Putative DUF1126 repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Repeat of unknown function (DUF1126), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H688_LEIDO

TriTrypDb:

LdBPK_081030.1 , LdCL_080015900 , LDHU3_08.1480

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 25
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0005819	spindle	5	3
GO:0005930	axoneme	2	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0072686	mitotic spindle	6	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S5H688

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H688

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0000281	mitotic cytokinesis	4	3
GO:0000910	cytokinesis	3	3
GO:0001539	cilium or flagellum-dependent cell motility	3	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	3
GO:0007051	spindle organization	3	3
GO:0007052	mitotic spindle organization	4	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022402	cell cycle process	2	3
GO:0048870	cell motility	2	3
GO:0060285	cilium-dependent cell motility	4	3
GO:0061640	cytoskeleton-dependent cytokinesis	4	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	3
GO:1903047	mitotic cell cycle process	3	3

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	18
GO:0005509	calcium ion binding	5	17
GO:0043167	ion binding	2	17
GO:0043169	cation binding	3	17
GO:0046872	metal ion binding	4	17
GO:0005515	protein binding	2	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0043014	alpha-tubulin binding	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.532
CLV_C14_Caspase3-7	290	294	PF00656	0.429
CLV_C14_Caspase3-7	450	454	PF00656	0.761
CLV_C14_Caspase3-7	599	603	PF00656	0.490
CLV_C14_Caspase3-7	741	745	PF00656	0.538
CLV_MEL_PAP_1	30	36	PF00089	0.576
CLV_NRD_NRD_1	100	102	PF00675	0.592
CLV_NRD_NRD_1	140	142	PF00675	0.280
CLV_NRD_NRD_1	301	303	PF00675	0.274
CLV_NRD_NRD_1	423	425	PF00675	0.734
CLV_NRD_NRD_1	497	499	PF00675	0.261
CLV_NRD_NRD_1	530	532	PF00675	0.303
CLV_NRD_NRD_1	728	730	PF00675	0.531
CLV_NRD_NRD_1	767	769	PF00675	0.574
CLV_NRD_NRD_1	789	791	PF00675	0.396
CLV_NRD_NRD_1	864	866	PF00675	0.711
CLV_PCSK_FUR_1	765	769	PF00082	0.636
CLV_PCSK_KEX2_1	140	142	PF00082	0.238
CLV_PCSK_KEX2_1	172	174	PF00082	0.287
CLV_PCSK_KEX2_1	301	303	PF00082	0.316
CLV_PCSK_KEX2_1	423	425	PF00082	0.714
CLV_PCSK_KEX2_1	497	499	PF00082	0.267
CLV_PCSK_KEX2_1	529	531	PF00082	0.295
CLV_PCSK_KEX2_1	728	730	PF00082	0.545
CLV_PCSK_KEX2_1	767	769	PF00082	0.577
CLV_PCSK_KEX2_1	789	791	PF00082	0.403
CLV_PCSK_KEX2_1	840	842	PF00082	0.463
