Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H675_LEIDO

TriTrypDb:

LdBPK_080870.1 , LdBPK_292680.1 , LdCL_080014100 , LDHU3_08.1220

Length:

1153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H675

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H675

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.526
CLV_C14_Caspase3-7	329	333	PF00656	0.566
CLV_C14_Caspase3-7	780	784	PF00656	0.780
CLV_C14_Caspase3-7	791	795	PF00656	0.720
CLV_C14_Caspase3-7	855	859	PF00656	0.771
CLV_C14_Caspase3-7	950	954	PF00656	0.525
CLV_NRD_NRD_1	124	126	PF00675	0.519
CLV_NRD_NRD_1	178	180	PF00675	0.488
CLV_NRD_NRD_1	24	26	PF00675	0.642
CLV_NRD_NRD_1	301	303	PF00675	0.526
CLV_NRD_NRD_1	459	461	PF00675	0.813
CLV_NRD_NRD_1	552	554	PF00675	0.756
CLV_NRD_NRD_1	609	611	PF00675	0.867
CLV_NRD_NRD_1	774	776	PF00675	0.763
CLV_PCSK_KEX2_1	124	126	PF00082	0.386
CLV_PCSK_KEX2_1	178	180	PF00082	0.488
CLV_PCSK_KEX2_1	300	302	PF00082	0.526
CLV_PCSK_KEX2_1	425	427	PF00082	0.792
CLV_PCSK_KEX2_1	458	460	PF00082	0.808
CLV_PCSK_KEX2_1	552	554	PF00082	0.756
CLV_PCSK_KEX2_1	609	611	PF00082	0.866
CLV_PCSK_KEX2_1	774	776	PF00082	0.763
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.792
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.808
CLV_PCSK_SKI1_1	178	182	PF00082	0.368
CLV_PCSK_SKI1_1	183	187	PF00082	0.368
CLV_PCSK_SKI1_1	531	535	PF00082	0.758
CLV_PCSK_SKI1_1	649	653	PF00082	0.585
CLV_PCSK_SKI1_1	764	768	PF00082	0.641
CLV_PCSK_SKI1_1	911	915	PF00082	0.649
DEG_APCC_DBOX_1	915	923	PF00400	0.650
DEG_Nend_UBRbox_3	1	3	PF02207	0.719
DEG_SPOP_SBC_1	397	401	PF00917	0.703
DOC_CDC14_PxL_1	315	323	PF14671	0.664
DOC_CKS1_1	700	705	PF01111	0.596
DOC_CYCLIN_RxL_1	55	66	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	1073	1079	PF00134	0.837
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.594
DOC_MAPK_gen_1	183	192	PF00069	0.526
DOC_MAPK_gen_1	25	32	PF00069	0.613
DOC_MAPK_MEF2A_6	17	24	PF00069	0.645
DOC_MAPK_RevD_3	11	26	PF00069	0.679
DOC_PP1_RVXF_1	762	768	PF00149	0.579
DOC_PP2B_LxvP_1	1120	1123	PF13499	0.569
DOC_PP2B_LxvP_1	593	596	PF13499	0.828
DOC_PP2B_LxvP_1	820	823	PF13499	0.847
DOC_PP2B_LxvP_1	946	949	PF13499	0.735
DOC_PP4_FxxP_1	47	50	PF00568	0.526
DOC_PP4_FxxP_1	534	537	PF00568	0.820
DOC_PP4_FxxP_1	767	770	PF00568	0.746
DOC_PP4_MxPP_1	535	538	PF00568	0.814
DOC_USP7_MATH_1	145	149	PF00917	0.311
DOC_USP7_MATH_1	214	218	PF00917	0.526
