Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H694_LEIDO

TriTrypDb:

LdBPK_081120.1 , LdCL_080016800 , LDHU3_08.1590

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H694

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H694

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.671
CLV_PCSK_KEX2_1	11	13	PF00082	0.671
CLV_PCSK_SKI1_1	167	171	PF00082	0.486
CLV_PCSK_SKI1_1	192	196	PF00082	0.539
CLV_PCSK_SKI1_1	294	298	PF00082	0.507
CLV_PCSK_SKI1_1	52	56	PF00082	0.554
CLV_Separin_Metazoa	134	138	PF03568	0.485
DEG_APCC_DBOX_1	356	364	PF00400	0.465
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DEG_SPOP_SBC_1	36	40	PF00917	0.510
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.503
DOC_MAPK_gen_1	11	18	PF00069	0.573
DOC_MAPK_MEF2A_6	11	18	PF00069	0.624
DOC_MAPK_MEF2A_6	141	150	PF00069	0.433
DOC_MAPK_NFAT4_5	11	19	PF00069	0.614
DOC_PP2B_LxvP_1	16	19	PF13499	0.578
DOC_PP2B_LxvP_1	358	361	PF13499	0.570
DOC_PP4_FxxP_1	332	335	PF00568	0.425
DOC_USP7_MATH_1	119	123	PF00917	0.652
DOC_USP7_MATH_1	157	161	PF00917	0.485
DOC_USP7_MATH_1	177	181	PF00917	0.477
DOC_USP7_MATH_1	206	210	PF00917	0.535
DOC_USP7_MATH_1	250	254	PF00917	0.602
DOC_USP7_MATH_1	275	279	PF00917	0.636
DOC_USP7_MATH_1	369	373	PF00917	0.522
DOC_WW_Pin1_4	185	190	PF00397	0.700
DOC_WW_Pin1_4	251	256	PF00397	0.613
DOC_WW_Pin1_4	75	80	PF00397	0.438
LIG_14-3-3_CanoR_1	273	283	PF00244	0.500
LIG_14-3-3_CanoR_1	318	325	PF00244	0.507
LIG_14-3-3_CanoR_1	382	391	PF00244	0.467
LIG_14-3-3_CanoR_1	52	62	PF00244	0.506
LIG_BRCT_BRCA1_1	301	305	PF00533	0.428
LIG_Clathr_ClatBox_1	230	234	PF01394	0.470
LIG_FHA_1	37	43	PF00498	0.514
LIG_FHA_1	4	10	PF00498	0.591
LIG_FHA_2	69	75	PF00498	0.500
LIG_LIR_Apic_2	329	335	PF02991	0.563
LIG_LIR_Apic_2	348	352	PF02991	0.323
LIG_LIR_Gen_1	96	104	PF02991	0.497
LIG_LIR_Nem_3	193	198	PF02991	0.644
LIG_LIR_Nem_3	96	101	PF02991	0.455
LIG_MYND_1	45	49	PF01753	0.472
LIG_PCNA_APIM_2	292	298	PF02747	0.312
LIG_Pex14_2	390	394	PF04695	0.456
LIG_REV1ctd_RIR_1	293	302	PF16727	0.462
LIG_REV1ctd_RIR_1	388	394	PF16727	0.464
LIG_SH2_CRK	115	119	PF00017	0.653
LIG_SH2_CRK	289	293	PF00017	0.461
LIG_SH2_CRK	29	33	PF00017	0.455
LIG_SH2_CRK	349	353	PF00017	0.442
LIG_SH2_CRK	84	88	PF00017	0.748
LIG_SH2_NCK_1	289	293	PF00017	0.461
LIG_SH2_PTP2	197	200	PF00017	0.452
LIG_SH2_STAP1	109	113	PF00017	0.464
LIG_SH2_STAT5	197	200	PF00017	0.452
LIG_SH2_STAT5	389	392	PF00017	0.329
LIG_SH2_STAT5	64	67	PF00017	0.372
LIG_SH3_3	195	201	PF00018	0.525
LIG_SH3_3	279	285	PF00018	0.507
LIG_SH3_3	358	364	PF00018	0.585
LIG_TRAF2_1	269	272	PF00917	0.523