CLV_PCSK_KEX2_1	864	866	PF00082	0.759
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.281
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.304
CLV_PCSK_PC1ET2_1	840	842	PF00082	0.581
CLV_PCSK_SKI1_1	110	114	PF00082	0.399
CLV_PCSK_SKI1_1	220	224	PF00082	0.423
CLV_PCSK_SKI1_1	385	389	PF00082	0.277
CLV_PCSK_SKI1_1	397	401	PF00082	0.378
CLV_PCSK_SKI1_1	424	428	PF00082	0.707
CLV_PCSK_SKI1_1	434	438	PF00082	0.675
CLV_PCSK_SKI1_1	447	451	PF00082	0.750
CLV_PCSK_SKI1_1	483	487	PF00082	0.324
CLV_PCSK_SKI1_1	497	501	PF00082	0.311
CLV_PCSK_SKI1_1	532	536	PF00082	0.321
CLV_PCSK_SKI1_1	728	732	PF00082	0.516
CLV_PCSK_SKI1_1	737	741	PF00082	0.428
DEG_APCC_DBOX_1	219	227	PF00400	0.400
DEG_SPOP_SBC_1	858	862	PF00917	0.529
DOC_CKS1_1	782	787	PF01111	0.435
DOC_CYCLIN_RxL_1	431	439	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	29	32	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	408	414	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	486	492	PF00134	0.554
DOC_MAPK_DCC_7	779	788	PF00069	0.419
DOC_MAPK_FxFP_2	811	814	PF00069	0.396
DOC_MAPK_gen_1	140	146	PF00069	0.508
DOC_MAPK_gen_1	301	309	PF00069	0.464
DOC_MAPK_gen_1	529	536	PF00069	0.429
DOC_MAPK_gen_1	644	652	PF00069	0.422
DOC_MAPK_MEF2A_6	301	309	PF00069	0.504
DOC_MAPK_MEF2A_6	370	378	PF00069	0.506
DOC_PP1_RVXF_1	115	122	PF00149	0.429
DOC_PP1_RVXF_1	279	286	PF00149	0.462
DOC_PP2B_LxvP_1	29	32	PF13499	0.560
DOC_PP2B_LxvP_1	408	411	PF13499	0.556
DOC_PP4_FxxP_1	125	128	PF00568	0.544
DOC_PP4_FxxP_1	71	74	PF00568	0.720
DOC_PP4_FxxP_1	774	777	PF00568	0.642
DOC_PP4_FxxP_1	811	814	PF00568	0.374
DOC_SPAK_OSR1_1	498	502	PF12202	0.502
DOC_USP7_MATH_1	12	16	PF00917	0.706
DOC_USP7_MATH_1	432	436	PF00917	0.682
DOC_USP7_MATH_1	462	466	PF00917	0.523
DOC_USP7_MATH_1	730	734	PF00917	0.568
DOC_USP7_MATH_1	857	861	PF00917	0.739
DOC_USP7_MATH_1	88	92	PF00917	0.544
DOC_USP7_UBL2_3	535	539	PF12436	0.507
DOC_WW_Pin1_4	319	324	PF00397	0.485
DOC_WW_Pin1_4	472	477	PF00397	0.681
DOC_WW_Pin1_4	781	786	PF00397	0.405
LIG_14-3-3_CanoR_1	110	115	PF00244	0.330
LIG_14-3-3_CanoR_1	141	147	PF00244	0.503
LIG_14-3-3_CanoR_1	204	213	PF00244	0.429
LIG_14-3-3_CanoR_1	319	323	PF00244	0.527
LIG_14-3-3_CanoR_1	403	409	PF00244	0.571
LIG_14-3-3_CanoR_1	423	427	PF00244	0.604
LIG_14-3-3_CanoR_1	497	502	PF00244	0.448
LIG_14-3-3_CanoR_1	67	72	PF00244	0.686
LIG_14-3-3_CanoR_1	710	715	PF00244	0.667
LIG_14-3-3_CanoR_1	755	761	PF00244	0.374
LIG_14-3-3_CanoR_1	8	12	PF00244	0.706
LIG_APCC_ABBA_1	305	310	PF00400	0.512
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_4	456	460	PF00653	0.563