DOC_USP7_MATH_1	235	239	PF00917	0.526
DOC_USP7_MATH_1	258	262	PF00917	0.526
DOC_USP7_MATH_1	31	35	PF00917	0.526
DOC_USP7_MATH_1	349	353	PF00917	0.660
DOC_USP7_MATH_1	397	401	PF00917	0.749
DOC_USP7_MATH_1	403	407	PF00917	0.687
DOC_USP7_MATH_1	475	479	PF00917	0.859
DOC_USP7_MATH_1	527	531	PF00917	0.856
DOC_USP7_MATH_1	63	67	PF00917	0.433
DOC_USP7_MATH_1	912	916	PF00917	0.741
DOC_USP7_MATH_1	962	966	PF00917	0.774
DOC_USP7_MATH_2	826	832	PF00917	0.579
DOC_WW_Pin1_4	1021	1026	PF00397	0.795
DOC_WW_Pin1_4	1028	1033	PF00397	0.713
DOC_WW_Pin1_4	143	148	PF00397	0.375
DOC_WW_Pin1_4	219	224	PF00397	0.526
DOC_WW_Pin1_4	308	313	PF00397	0.526
DOC_WW_Pin1_4	352	357	PF00397	0.625
DOC_WW_Pin1_4	367	372	PF00397	0.637
DOC_WW_Pin1_4	398	403	PF00397	0.789
DOC_WW_Pin1_4	414	419	PF00397	0.667
DOC_WW_Pin1_4	484	489	PF00397	0.844
DOC_WW_Pin1_4	518	523	PF00397	0.834
DOC_WW_Pin1_4	559	564	PF00397	0.840
DOC_WW_Pin1_4	687	692	PF00397	0.843
DOC_WW_Pin1_4	693	698	PF00397	0.746
DOC_WW_Pin1_4	699	704	PF00397	0.660
DOC_WW_Pin1_4	766	771	PF00397	0.745
DOC_WW_Pin1_4	818	823	PF00397	0.761
DOC_WW_Pin1_4	958	963	PF00397	0.797
LIG_14-3-3_CanoR_1	1081	1086	PF00244	0.630
LIG_14-3-3_CanoR_1	1093	1101	PF00244	0.477
LIG_14-3-3_CanoR_1	350	358	PF00244	0.661
LIG_14-3-3_CanoR_1	514	522	PF00244	0.589
LIG_14-3-3_CanoR_1	911	919	PF00244	0.630
LIG_APCC_ABBA_1	44	49	PF00400	0.526
LIG_APCC_ABBAyCdc20_2	178	184	PF00400	0.526
LIG_BIR_III_4	794	798	PF00653	0.815
LIG_BRCT_BRCA1_1	187	191	PF00533	0.526
LIG_CSL_BTD_1	1027	1030	PF09270	0.752
LIG_EH1_1	437	445	PF00400	0.691
LIG_FHA_1	1043	1049	PF00498	0.757
LIG_FHA_1	1139	1145	PF00498	0.531
LIG_FHA_1	150	156	PF00498	0.526
LIG_FHA_1	167	173	PF00498	0.248
LIG_FHA_1	469	475	PF00498	0.852
LIG_FHA_1	669	675	PF00498	0.688
LIG_FHA_1	847	853	PF00498	0.706
LIG_FHA_1	874	880	PF00498	0.713
LIG_FHA_1	903	909	PF00498	0.726
LIG_FHA_2	327	333	PF00498	0.595
LIG_FHA_2	780	786	PF00498	0.784
LIG_FHA_2	796	802	PF00498	0.609
LIG_GSK3_LRP6_1	693	698	PF00069	0.797
LIG_GSK3_LRP6_1	822	827	PF00069	0.583
LIG_Integrin_RGD_1	589	591	PF01839	0.609
LIG_LIR_Apic_2	222	228	PF02991	0.526
LIG_LIR_Gen_1	112	120	PF02991	0.526
LIG_LIR_Gen_1	286	295	PF02991	0.521
LIG_LIR_Gen_1	944	952	PF02991	0.733
LIG_LIR_Nem_3	112	117	PF02991	0.526
LIG_LIR_Nem_3	27	32	PF02991	0.595
LIG_LIR_Nem_3	286	291	PF02991	0.521
LIG_LIR_Nem_3	868	873	PF02991	0.639
LIG_LIR_Nem_3	920	926	PF02991	0.715
