Zinc finger, C3HC4 type (RING finger)/Ring finger domain/zinc-RING finger domain/zinc finger of C3HC4-type, RING, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H6A1_LEIDO

TriTrypDb:

LdBPK_081130.1 , LdCL_080017700 , LdCL_080018400 , LDHU3_08.1690

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A0A3S5H6A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H6A1

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.552
CLV_NRD_NRD_1	163	165	PF00675	0.377
CLV_NRD_NRD_1	189	191	PF00675	0.483
CLV_NRD_NRD_1	210	212	PF00675	0.408
CLV_NRD_NRD_1	383	385	PF00675	0.422
CLV_NRD_NRD_1	431	433	PF00675	0.530
CLV_NRD_NRD_1	50	52	PF00675	0.522
CLV_NRD_NRD_1	556	558	PF00675	0.659
CLV_NRD_NRD_1	64	66	PF00675	0.379
CLV_NRD_NRD_1	94	96	PF00675	0.451
CLV_PCSK_KEX2_1	189	191	PF00082	0.431
CLV_PCSK_KEX2_1	201	203	PF00082	0.339
CLV_PCSK_KEX2_1	210	212	PF00082	0.385
CLV_PCSK_KEX2_1	383	385	PF00082	0.532
CLV_PCSK_KEX2_1	431	433	PF00082	0.534
CLV_PCSK_KEX2_1	50	52	PF00082	0.528
CLV_PCSK_KEX2_1	508	510	PF00082	0.585
CLV_PCSK_KEX2_1	64	66	PF00082	0.369
CLV_PCSK_KEX2_1	94	96	PF00082	0.487
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.397
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.555
CLV_PCSK_SKI1_1	12	16	PF00082	0.412
CLV_PCSK_SKI1_1	288	292	PF00082	0.396
CLV_PCSK_SKI1_1	318	322	PF00082	0.625
CLV_PCSK_SKI1_1	349	353	PF00082	0.471
CLV_PCSK_SKI1_1	414	418	PF00082	0.492
CLV_PCSK_SKI1_1	558	562	PF00082	0.598
CLV_PCSK_SKI1_1	64	68	PF00082	0.390
DEG_APCC_DBOX_1	287	295	PF00400	0.509
DEG_APCC_DBOX_1	76	84	PF00400	0.525
DEG_SCF_FBW7_2	247	254	PF00400	0.413
DEG_SCF_FBW7_2	319	326	PF00400	0.696
DEG_SPOP_SBC_1	532	536	PF00917	0.706
DOC_CKS1_1	172	177	PF01111	0.441
DOC_CKS1_1	248	253	PF01111	0.421
DOC_CKS1_1	320	325	PF01111	0.699
DOC_CYCLIN_RxL_1	285	292	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.395
DOC_MAPK_gen_1	383	394	PF00069	0.371
DOC_MAPK_gen_1	94	102	PF00069	0.542
DOC_PP2B_LxvP_1	217	220	PF13499	0.585
DOC_PP2B_LxvP_1	408	411	PF13499	0.479
DOC_PP2B_LxvP_1	481	484	PF13499	0.630
DOC_PP4_FxxP_1	124	127	PF00568	0.305
DOC_USP7_MATH_1	532	536	PF00917	0.651
DOC_USP7_MATH_1	544	548	PF00917	0.432
DOC_USP7_MATH_1	560	564	PF00917	0.552
DOC_USP7_UBL2_3	352	356	PF12436	0.476
DOC_USP7_UBL2_3	550	554	PF12436	0.606
DOC_USP7_UBL2_3	558	562	PF12436	0.717