LIG_BIR_III_4	609	613	PF00653	0.596
LIG_BIR_III_4	697	701	PF00653	0.422
LIG_BRCT_BRCA1_1	192	196	PF00533	0.569
LIG_BRCT_BRCA1_1	253	257	PF00533	0.574
LIG_BRCT_BRCA1_1	271	275	PF00533	0.410
LIG_BRCT_BRCA1_1	414	418	PF00533	0.568
LIG_BRCT_BRCA1_1	506	510	PF00533	0.466
LIG_FHA_1	150	156	PF00498	0.450
LIG_FHA_1	377	383	PF00498	0.471
LIG_FHA_1	431	437	PF00498	0.655
LIG_FHA_1	475	481	PF00498	0.501
LIG_FHA_1	828	834	PF00498	0.537
LIG_FHA_2	111	117	PF00498	0.502
LIG_FHA_2	448	454	PF00498	0.669
LIG_FHA_2	473	479	PF00498	0.631
LIG_FHA_2	503	509	PF00498	0.460
LIG_FHA_2	557	563	PF00498	0.477
LIG_FHA_2	593	599	PF00498	0.610
LIG_FHA_2	686	692	PF00498	0.395
LIG_FHA_2	773	779	PF00498	0.609
LIG_FHA_2	799	805	PF00498	0.417
LIG_GBD_Chelix_1	620	628	PF00786	0.486
LIG_LIR_Apic_2	69	74	PF02991	0.508
LIG_LIR_Apic_2	773	777	PF02991	0.587
LIG_LIR_Apic_2	810	814	PF02991	0.462
LIG_LIR_Gen_1	189	199	PF02991	0.461
LIG_LIR_Gen_1	638	645	PF02991	0.457
LIG_LIR_Gen_1	684	693	PF02991	0.444
LIG_LIR_Nem_3	108	112	PF02991	0.463
LIG_LIR_Nem_3	145	149	PF02991	0.563
LIG_LIR_Nem_3	189	194	PF02991	0.439
LIG_LIR_Nem_3	208	213	PF02991	0.483
LIG_LIR_Nem_3	243	248	PF02991	0.486
LIG_LIR_Nem_3	254	260	PF02991	0.510
LIG_LIR_Nem_3	366	372	PF02991	0.538
LIG_LIR_Nem_3	479	485	PF02991	0.547
LIG_LIR_Nem_3	507	513	PF02991	0.525
LIG_LIR_Nem_3	638	642	PF02991	0.412
LIG_LIR_Nem_3	684	690	PF02991	0.476
LIG_LIR_Nem_3	810	816	PF02991	0.473
LIG_MLH1_MIPbox_1	414	418	PF16413	0.568
LIG_MYND_1	27	31	PF01753	0.656
LIG_PCNA_PIPBox_1	805	814	PF02747	0.394
LIG_PCNA_yPIPBox_3	80	90	PF02747	0.409
LIG_Pex14_2	121	125	PF04695	0.468
LIG_Pex14_2	218	222	PF04695	0.487
LIG_REV1ctd_RIR_1	397	407	PF16727	0.375
LIG_SH2_GRB2like	504	507	PF00017	0.589
LIG_SH2_NCK_1	513	517	PF00017	0.544
LIG_SH2_PTP2	191	194	PF00017	0.554
LIG_SH2_SRC	627	630	PF00017	0.523
LIG_SH2_STAP1	395	399	PF00017	0.535
LIG_SH2_STAP1	513	517	PF00017	0.510
LIG_SH2_STAP1	589	593	PF00017	0.616
LIG_SH2_STAP1	831	835	PF00017	0.518
LIG_SH2_STAT5	191	194	PF00017	0.516
LIG_SH2_STAT5	21	24	PF00017	0.593
LIG_SH2_STAT5	330	333	PF00017	0.524
LIG_SH2_STAT5	395	398	PF00017	0.550
LIG_SH2_STAT5	417	420	PF00017	0.605
LIG_SH2_STAT5	504	507	PF00017	0.458
LIG_SH2_STAT5	558	561	PF00017	0.474
LIG_SH2_STAT5	627	630	PF00017	0.427
LIG_SH2_STAT5	686	689	PF00017	0.432
LIG_SH2_STAT5	821	824	PF00017	0.537
LIG_SH2_STAT5	843	846	PF00017	0.367
LIG_SH3_1	543	549	PF00018	0.536
LIG_SH3_3	174	180	PF00018	0.553
LIG_SH3_3	227	233	PF00018	0.405
LIG_SH3_3	442	448	PF00018	0.717