LIG_LIR_Nem_3	944	948	PF02991	0.703
LIG_MYND_1	484	488	PF01753	0.747
LIG_MYND_1	956	960	PF01753	0.545
LIG_NBox_RRM_1	792	802	PF00076	0.806
LIG_NRBOX	244	250	PF00104	0.526
LIG_NRBOX	6	12	PF00104	0.716
LIG_OCRL_FandH_1	54	66	PF00620	0.526
LIG_PTAP_UEV_1	696	701	PF05743	0.600
LIG_SH2_CRK	1101	1105	PF00017	0.667
LIG_SH2_CRK	114	118	PF00017	0.526
LIG_SH2_CRK	603	607	PF00017	0.727
LIG_SH2_PTP2	29	32	PF00017	0.433
LIG_SH2_SRC	107	110	PF00017	0.330
LIG_SH2_SRC	29	32	PF00017	0.526
LIG_SH2_SRC	95	98	PF00017	0.526
LIG_SH2_STAP1	250	254	PF00017	0.526
LIG_SH2_STAP1	283	287	PF00017	0.433
LIG_SH2_STAP1	710	714	PF00017	0.596
LIG_SH2_STAT3	710	713	PF00017	0.597
LIG_SH2_STAT5	102	105	PF00017	0.398
LIG_SH2_STAT5	1101	1104	PF00017	0.615
LIG_SH2_STAT5	225	228	PF00017	0.526
LIG_SH2_STAT5	29	32	PF00017	0.526
LIG_SH2_STAT5	54	57	PF00017	0.526
LIG_SH2_STAT5	91	94	PF00017	0.475
LIG_SH3_1	274	280	PF00018	0.368
LIG_SH3_1	413	419	PF00018	0.763
LIG_SH3_2	357	362	PF14604	0.845
LIG_SH3_3	1015	1021	PF00018	0.792
LIG_SH3_3	1024	1030	PF00018	0.689
LIG_SH3_3	12	18	PF00018	0.714
LIG_SH3_3	137	143	PF00018	0.269
LIG_SH3_3	274	280	PF00018	0.368
LIG_SH3_3	353	359	PF00018	0.835
LIG_SH3_3	399	405	PF00018	0.658
LIG_SH3_3	412	418	PF00018	0.682
LIG_SH3_3	534	540	PF00018	0.827
LIG_SH3_3	552	558	PF00018	0.562
LIG_SH3_3	671	677	PF00018	0.730
LIG_SH3_3	685	691	PF00018	0.734
LIG_SH3_3	694	700	PF00018	0.718
LIG_SH3_3	820	826	PF00018	0.656
LIG_SH3_CIN85_PxpxPR_1	357	362	PF14604	0.868
LIG_SUMO_SIM_anti_2	1131	1136	PF11976	0.669
LIG_SUMO_SIM_par_1	1140	1145	PF11976	0.504
LIG_SUMO_SIM_par_1	553	559	PF11976	0.644
LIG_TRAF2_1	439	442	PF00917	0.690
LIG_TYR_ITIM	1099	1104	PF00017	0.651
LIG_UBA3_1	164	173	PF00899	0.223
LIG_UBA3_1	267	274	PF00899	0.526
LIG_UBA3_1	290	297	PF00899	0.526
LIG_WRC_WIRS_1	923	928	PF05994	0.689
LIG_WW_2	537	540	PF00397	0.825
LIG_WW_3	275	279	PF00397	0.433
LIG_WW_3	359	363	PF00397	0.851
MOD_CDC14_SPxK_1	370	373	PF00782	0.636
MOD_CDK_SPK_2	1028	1033	PF00069	0.589
MOD_CDK_SPK_2	699	704	PF00069	0.600
MOD_CDK_SPxK_1	367	373	PF00069	0.646
MOD_CDK_SPxxK_3	559	566	PF00069	0.737
MOD_CK1_1	1083	1089	PF00069	0.704
MOD_CK1_1	115	121	PF00069	0.526
MOD_CK1_1	136	142	PF00069	0.454
MOD_CK1_1	146	152	PF00069	0.323
MOD_CK1_1	352	358	PF00069	0.613
MOD_CK1_1	401	407	PF00069	0.706
MOD_CK1_1	562	568	PF00069	0.857
MOD_CK1_1	64	70	PF00069	0.433
MOD_CK1_1	641	647	PF00069	0.682
