LeishMANIAdb
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Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Myotubularin phosphatase domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S5H698_LEIDO
TriTrypDb:
LdBPK_081191.1 , LdCL_080017300 , LdCL_080018000 , LDHU3_08.1630
Length:
432

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H698
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H698

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 346 350 PF00656 0.768
CLV_NRD_NRD_1 270 272 PF00675 0.522
CLV_NRD_NRD_1 337 339 PF00675 0.732
CLV_NRD_NRD_1 87 89 PF00675 0.684
CLV_PCSK_KEX2_1 270 272 PF00082 0.522
CLV_PCSK_KEX2_1 337 339 PF00082 0.732
CLV_PCSK_KEX2_1 87 89 PF00082 0.684
CLV_PCSK_SKI1_1 234 238 PF00082 0.752
CLV_PCSK_SKI1_1 408 412 PF00082 0.505
CLV_PCSK_SKI1_1 87 91 PF00082 0.671
DEG_SPOP_SBC_1 19 23 PF00917 0.746
DOC_MAPK_gen_1 270 276 PF00069 0.495
DOC_MAPK_gen_1 87 95 PF00069 0.686
DOC_MAPK_MEF2A_6 257 265 PF00069 0.620
DOC_PP4_FxxP_1 295 298 PF00568 0.736
DOC_USP7_MATH_1 241 245 PF00917 0.592
DOC_USP7_MATH_1 298 302 PF00917 0.732
DOC_USP7_MATH_1 30 34 PF00917 0.770
DOC_USP7_MATH_1 305 309 PF00917 0.690
DOC_USP7_MATH_1 4 8 PF00917 0.709
DOC_USP7_MATH_1 426 430 PF00917 0.648
DOC_USP7_MATH_1 57 61 PF00917 0.747
DOC_WW_Pin1_4 11 16 PF00397 0.712
DOC_WW_Pin1_4 140 145 PF00397 0.684
DOC_WW_Pin1_4 256 261 PF00397 0.651
DOC_WW_Pin1_4 276 281 PF00397 0.732
DOC_WW_Pin1_4 308 313 PF00397 0.713
DOC_WW_Pin1_4 336 341 PF00397 0.625
DOC_WW_Pin1_4 417 422 PF00397 0.750
DOC_WW_Pin1_4 95 100 PF00397 0.744
LIG_14-3-3_CanoR_1 304 313 PF00244 0.701
LIG_14-3-3_CanoR_1 329 335 PF00244 0.648
LIG_14-3-3_CanoR_1 408 415 PF00244 0.510
LIG_APCC_ABBA_1 387 392 PF00400 0.658
LIG_BIR_III_2 349 353 PF00653 0.696
LIG_CSL_BTD_1 421 424 PF09270 0.667
LIG_FHA_1 122 128 PF00498 0.633
LIG_FHA_1 129 135 PF00498 0.673
LIG_FHA_1 154 160 PF00498 0.661
LIG_FHA_1 181 187 PF00498 0.630
LIG_FHA_1 192 198 PF00498 0.609
LIG_FHA_1 337 343 PF00498 0.637
LIG_FHA_1 410 416 PF00498 0.644
LIG_FHA_1 53 59 PF00498 0.716
LIG_FHA_2 409 415 PF00498 0.637
LIG_GBD_Chelix_1 261 269 PF00786 0.679
LIG_LIR_Apic_2 373 379 PF02991 0.622
LIG_LIR_Gen_1 36 44 PF02991 0.649
LIG_LIR_Gen_1 381 389 PF02991 0.736
LIG_LIR_Nem_3 143 149 PF02991 0.672
LIG_LIR_Nem_3 36 42 PF02991 0.651
LIG_LIR_Nem_3 381 387 PF02991 0.740
LIG_PCNA_yPIPBox_3 243 257 PF02747 0.672
LIG_PDZ_Class_2 427 432 PF00595 0.707
LIG_PDZ_Wminus1_1 430 432 PF00595 0.715
LIG_Pex14_2 295 299 PF04695 0.528
LIG_SH2_CRK 384 388 PF00017 0.739
LIG_SH2_PTP2 148 151 PF00017 0.628
LIG_SH2_PTP2 376 379 PF00017 0.635
LIG_SH2_PTP2 39 42 PF00017 0.650
LIG_SH2_SRC 376 379 PF00017 0.635
