.555
LIG_MYND_1	138	142	PF01753	0.637
LIG_NRBOX	130	136	PF00104	0.774
LIG_NRBOX	295	301	PF00104	0.545
LIG_SH2_STAT5	309	312	PF00017	0.491
LIG_SH2_STAT5	389	392	PF00017	0.522
LIG_SH2_STAT5	485	488	PF00017	0.728
LIG_SH3_3	110	116	PF00018	0.787
LIG_SH3_3	442	448	PF00018	0.739
LIG_SUMO_SIM_par_1	297	303	PF11976	0.581
LIG_SUMO_SIM_par_1	358	366	PF11976	0.705
LIG_TRAF2_1	273	276	PF00917	0.707
LIG_TRAF2_1	474	477	PF00917	0.787
LIG_WW_3	37	41	PF00397	0.683
MOD_CK1_1	130	136	PF00069	0.774
MOD_CK1_1	206	212	PF00069	0.743
MOD_CK1_1	226	232	PF00069	0.754
MOD_CK1_1	292	298	PF00069	0.571
MOD_CK1_1	400	406	PF00069	0.619
MOD_CK2_1	149	155	PF00069	0.626
MOD_CK2_1	270	276	PF00069	0.712
MOD_CK2_1	404	410	PF00069	0.499
MOD_CK2_1	471	477	PF00069	0.683
MOD_GlcNHglycan	145	149	PF01048	0.780
MOD_GlcNHglycan	205	208	PF01048	0.645
MOD_GlcNHglycan	215	218	PF01048	0.710
MOD_GlcNHglycan	330	333	PF01048	0.698
MOD_GlcNHglycan	434	437	PF01048	0.734
MOD_GlcNHglycan	46	49	PF01048	0.772
MOD_GlcNHglycan	84	88	PF01048	0.812
MOD_GSK3_1	140	147	PF00069	0.750
MOD_GSK3_1	16	23	PF00069	0.794
MOD_GSK3_1	209	216	PF00069	0.624
MOD_GSK3_1	287	294	PF00069	0.627
MOD_GSK3_1	400	407	PF00069	0.588
MOD_GSK3_1	59	66	PF00069	0.724
MOD_GSK3_1	79	86	PF00069	0.706
MOD_N-GLC_1	149	154	PF02516	0.510
MOD_N-GLC_1	369	374	PF02516	0.687
MOD_NEK2_1	188	193	PF00069	0.620
MOD_NEK2_1	213	218	PF00069	0.688
MOD_NEK2_1	263	268	PF00069	0.662
MOD_NEK2_1	300	305	PF00069	0.492
MOD_NEK2_1	397	402	PF00069	0.599
MOD_NEK2_1	59	64	PF00069	0.742
MOD_NEK2_1	65	70	PF00069	0.723
MOD_NEK2_1	71	76	PF00069	0.724
MOD_NEK2_2	336	341	PF00069	0.598
MOD_PIKK_1	16	22	PF00454	0.682
MOD_PKA_1	494	500	PF00069	0.749
MOD_PKA_2	125	131	PF00069	0.743
MOD_PKA_2	140	146	PF00069	0.728
MOD_PKA_2	203	209	PF00069	0.590
MOD_PKA_2	336	342	PF00069	0.608
MOD_PKA_2	405	411	PF00069	0.539
MOD_PKA_2	494	500	PF00069	0.716
MOD_PKA_2	72	78	PF00069	0.700
MOD_Plk_1	154	160	PF00069	0.600
MOD_Plk_1	234	240	PF00069	0.637
MOD_Plk_2-3	405	411	PF00069	0.539
MOD_Plk_2-3	472	478	PF00069	0.731
MOD_Plk_4	130	136	PF00069	0.774
MOD_Plk_4	209	215	PF00069	0.744
MOD_Plk_4	397	403	PF00069	0.623
MOD_Plk_4	481	487	PF00069	0.693
MOD_Plk_4	65	71	PF00069	0.730
MOD_Plk_4	72	78	PF00069	0.715
MOD_ProDKin_1	105	111	PF00069	0.755
MOD_ProDKin_1	149	155	PF00069	0.708
MOD_ProDKin_1	206	212	PF00069	0.718
MOD_ProDKin_1	289	295	PF00069	0.672
MOD_ProDKin_1	427	433	PF00069	0.627
MOD_SUMO_rev_2	339	345	PF00179	0.499
TRG_DiLeu_BaEn_1	155	160	PF01217	0.602
TRG_DiLeu_LyEn_5	155	160	PF01217	0.647
TRG_ER_diArg_1	11	14	PF00400	0.686
TRG_ER_diArg_1	492	495	PF00400	0.770
TRG_ER_diArg_1	498	501	PF00400	0.733
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK83	Leptomonas seymouri	43%	100%
A0A422NFT6	Trypanosoma rangeli	31%	100%
A4HC43	Leishmania braziliensis	74%	98%
E9AG89	Leishmania infantum	99%	100%
E9AMJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QI40	Leishmania major	91%	100%
V5AUD8	Trypanosoma cruzi	30%	100%