LIG_TRFH_1	349	353	PF08558	0.575
LIG_TYR_ITIM	287	292	PF00017	0.465
LIG_TYR_ITIM	82	87	PF00017	0.539
MOD_CDK_SPK_2	75	80	PF00069	0.438
MOD_CDK_SPxxK_3	185	192	PF00069	0.720
MOD_CDK_SPxxK_3	253	260	PF00069	0.531
MOD_CK1_1	100	106	PF00069	0.542
MOD_CK1_1	181	187	PF00069	0.643
MOD_CK1_1	253	259	PF00069	0.791
MOD_CK1_1	261	267	PF00069	0.684
MOD_CK1_1	278	284	PF00069	0.375
MOD_CK2_1	261	267	PF00069	0.710
MOD_CK2_1	68	74	PF00069	0.378
MOD_GlcNHglycan	109	112	PF01048	0.568
MOD_GlcNHglycan	206	209	PF01048	0.651
MOD_GlcNHglycan	212	215	PF01048	0.575
MOD_GlcNHglycan	263	266	PF01048	0.651
MOD_GlcNHglycan	277	280	PF01048	0.443
MOD_GlcNHglycan	301	304	PF01048	0.553
MOD_GlcNHglycan	319	322	PF01048	0.517
MOD_GlcNHglycan	84	87	PF01048	0.519
MOD_GSK3_1	157	164	PF00069	0.399
MOD_GSK3_1	177	184	PF00069	0.479
MOD_GSK3_1	202	209	PF00069	0.529
MOD_GSK3_1	271	278	PF00069	0.703
MOD_GSK3_1	64	71	PF00069	0.358
MOD_N-GLC_1	151	156	PF02516	0.546
MOD_NEK2_1	107	112	PF00069	0.497
MOD_NEK2_1	151	156	PF00069	0.482
MOD_NEK2_1	161	166	PF00069	0.460
MOD_NEK2_1	22	27	PF00069	0.417
MOD_NEK2_1	299	304	PF00069	0.447
MOD_NEK2_1	37	42	PF00069	0.484
MOD_NEK2_1	383	388	PF00069	0.441
MOD_NEK2_1	50	55	PF00069	0.362
MOD_NEK2_1	68	73	PF00069	0.257
MOD_NEK2_1	97	102	PF00069	0.487
MOD_NEK2_2	369	374	PF00069	0.397
MOD_PIKK_1	178	184	PF00454	0.683
MOD_PKA_2	261	267	PF00069	0.781
MOD_PKA_2	317	323	PF00069	0.540
MOD_Plk_1	119	125	PF00069	0.629
MOD_Plk_1	12	18	PF00069	0.619
MOD_Plk_1	258	264	PF00069	0.523
MOD_Plk_4	119	125	PF00069	0.661
MOD_Plk_4	146	152	PF00069	0.389
MOD_Plk_4	157	163	PF00069	0.370
MOD_Plk_4	278	284	PF00069	0.626
MOD_Plk_4	37	43	PF00069	0.507
MOD_Plk_4	4	10	PF00069	0.583
MOD_Plk_4	64	70	PF00069	0.343
MOD_ProDKin_1	185	191	PF00069	0.698
MOD_ProDKin_1	251	257	PF00069	0.615
MOD_ProDKin_1	75	81	PF00069	0.447
MOD_SUMO_rev_2	143	149	PF00179	0.527
TRG_DiLeu_BaEn_1	17	22	PF01217	0.563
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.337
TRG_ENDOCYTIC_2	227	230	PF00928	0.524
TRG_ENDOCYTIC_2	289	292	PF00928	0.463
TRG_ENDOCYTIC_2	29	32	PF00928	0.455
TRG_ENDOCYTIC_2	84	87	PF00928	0.748
TRG_ER_diArg_1	10	12	PF00400	0.677
TRG_ER_diArg_1	260	263	PF00400	0.608
TRG_ER_diArg_1	354	357	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE21	Leptomonas seymouri	61%	87%
A0A0S4INY1	Bodo saltans	32%	86%
A0A1X0NGS9	Trypanosomatidae	36%	100%
A4HC41	Leishmania braziliensis	82%	100%
A4HTQ4	Leishmania infantum	99%	100%
C9ZPG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AMJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QI48	Leishmania major	93%	100%
V5BEE3	Trypanosoma cruzi	34%	100%