Tuzin, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tuzin, putative

Gene product:

tuzin, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H668_LEIDO

TriTrypDb:

LdBPK_080730.1 , LdCL_080012800 , LDHU3_08.1010

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A0A3S5H668

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H668

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	16	22	PF00089	0.401
CLV_NRD_NRD_1	126	128	PF00675	0.287
CLV_NRD_NRD_1	161	163	PF00675	0.446
CLV_NRD_NRD_1	193	195	PF00675	0.627
CLV_NRD_NRD_1	214	216	PF00675	0.771
CLV_NRD_NRD_1	240	242	PF00675	0.597
CLV_NRD_NRD_1	268	270	PF00675	0.552
CLV_NRD_NRD_1	350	352	PF00675	0.509
CLV_NRD_NRD_1	423	425	PF00675	0.604
CLV_NRD_NRD_1	437	439	PF00675	0.604
CLV_NRD_NRD_1	91	93	PF00675	0.332
CLV_PCSK_FUR_1	159	163	PF00082	0.367
CLV_PCSK_FUR_1	191	195	PF00082	0.468
CLV_PCSK_KEX2_1	161	163	PF00082	0.426
CLV_PCSK_KEX2_1	190	192	PF00082	0.652
CLV_PCSK_KEX2_1	193	195	PF00082	0.653
CLV_PCSK_KEX2_1	214	216	PF00082	0.672
CLV_PCSK_KEX2_1	240	242	PF00082	0.597
CLV_PCSK_KEX2_1	350	352	PF00082	0.509
CLV_PCSK_KEX2_1	437	439	PF00082	0.629
CLV_PCSK_KEX2_1	91	93	PF00082	0.323
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.477
CLV_PCSK_PC7_1	236	242	PF00082	0.603
CLV_PCSK_SKI1_1	149	153	PF00082	0.385
CLV_PCSK_SKI1_1	22	26	PF00082	0.372
CLV_PCSK_SKI1_1	236	240	PF00082	0.604
CLV_PCSK_SKI1_1	273	277	PF00082	0.494
CLV_PCSK_SKI1_1	292	296	PF00082	0.563
CLV_PCSK_SKI1_1	315	319	PF00082	0.632
CLV_PCSK_SKI1_1	385	389	PF00082	0.648
CLV_PCSK_SKI1_1	454	458	PF00082	0.461
CLV_PCSK_SKI1_1	493	497	PF00082	0.583
DEG_APCC_DBOX_1	235	243	PF00400	0.430
DEG_APCC_DBOX_1	453	461	PF00400	0.374
DEG_APCC_DBOX_1	94	102	PF00400	0.535
DEG_Nend_UBRbox_2	1	3	PF02207	0.598
DOC_MAPK_DCC_7	318	328	PF00069	0.346
DOC_MAPK_gen_1	105	114	PF00069	0.553
DOC_MAPK_gen_1	127	135	PF00069	0.576
DOC_MAPK_gen_1	269	280	PF00069	0.333
DOC_MAPK_gen_1	91	100	PF00069	0.562
DOC_MAPK_MEF2A_6	269	278	PF00069	0.301
DOC_MAPK_MEF2A_6	318	327	PF00069	0.355
DOC_PP1_RVXF_1	371	377	PF00149	0.323
DOC_PP1_RVXF_1	95	101	PF00149	0.436
DOC_PP2B_LxvP_1	364	367	PF13499	0.428
DOC_PP2B_PxIxI_1	246	252	PF00149	0.315
DOC_USP7_MATH_1	10	14	PF00917	0.670
DOC_USP7_MATH_1	360	364	PF00917	0.280
DOC_USP7_MATH_1	55	59	PF00917	0.504
DOC_WW_Pin1_4	215	220	PF00397	0.527
DOC_WW_Pin1_4	4	9	PF00397	0.562
LIG_14-3-3_CanoR_1	127	131	PF00244	0.534
LIG_14-3-3_CanoR_1	194	200	PF00244	0.428
LIG_14-3-3_CanoR_1	214	219	PF00244	0.582
