SET domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H671_LEIDO

TriTrypDb:

LdBPK_080820.1 , LdCL_080013500 , LDHU3_08.1160

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H671

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H671

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.541
CLV_C14_Caspase3-7	528	532	PF00656	0.535
CLV_NRD_NRD_1	167	169	PF00675	0.626
CLV_NRD_NRD_1	171	173	PF00675	0.494
CLV_NRD_NRD_1	310	312	PF00675	0.648
CLV_NRD_NRD_1	450	452	PF00675	0.568
CLV_NRD_NRD_1	560	562	PF00675	0.417
CLV_PCSK_KEX2_1	167	169	PF00082	0.620
CLV_PCSK_KEX2_1	171	173	PF00082	0.497
CLV_PCSK_KEX2_1	310	312	PF00082	0.716
CLV_PCSK_KEX2_1	315	317	PF00082	0.693
CLV_PCSK_KEX2_1	450	452	PF00082	0.568
CLV_PCSK_KEX2_1	560	562	PF00082	0.363
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.585
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.679
CLV_PCSK_PC7_1	311	317	PF00082	0.677
CLV_PCSK_SKI1_1	626	630	PF00082	0.419
DEG_APCC_DBOX_1	323	331	PF00400	0.495
DEG_SCF_TRCP1_1	287	293	PF00400	0.525
DEG_SPOP_SBC_1	248	252	PF00917	0.588
DEG_SPOP_SBC_1	415	419	PF00917	0.517
DEG_SPOP_SBC_1	573	577	PF00917	0.503
DEG_SPOP_SBC_1	580	584	PF00917	0.453
DOC_ANK_TNKS_1	51	58	PF00023	0.499
DOC_CYCLIN_RxL_1	623	630	PF00134	0.401
DOC_MAPK_gen_1	167	179	PF00069	0.560
DOC_MAPK_gen_1	486	494	PF00069	0.402
DOC_MAPK_MEF2A_6	24	33	PF00069	0.469
DOC_MAPK_NFAT4_5	24	32	PF00069	0.469
DOC_PP2B_LxvP_1	276	279	PF13499	0.446
DOC_PP2B_LxvP_1	31	34	PF13499	0.458
DOC_PP2B_PxIxI_1	189	195	PF00149	0.415
DOC_PP4_FxxP_1	186	189	PF00568	0.355
DOC_USP7_MATH_1	139	143	PF00917	0.546
DOC_USP7_MATH_1	20	24	PF00917	0.463
DOC_USP7_MATH_1	249	253	PF00917	0.731
DOC_USP7_MATH_1	443	447	PF00917	0.638
DOC_USP7_MATH_1	48	52	PF00917	0.514
DOC_USP7_MATH_1	574	578	PF00917	0.535
DOC_USP7_MATH_1	60	64	PF00917	0.440
DOC_USP7_MATH_1	98	102	PF00917	0.477
DOC_WW_Pin1_4	18	23	PF00397	0.457
DOC_WW_Pin1_4	194	199	PF00397	0.384
DOC_WW_Pin1_4	237	242	PF00397	0.670
DOC_WW_Pin1_4	244	249	PF00397	0.588
DOC_WW_Pin1_4	576	581	PF00397	0.483
DOC_WW_Pin1_4	583	588	PF00397	0.487
LIG_14-3-3_CanoR_1	118	123	PF00244	0.473
LIG_14-3-3_CanoR_1	16	20	PF00244	0.452
LIG_14-3-3_CanoR_1	172	178	PF00244	0.464
LIG_14-3-3_CanoR_1	377	383	PF00244	0.497
LIG_14-3-3_CanoR_1	404	410	PF00244	0.391
LIG_14-3-3_CanoR_1	472	478	PF00244	0.527
LIG_14-3-3_CanoR_1	542	551	PF00244	0.499
LIG_14-3-3_CanoR_1	560	570	PF00244	0.560
LIG_14-3-3_CanoR_1	571	581	PF00244	0.467
LIG_14-3-3_CanoR_1	633	642	PF00244	0.473
LIG_14-3-3_CanoR_1	64	72	PF00244	0.454
LIG_BRCT_BRCA1_1	490	494	PF00533	0.426
LIG_FHA_1	117	123	PF00498	0.475
