Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H670_LEIDO

TriTrypDb:

LdBPK_080800.1 , LdCL_080013300 , LDHU3_08.1140

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H670

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H670

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.712
CLV_C14_Caspase3-7	157	161	PF00656	0.697
CLV_C14_Caspase3-7	177	181	PF00656	0.687
CLV_C14_Caspase3-7	9	13	PF00656	0.601
CLV_NRD_NRD_1	140	142	PF00675	0.696
CLV_NRD_NRD_1	167	169	PF00675	0.677
CLV_NRD_NRD_1	214	216	PF00675	0.763
CLV_NRD_NRD_1	29	31	PF00675	0.752
CLV_NRD_NRD_1	6	8	PF00675	0.755
CLV_PCSK_KEX2_1	139	141	PF00082	0.693
CLV_PCSK_KEX2_1	167	169	PF00082	0.677
CLV_PCSK_KEX2_1	214	216	PF00082	0.763
CLV_PCSK_KEX2_1	29	31	PF00082	0.752
CLV_PCSK_KEX2_1	5	7	PF00082	0.760
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.700
CLV_PCSK_PC7_1	135	141	PF00082	0.608
DOC_MAPK_gen_1	101	109	PF00069	0.740
DOC_PP4_MxPP_1	199	202	PF00568	0.704
DOC_USP7_MATH_1	20	24	PF00917	0.709
DOC_USP7_MATH_1	210	214	PF00917	0.734
DOC_USP7_MATH_1	225	229	PF00917	0.677
DOC_USP7_MATH_1	47	51	PF00917	0.638
DOC_WW_Pin1_4	22	27	PF00397	0.700
DOC_WW_Pin1_4	221	226	PF00397	0.647
DOC_WW_Pin1_4	233	238	PF00397	0.697
DOC_WW_Pin1_4	257	262	PF00397	0.665
LIG_14-3-3_CanoR_1	140	148	PF00244	0.682
LIG_14-3-3_CanoR_1	175	179	PF00244	0.578
LIG_14-3-3_CanoR_1	7	16	PF00244	0.638
LIG_AP2alpha_1	205	209	PF02296	0.758
LIG_AP2alpha_2	187	189	PF02296	0.728
LIG_AP2alpha_2	284	286	PF02296	0.471
LIG_BIR_III_2	207	211	PF00653	0.658
LIG_BRCT_BRCA1_1	80	84	PF00533	0.516
LIG_deltaCOP1_diTrp_1	183	189	PF00928	0.676
LIG_EVH1_2	201	205	PF00568	0.733
LIG_FHA_1	37	43	PF00498	0.574
LIG_FHA_2	62	68	PF00498	0.457
LIG_LIR_Apic_2	183	188	PF02991	0.683
LIG_LIR_Gen_1	284	290	PF02991	0.475
LIG_LIR_Nem_3	284	289	PF02991	0.494
LIG_LIR_Nem_3	50	56	PF02991	0.538
LIG_LIR_Nem_3	81	87	PF02991	0.507
LIG_Pex14_2	205	209	PF04695	0.758
LIG_Pex14_2	248	252	PF04695	0.549
LIG_Pex14_2	65	69	PF04695	0.600
LIG_SH2_GRB2like	131	134	PF00017	0.618
LIG_SH2_GRB2like	56	59	PF00017	0.478
LIG_SH2_NCK_1	158	162	PF00017	0.697
LIG_SH2_SRC	131	134	PF00017	0.618
LIG_SH2_STAP1	53	57	PF00017	0.510
LIG_SH2_STAT5	86	89	PF00017	0.593
LIG_SH3_2	258	263	PF14604	0.606
LIG_SH3_3	106	112	PF00018	0.745
LIG_SH3_3	146	152	PF00018	0.656
LIG_SH3_3	255	261	PF00018	0.578
LIG_SUMO_SIM_par_1	105	111	PF11976	0.761
LIG_TRAF2_1	64	67	PF00917	0.488
MOD_CDC14_SPxK_1	260	263	PF00782	0.598
MOD_CDK_SPxK_1	257	263	PF00069	0.606
MOD_CDK_SPxxK_3	22	29	PF00069	0.653
MOD_CDK_SPxxK_3	233	240	PF00069	0.696
MOD_CK1_1	121	127	PF00069	0.676
MOD_CK1_1	228	234	PF00069	0.800
MOD_CK1_1	236	242	PF00069	0.704
MOD_CK1_1	8	14	PF00069	0.668
MOD_CK2_1	22	28	PF00069	0.595
MOD_CK2_1	61	67	PF00069	0.455
MOD_Cter_Amidation	169	172	PF01082	0.781
MOD_GlcNHglycan	123	126	PF01048	0.752
MOD_GlcNHglycan	168	171	PF01048	0.678
MOD_GlcNHglycan	21	25	PF01048	0.606
MOD_GlcNHglycan	225	228	PF01048	0.689
MOD_GlcNHglycan	80	83	PF01048	0.633
MOD_GSK3_1	221	228	PF00069	0.730
MOD_GSK3_1	34	41	PF00069	0.538
MOD_GSK3_1	52	59	PF00069	0.590
MOD_GSK3_1	78	85	PF00069	0.515
MOD_NEK2_1	252	257	PF00069	0.630
MOD_NEK2_1	52	57	PF00069	0.599
MOD_NEK2_1	78	83	PF00069	0.521
MOD_PKA_1	139	145	PF00069	0.685
MOD_PKA_1	5	11	PF00069	0.698
MOD_PKA_2	139	145	PF00069	0.700
MOD_PKA_2	166	172	PF00069	0.661
MOD_PKA_2	174	180	PF00069	0.596
MOD_PKA_2	5	11	PF00069	0.665
MOD_Plk_2-3	61	67	PF00069	0.455
MOD_Plk_4	190	196	PF00069	0.658
MOD_Plk_4	38	44	PF00069	0.499
MOD_Plk_4	52	58	PF00069	0.636
MOD_ProDKin_1	22	28	PF00069	0.692
MOD_ProDKin_1	221	227	PF00069	0.644
MOD_ProDKin_1	233	239	PF00069	0.696
MOD_ProDKin_1	257	263	PF00069	0.665
TRG_ER_diArg_1	103	106	PF00400	0.718
TRG_ER_diArg_1	29	32	PF00400	0.745
TRG_ER_diArg_1	5	7	PF00400	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEG2	Leptomonas seymouri	38%	100%
A4H6C7	Leishmania braziliensis	58%	100%
A4HTM6	Leishmania infantum	99%	100%
E9AMG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QI83	Leishmania major	87%	100%