Amastin surface glycoprotein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H666_LEIDO

TriTrypDb:

LdBPK_341050.1 , LdCL_080012500 , LDHU3_08.0870

Length:

193

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 208
NetGPI	no	yes: 0, no: 219

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	196
GO:0110165	cellular anatomical entity	1	196

Expansion

Sequence features

A0A3S5H666

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H666

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.402
CLV_PCSK_SKI1_1	35	39	PF00082	0.409
DEG_MDM2_SWIB_1	157	165	PF02201	0.489
DOC_CKS1_1	23	28	PF01111	0.353
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.604
DOC_MAPK_gen_1	145	154	PF00069	0.320
DOC_MAPK_MEF2A_6	35	44	PF00069	0.388
DOC_PP2B_LxvP_1	171	174	PF13499	0.596
DOC_PP4_FxxP_1	140	143	PF00568	0.299
DOC_WW_Pin1_4	22	27	PF00397	0.356
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BIR_III_1	1	5	PF00653	0.498
LIG_BIR_III_3	1	5	PF00653	0.595
LIG_deltaCOP1_diTrp_1	63	68	PF00928	0.209
LIG_EH1_1	113	121	PF00400	0.496
LIG_EH1_1	2	10	PF00400	0.516
LIG_EH1_1	75	83	PF00400	0.307
LIG_eIF4E_1	90	96	PF01652	0.503
LIG_FHA_1	119	125	PF00498	0.387
LIG_FHA_1	32	38	PF00498	0.308
LIG_FHA_2	23	29	PF00498	0.398
LIG_FHA_2	31	37	PF00498	0.331
LIG_GBD_Chelix_1	92	100	PF00786	0.361
LIG_LIR_Apic_2	137	143	PF02991	0.373
LIG_LIR_Apic_2	55	61	PF02991	0.200
LIG_LIR_Gen_1	125	133	PF02991	0.305
LIG_LIR_Nem_3	125	131	PF02991	0.293
LIG_NRBOX	91	97	PF00104	0.382
LIG_Pex14_1	47	51	PF04695	0.378
LIG_Pex14_2	150	154	PF04695	0.425
LIG_Pex14_2	157	161	PF04695	0.395
LIG_PTB_Apo_2	164	171	PF02174	0.457
LIG_SH2_CRK	10	14	PF00017	0.358
LIG_SH2_CRK	58	62	PF00017	0.204
LIG_SH2_NCK_1	58	62	PF00017	0.199
LIG_SH2_NCK_1	90	94	PF00017	0.213
LIG_SH2_STAP1	90	94	PF00017	0.216
LIG_SH2_STAT3	189	192	PF00017	0.577
LIG_SH2_STAT5	189	192	PF00017	0.742
LIG_SH3_3	20	26	PF00018	0.359
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.334
LIG_SUMO_SIM_par_1	80	86	PF11976	0.390
LIG_TRAF2_1	190	193	PF00917	0.756
LIG_TRFH_1	170	174	PF08558	0.264
LIG_TYR_ITIM	8	13	PF00017	0.458
MOD_CK1_1	180	186	PF00069	0.566
MOD_CK1_1	83	89	PF00069	0.291
MOD_CK2_1	187	193	PF00069	0.807
MOD_CK2_1	46	52	PF00069	0.360
MOD_GSK3_1	118	125	PF00069	0.298
MOD_GSK3_1	183	190	PF00069	0.774
MOD_GSK3_1	38	45	PF00069	0.284
MOD_N-GLC_1	135	140	PF02516	0.580
MOD_N-GLC_1	38	43	PF02516	0.428
MOD_N-GLC_2	67	69	PF02516	0.395
MOD_NEK2_1	122	127	PF00069	0.365
MOD_NEK2_1	30	35	PF00069	0.333
MOD_NEK2_1	38	43	PF00069	0.290
MOD_NEK2_1	46	51	PF00069	0.324
MOD_PKA_2	30	36	PF00069	0.331
MOD_Plk_1	135	141	PF00069	0.372
MOD_Plk_1	38	44	PF00069	0.348
MOD_Plk_4	102	108	PF00069	0.370
MOD_Plk_4	52	58	PF00069	0.315
MOD_Plk_4	80	86	PF00069	0.303
MOD_ProDKin_1	22	28	PF00069	0.356
TRG_ENDOCYTIC_2	10	13	PF00928	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	30%	100%
A0A0N0P547	Leptomonas seymouri	42%	100%
A0A0N0P6P9	Leptomonas seymouri	27%	84%
A0A0N0P993	Leptomonas seymouri	25%	86%
A0A0N1HWY5	Leptomonas seymouri	29%	99%
A0A0N1PAD5	Leptomonas seymouri	25%	77%
A0A0N1PDH0	Leptomonas seymouri	42%	96%