MOD_CK1_1	668	674	PF00069	0.735
MOD_CK1_1	833	839	PF00069	0.772
MOD_CK2_1	436	442	PF00069	0.792
MOD_CK2_1	642	648	PF00069	0.686
MOD_CK2_1	822	828	PF00069	0.841
MOD_CK2_1	969	975	PF00069	0.593
MOD_GlcNHglycan	1035	1038	PF01048	0.828
MOD_GlcNHglycan	1094	1097	PF01048	0.465
MOD_GlcNHglycan	118	121	PF01048	0.526
MOD_GlcNHglycan	135	138	PF01048	0.299
MOD_GlcNHglycan	148	151	PF01048	0.276
MOD_GlcNHglycan	26	29	PF01048	0.614
MOD_GlcNHglycan	334	337	PF01048	0.777
MOD_GlcNHglycan	340	343	PF01048	0.789
MOD_GlcNHglycan	351	354	PF01048	0.632
MOD_GlcNHglycan	461	464	PF01048	0.833
MOD_GlcNHglycan	477	480	PF01048	0.556
MOD_GlcNHglycan	515	518	PF01048	0.855
MOD_GlcNHglycan	569	572	PF01048	0.778
MOD_GlcNHglycan	578	581	PF01048	0.670
MOD_GlcNHglycan	593	596	PF01048	0.714
MOD_GlcNHglycan	617	622	PF01048	0.869
MOD_GlcNHglycan	624	627	PF01048	0.747
MOD_GlcNHglycan	634	639	PF01048	0.417
MOD_GlcNHglycan	697	700	PF01048	0.851
MOD_GlcNHglycan	808	811	PF01048	0.683
MOD_GlcNHglycan	830	833	PF01048	0.796
MOD_GlcNHglycan	835	838	PF01048	0.705
MOD_GlcNHglycan	977	980	PF01048	0.823
MOD_GSK3_1	1077	1084	PF00069	0.737
MOD_GSK3_1	112	119	PF00069	0.526
MOD_GSK3_1	145	152	PF00069	0.318
MOD_GSK3_1	20	27	PF00069	0.632
MOD_GSK3_1	204	211	PF00069	0.526
MOD_GSK3_1	215	222	PF00069	0.347
MOD_GSK3_1	378	385	PF00069	0.732
MOD_GSK3_1	397	404	PF00069	0.832
MOD_GSK3_1	617	624	PF00069	0.737
MOD_GSK3_1	634	641	PF00069	0.514
MOD_GSK3_1	664	671	PF00069	0.681
MOD_GSK3_1	695	702	PF00069	0.799
MOD_GSK3_1	784	791	PF00069	0.846
MOD_GSK3_1	818	825	PF00069	0.758
MOD_GSK3_1	842	849	PF00069	0.800
MOD_GSK3_1	879	886	PF00069	0.648
MOD_GSK3_1	922	929	PF00069	0.688
MOD_GSK3_1	958	965	PF00069	0.701
MOD_LATS_1	1079	1085	PF00433	0.589
MOD_N-GLC_2	1013	1015	PF02516	0.603
MOD_NEK2_1	116	121	PF00069	0.526
MOD_NEK2_1	126	131	PF00069	0.363
MOD_NEK2_1	203	208	PF00069	0.526
MOD_NEK2_1	209	214	PF00069	0.428
MOD_NEK2_1	215	220	PF00069	0.330
MOD_NEK2_1	24	29	PF00069	0.618
MOD_NEK2_1	259	264	PF00069	0.526
MOD_NEK2_1	499	504	PF00069	0.608
MOD_NEK2_1	842	847	PF00069	0.780
MOD_NEK2_1	865	870	PF00069	0.698
MOD_NEK2_1	879	884	PF00069	0.548
MOD_NEK2_1	903	908	PF00069	0.732
MOD_NEK2_1	936	941	PF00069	0.666
MOD_NEK2_2	665	670	PF00069	0.587
MOD_PIKK_1	281	287	PF00454	0.433
MOD_PIKK_1	403	409	PF00454	0.789
MOD_PIKK_1	733	739	PF00454	0.734
MOD_PIKK_1	786	792	PF00454	0.746
MOD_PK_1	647	653	PF00069	0.724