LIG_SH2_SRC 39 42 PF00017 0.650
LIG_SH2_STAP1 318 322 PF00017 0.739
LIG_SH2_STAP1 52 56 PF00017 0.707
LIG_SH2_STAT5 148 151 PF00017 0.481
LIG_SH2_STAT5 294 297 PF00017 0.718
LIG_SH2_STAT5 376 379 PF00017 0.635
LIG_SH2_STAT5 39 42 PF00017 0.650
LIG_SH2_STAT5 406 409 PF00017 0.726
LIG_SH3_3 148 154 PF00018 0.631
LIG_SH3_3 309 315 PF00018 0.775
LIG_SH3_3 418 424 PF00018 0.668
LIG_SUMO_SIM_par_1 92 98 PF11976 0.715
LIG_WRC_WIRS_1 331 336 PF05994 0.598
LIG_WW_1 144 147 PF00397 0.694
MOD_CK1_1 180 186 PF00069 0.593
MOD_CK1_1 21 27 PF00069 0.758
MOD_CK1_1 279 285 PF00069 0.753
MOD_CK1_1 308 314 PF00069 0.777
MOD_CK1_1 33 39 PF00069 0.556
MOD_CK1_1 333 339 PF00069 0.628
MOD_CK1_1 60 66 PF00069 0.735
MOD_CK1_1 69 75 PF00069 0.676
MOD_CK2_1 408 414 PF00069 0.611
MOD_GlcNHglycan 239 242 PF01048 0.739
MOD_GlcNHglycan 307 310 PF01048 0.723
MOD_GlcNHglycan 320 323 PF01048 0.512
MOD_GlcNHglycan 33 36 PF01048 0.732
MOD_GlcNHglycan 346 349 PF01048 0.603
MOD_GlcNHglycan 362 365 PF01048 0.591
MOD_GlcNHglycan 60 63 PF01048 0.741
MOD_GlcNHglycan 68 71 PF01048 0.692
MOD_GSK3_1 112 119 PF00069 0.535
MOD_GSK3_1 19 26 PF00069 0.718
MOD_GSK3_1 191 198 PF00069 0.596
MOD_GSK3_1 237 244 PF00069 0.635
MOD_GSK3_1 276 283 PF00069 0.618
MOD_GSK3_1 304 311 PF00069 0.620
MOD_GSK3_1 57 64 PF00069 0.724
MOD_N-GLC_1 31 36 PF02516 0.547
MOD_NEK2_1 128 133 PF00069 0.666
MOD_NEK2_1 168 173 PF00069 0.640
MOD_NEK2_1 237 242 PF00069 0.667
MOD_NEK2_1 287 292 PF00069 0.747
MOD_NEK2_1 303 308 PF00069 0.531
MOD_NEK2_1 330 335 PF00069 0.597
MOD_NEK2_1 342 347 PF00069 0.566
MOD_NEK2_1 358 363 PF00069 0.571
MOD_OFUCOSY 111 116 PF10250 0.670
MOD_PIKK_1 205 211 PF00454 0.723
MOD_PKA_2 121 127 PF00069 0.622
MOD_PKA_2 303 309 PF00069 0.705
MOD_PKA_2 392 398 PF00069 0.692
MOD_Plk_4 168 174 PF00069 0.662
MOD_Plk_4 264 270 PF00069 0.678
MOD_Plk_4 313 319 PF00069 0.680
MOD_ProDKin_1 11 17 PF00069 0.716
MOD_ProDKin_1 140 146 PF00069 0.686
MOD_ProDKin_1 256 262 PF00069 0.645
MOD_ProDKin_1 276 282 PF00069 0.728
MOD_ProDKin_1 308 314 PF00069 0.712
MOD_ProDKin_1 336 342 PF00069 0.627
MOD_ProDKin_1 417 423 PF00069 0.750
MOD_ProDKin_1 95 101 PF00069 0.749
TRG_DiLeu_BaEn_1 326 331 PF01217 0.685
TRG_DiLeu_LyEn_5 326 331 PF01217 0.685
TRG_ENDOCYTIC_2 146 149 PF00928 0.657
TRG_ENDOCYTIC_2 294 297 PF00928 0.611
TRG_ENDOCYTIC_2 384 387 PF00928 0.738
TRG_ENDOCYTIC_2 39 42 PF00928 0.575
TRG_ER_diArg_1 269 271 PF00400 0.603
TRG_ER_diArg_1 86 88 PF00400 0.672

Homologs

Protein Taxonomy Sequence identity Coverage
A4HC45 Leishmania braziliensis 72% 98%
E9ACQ6 Leishmania major 94% 100%
E9AG91 Leishmania infantum 100% 100%
E9AMJ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS