Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H674_LEIDO

TriTrypDb:

LdBPK_080860.1 , LdCL_080013900 , LDHU3_08.1200

Length:

204

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H674

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H674

PDB structure(s): 7aih_D , 7ane_D

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.503
CLV_NRD_NRD_1	40	42	PF00675	0.476
CLV_NRD_NRD_1	83	85	PF00675	0.408
CLV_PCSK_KEX2_1	32	34	PF00082	0.502
CLV_PCSK_KEX2_1	40	42	PF00082	0.478
CLV_PCSK_KEX2_1	83	85	PF00082	0.393
CLV_PCSK_PC7_1	36	42	PF00082	0.372
CLV_PCSK_SKI1_1	123	127	PF00082	0.430
CLV_PCSK_SKI1_1	130	134	PF00082	0.378
CLV_Separin_Metazoa	112	116	PF03568	0.549
DOC_CDC14_PxL_1	131	139	PF14671	0.406
DOC_MAPK_gen_1	40	46	PF00069	0.347
DOC_MAPK_MEF2A_6	123	131	PF00069	0.400
DOC_MAPK_MEF2A_6	136	145	PF00069	0.428
DOC_MAPK_MEF2A_6	16	24	PF00069	0.550
DOC_PP2B_LxvP_1	143	146	PF13499	0.452
DOC_USP7_MATH_1	12	16	PF00917	0.633
DOC_USP7_MATH_1	185	189	PF00917	0.729
DOC_USP7_MATH_1	190	194	PF00917	0.655
DOC_USP7_MATH_1	91	95	PF00917	0.560
DOC_WW_Pin1_4	16	21	PF00397	0.515
DOC_WW_Pin1_4	46	51	PF00397	0.522
LIG_14-3-3_CanoR_1	123	128	PF00244	0.476
LIG_14-3-3_CanoR_1	40	48	PF00244	0.524
LIG_Actin_WH2_2	7	25	PF00022	0.640
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_FHA_1	108	114	PF00498	0.417
LIG_FHA_1	124	130	PF00498	0.532
LIG_FHA_1	173	179	PF00498	0.756
LIG_LIR_Gen_1	147	156	PF02991	0.581
LIG_LIR_Nem_3	119	125	PF02991	0.496
LIG_LIR_Nem_3	51	56	PF02991	0.501
LIG_SH2_STAT5	29	32	PF00017	0.559
LIG_SH2_STAT5	48	51	PF00017	0.518
LIG_SH2_STAT5	52	55	PF00017	0.515
LIG_SH3_1	111	117	PF00018	0.421
LIG_SH3_3	111	117	PF00018	0.457
LIG_SUMO_SIM_par_1	105	110	PF11976	0.390
LIG_UBA3_1	124	130	PF00899	0.471
MOD_CDK_SPK_2	16	21	PF00069	0.573
MOD_CDK_SPxxK_3	16	23	PF00069	0.556
MOD_CK1_1	147	153	PF00069	0.598
MOD_CK1_1	155	161	PF00069	0.629
MOD_CK1_1	186	192	PF00069	0.774
MOD_CK1_1	193	199	PF00069	0.604
MOD_GlcNHglycan	185	188	PF01048	0.773
MOD_GlcNHglycan	194	198	PF01048	0.636
MOD_GlcNHglycan	41	44	PF01048	0.474
MOD_GlcNHglycan	80	83	PF01048	0.509
MOD_GSK3_1	12	19	PF00069	0.537
MOD_GSK3_1	186	193	PF00069	0.713
MOD_GSK3_1	48	55	PF00069	0.538
MOD_PKA_2	39	45	PF00069	0.577
MOD_Plk_4	144	150	PF00069	0.499
MOD_Plk_4	152	158	PF00069	0.503
MOD_Plk_4	48	54	PF00069	0.453
MOD_ProDKin_1	16	22	PF00069	0.505
MOD_ProDKin_1	46	52	PF00069	0.517
MOD_SUMO_rev_2	167	175	PF00179	0.601
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.498
TRG_ER_diArg_1	20	23	PF00400	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU7	Leptomonas seymouri	80%	100%
A0A0S4J9I7	Bodo saltans	42%	100%
A0A1X0NP61	Trypanosomatidae	57%	100%
A0A3R7NPP0	Trypanosoma rangeli	54%	100%
A4H5D7	Leishmania braziliensis	86%	100%
A4HTN2	Leishmania infantum	100%	100%
C9ZPD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AMG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QI77	Leishmania major	96%	100%
V5BGW6	Trypanosoma cruzi	53%	97%