MOD_PKA_1	459	465	PF00069	0.834
MOD_PKA_1	774	780	PF00069	0.766
MOD_PKA_2	1080	1086	PF00069	0.591
MOD_PKA_2	1092	1098	PF00069	0.423
MOD_PKA_2	24	30	PF00069	0.616
MOD_PKA_2	349	355	PF00069	0.661
MOD_PKA_2	459	465	PF00069	0.834
MOD_PKA_2	513	519	PF00069	0.843
MOD_PKA_2	567	573	PF00069	0.868
MOD_PKA_2	745	751	PF00069	0.602
MOD_PKA_2	774	780	PF00069	0.766
MOD_PKA_2	883	889	PF00069	0.646
MOD_PKA_2	934	940	PF00069	0.705
MOD_PKA_2	975	981	PF00069	0.737
MOD_Plk_1	259	265	PF00069	0.526
MOD_Plk_1	634	640	PF00069	0.658
MOD_Plk_1	641	647	PF00069	0.601
MOD_Plk_1	784	790	PF00069	0.710
MOD_Plk_2-3	1128	1134	PF00069	0.677
MOD_Plk_2-3	642	648	PF00069	0.686
MOD_Plk_4	1105	1111	PF00069	0.585
MOD_Plk_4	112	118	PF00069	0.526
MOD_Plk_4	204	210	PF00069	0.526
MOD_Plk_4	788	794	PF00069	0.832
MOD_Plk_4	860	866	PF00069	0.773
MOD_Plk_4	917	923	PF00069	0.738
MOD_ProDKin_1	1021	1027	PF00069	0.802
MOD_ProDKin_1	1028	1034	PF00069	0.714
MOD_ProDKin_1	143	149	PF00069	0.375
MOD_ProDKin_1	219	225	PF00069	0.526
MOD_ProDKin_1	308	314	PF00069	0.526
MOD_ProDKin_1	352	358	PF00069	0.624
MOD_ProDKin_1	367	373	PF00069	0.636
MOD_ProDKin_1	398	404	PF00069	0.790
MOD_ProDKin_1	414	420	PF00069	0.671
MOD_ProDKin_1	484	490	PF00069	0.846
MOD_ProDKin_1	518	524	PF00069	0.834
MOD_ProDKin_1	559	565	PF00069	0.843
MOD_ProDKin_1	687	693	PF00069	0.837
MOD_ProDKin_1	699	705	PF00069	0.659
MOD_ProDKin_1	766	772	PF00069	0.746
MOD_ProDKin_1	818	824	PF00069	0.760
MOD_ProDKin_1	958	964	PF00069	0.797
MOD_SUMO_for_1	991	994	PF00179	0.722
TRG_DiLeu_BaEn_1	1145	1150	PF01217	0.670
TRG_DiLeu_BaEn_1	286	291	PF01217	0.433
TRG_DiLeu_BaEn_1	6	11	PF01217	0.713
TRG_DiLeu_BaEn_4	96	102	PF01217	0.526
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.526
TRG_ENDOCYTIC_2	102	105	PF00928	0.526
TRG_ENDOCYTIC_2	1101	1104	PF00928	0.654
TRG_ENDOCYTIC_2	114	117	PF00928	0.330
TRG_ENDOCYTIC_2	29	32	PF00928	0.526
TRG_ENDOCYTIC_2	54	57	PF00928	0.526
TRG_ENDOCYTIC_2	923	926	PF00928	0.673
TRG_ER_diArg_1	124	126	PF00400	0.386
TRG_ER_diArg_1	178	180	PF00400	0.475
TRG_ER_diArg_1	300	302	PF00400	0.526
TRG_ER_diArg_1	483	486	PF00400	0.758
TRG_ER_diArg_1	552	554	PF00400	0.756
TRG_ER_diArg_1	762	765	PF00400	0.576
TRG_NLS_MonoCore_2	457	462	PF00514	0.809
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H5D8	Leishmania braziliensis	68%	98%
E9AMG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QI76	Leishmania major	89%	100%