Tuzin_putative/GeneDB:LmjF.08.0790

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tuzin, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H669_LEIDO

TriTrypDb:

LdBPK_080740.1 , LdCL_080012900 , LDHU3_08.1020

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A0A3S5H669

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H669

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.458
CLV_NRD_NRD_1	39	41	PF00675	0.399
CLV_NRD_NRD_1	474	476	PF00675	0.513
CLV_NRD_NRD_1	565	567	PF00675	0.618
CLV_NRD_NRD_1	68	70	PF00675	0.392
CLV_NRD_NRD_1	7	9	PF00675	0.501
CLV_PCSK_FUR_1	263	267	PF00082	0.383
CLV_PCSK_KEX2_1	265	267	PF00082	0.438
CLV_PCSK_KEX2_1	39	41	PF00082	0.398
CLV_PCSK_KEX2_1	474	476	PF00082	0.513
CLV_PCSK_KEX2_1	565	567	PF00082	0.639
CLV_PCSK_KEX2_1	582	584	PF00082	0.576
CLV_PCSK_KEX2_1	68	70	PF00082	0.390
CLV_PCSK_KEX2_1	7	9	PF00082	0.507
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.599
CLV_PCSK_SKI1_1	131	135	PF00082	0.324
CLV_PCSK_SKI1_1	225	229	PF00082	0.392
CLV_PCSK_SKI1_1	359	363	PF00082	0.595
CLV_PCSK_SKI1_1	40	44	PF00082	0.357
CLV_PCSK_SKI1_1	440	444	PF00082	0.641
CLV_PCSK_SKI1_1	559	563	PF00082	0.497
CLV_PCSK_SKI1_1	8	12	PF00082	0.438
DEG_Kelch_actinfilin_1	447	451	PF01344	0.229
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DEG_SPOP_SBC_1	17	21	PF00917	0.620
DEG_SPOP_SBC_1	22	26	PF00917	0.630
DOC_CYCLIN_RxL_1	5	15	PF00134	0.602
DOC_MAPK_DCC_7	93	101	PF00069	0.637
DOC_MAPK_gen_1	209	218	PF00069	0.554
DOC_MAPK_gen_1	474	481	PF00069	0.281
DOC_MAPK_gen_1	68	74	PF00069	0.557
DOC_MAPK_MEF2A_6	446	454	PF00069	0.335
DOC_MAPK_MEF2A_6	474	483	PF00069	0.293
DOC_MAPK_MEF2A_6	93	101	PF00069	0.639
DOC_PP1_RVXF_1	181	188	PF00149	0.453
DOC_PP1_RVXF_1	495	501	PF00149	0.344
DOC_PP1_RVXF_1	606	613	PF00149	0.319
DOC_PP2B_LxvP_1	159	162	PF13499	0.525
DOC_PP2B_LxvP_1	417	420	PF13499	0.371
DOC_PP2B_LxvP_1	94	97	PF13499	0.543
DOC_PP2B_PxIxI_1	369	375	PF00149	0.301
DOC_PP4_FxxP_1	43	46	PF00568	0.668
DOC_SPAK_OSR1_1	306	310	PF12202	0.381
DOC_USP7_MATH_1	13	17	PF00917	0.632
DOC_USP7_MATH_1	22	26	PF00917	0.705
DOC_USP7_MATH_1	234	238	PF00917	0.569
DOC_USP7_MATH_1	484	488	PF00917	0.301
DOC_USP7_MATH_1	97	101	PF00917	0.683
DOC_USP7_UBL2_3	310	314	PF12436	0.373
DOC_USP7_UBL2_3	578	582	PF12436	0.371
LIG_14-3-3_CanoR_1	235	239	PF00244	0.518
LIG_14-3-3_CanoR_1	265	275	PF00244	0.617
LIG_14-3-3_CanoR_1	294	303	PF00244	0.438
LIG_14-3-3_CanoR_1	39	46	PF00244	0.678
LIG_14-3-3_CanoR_1	549	555	PF00244	0.376
LIG_14-3-3_CanoR_1	8	17	PF00244	0.648
LIG_Actin_WH2_2	169	185	PF00022	0.479