LIG_SH3_3	534	540	PF00018	0.571
LIG_SH3_3	543	549	PF00018	0.533
LIG_SH3_3	647	653	PF00018	0.542
LIG_SH3_3	779	785	PF00018	0.550
LIG_SH3_3	811	817	PF00018	0.414
LIG_SH3_CIN85_PxpxPR_1	538	543	PF14604	0.554
LIG_SUMO_SIM_anti_2	313	318	PF11976	0.434
LIG_SUMO_SIM_anti_2	688	694	PF11976	0.533
LIG_SUMO_SIM_par_1	150	157	PF11976	0.472
LIG_SUMO_SIM_par_1	410	416	PF11976	0.576
LIG_SUMO_SIM_par_1	613	618	PF11976	0.523
LIG_SUMO_SIM_par_1	647	654	PF11976	0.427
LIG_TRAF2_1	187	190	PF00917	0.502
LIG_WRC_WIRS_1	143	148	PF05994	0.437
LIG_WRC_WIRS_1	636	641	PF05994	0.454
LIG_WRC_WIRS_1	771	776	PF05994	0.460
LIG_WW_3	30	34	PF00397	0.583
MOD_CK1_1	261	267	PF00069	0.567
MOD_CK1_1	322	328	PF00069	0.435
MOD_CK1_1	713	719	PF00069	0.598
MOD_CK1_1	860	866	PF00069	0.490
MOD_CK2_1	262	268	PF00069	0.598
MOD_CK2_1	318	324	PF00069	0.347
MOD_CK2_1	502	508	PF00069	0.335
MOD_CK2_1	592	598	PF00069	0.565
MOD_CK2_1	648	654	PF00069	0.430
MOD_CK2_1	798	804	PF00069	0.441
MOD_Cter_Amidation	421	424	PF01082	0.622
MOD_Cter_Amidation	765	768	PF01082	0.585
MOD_GlcNHglycan	162	165	PF01048	0.321
MOD_GlcNHglycan	253	256	PF01048	0.592
MOD_GlcNHglycan	263	267	PF01048	0.579
MOD_GlcNHglycan	338	341	PF01048	0.379
MOD_GlcNHglycan	464	467	PF01048	0.699
MOD_GlcNHglycan	514	517	PF01048	0.335
MOD_GlcNHglycan	715	718	PF01048	0.658
MOD_GSK3_1	258	265	PF00069	0.610
MOD_GSK3_1	318	325	PF00069	0.360
MOD_GSK3_1	422	429	PF00069	0.621
MOD_GSK3_1	472	479	PF00069	0.641
MOD_GSK3_1	619	626	PF00069	0.475
MOD_GSK3_1	627	634	PF00069	0.398
MOD_GSK3_1	63	70	PF00069	0.694
MOD_GSK3_1	681	688	PF00069	0.451
MOD_GSK3_1	794	801	PF00069	0.565
MOD_GSK3_1	860	867	PF00069	0.540
MOD_LATS_1	629	635	PF00433	0.554
MOD_N-GLC_1	12	17	PF02516	0.624
MOD_N-GLC_1	205	210	PF02516	0.262
MOD_N-GLC_1	67	72	PF02516	0.654
MOD_N-GLC_1	826	831	PF02516	0.536
MOD_NEK2_1	329	334	PF00069	0.344
MOD_NEK2_1	383	388	PF00069	0.447
MOD_NEK2_1	499	504	PF00069	0.280
MOD_NEK2_1	57	62	PF00069	0.673
MOD_NEK2_1	7	12	PF00069	0.655
MOD_NEK2_1	756	761	PF00069	0.378
MOD_NEK2_1	78	83	PF00069	0.566
MOD_NEK2_1	89	94	PF00069	0.480
MOD_NEK2_2	404	409	PF00069	0.386
MOD_NEK2_2	476	481	PF00069	0.581
MOD_PIKK_1	258	264	PF00454	0.545
MOD_PIKK_1	819	825	PF00454	0.603
MOD_PK_1	338	344	PF00069	0.396
MOD_PKA_1	497	503	PF00069	0.340
MOD_PKA_2	291	297	PF00069	0.396
MOD_PKA_2	318	324	PF00069	0.351
MOD_PKA_2	422	428	PF00069	0.660
MOD_PKA_2	497	503	PF00069	0.353
MOD_PKA_2	57	63	PF00069	0.669
MOD_PKA_2	66	72	PF00069	0.725
MOD_PKA_2	681	687	PF00069	0.555
MOD_PKA_2	7	13	PF00069	0.709
MOD_PKA_2	778	784	PF00069	0.517
