Cysteine peptidase B (CPB)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase A (CBA)

Species:

Leishmania donovani

UniProt:

A0A3S5H684_LEIDO

TriTrypDb:

LdBPK_191460.1 , LdCL_080015200 , LDHU3_08.1360

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 35, no: 5
NetGPI	no	yes: 0, no: 40

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	9
GO:0000323	lytic vacuole	6	8
GO:0005615	extracellular space	2	8
GO:0005764	lysosome	7	8
GO:0005773	vacuole	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

A0A3S5H684

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H684

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	41
GO:0006807	nitrogen compound metabolic process	2	41
GO:0008152	metabolic process	1	41
GO:0019538	protein metabolic process	3	41
GO:0043170	macromolecule metabolic process	3	41
GO:0044238	primary metabolic process	2	41
GO:0071704	organic substance metabolic process	2	41
GO:1901564	organonitrogen compound metabolic process	3	41
GO:0051603	proteolysis involved in protein catabolic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	41
GO:0004175	endopeptidase activity	4	27
GO:0004197	cysteine-type endopeptidase activity	5	27
GO:0008233	peptidase activity	3	41
GO:0008234	cysteine-type peptidase activity	4	41
GO:0016787	hydrolase activity	2	41
GO:0140096	catalytic activity, acting on a protein	2	41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.390
CLV_C14_Caspase3-7	422	426	PF00656	0.565
CLV_NRD_NRD_1	116	118	PF00675	0.541
CLV_NRD_NRD_1	46	48	PF00675	0.237
CLV_PCSK_KEX2_1	358	360	PF00082	0.245
CLV_PCSK_KEX2_1	42	44	PF00082	0.405
CLV_PCSK_KEX2_1	46	48	PF00082	0.355
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.244
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.398
CLV_PCSK_SKI1_1	342	346	PF00082	0.390
CLV_PCSK_SKI1_1	358	362	PF00082	0.185
CLV_PCSK_SKI1_1	378	382	PF00082	0.232
CLV_PCSK_SKI1_1	5	9	PF00082	0.572
CLV_Separin_Metazoa	67	71	PF03568	0.399
DEG_APCC_DBOX_1	119	127	PF00400	0.504
DEG_APCC_DBOX_1	4	12	PF00400	0.594
DOC_CKS1_1	30	35	PF01111	0.606
DOC_CKS1_1	421	426	PF01111	0.303
DOC_CYCLIN_RxL_1	373	382	PF00134	0.221
DOC_CYCLIN_RxL_1	58	71	PF00134	0.399
DOC_MAPK_MEF2A_6	317	324	PF00069	0.367
DOC_SPAK_OSR1_1	80	84	PF12202	0.349
DOC_USP7_MATH_1	146	150	PF00917	0.497
DOC_USP7_MATH_1	215	219	PF00917	0.328
DOC_WW_Pin1_4	136	141	PF00397	0.376
DOC_WW_Pin1_4	29	34	PF00397	0.563
DOC_WW_Pin1_4	342	347	PF00397	0.307
DOC_WW_Pin1_4	420	425	PF00397	0.321
LIG_14-3-3_CanoR_1	359	363	PF00244	0.258
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_FHA_1	296	302	PF00498	0.406
LIG_FHA_1	380	386	PF00498	0.334
LIG_FHA_2	348	354	PF00498	0.294
LIG_FHA_2	49	55	PF00498	0.406
LIG_GBD_Chelix_1	322	330	PF00786	0.190
LIG_LIR_Apic_2	408	412	PF02991	0.215
LIG_LIR_Gen_1	239	245	PF02991	0.447
LIG_LIR_Gen_1	316	326	PF02991	0.368
LIG_LIR_Nem_3	239	244	PF02991	0.373
LIG_LIR_Nem_3	268	273	PF02991	0.316
LIG_LIR_Nem_3	316	322	PF02991	0.300
LIG_LIR_Nem_3	84	89	PF02991	0.402
LIG_SH2_CRK	205	209	PF00017	0.441
LIG_SH2_CRK	409	413	PF00017	0.394
LIG_SH2_CRK	49	53	PF00017	0.349
LIG_SH2_GRB2like	409	412	PF00017	0.405
LIG_SH2_GRB2like	98	101	PF00017	0.420
LIG_SH2_PTP2	241	244	PF00017	0.233
LIG_SH2_PTP2	319	322	PF00017	0.325