DOC_WW_Pin1_4	117	122	PF00397	0.456
DOC_WW_Pin1_4	171	176	PF00397	0.537
DOC_WW_Pin1_4	247	252	PF00397	0.420
DOC_WW_Pin1_4	309	314	PF00397	0.563
DOC_WW_Pin1_4	319	324	PF00397	0.631
DOC_WW_Pin1_4	460	465	PF00397	0.529
DOC_WW_Pin1_4	568	573	PF00397	0.731
LIG_14-3-3_CanoR_1	137	145	PF00244	0.344
LIG_14-3-3_CanoR_1	210	217	PF00244	0.517
LIG_14-3-3_CanoR_1	245	251	PF00244	0.469
LIG_14-3-3_CanoR_1	318	323	PF00244	0.730
LIG_14-3-3_CanoR_1	437	445	PF00244	0.486
LIG_Actin_WH2_2	343	360	PF00022	0.487
LIG_AP2alpha_2	214	216	PF02296	0.534
LIG_APCC_ABBA_1	330	335	PF00400	0.491
LIG_FHA_1	274	280	PF00498	0.588
LIG_FHA_1	365	371	PF00498	0.427
LIG_FHA_1	380	386	PF00498	0.370
LIG_FHA_1	473	479	PF00498	0.669
LIG_FHA_1	84	90	PF00498	0.476
LIG_FHA_2	118	124	PF00498	0.424
LIG_FHA_2	319	325	PF00498	0.607
LIG_Integrin_RGD_1	526	528	PF01839	0.646
LIG_LIR_Apic_2	122	127	PF02991	0.338
LIG_LIR_Apic_2	48	52	PF02991	0.624
LIG_LIR_Gen_1	477	484	PF02991	0.634
LIG_LIR_Nem_3	442	448	PF02991	0.447
LIG_LIR_Nem_3	477	483	PF02991	0.582
LIG_PTAP_UEV_1	132	137	PF05743	0.316
LIG_PTB_Apo_2	68	75	PF02174	0.284
LIG_SH2_CRK	145	149	PF00017	0.344
LIG_SH2_CRK	49	53	PF00017	0.497
LIG_SH2_GRB2like	452	455	PF00017	0.468
LIG_SH2_SRC	333	336	PF00017	0.375
LIG_SH2_STAP1	259	263	PF00017	0.564
LIG_SH2_STAT5	145	148	PF00017	0.300
LIG_SH2_STAT5	176	179	PF00017	0.492
LIG_SH2_STAT5	246	249	PF00017	0.341
LIG_SH2_STAT5	342	345	PF00017	0.355
LIG_SH2_STAT5	448	451	PF00017	0.450
LIG_SH2_STAT5	480	483	PF00017	0.634
LIG_SH3_3	130	136	PF00018	0.344
LIG_SH3_3	217	223	PF00018	0.586
LIG_SH3_3	311	317	PF00018	0.596
LIG_SH3_3	518	524	PF00018	0.565
LIG_SH3_3	566	572	PF00018	0.598
LIG_SUMO_SIM_par_1	79	86	PF11976	0.591
LIG_TRAF2_1	120	123	PF00917	0.445
LIG_TRFH_1	176	180	PF08558	0.462
LIG_TYR_ITIM	478	483	PF00017	0.675
LIG_UBA3_1	150	158	PF00899	0.344
LIG_UBA3_1	290	299	PF00899	0.506
MOD_CDK_SPK_2	568	573	PF00069	0.569
MOD_CK1_1	241	247	PF00069	0.381
MOD_CK1_1	41	47	PF00069	0.515
MOD_CK1_1	453	459	PF00069	0.690
MOD_CK1_1	463	469	PF00069	0.549
MOD_CK1_1	472	478	PF00069	0.533
MOD_CK1_1	485	491	PF00069	0.569
MOD_CK2_1	117	123	PF00069	0.389
MOD_CK2_1	279	285	PF00069	0.515
MOD_CK2_1	318	324	PF00069	0.774
MOD_CK2_1	516	522	PF00069	0.706
MOD_GlcNHglycan	224	227	PF01048	0.617
MOD_GlcNHglycan	30	33	PF01048	0.719
MOD_GlcNHglycan	455	458	PF01048	0.615