MOD_Plk_1	149	155	PF00069	0.320
MOD_Plk_1	269	275	PF00069	0.591
MOD_Plk_1	310	316	PF00069	0.298
MOD_Plk_1	346	352	PF00069	0.344
MOD_Plk_1	412	418	PF00069	0.494
MOD_Plk_1	653	659	PF00069	0.531
MOD_Plk_1	67	73	PF00069	0.690
MOD_Plk_4	133	139	PF00069	0.367
MOD_Plk_4	149	155	PF00069	0.202
MOD_Plk_4	413	419	PF00069	0.601
MOD_Plk_4	432	438	PF00069	0.693
MOD_Plk_4	440	446	PF00069	0.631
MOD_Plk_4	499	505	PF00069	0.290
MOD_Plk_4	584	590	PF00069	0.503
MOD_Plk_4	635	641	PF00069	0.510
MOD_Plk_4	778	784	PF00069	0.514
MOD_Plk_4	846	852	PF00069	0.625
MOD_ProDKin_1	319	325	PF00069	0.341
MOD_ProDKin_1	472	478	PF00069	0.662
MOD_ProDKin_1	781	787	PF00069	0.402
MOD_SUMO_rev_2	561	569	PF00179	0.396
MOD_SUMO_rev_2	716	726	PF00179	0.581
MOD_SUMO_rev_2	733	741	PF00179	0.449
TRG_DiLeu_BaEn_1	804	809	PF01217	0.323
TRG_DiLeu_BaEn_2	303	309	PF01217	0.340
TRG_DiLeu_BaEn_4	189	195	PF01217	0.437
TRG_ENDOCYTIC_2	122	125	PF00928	0.355
TRG_ENDOCYTIC_2	191	194	PF00928	0.416
TRG_ENDOCYTIC_2	286	289	PF00928	0.391
TRG_ENDOCYTIC_2	369	372	PF00928	0.437
TRG_ENDOCYTIC_2	842	845	PF00928	0.463
TRG_ER_diArg_1	140	142	PF00400	0.224
TRG_ER_diArg_1	180	183	PF00400	0.332
TRG_ER_diArg_1	300	302	PF00400	0.431
TRG_ER_diArg_1	497	499	PF00400	0.330
TRG_ER_diArg_1	764	767	PF00400	0.582
TRG_ER_diArg_1	788	790	PF00400	0.377
TRG_NLS_MonoCore_2	528	533	PF00514	0.437
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	734	738	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	790	794	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H4	Leptomonas seymouri	71%	100%
A0A0N1HZ98	Leptomonas seymouri	22%	100%
A0A0N1PBW1	Leptomonas seymouri	26%	100%
A0A0S4IJW8	Bodo saltans	36%	100%
A0A1X0NEV8	Trypanosomatidae	47%	100%
A0A1X0NLI2	Trypanosomatidae	24%	100%
A0A3Q8IDH4	Leishmania donovani	23%	100%
A0A3R7KM50	Trypanosoma rangeli	47%	100%
A0A3R7L048	Trypanosoma rangeli	24%	100%
A0A422NK00	Trypanosoma rangeli	26%	100%
A4HE78	Leishmania braziliensis	22%	99%
A4HFK9	Leishmania braziliensis	23%	100%
A4HTP5	Leishmania infantum	99%	100%
A4I1J2	Leishmania infantum	23%	100%
C9ZJX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
C9ZPE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A5T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AD64	Leishmania major	22%	100%
E9AI34	Leishmania braziliensis	87%	100%
E9AMI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AXM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q9U5	Leishmania major	23%	100%
Q4QI57	Leishmania major	96%	100%
V5ASV2	Trypanosoma cruzi	24%	100%
V5D3X9	Trypanosoma cruzi	22%	100%