LIG_14-3-3_CanoR_1	241	247	PF00244	0.406
LIG_14-3-3_CanoR_1	493	501	PF00244	0.359
LIG_APCC_ABBAyCdc20_2	273	279	PF00400	0.357
LIG_deltaCOP1_diTrp_1	492	496	PF00928	0.326
LIG_FHA_1	286	292	PF00498	0.389
LIG_FHA_1	41	47	PF00498	0.578
LIG_FHA_1	471	477	PF00498	0.408
LIG_FHA_1	495	501	PF00498	0.345
LIG_FHA_2	207	213	PF00498	0.448
LIG_FHA_2	23	29	PF00498	0.724
LIG_FHA_2	327	333	PF00498	0.347
LIG_LIR_Apic_2	375	380	PF02991	0.347
LIG_LIR_Gen_1	14	24	PF02991	0.520
LIG_LIR_Gen_1	304	313	PF02991	0.333
LIG_LIR_Nem_3	14	20	PF02991	0.581
LIG_LIR_Nem_3	173	179	PF02991	0.288
LIG_LIR_Nem_3	304	308	PF02991	0.342
LIG_LIR_Nem_3	375	379	PF02991	0.325
LIG_MYND_3	296	300	PF01753	0.279
LIG_NRBOX	97	103	PF00104	0.530
LIG_PTB_Apo_2	47	54	PF02174	0.572
LIG_SH2_CRK	377	381	PF00017	0.356
LIG_SH2_CRK	487	491	PF00017	0.358
LIG_SH2_NCK_1	377	381	PF00017	0.308
LIG_SH2_NCK_1	487	491	PF00017	0.353
LIG_SH2_PTP2	17	20	PF00017	0.592
LIG_SH2_SRC	487	490	PF00017	0.374
LIG_SH2_STAP1	357	361	PF00017	0.324
LIG_SH2_STAT3	163	166	PF00017	0.599
LIG_SH2_STAT3	431	434	PF00017	0.294
LIG_SH2_STAT3	466	469	PF00017	0.378
LIG_SH2_STAT5	113	116	PF00017	0.551
LIG_SH2_STAT5	125	128	PF00017	0.567
LIG_SH2_STAT5	163	166	PF00017	0.525
LIG_SH2_STAT5	17	20	PF00017	0.565
LIG_SH2_STAT5	305	308	PF00017	0.351
LIG_SH2_STAT5	390	393	PF00017	0.353
LIG_SH2_STAT5	431	434	PF00017	0.356
LIG_SH2_STAT5	466	469	PF00017	0.399
LIG_SH3_3	216	222	PF00018	0.504
LIG_SH3_3	366	372	PF00018	0.333
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.647
LIG_SUMO_SIM_par_1	322	329	PF11976	0.355
LIG_SUMO_SIM_par_1	60	66	PF11976	0.584
LIG_TRAF2_1	229	232	PF00917	0.383
LIG_TRFH_1	113	117	PF08558	0.466
LIG_TYR_ITIM	485	490	PF00017	0.331
LIG_UBA3_1	417	425	PF00899	0.262
MOD_CK1_1	334	340	PF00069	0.366
MOD_CK1_1	40	46	PF00069	0.591
MOD_CK1_1	69	75	PF00069	0.640
MOD_CK2_1	326	332	PF00069	0.319
MOD_CK2_1	424	430	PF00069	0.371
MOD_DYRK1A_RPxSP_1	215	219	PF00069	0.388
MOD_GlcNHglycan	168	171	PF01048	0.287
MOD_GlcNHglycan	172	175	PF01048	0.280
MOD_GlcNHglycan	265	268	PF01048	0.570
MOD_GlcNHglycan	85	88	PF01048	0.352
MOD_GSK3_1	166	173	PF00069	0.447
MOD_GSK3_1	204	211	PF00069	0.428
MOD_GSK3_1	259	266	PF00069	0.342
MOD_GSK3_1	307	314	PF00069	0.427
MOD_N-GLC_1	242	247	PF02516	0.464
MOD_N-GLC_1	340	345	PF02516	0.520
MOD_N-GLC_1	40	45	PF02516	0.377
MOD_N-GLC_1	470	475	PF02516	0.501
MOD_N-GLC_1	49	54	PF02516	0.396
MOD_NEK2_1	126	131	PF00069	0.502
MOD_NEK2_1	242	247	PF00069	0.415
MOD_NEK2_1	263	268	PF00069	0.308
MOD_NEK2_1	326	331	PF00069	0.320
