Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H663_LEIDO

TriTrypDb:

LdBPK_080720.1 , LdCL_080011900 , LDHU3_08.0990

Length:

202

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 190
NetGPI	no	yes: 0, no: 201

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	179
GO:0110165	cellular anatomical entity	1	179

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Expansion

Sequence features

A0A3S5H663

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H663

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.215
CLV_NRD_NRD_1	53	55	PF00675	0.582
CLV_NRD_NRD_1	72	74	PF00675	0.488
CLV_PCSK_KEX2_1	72	74	PF00082	0.502
CLV_PCSK_SKI1_1	197	201	PF00082	0.434
DEG_MDM2_SWIB_1	156	164	PF02201	0.326
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.426
DOC_MAPK_gen_1	54	60	PF00069	0.215
DOC_MAPK_MEF2A_6	108	116	PF00069	0.580
DOC_MAPK_MEF2A_6	4	13	PF00069	0.535

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	35%	100%
A0A0N0P547	Leptomonas seymouri	38%	100%
A0A0N0P6P9	Leptomonas seymouri	24%	88%
A0A0N0P993	Leptomonas seymouri	28%	90%
A0A0N1HWY5	Leptomonas seymouri	26%	100%
A0A0N1PAD5	Leptomonas seymouri	24%	80%
A0A0N1PDH0	Leptomonas seymouri	36%	100%
A0A1X0NQ58	Trypanosomatidae	33%	100%
A0A1X0NUH1	Trypanosomatidae	29%	89%
A0A1X0NVN5	Trypanosomatidae	29%	100%

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