LIG_SH2_SRC	98	101	PF00017	0.456
LIG_SH2_STAT5	104	107	PF00017	0.410
LIG_SH2_STAT5	216	219	PF00017	0.323
LIG_SH2_STAT5	241	244	PF00017	0.335
LIG_SH2_STAT5	29	32	PF00017	0.493
LIG_SH2_STAT5	319	322	PF00017	0.325
LIG_SH2_STAT5	371	374	PF00017	0.455
LIG_SH2_STAT5	431	434	PF00017	0.490
LIG_SH2_STAT5	98	101	PF00017	0.414
LIG_SH3_3	239	245	PF00018	0.268
LIG_SH3_3	27	33	PF00018	0.539
LIG_SUMO_SIM_par_1	169	175	PF11976	0.348
LIG_TYR_ITIM	301	306	PF00017	0.406
MOD_CDK_SPxK_1	136	142	PF00069	0.372
MOD_CDK_SPxxK_3	420	427	PF00069	0.321
MOD_CK1_1	246	252	PF00069	0.259
MOD_CK1_1	269	275	PF00069	0.321
MOD_CK1_1	379	385	PF00069	0.259
MOD_CK1_1	394	400	PF00069	0.263
MOD_CK2_1	169	175	PF00069	0.303
MOD_CK2_1	306	312	PF00069	0.342
MOD_CK2_1	347	353	PF00069	0.276
MOD_CK2_1	48	54	PF00069	0.384
MOD_CK2_1	87	93	PF00069	0.315
MOD_DYRK1A_RPxSP_1	342	346	PF00069	0.399
MOD_GlcNHglycan	122	126	PF01048	0.568
MOD_GlcNHglycan	217	220	PF01048	0.320
MOD_GlcNHglycan	274	277	PF01048	0.420
MOD_GlcNHglycan	336	339	PF01048	0.379
MOD_GSK3_1	210	217	PF00069	0.363
MOD_GSK3_1	265	272	PF00069	0.332
MOD_GSK3_1	432	439	PF00069	0.433
MOD_N-GLC_1	227	232	PF02516	0.425
MOD_N-GLC_1	246	251	PF02516	0.233
MOD_N-GLC_1	295	300	PF02516	0.412
MOD_N-GLC_2	186	188	PF02516	0.440
MOD_N-GLC_2	327	329	PF02516	0.347
MOD_N-GLC_2	384	386	PF02516	0.407
MOD_N-GLC_2	438	440	PF02516	0.399
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	227	232	PF00069	0.401
MOD_NEK2_1	405	410	PF00069	0.352
MOD_NEK2_1	41	46	PF00069	0.444
MOD_NEK2_1	432	437	PF00069	0.448
MOD_NEK2_1	81	86	PF00069	0.419
MOD_PIKK_1	158	164	PF00454	0.448
MOD_PKA_1	358	364	PF00069	0.244
MOD_PKA_2	358	364	PF00069	0.245
MOD_Plk_1	121	127	PF00069	0.598
MOD_Plk_1	210	216	PF00069	0.307
MOD_Plk_1	246	252	PF00069	0.260
MOD_Plk_1	265	271	PF00069	0.328
MOD_Plk_4	246	252	PF00069	0.419
MOD_Plk_4	266	272	PF00069	0.339
MOD_Plk_4	376	382	PF00069	0.403
MOD_Plk_4	432	438	PF00069	0.441
MOD_ProDKin_1	136	142	PF00069	0.376
MOD_ProDKin_1	29	35	PF00069	0.558
MOD_ProDKin_1	342	348	PF00069	0.307
MOD_ProDKin_1	420	426	PF00069	0.323
MOD_SUMO_for_1	331	334	PF00179	0.161
MOD_SUMO_rev_2	39	44	PF00179	0.479
MOD_SUMO_rev_2	422	429	PF00179	0.330
TRG_DiLeu_BaEn_4	54	60	PF01217	0.396
TRG_ENDOCYTIC_2	205	208	PF00928	0.341
TRG_ENDOCYTIC_2	241	244	PF00928	0.359
TRG_ENDOCYTIC_2	303	306	PF00928	0.315
TRG_ENDOCYTIC_2	319	322	PF00928	0.315
TRG_ENDOCYTIC_2	49	52	PF00928	0.392
TRG_ER_diArg_1	45	47	PF00400	0.238
TRG_NES_CRM1_1	57	71	PF08389	0.399
TRG_NLS_MonoExtC_3	116	122	PF00514	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	39%	100%
A0A0N0P293	Leptomonas seymouri	34%	100%
A0A0N0P8D1	Leptomonas seymouri	26%	100%
A0A0N1PA65	Leptomonas seymouri	46%	95%
A0A0S4IMD3	Bodo saltans	46%	100%
A0A0S4ISD8	Bodo saltans	41%	83%
A0A0S4IWQ5	Bodo saltans	35%	100%
A0A0S4IY45	Bodo saltans	34%	100%
A0A0S4J328	Bodo saltans	48%	100%
A0A0S4J3Q7	Bodo saltans	30%	100%
A0A0S4J628	Bodo saltans	41%	81%
A0A0S4J918	Bodo saltans	40%	100%
A0A0S4J9K9	Bodo saltans	46%	100%
A0A0S4JPQ2	Bodo saltans	33%	100%
A0A0S4JSZ3	Bodo saltans	33%	100%
A0A0S4JV57	Bodo saltans	34%	100%
A0A0S4JXJ3	Bodo saltans	30%	100%
A0A0S4KI32	Bodo saltans	31%	100%
A0A0S4KJA5	Bodo saltans	45%	95%
A0A1X0NIG8	Trypanosomatidae	31%	100%
A0A1X0NM52	Trypanosomatidae	54%	100%
