Mitochondrial DNA polymerase beta-PAK, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial DNA polymerase beta-PAK, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H672_LEIDO

TriTrypDb:

LdBPK_080840.1 , LdCL_080013700 , LDHU3_08.1180

Length:

1480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

A0A3S5H672

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006259	DNA metabolic process	4	4
GO:0006281	DNA repair	5	4
GO:0006396	RNA processing	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0006950	response to stress	2	4
GO:0006974	DNA damage response	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003824	catalytic activity	1	4
GO:0003887	DNA-directed DNA polymerase activity	5	4
GO:0005488	binding	1	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	4
GO:0034061	DNA polymerase activity	4	4
GO:0050265	RNA uridylyltransferase activity	4	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1131	1135	PF00656	0.545
CLV_C14_Caspase3-7	341	345	PF00656	0.601
CLV_C14_Caspase3-7	37	41	PF00656	0.524
CLV_C14_Caspase3-7	409	413	PF00656	0.619
CLV_C14_Caspase3-7	587	591	PF00656	0.701
CLV_C14_Caspase3-7	667	671	PF00656	0.533
CLV_C14_Caspase3-7	92	96	PF00656	0.584
CLV_MEL_PAP_1	414	420	PF00089	0.625
CLV_NRD_NRD_1	1186	1188	PF00675	0.429
CLV_NRD_NRD_1	119	121	PF00675	0.783

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4H5D5	Leishmania braziliensis	68%	100%
A4HTN0	Leishmania infantum	99%	100%

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