A0A0N1PFN2	Leptomonas seymouri	22%	100%
A0A0S4J784	Bodo saltans	29%	87%
A0A1X0NQ58	Trypanosomatidae	27%	100%
A0A1X0NUH1	Trypanosomatidae	31%	85%
A0A1X0NVN5	Trypanosomatidae	26%	100%
A0A1X0NVT7	Trypanosomatidae	26%	100%
A0A1X0P2R3	Trypanosomatidae	26%	91%
A0A1X0P988	Trypanosomatidae	42%	100%
A0A381MTA7	Leishmania infantum	47%	100%
A0A381MTB8	Leishmania infantum	42%	100%
A0A381MTC7	Leishmania infantum	42%	100%
A0A381MTN2	Leishmania infantum	63%	100%
A0A381MVY0	Leishmania infantum	47%	99%
A0A3Q8ID16	Leishmania donovani	29%	100%
A0A3Q8IE85	Leishmania donovani	50%	100%
A0A3Q8IEC2	Leishmania donovani	44%	100%
A0A3Q8IEI1	Leishmania donovani	55%	100%
A0A3Q8IF65	Leishmania donovani	43%	100%
A0A3Q8IFB9	Leishmania donovani	42%	100%
A0A3Q8IFH7	Leishmania donovani	42%	100%
A0A3Q8IFI8	Leishmania donovani	25%	100%
A0A3Q8IH65	Leishmania donovani	43%	100%
A0A3Q8IHN2	Leishmania donovani	55%	100%
A0A3Q8IHW7	Leishmania donovani	49%	100%
A0A3Q8IHZ6	Leishmania donovani	49%	100%
A0A3Q8IIH1	Leishmania donovani	43%	100%
A0A3Q8IL03	Leishmania donovani	43%	100%
A0A3Q8IMR4	Leishmania donovani	22%	100%
A0A3Q8IUK8	Leishmania donovani	44%	100%
A0A3Q8IUR5	Leishmania donovani	63%	100%
A0A3S5H662	Leishmania donovani	47%	100%
A0A3S5H663	Leishmania donovani	47%	100%
A0A3S5H665	Leishmania donovani	46%	100%
A0A3S5H667	Leishmania donovani	45%	95%
A0A3S5H7D2	Leishmania donovani	33%	100%
A0A3S5H7L2	Leishmania donovani	42%	94%
A0A3S5H7V9	Leishmania donovani	44%	97%
A0A3S5H7W2	Leishmania donovani	29%	100%
A0A3S5H7W6	Leishmania donovani	43%	97%
A0A3S7WQA0	Leishmania donovani	46%	95%
A0A3S7WQA8	Leishmania donovani	50%	100%
A0A3S7WQC1	Leishmania donovani	48%	100%
A0A3S7X2E6	Leishmania donovani	46%	100%
A0A3S7X357	Leishmania donovani	25%	87%
A0A3S7X381	Leishmania donovani	24%	97%
A0A3S7X453	Leishmania donovani	42%	98%
A0A3S7X472	Leishmania donovani	44%	97%
A0A3S7X7E5	Leishmania donovani	47%	77%
A0A3S7X7M4	Leishmania donovani	48%	91%
A0A3S7X7U1	Leishmania donovani	42%	92%
A0A3S7X7U4	Leishmania donovani	48%	75%
A0A3S7X7W2	Leishmania donovani	38%	92%
A0A3S7X7Y0	Leishmania donovani	42%	99%
A4H595	Leishmania braziliensis	44%	100%
A4H596	Leishmania braziliensis	45%	100%
A4H597	Leishmania braziliensis	44%	100%
A4H5D1	Leishmania braziliensis	47%	100%
A4H5D2	Leishmania braziliensis	43%	100%
A4H5G0	Leishmania braziliensis	53%	100%
A4H5G4	Leishmania braziliensis	47%	100%
A4H5G6	Leishmania braziliensis	42%	100%
A4H5G7	Leishmania braziliensis	45%	100%
A4H5G9	Leishmania braziliensis	48%	100%
A4H5H0	Leishmania braziliensis	48%	100%
A4H5H1	Leishmania braziliensis	51%	100%
A4H5H2	Leishmania braziliensis	49%	100%
A4H5H3	Leishmania braziliensis	46%	100%
A4H6C8	Leishmania braziliensis	51%	100%
A4H7D7	Leishmania braziliensis	46%	100%
A4H9E8	Leishmania braziliensis	48%	100%
A4H9E9	Leishmania braziliensis	45%	100%
A4HAJ4	Leishmania braziliensis	49%	100%
A4HAJ5	Leishmania braziliensis	44%	100%
A4HAJ6	Leishmania braziliensis	44%	100%
A4HAL1	Leishmania braziliensis	45%	100%
A4HAL2	Leishmania braziliensis	32%	100%
A4HAM2	Leishmania braziliensis	43%	100%
A4HAM4	Leishmania braziliensis	43%	100%
A4HAR1	Leishmania braziliensis	50%	100%
A4HAZ8	Leishmania braziliensis	49%	100%
A4HB00	Leishmania braziliensis	48%	100%
A4HB02	Leishmania braziliensis	47%	100%
A4HB47	Leishmania braziliensis	41%	100%
A4HBJ0	Leishmania braziliensis	45%	100%
A4HBJ1	Leishmania braziliensis	43%	100%
A4HBJ2	Leishmania braziliensis	44%	100%
A4HDI3	Leishmania braziliensis	33%	100%
A4HDI4	Leishmania braziliensis	29%	100%
A4HDL3	Leishmania braziliensis	31%	100%
A4HDL4	Leishmania braziliensis	29%	100%
A4HI43	Leishmania braziliensis	23%	91%
A4HTM3	Leishmania infantum	52%	100%
A4HTM4	Leishmania infantum	50%	100%
A4HTM5	Leishmania infantum	53%	100%
A4I0W4	Leishmania infantum	33%	98%
A4I0W5	Leishmania infantum	29%	100%
A4I4J2	Leishmania infantum	44%	100%
A4I4J3	Leishmania infantum	47%	100%
A4I5B8	Leishmania infantum	25%	100%
A4I5B9	Leishmania infantum	24%	100%
A4I6E5	Leishmania infantum	44%	100%
A4I9Q4	Leishmania infantum	47%	100%
A4I9R4	Leishmania infantum	29%	100%
A4I9R5	Leishmania infantum	41%	100%
A4I9R7	Leishmania infantum	51%	100%
A4I9W8	Leishmania infantum	49%	100%
A4I9X0	Leishmania infantum	39%	100%
A4IA59	Leishmania infantum	63%	100%
A4IAL7	Leishmania infantum	49%	100%
A4IAM1	Leishmania infantum	56%	100%
A4IAM2	Leishmania infantum	56%	100%
C6K3X9	Leptomonas seymouri	23%	100%
E8NHC3	Leishmania infantum	48%	100%
E8NHD3	Leishmania infantum	46%	100%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	99%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AG81	Leishmania infantum	47%	100%
E9AG82	Leishmania infantum	48%	100%
E9AG83	Leishmania infantum	97%	100%
E9AG85	Leishmania infantum	48%	100%
E9AHI9	Leishmania infantum	47%	100%
E9AHT2	Leishmania infantum	51%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	99%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	99%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
Q4Q1U9	Leishmania major	44%	99%
Q4Q305	Leishmania major	41%	99%
Q4Q309	Leishmania major	47%	100%
Q4Q313	Leishmania major	41%	99%
Q4Q317	Leishmania major	43%	100%
Q4Q325	Leishmania major	43%	100%
Q4Q327	Leishmania major	46%	99%
Q4Q329	Leishmania major	41%	99%
Q4Q333	Leishmania major	42%	99%
Q4Q335	Leishmania major	42%	99%
Q4Q337	Leishmania major	42%	99%
Q4Q339	Leishmania major	41%	99%
Q4Q341	Leishmania major	45%	100%
Q4Q397	Leishmania major	50%	100%
Q4Q3A7	Leishmania major	30%	100%
Q4Q3A8	Leishmania major	42%	100%
Q4Q3A9	Leishmania major	50%	100%
Q4Q3F7	Leishmania major	51%	100%
Q4Q6L8	Leishmania major	44%	100%
Q4Q7L6	Leishmania major	25%	100%
Q4Q7L7	Leishmania major	25%	100%
Q4Q7L8	Leishmania major	25%	100%
Q4QAK4	Leishmania major	22%	100%
Q4QAK5	Leishmania major	27%	100%
Q4QAK6	Leishmania major	34%	98%
Q4QAK7	Leishmania major	23%	98%
Q4QI84	Leishmania major	51%	100%
Q4QI85	Leishmania major	53%	100%
Q4QI86	Leishmania major	51%	100%
Q4QI87	Leishmania major	53%	100%
Q4QI88	Leishmania major	50%	100%
Q4QI92	Leishmania major	45%	100%
Q4QI93	Leishmania major	45%	100%
Q4QI95	Leishmania major	44%	100%
Q4QI97	Leishmania major	45%	100%
Q4QIA0	Leishmania major	45%	100%
Q4QIA1	Leishmania major	45%	100%