LIG_Actin_WH2_2	396	413	PF00022	0.364
LIG_APCC_ABBA_1	524	529	PF00400	0.343
LIG_BIR_III_4	520	524	PF00653	0.280
LIG_BRCT_BRCA1_1	129	133	PF00533	0.535
LIG_BRCT_BRCA1_1	278	282	PF00533	0.275
LIG_BRCT_BRCA1_1	82	86	PF00533	0.610
LIG_deltaCOP1_diTrp_1	355	362	PF00928	0.365
LIG_deltaCOP1_diTrp_1	618	622	PF00928	0.320
LIG_EH1_1	132	140	PF00400	0.484
LIG_eIF4E_1	555	561	PF01652	0.318
LIG_FHA_1	145	151	PF00498	0.572
LIG_FHA_1	167	173	PF00498	0.585
LIG_FHA_1	194	200	PF00498	0.514
LIG_FHA_1	489	495	PF00498	0.431
LIG_FHA_2	329	335	PF00498	0.606
LIG_LIR_Apic_2	41	46	PF02991	0.675
LIG_LIR_Apic_2	499	504	PF02991	0.360
LIG_LIR_Gen_1	509	519	PF02991	0.367
LIG_LIR_Nem_3	103	109	PF02991	0.564
LIG_LIR_Nem_3	269	275	PF02991	0.460
LIG_LIR_Nem_3	499	503	PF02991	0.338
LIG_LIR_Nem_3	509	515	PF02991	0.345
LIG_NRBOX	147	153	PF00104	0.468
LIG_NRBOX	537	543	PF00104	0.336
LIG_Pex14_2	282	286	PF04695	0.315
LIG_Pex14_2	86	90	PF04695	0.614
LIG_SH2_CRK	272	276	PF00017	0.283
LIG_SH2_CRK	501	505	PF00017	0.369
LIG_SH2_CRK	613	617	PF00017	0.357
LIG_SH2_GRB2like	555	558	PF00017	0.293
LIG_SH2_NCK_1	501	505	PF00017	0.321
LIG_SH2_NCK_1	613	617	PF00017	0.352
LIG_SH2_SRC	512	515	PF00017	0.412
LIG_SH2_SRC	589	592	PF00017	0.326
LIG_SH2_STAT3	555	558	PF00017	0.306
LIG_SH2_STAT5	106	109	PF00017	0.545
LIG_SH2_STAT5	181	184	PF00017	0.537
LIG_SH2_STAT5	217	220	PF00017	0.556
LIG_SH2_STAT5	296	299	PF00017	0.383
LIG_SH2_STAT5	378	381	PF00017	0.347
LIG_SH2_STAT5	501	504	PF00017	0.369
LIG_SH2_STAT5	514	517	PF00017	0.342
LIG_SH2_STAT5	555	558	PF00017	0.369
LIG_SH3_3	478	484	PF00018	0.316
LIG_SH3_3	55	61	PF00018	0.677
LIG_SUMO_SIM_par_1	371	376	PF11976	0.296
LIG_TYR_ITIM	611	616	PF00017	0.328
MOD_CK1_1	100	106	PF00069	0.668
MOD_CK1_1	15	21	PF00069	0.691
MOD_CK1_1	3	9	PF00069	0.603
MOD_CK1_1	320	326	PF00069	0.479
MOD_CK1_1	336	342	PF00069	0.532
MOD_CK1_1	487	493	PF00069	0.424
MOD_CK1_1	600	606	PF00069	0.383
MOD_CK2_1	234	240	PF00069	0.549
MOD_CK2_1	328	334	PF00069	0.624
MOD_CK2_1	548	554	PF00069	0.391
MOD_GlcNHglycan	189	192	PF01048	0.361
MOD_GlcNHglycan	232	235	PF01048	0.330
MOD_GlcNHglycan	25	28	PF01048	0.541
MOD_GlcNHglycan	268	271	PF01048	0.352
MOD_GlcNHglycan	276	279	PF01048	0.286
MOD_GlcNHglycan	319	322	PF01048	0.709
MOD_GlcNHglycan	339	342	PF01048	0.668
MOD_GlcNHglycan	34	38	PF01048	0.514
MOD_GlcNHglycan	40	43	PF01048	0.475
MOD_GlcNHglycan	550	553	PF01048	0.519
MOD_GSK3_1	17	24	PF00069	0.680
MOD_GSK3_1	187	194	PF00069	0.504
MOD_GSK3_1	219	226	PF00069	0.521
MOD_GSK3_1	230	237	PF00069	0.476
MOD_GSK3_1	295	302	PF00069	0.414
MOD_GSK3_1	328	335	PF00069	0.548