LIG_FHA_1	174	180	PF00498	0.429
LIG_FHA_1	301	307	PF00498	0.606
LIG_FHA_1	353	359	PF00498	0.378
LIG_FHA_1	418	424	PF00498	0.539
LIG_FHA_1	596	602	PF00498	0.533
LIG_FHA_1	635	641	PF00498	0.389
LIG_FHA_2	160	166	PF00498	0.498
LIG_FHA_2	573	579	PF00498	0.535
LIG_LIR_Apic_2	141	146	PF02991	0.624
LIG_LIR_Apic_2	15	20	PF02991	0.450
LIG_LIR_Gen_1	123	131	PF02991	0.457
LIG_LIR_Gen_1	354	364	PF02991	0.356
LIG_LIR_Gen_1	476	485	PF02991	0.420
LIG_LIR_Gen_1	608	617	PF02991	0.551
LIG_LIR_Nem_3	123	128	PF02991	0.457
LIG_LIR_Nem_3	354	360	PF02991	0.365
LIG_LIR_Nem_3	476	480	PF02991	0.491
LIG_LIR_Nem_3	608	614	PF02991	0.477
LIG_LIR_Nem_3	630	635	PF02991	0.410
LIG_LIR_Nem_3	67	72	PF02991	0.452
LIG_NRP_CendR_1	648	649	PF00754	0.560
LIG_Pex14_2	87	91	PF04695	0.461
LIG_Rb_pABgroove_1	521	529	PF01858	0.470
LIG_SH2_CRK	131	135	PF00017	0.454
LIG_SH2_CRK	266	270	PF00017	0.468
LIG_SH2_CRK	341	345	PF00017	0.382
LIG_SH2_CRK	632	636	PF00017	0.391
LIG_SH2_CRK	72	76	PF00017	0.448
LIG_SH2_NCK_1	527	531	PF00017	0.517
LIG_SH2_PTP2	143	146	PF00017	0.627
LIG_SH2_PTP2	611	614	PF00017	0.415
LIG_SH2_SRC	143	146	PF00017	0.627
LIG_SH2_STAP1	581	585	PF00017	0.499
LIG_SH2_STAT5	143	146	PF00017	0.627
LIG_SH2_STAT5	266	269	PF00017	0.462
LIG_SH2_STAT5	341	344	PF00017	0.374
LIG_SH2_STAT5	369	372	PF00017	0.357
LIG_SH2_STAT5	611	614	PF00017	0.415
LIG_SH3_2	89	94	PF14604	0.458
LIG_SH3_3	42	48	PF00018	0.488
LIG_SH3_3	465	471	PF00018	0.550
LIG_SH3_3	86	92	PF00018	0.460
LIG_SUMO_SIM_anti_2	191	197	PF11976	0.353
LIG_SUMO_SIM_par_1	522	529	PF11976	0.502
LIG_TRAF2_1	158	161	PF00917	0.504
LIG_TRAF2_1	603	606	PF00917	0.477
LIG_TYR_ITIM	609	614	PF00017	0.540
LIG_WRC_WIRS_1	406	411	PF05994	0.416
LIG_WW_1	470	473	PF00397	0.395
LIG_WW_3	469	473	PF00397	0.488
LIG_WW_3	58	62	PF00397	0.462
MOD_CDC14_SPxK_1	21	24	PF00782	0.463
MOD_CDK_SPxK_1	18	24	PF00069	0.459
MOD_CDK_SPxxK_3	194	201	PF00069	0.452
MOD_CK1_1	133	139	PF00069	0.463
MOD_CK1_1	247	253	PF00069	0.630
MOD_CK1_1	295	301	PF00069	0.686
MOD_CK1_1	387	393	PF00069	0.521
MOD_CK1_1	576	582	PF00069	0.477
MOD_CK1_1	9	15	PF00069	0.427
MOD_CK2_1	572	578	PF00069	0.514
MOD_Cter_Amidation	169	172	PF01082	0.520
MOD_GlcNHglycan	135	138	PF01048	0.466
MOD_GlcNHglycan	287	290	PF01048	0.471
MOD_GlcNHglycan	294	297	PF01048	0.566
MOD_GlcNHglycan	427	430	PF01048	0.670
MOD_GlcNHglycan	445	448	PF01048	0.719
MOD_GlcNHglycan	462	465	PF01048	0.452
MOD_GlcNHglycan	528	531	PF01048	0.352
MOD_GSK3_1	116	123	PF00069	0.476
MOD_GSK3_1	129	136	PF00069	0.437
MOD_GSK3_1	2	9	PF00069	0.412
MOD_GSK3_1	233	240	PF00069	0.723
MOD_GSK3_1	243	250	PF00069	0.552
