LeishMANIAdb
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MIX protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MIX protein
Gene product:
MIX protein
Species:
Leishmania donovani
UniProt:
A0A3S5H693_LEIDO
TriTrypDb:
LdBPK_081110.1 * , LdCL_080016700 , LDHU3_08.1560
Length:
195

Annotations

LeishMANIAdb annotations

Appears to be a small signal-anchored protein, specific to Kinetoplastids. Generally not duplicated, only in Strigomonas

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A0A3S5H693
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H693

PDB structure(s): 3ha4_A , 3ha4_B , 3ha4_C , 3ha4_D , 3ha4_E , 3ha4_F , 3ha4_G , 3ha4_H

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0042802 identical protein binding 3 1
GO:0042803 protein homodimerization activity 4 1
GO:0046983 protein dimerization activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 138 140 PF00675 0.296
CLV_NRD_NRD_1 7 9 PF00675 0.660
CLV_NRD_NRD_1 71 73 PF00675 0.297
CLV_PCSK_KEX2_1 7 9 PF00082 0.660
CLV_PCSK_KEX2_1 71 73 PF00082 0.287
CLV_PCSK_PC7_1 3 9 PF00082 0.667
CLV_PCSK_SKI1_1 140 144 PF00082 0.296
CLV_PCSK_SKI1_1 26 30 PF00082 0.484
CLV_PCSK_SKI1_1 81 85 PF00082 0.274
DEG_Nend_Nbox_1 1 3 PF02207 0.482
DOC_MAPK_gen_1 139 146 PF00069 0.496
DOC_MAPK_gen_1 46 56 PF00069 0.516
DOC_USP7_UBL2_3 46 50 PF12436 0.495
LIG_14-3-3_CanoR_1 3 9 PF00244 0.483
LIG_Actin_WH2_2 142 160 PF00022 0.405
LIG_BRCT_BRCA1_1 35 39 PF00533 0.355
LIG_Clathr_ClatBox_1 111 115 PF01394 0.482
LIG_CtBP_PxDLS_1 113 117 PF00389 0.534
LIG_eIF4E_1 106 112 PF01652 0.482
LIG_FHA_1 115 121 PF00498 0.496
LIG_FHA_2 14 20 PF00498 0.507
LIG_LIR_Apic_2 109 113 PF02991 0.487
LIG_LIR_Gen_1 36 45 PF02991 0.337
LIG_LIR_Nem_3 13 18 PF02991 0.493
LIG_LIR_Nem_3 36 42 PF02991 0.337
LIG_NRBOX 142 148 PF00104 0.496
LIG_Pex14_2 29 33 PF04695 0.322
LIG_PTB_Apo_2 145 152 PF02174 0.496
LIG_PTB_Phospho_1 145 151 PF10480 0.496
LIG_SH2_STAT5 127 130 PF00017 0.483
LIG_SH2_STAT5 131 134 PF00017 0.489
LIG_SH2_STAT5 23 26 PF00017 0.384
LIG_SH3_3 129 135 PF00018 0.482
LIG_SH3_3 186 192 PF00018 0.534
LIG_SH3_3 67 73 PF00018 0.482
LIG_SUMO_SIM_anti_2 93 100 PF11976 0.534
LIG_SUMO_SIM_par_1 112 117 PF11976 0.496
LIG_SUMO_SIM_par_1 52 59 PF11976 0.534
LIG_SUMO_SIM_par_1 81 87 PF11976 0.525
LIG_UBA3_1 143 150 PF00899 0.497
LIG_WRC_WIRS_1 12 17 PF05994 0.515
MOD_CK1_1 10 16 PF00069 0.512
MOD_CK1_1 41 47 PF00069 0.355
MOD_CK2_1 13 19 PF00069 0.511
MOD_CK2_1 41 47 PF00069 0.339
MOD_GlcNHglycan 123 126 PF01048 0.296
MOD_GlcNHglycan 184 187 PF01048 0.267
MOD_GSK3_1 41 48 PF00069 0.377
MOD_GSK3_1 7 14 PF00069 0.518
MOD_NEK2_1 114 119 PF00069 0.482
MOD_NEK2_1 120 125 PF00069 0.482
MOD_NEK2_1 2 7 PF00069 0.459
MOD_NEK2_1 33 38 PF00069 0.359
MOD_NEK2_2 38 43 PF00069 0.355
MOD_PIKK_1 114 120 PF00454 0.482
MOD_PKA_1 7 13 PF00069 0.495
MOD_PKA_2 152 158 PF00069 0.562
MOD_PKA_2 2 8 PF00069 0.468
MOD_Plk_1 114 120 PF00069 0.482
MOD_Plk_4 127 133 PF00069 0.544
MOD_Plk_4 24 30 PF00069 0.302
MOD_Plk_4 38 44 PF00069 0.279
MOD_SUMO_rev_2 41 51 PF00179 0.355
TRG_DiLeu_BaEn_1 93 98 PF01217 0.562
TRG_DiLeu_BaLyEn_6 73 78 PF01217 0.496
TRG_ER_diArg_1 7 9 PF00400 0.462
TRG_ER_diArg_1 70 72 PF00400 0.493

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3I0 Leptomonas seymouri 91% 100%
A0A0S4IQY8 Bodo saltans 54% 100%
A0A1X0NFN6 Trypanosomatidae 72% 98%
A0A3R7KDG8 Trypanosoma rangeli 72% 98%
A4H5F8 Leishmania braziliensis 93% 100%
A4HTQ3 Leishmania infantum 99% 100%
C9ZPF9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 98%
E9AMJ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QI49 Leishmania major 97% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS