Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H676_LEIDO

TriTrypDb:

LdBPK_080880.1 , LdCL_080014200 , LDHU3_08.1230

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H676

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H676

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.644
CLV_NRD_NRD_1	113	115	PF00675	0.725
CLV_NRD_NRD_1	217	219	PF00675	0.629
CLV_NRD_NRD_1	50	52	PF00675	0.640
CLV_PCSK_FUR_1	215	219	PF00082	0.663
CLV_PCSK_KEX2_1	113	115	PF00082	0.728
CLV_PCSK_KEX2_1	135	137	PF00082	0.601
CLV_PCSK_KEX2_1	19	21	PF00082	0.696
CLV_PCSK_KEX2_1	217	219	PF00082	0.629
CLV_PCSK_KEX2_1	50	52	PF00082	0.640
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.571
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.664
CLV_PCSK_SKI1_1	4	8	PF00082	0.618
CLV_PCSK_SKI1_1	76	80	PF00082	0.471
DOC_ANK_TNKS_1	115	122	PF00023	0.687
DOC_CDC14_PxL_1	5	13	PF14671	0.583
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.466
DOC_PP1_RVXF_1	2	8	PF00149	0.584
DOC_PP4_FxxP_1	7	10	PF00568	0.519
DOC_PP4_MxPP_1	70	73	PF00568	0.527
DOC_USP7_MATH_1	128	132	PF00917	0.639
DOC_USP7_MATH_1	143	147	PF00917	0.552
DOC_USP7_MATH_1	156	160	PF00917	0.699
DOC_USP7_MATH_1	207	211	PF00917	0.668
DOC_USP7_MATH_1	55	59	PF00917	0.702
DOC_WW_Pin1_4	202	207	PF00397	0.765
DOC_WW_Pin1_4	230	235	PF00397	0.708
DOC_WW_Pin1_4	79	84	PF00397	0.466
LIG_14-3-3_CanoR_1	186	191	PF00244	0.634
LIG_14-3-3_CanoR_1	20	26	PF00244	0.749
LIG_14-3-3_CanoR_1	253	263	PF00244	0.574
LIG_14-3-3_CanoR_1	59	65	PF00244	0.496
LIG_APCC_ABBA_1	64	69	PF00400	0.601
LIG_BIR_III_4	30	34	PF00653	0.639
LIG_BRCT_BRCA1_1	36	40	PF00533	0.555
LIG_CSL_BTD_1	80	83	PF09270	0.592
LIG_FHA_1	125	131	PF00498	0.611
LIG_FHA_1	142	148	PF00498	0.716
LIG_FHA_1	155	161	PF00498	0.643
LIG_FHA_1	173	179	PF00498	0.526
LIG_FHA_1	231	237	PF00498	0.587
LIG_FHA_1	255	261	PF00498	0.530
LIG_FHA_2	22	28	PF00498	0.706
LIG_LIR_Gen_1	210	219	PF02991	0.752
LIG_LIR_Gen_1	37	48	PF02991	0.574
LIG_LIR_Gen_1	58	68	PF02991	0.511
LIG_LIR_Nem_3	103	109	PF02991	0.526
LIG_LIR_Nem_3	210	214	PF02991	0.745
LIG_LIR_Nem_3	37	43	PF02991	0.543
LIG_LIR_Nem_3	58	64	PF02991	0.679
LIG_SH2_CRK	61	65	PF00017	0.516
LIG_SH2_NCK_1	263	267	PF00017	0.631
LIG_SH2_PTP2	108	111	PF00017	0.578
LIG_SH2_STAT5	108	111	PF00017	0.524
LIG_SH2_STAT5	263	266	PF00017	0.650
LIG_SH2_STAT5	61	64	PF00017	0.548
LIG_SH2_STAT5	67	70	PF00017	0.444
LIG_SH2_STAT5	99	102	PF00017	0.542
LIG_SH3_3	106	112	PF00018	0.618
LIG_TRAF2_1	235	238	PF00917	0.742
LIG_WRC_WIRS_1	208	213	PF05994	0.738
MOD_CK1_1	124	130	PF00069	0.607
MOD_CK1_1	141	147	PF00069	0.614
MOD_CK1_1	174	180	PF00069	0.597
MOD_CK1_1	23	29	PF00069	0.625
MOD_CK2_1	207	213	PF00069	0.737
MOD_GlcNHglycan	124	127	PF01048	0.727
MOD_GlcNHglycan	154	157	PF01048	0.725
MOD_GlcNHglycan	36	39	PF01048	0.554
MOD_GlcNHglycan	52	56	PF01048	0.517
MOD_GSK3_1	124	131	PF00069	0.614
MOD_GSK3_1	137	144	PF00069	0.705
MOD_GSK3_1	152	159	PF00069	0.753
MOD_GSK3_1	173	180	PF00069	0.580
MOD_GSK3_1	226	233	PF00069	0.619
MOD_GSK3_1	51	58	PF00069	0.576
MOD_N-GLC_1	55	60	PF02516	0.602
MOD_NEK2_1	11	16	PF00069	0.659
MOD_NEK2_1	21	26	PF00069	0.758
MOD_NEK2_1	236	241	PF00069	0.661
MOD_NEK2_2	207	212	PF00069	0.737
MOD_PIKK_1	166	172	PF00454	0.681
MOD_PIKK_1	254	260	PF00454	0.673
MOD_PK_1	186	192	PF00069	0.624
MOD_PKA_2	31	37	PF00069	0.625
MOD_PKB_1	57	65	PF00069	0.506
MOD_Plk_1	236	242	PF00069	0.664
MOD_Plk_4	129	135	PF00069	0.629
MOD_Plk_4	143	149	PF00069	0.619
MOD_Plk_4	174	180	PF00069	0.648
MOD_Plk_4	62	68	PF00069	0.493
MOD_ProDKin_1	202	208	PF00069	0.766
MOD_ProDKin_1	230	236	PF00069	0.706
MOD_ProDKin_1	79	85	PF00069	0.467
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.481
TRG_ENDOCYTIC_2	108	111	PF00928	0.506
TRG_ENDOCYTIC_2	46	49	PF00928	0.495
TRG_ENDOCYTIC_2	61	64	PF00928	0.515
TRG_ENDOCYTIC_2	67	70	PF00928	0.473
TRG_ER_diArg_1	112	114	PF00400	0.716
TRG_ER_diArg_1	115	118	PF00400	0.675
TRG_ER_diArg_1	214	217	PF00400	0.639
TRG_ER_diArg_1	49	51	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUT6	Leptomonas seymouri	37%	66%
A4H5D9	Leishmania braziliensis	68%	100%
A4HTN4	Leishmania infantum	100%	100%
E9AMG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QI75	Leishmania major	90%	100%