MOD_GSK3_1	291	298	PF00069	0.574
MOD_GSK3_1	340	347	PF00069	0.403
MOD_GSK3_1	413	420	PF00069	0.579
MOD_GSK3_1	431	438	PF00069	0.514
MOD_GSK3_1	480	487	PF00069	0.386
MOD_GSK3_1	495	502	PF00069	0.375
MOD_GSK3_1	572	579	PF00069	0.583
MOD_GSK3_1	581	588	PF00069	0.460
MOD_GSK3_1	60	67	PF00069	0.455
MOD_N-GLC_1	352	357	PF02516	0.400
MOD_N-GLC_1	384	389	PF02516	0.531
MOD_N-GLC_1	513	518	PF02516	0.293
MOD_NEK2_1	130	135	PF00069	0.453
MOD_NEK2_1	285	290	PF00069	0.461
MOD_NEK2_1	370	375	PF00069	0.379
MOD_NEK2_1	480	485	PF00069	0.409
MOD_NEK2_1	506	511	PF00069	0.491
MOD_NEK2_1	513	518	PF00069	0.484
MOD_NEK2_1	80	85	PF00069	0.464
MOD_NEK2_2	98	103	PF00069	0.478
MOD_OFUCOSY	511	517	PF10250	0.277
MOD_OFUCOSY	62	68	PF10250	0.455
MOD_OFUCOSY	95	102	PF10250	0.474
MOD_PIKK_1	144	150	PF00454	0.678
MOD_PIKK_1	2	8	PF00454	0.410
MOD_PIKK_1	552	558	PF00454	0.499
MOD_PIKK_1	643	649	PF00454	0.466
MOD_PK_1	120	126	PF00069	0.464
MOD_PK_1	316	322	PF00069	0.622
MOD_PK_1	488	494	PF00069	0.489
MOD_PKA_1	561	567	PF00069	0.535
MOD_PKA_2	15	21	PF00069	0.451
MOD_PKA_2	460	466	PF00069	0.646
MOD_PKA_2	48	54	PF00069	0.509
MOD_PKA_2	480	486	PF00069	0.262
MOD_PKA_2	60	66	PF00069	0.440
MOD_PKB_1	118	126	PF00069	0.468
MOD_PKB_1	486	494	PF00069	0.402
MOD_Plk_1	384	390	PF00069	0.526
MOD_Plk_1	513	519	PF00069	0.493
MOD_Plk_1	605	611	PF00069	0.477
MOD_Plk_2-3	613	619	PF00069	0.537
MOD_Plk_4	120	126	PF00069	0.467
MOD_Plk_4	139	145	PF00069	0.525
MOD_Plk_4	316	322	PF00069	0.557
MOD_Plk_4	480	486	PF00069	0.459
MOD_ProDKin_1	18	24	PF00069	0.459
MOD_ProDKin_1	194	200	PF00069	0.381
MOD_ProDKin_1	237	243	PF00069	0.669
MOD_ProDKin_1	244	250	PF00069	0.589
MOD_ProDKin_1	576	582	PF00069	0.483
MOD_ProDKin_1	583	589	PF00069	0.487
TRG_DiLeu_BaEn_2	629	635	PF01217	0.411
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.474
TRG_ENDOCYTIC_2	131	134	PF00928	0.451
TRG_ENDOCYTIC_2	196	199	PF00928	0.379
TRG_ENDOCYTIC_2	341	344	PF00928	0.374
TRG_ENDOCYTIC_2	611	614	PF00928	0.415
TRG_ENDOCYTIC_2	632	635	PF00928	0.403
TRG_ER_diArg_1	171	173	PF00400	0.506
TRG_ER_diArg_1	449	451	PF00400	0.615
TRG_ER_diArg_1	458	461	PF00400	0.588
TRG_ER_diArg_1	485	488	PF00400	0.387
TRG_ER_diArg_1	642	645	PF00400	0.480
TRG_NLS_MonoExtC_3	166	171	PF00514	0.565
TRG_NLS_MonoExtN_4	164	171	PF00514	0.647
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	626	630	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I8	Leptomonas seymouri	49%	100%
A4H6C5	Leishmania braziliensis	84%	99%
A4HTM8	Leishmania infantum	100%	100%
E9AMG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QI81	Leishmania major	94%	100%