A0A1X0NXC8	Trypanosomatidae	31%	100%
A0A3R7L7E7	Trypanosoma rangeli	47%	84%
A0A3S5H682	Leishmania donovani	97%	100%
A0A3S5H683	Leishmania donovani	98%	100%
A0A3S5H685	Leishmania donovani	98%	100%
A0A3S7WQD0	Leishmania donovani	98%	100%
A0A6L0WJ22	Leishmania infantum	99%	100%
A0E358	Paramecium tetraurelia	35%	100%
A1KXI0	Blomia tropicalis	31%	100%
A2XQE8	Oryza sativa subsp. indica	36%	100%
A4H5E4	Leishmania braziliensis	68%	100%
A4H5E5	Leishmania braziliensis	65%	100%
A4H5E6	Leishmania braziliensis	66%	100%
A4HA92	Leishmania braziliensis	45%	100%
A4HH90	Leishmania braziliensis	29%	100%
A4HTP0	Leishmania infantum	95%	100%
A4HYH2	Leishmania infantum	48%	100%
A4I4D6	Leishmania infantum	33%	100%
A5HII1	Actinidia deliciosa	33%	100%
B2LSD2	Mucuna pruriens	38%	100%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D3ZZ07	Rattus norvegicus	34%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9ADT5	Leishmania major	31%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
F4JNL3	Arabidopsis thaliana	32%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	36%	100%
O23791	Ananas comosus	32%	100%
O35186	Rattus norvegicus	36%	100%
O45734	Caenorhabditis elegans	41%	100%
O46427	Sus scrofa	36%	100%
O60911	Homo sapiens	38%	100%
O65039	Ricinus communis	38%	100%
O65493	Arabidopsis thaliana	36%	100%
O70370	Mus musculus	35%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	36%	100%
O97397	Phaedon cochleariae	35%	100%
P00785	Actinidia chinensis var. chinensis	32%	100%
P00786	Rattus norvegicus	36%	100%
P04988	Dictyostelium discoideum	38%	100%
P04989	Dictyostelium discoideum	35%	100%
P05167	Hordeum vulgare	40%	100%
P06797	Mus musculus	38%	100%
P07154	Rattus norvegicus	39%	100%
P07711	Homo sapiens	36%	100%
P08176	Dermatophagoides pteronyssinus	29%	100%
P09668	Homo sapiens	38%	100%
P13277	Homarus americanus	40%	100%
P14658	Trypanosoma brucei brucei	46%	98%
P15242	Rattus norvegicus	35%	100%
P16311	Dermatophagoides farinae	31%	100%
P22497	Theileria parva	34%	100%
P22895	Glycine max	38%	100%
P25249	Hordeum vulgare	41%	100%
P25250	Hordeum vulgare	41%	100%
P25326	Bos taurus	35%	100%
P25773	Felis catus	36%	100%
P25774	Homo sapiens	35%	100%
P25775	Leishmania mexicana	48%	100%
P25776	Oryza sativa subsp. japonica	39%	97%
P25778	Oryza sativa subsp. japonica	41%	100%
P25779	Trypanosoma cruzi	48%	95%
P25780	Euroglyphus maynei	29%	100%
P25781	Theileria annulata	34%	100%
P25782	Homarus americanus	36%	100%
P25783	Autographa californica nuclear polyhedrosis virus	38%	100%
P25784	Homarus americanus	37%	100%
P25804	Pisum sativum	43%	100%
P25805	Plasmodium falciparum	29%	78%
P25975	Bos taurus	38%	100%
P35591	Leishmania pifanoi	48%	100%
P36400	Leishmania mexicana	80%	100%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	39%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	37%	100%
P42666	Plasmodium vivax (strain Salvador I)	28%	76%
P43156	Hemerocallis sp.	40%	100%
P43235	Homo sapiens	37%	100%
P43236	Oryctolagus cuniculus	36%	100%
P43295	Arabidopsis thaliana	42%	100%
P43296	Arabidopsis thaliana	41%	100%
P43297	Arabidopsis thaliana	38%	96%
P43510	Caenorhabditis elegans	24%	100%
P46102	Plasmodium vinckei	30%	88%
P49935	Mus musculus	37%	100%
P54639	Dictyostelium discoideum	33%	100%