MOD_GSK3_1	343	350	PF00069	0.406
MOD_GSK3_1	382	389	PF00069	0.329
MOD_GSK3_1	484	491	PF00069	0.301
MOD_GSK3_1	9	16	PF00069	0.659
MOD_N-GLC_1	144	149	PF02516	0.378
MOD_N-GLC_1	504	509	PF02516	0.546
MOD_NEK2_1	230	235	PF00069	0.513
MOD_NEK2_1	276	281	PF00069	0.343
MOD_NEK2_1	33	38	PF00069	0.710
MOD_NEK2_1	337	342	PF00069	0.401
MOD_NEK2_1	386	391	PF00069	0.290
MOD_NEK2_1	488	493	PF00069	0.373
MOD_NEK2_1	506	511	PF00069	0.347
MOD_NEK2_1	527	532	PF00069	0.328
MOD_NEK2_1	597	602	PF00069	0.341
MOD_NEK2_1	612	617	PF00069	0.355
MOD_NEK2_2	284	289	PF00069	0.292
MOD_PIKK_1	115	121	PF00454	0.692
MOD_PIKK_1	228	234	PF00454	0.501
MOD_PIKK_1	506	512	PF00454	0.356
MOD_PIKK_1	63	69	PF00454	0.588
MOD_PK_1	438	444	PF00069	0.269
MOD_PKA_2	234	240	PF00069	0.523
MOD_PKA_2	343	349	PF00069	0.410
MOD_PKA_2	38	44	PF00069	0.580
MOD_PKA_2	548	554	PF00069	0.391
MOD_Plk_1	33	39	PF00069	0.588
MOD_Plk_1	333	339	PF00069	0.506
MOD_Plk_1	406	412	PF00069	0.416
MOD_Plk_1	597	603	PF00069	0.329
MOD_Plk_4	234	240	PF00069	0.511
MOD_Plk_4	490	496	PF00069	0.287
MOD_Plk_4	80	86	PF00069	0.548
TRG_DiLeu_BaEn_1	214	219	PF01217	0.540
TRG_ENDOCYTIC_2	181	184	PF00928	0.527
TRG_ENDOCYTIC_2	272	275	PF00928	0.304
TRG_ENDOCYTIC_2	512	515	PF00928	0.358
TRG_ENDOCYTIC_2	613	616	PF00928	0.350
TRG_ER_diArg_1	265	267	PF00400	0.662
TRG_ER_diArg_1	38	40	PF00400	0.636
TRG_ER_diArg_1	564	566	PF00400	0.458
TRG_ER_diArg_1	68	70	PF00400	0.696
TRG_NES_CRM1_1	408	423	PF08389	0.361
TRG_NES_CRM1_1	513	525	PF08389	0.368
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	41%	97%
A0A0N1PB02	Leptomonas seymouri	49%	97%
A0A0S4J6C6	Bodo saltans	44%	98%
A0A1X0P9A6	Trypanosomatidae	43%	93%
A0A3Q8IHH1	Leishmania donovani	37%	100%
A0A3R7K2Y9	Trypanosoma rangeli	51%	93%
A0A3S5H668	Leishmania donovani	48%	100%
A0A3S7X835	Leishmania donovani	46%	100%
A4H5C9	Leishmania braziliensis	46%	100%
A4H5D0	Leishmania braziliensis	75%	99%
A4HAZ7	Leishmania braziliensis	44%	97%
A4HAZ9	Leishmania braziliensis	45%	100%
A4HB01	Leishmania braziliensis	46%	100%
A4HTM0	Leishmania infantum	47%	100%
A4HTM1	Leishmania infantum	100%	100%
A4IA57	Leishmania infantum	47%	99%
C6K3V8	Leptomonas seymouri	44%	100%
C6K3V9	Leptomonas seymouri	72%	97%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	94%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	98%
Q4Q1U8	Leishmania major	38%	100%
Q4Q2R4	Leishmania major	47%	99%
Q4Q310	Leishmania major	38%	100%
Q4Q312	Leishmania major	38%	100%
Q4Q340	Leishmania major	39%	100%
Q4Q342	Leishmania major	39%	100%
Q4QI90	Leishmania major	94%	100%
Q4QI91	Leishmania major	47%	100%