MOD_NEK2_1	403	408	PF00069	0.328
MOD_NEK2_2	180	185	PF00069	0.286
MOD_PIKK_1	55	61	PF00454	0.611
MOD_PK_1	424	430	PF00069	0.379
MOD_PKA_1	214	220	PF00069	0.387
MOD_PKA_1	424	430	PF00069	0.420
MOD_PKA_2	126	132	PF00069	0.529
MOD_PKA_2	213	219	PF00069	0.593
MOD_PKA_2	232	238	PF00069	0.311
MOD_PKA_2	69	75	PF00069	0.596
MOD_Plk_1	283	289	PF00069	0.396
MOD_Plk_1	334	340	PF00069	0.307
MOD_Plk_1	391	397	PF00069	0.419
MOD_Plk_1	49	55	PF00069	0.625
MOD_Plk_2-3	49	55	PF00069	0.579
MOD_Plk_4	180	186	PF00069	0.238
MOD_Plk_4	259	265	PF00069	0.285
MOD_ProDKin_1	215	221	PF00069	0.525
MOD_ProDKin_1	4	10	PF00069	0.554
MOD_SUMO_rev_2	266	275	PF00179	0.348
MOD_SUMO_rev_2	427	436	PF00179	0.270
TRG_DiLeu_BaEn_1	147	152	PF01217	0.586
TRG_DiLeu_BaEn_1	322	327	PF01217	0.320
TRG_DiLeu_BaEn_2	95	101	PF01217	0.501
TRG_ENDOCYTIC_2	168	171	PF00928	0.298
TRG_ENDOCYTIC_2	17	20	PF00928	0.592
TRG_ENDOCYTIC_2	189	192	PF00928	0.347
TRG_ENDOCYTIC_2	305	308	PF00928	0.337
TRG_ENDOCYTIC_2	487	490	PF00928	0.353
TRG_ENDOCYTIC_2	77	80	PF00928	0.537
TRG_ER_diArg_1	159	162	PF00400	0.653
TRG_ER_diArg_1	192	194	PF00400	0.454
TRG_ER_diArg_1	239	241	PF00400	0.402
TRG_ER_diArg_1	350	352	PF00400	0.293
TRG_ER_diArg_1	436	438	PF00400	0.443
TRG_ER_diArg_1	68	71	PF00400	0.629
TRG_NES_CRM1_1	124	139	PF08389	0.625
TRG_NES_CRM1_1	285	300	PF08389	0.349
TRG_NES_CRM1_1	416	430	PF08389	0.266
TRG_NLS_MonoExtC_3	189	194	PF00514	0.265
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	42%	77%
A0A0N1PB02	Leptomonas seymouri	51%	78%
A0A0S4J6C6	Bodo saltans	43%	79%
A0A1X0P9A6	Trypanosomatidae	51%	75%
A0A3Q8IHH1	Leishmania donovani	40%	100%
A0A3R7K2Y9	Trypanosoma rangeli	49%	74%
A0A3S5H669	Leishmania donovani	48%	80%
A0A3S7X835	Leishmania donovani	50%	91%
A4H5C9	Leishmania braziliensis	76%	100%
A4H5D0	Leishmania braziliensis	44%	100%
A4HAZ7	Leishmania braziliensis	45%	100%
A4HAZ9	Leishmania braziliensis	47%	100%
A4HB01	Leishmania braziliensis	47%	100%
A4HTM0	Leishmania infantum	99%	100%
A4HTM1	Leishmania infantum	46%	100%
A4IA57	Leishmania infantum	50%	100%
C6K3V8	Leptomonas seymouri	78%	84%
C6K3V9	Leptomonas seymouri	42%	78%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	75%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
Q4Q1U8	Leishmania major	39%	100%
Q4Q2R4	Leishmania major	51%	100%
Q4Q310	Leishmania major	38%	100%
Q4Q312	Leishmania major	38%	100%
Q4Q340	Leishmania major	39%	100%
Q4Q342	Leishmania major	39%	100%
Q4QI90	Leishmania major	47%	100%
Q4QI91	Leishmania major	95%	100%