P54640	Dictyostelium discoideum	33%	100%
P55097	Mus musculus	35%	100%
P56202	Homo sapiens	33%	100%
P56203	Mus musculus	34%	100%
P61276	Macaca fascicularis	36%	100%
P61277	Macaca mulatta	36%	100%
P80884	Ananas comosus	32%	100%
P90850	Caenorhabditis elegans	30%	98%
Q01957	Entamoeba histolytica	34%	100%
Q02765	Rattus norvegicus	34%	100%
Q05094	Leishmania pifanoi	80%	100%
Q10716	Zea mays	40%	100%
Q10717	Zea mays	40%	100%
Q1EIQ3	Psoroptes ovis	31%	100%
Q23894	Dictyostelium discoideum	34%	100%
Q24940	Fasciola hepatica	40%	100%
Q26534	Schistosoma mansoni	38%	100%
Q26636	Sarcophaga peregrina	38%	100%
Q28944	Sus scrofa	37%	100%
Q3T0I2	Bos taurus	37%	100%
Q3ZKN1	Canis lupus familiaris	37%	100%
Q40143	Solanum lycopersicum	39%	100%
Q4QD68	Leishmania major	51%	100%
Q4QI61	Leishmania major	78%	100%
Q4QI62	Leishmania major	87%	100%
Q4QI64	Leishmania major	88%	100%
Q4QI65	Leishmania major	87%	100%
Q4QI66	Leishmania major	77%	100%
Q4QI67	Leishmania major	87%	100%
Q4QI68	Leishmania major	87%	100%
Q54TR1	Dictyostelium discoideum	37%	83%
Q5E968	Bos taurus	36%	100%
Q5E998	Bos taurus	38%	100%
Q63088	Rattus norvegicus	36%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	39%	100%
Q6YD92	Petrosia ficiformis	35%	100%
Q7XWK5	Oryza sativa subsp. japonica	36%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	38%	100%
Q80UB0	Mus musculus	34%	100%
Q86GF7	Pandalus borealis	37%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	38%	100%
Q8BM88	Mus musculus	36%	100%
Q8H166	Arabidopsis thaliana	41%	100%
Q8HY81	Canis lupus familiaris	37%	100%
Q8HY82	Saimiri boliviensis boliviensis	35%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	38%	100%
Q8RWQ9	Arabidopsis thaliana	39%	100%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	39%	100%
Q8VYS0	Arabidopsis thaliana	40%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	38%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	38%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	38%	100%
Q91ZF2	Mus musculus	33%	100%
Q94714	Paramecium tetraurelia	36%	100%
Q94B08	Arabidopsis thaliana	38%	100%
Q95029	Drosophila melanogaster	40%	100%
Q9BIE1	Leishmania donovani	46%	100%
Q9FGR9	Arabidopsis thaliana	38%	100%
Q9GKL8	Chlorocebus aethiops	36%	100%
Q9GL24	Canis lupus familiaris	38%	100%
Q9GLE3	Sus scrofa	35%	100%
Q9GQM5	Leishmania donovani	29%	100%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	38%	100%
Q9JI81	Mus musculus	33%	100%
Q9JIA9	Mus musculus	34%	100%
Q9JL96	Mus musculus	33%	100%
Q9LT77	Arabidopsis thaliana	36%	100%
Q9LT78	Arabidopsis thaliana	38%	98%
Q9LXW3	Arabidopsis thaliana	36%	100%
Q9PYY5	Xestia c-nigrum granulosis virus	40%	100%
Q9QZE3	Rattus norvegicus	32%	100%
Q9R013	Mus musculus	42%	96%
Q9R014	Mus musculus	36%	100%
Q9STL4	Arabidopsis thaliana	36%	100%
Q9STL5	Arabidopsis thaliana	37%	100%
Q9SUL1	Arabidopsis thaliana	40%	100%
Q9SUS9	Arabidopsis thaliana	36%	100%
Q9SUT0	Arabidopsis thaliana	34%	100%
Q9TST1	Felis catus	33%	100%
Q9UBX1	Homo sapiens	41%	92%
Q9VN93	Drosophila melanogaster	40%	72%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	36%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	40%	100%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	35%	100%
V5B261	Trypanosoma cruzi	35%	100%