MOD_GlcNHglycan	487	490	PF01048	0.616
MOD_GlcNHglycan	518	521	PF01048	0.684
MOD_GlcNHglycan	546	549	PF01048	0.598
MOD_GSK3_1	273	280	PF00069	0.592
MOD_GSK3_1	372	379	PF00069	0.444
MOD_GSK3_1	38	45	PF00069	0.680
MOD_GSK3_1	437	444	PF00069	0.499
MOD_GSK3_1	522	529	PF00069	0.692
MOD_GSK3_1	79	86	PF00069	0.534
MOD_N-GLC_1	453	458	PF02516	0.485
MOD_N-GLC_2	205	207	PF02516	0.393
MOD_NEK2_1	102	107	PF00069	0.493
MOD_NEK2_1	28	33	PF00069	0.454
MOD_NEK2_1	450	455	PF00069	0.504
MOD_NEK2_1	516	521	PF00069	0.697
MOD_NEK2_1	81	86	PF00069	0.569
MOD_PIKK_1	273	279	PF00454	0.575
MOD_PIKK_1	83	89	PF00454	0.578
MOD_PKA_2	136	142	PF00069	0.344
MOD_PKA_2	203	209	PF00069	0.470
MOD_PKA_2	38	44	PF00069	0.498
MOD_PKA_2	450	456	PF00069	0.633
MOD_PKA_2	504	510	PF00069	0.568
MOD_Plk_1	441	447	PF00069	0.481
MOD_Plk_1	469	475	PF00069	0.619
MOD_Plk_2-3	372	378	PF00069	0.500
MOD_Plk_4	102	108	PF00069	0.471
MOD_Plk_4	111	117	PF00069	0.442
MOD_Plk_4	304	310	PF00069	0.664
MOD_Plk_4	511	517	PF00069	0.618
MOD_ProDKin_1	117	123	PF00069	0.457
MOD_ProDKin_1	171	177	PF00069	0.533
MOD_ProDKin_1	247	253	PF00069	0.415
MOD_ProDKin_1	309	315	PF00069	0.565
MOD_ProDKin_1	319	325	PF00069	0.626
MOD_ProDKin_1	460	466	PF00069	0.530
MOD_SUMO_for_1	553	556	PF00179	0.705
MOD_SUMO_rev_2	296	304	PF00179	0.580
TRG_DiLeu_BaEn_2	284	290	PF01217	0.502
TRG_ENDOCYTIC_2	342	345	PF00928	0.410
TRG_ENDOCYTIC_2	386	389	PF00928	0.404
TRG_ENDOCYTIC_2	480	483	PF00928	0.643
TRG_ER_diArg_1	188	190	PF00400	0.511
TRG_ER_diArg_1	209	211	PF00400	0.436
TRG_ER_diArg_1	383	385	PF00400	0.529
TRG_ER_diArg_1	431	434	PF00400	0.532
TRG_ER_diArg_1	49	51	PF00400	0.543
TRG_ER_diArg_1	63	65	PF00400	0.283
TRG_ER_diArg_1	94	96	PF00400	0.487
TRG_NLS_Bipartite_1	189	205	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWK4	Leptomonas seymouri	69%	98%
A0A0S4IP20	Bodo saltans	28%	73%
A0A1X0NGG7	Trypanosomatidae	40%	100%
A0A3S7WQF9	Leishmania donovani	100%	100%
A0A422NFU0	Trypanosoma rangeli	39%	100%
A4HC42	Leishmania braziliensis	84%	99%
C9ZPG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AG88	Leishmania infantum	100%	100%
E9AMJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O94271	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	85%
Q32NQ8	Xenopus laevis	23%	76%
Q4QI41	Leishmania major	97%	100%
V5DAD1	Trypanosoma cruzi	41%	100%