Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H661_LEIDO

TriTrypDb:

LdBPK_080620.1 , LdCL_080011200 , LDHU3_08.0680

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H661

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H661

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.647
CLV_NRD_NRD_1	99	101	PF00675	0.462
CLV_PCSK_KEX2_1	14	16	PF00082	0.457
CLV_PCSK_KEX2_1	51	53	PF00082	0.647
CLV_PCSK_KEX2_1	98	100	PF00082	0.448
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.457
CLV_PCSK_SKI1_1	14	18	PF00082	0.365
DEG_Nend_UBRbox_2	1	3	PF02207	0.765
DEG_SCF_FBW7_1	41	47	PF00400	0.534
DOC_CKS1_1	41	46	PF01111	0.534
DOC_CYCLIN_RxL_1	8	18	PF00134	0.580
DOC_MAPK_gen_1	14	22	PF00069	0.522
DOC_MAPK_gen_1	51	58	PF00069	0.392
DOC_MAPK_MEF2A_6	51	60	PF00069	0.395
DOC_WW_Pin1_4	138	143	PF00397	0.701
DOC_WW_Pin1_4	40	45	PF00397	0.453
LIG_14-3-3_CanoR_1	129	139	PF00244	0.799
LIG_14-3-3_CanoR_1	15	22	PF00244	0.458
LIG_14-3-3_CanoR_1	51	55	PF00244	0.545
LIG_EH1_1	68	76	PF00400	0.389
LIG_FHA_1	45	51	PF00498	0.441
LIG_LIR_Apic_2	133	138	PF02991	0.681
LIG_LIR_Nem_3	62	67	PF02991	0.384
LIG_NRBOX	73	79	PF00104	0.299
LIG_PDZ_Class_1	138	143	PF00595	0.679
LIG_Pex14_1	65	69	PF04695	0.292
LIG_Pex14_2	61	65	PF04695	0.416
LIG_SH2_CRK	135	139	PF00017	0.680
LIG_SH2_CRK	84	88	PF00017	0.389
LIG_SH2_GRB2like	135	138	PF00017	0.680
LIG_SH2_NCK_1	84	88	PF00017	0.389
LIG_SH2_STAP1	54	58	PF00017	0.488
LIG_SH2_STAT5	49	52	PF00017	0.459
LIG_SH3_3	38	44	PF00018	0.551
LIG_SH3_3	53	59	PF00018	0.363
LIG_TYR_ITIM	82	87	PF00017	0.358
LIG_TYR_ITSM	60	67	PF00017	0.396
MOD_CDK_SPxxK_3	44	51	PF00069	0.513
MOD_CK1_1	130	136	PF00069	0.800
MOD_GlcNHglycan	111	114	PF01048	0.455
MOD_GlcNHglycan	129	132	PF01048	0.541
MOD_GSK3_1	127	134	PF00069	0.759
MOD_GSK3_1	40	47	PF00069	0.477
MOD_PIKK_1	118	124	PF00454	0.723
MOD_PIKK_1	59	65	PF00454	0.443
MOD_PKA_2	131	137	PF00069	0.668
MOD_PKA_2	50	56	PF00069	0.443
MOD_Plk_1	103	109	PF00069	0.681
MOD_ProDKin_1	40	46	PF00069	0.450
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.658
TRG_ENDOCYTIC_2	64	67	PF00928	0.387
TRG_ENDOCYTIC_2	84	87	PF00928	0.189
TRG_ER_diArg_1	50	52	PF00400	0.454
TRG_ER_diArg_1	97	100	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC93	Leptomonas seymouri	50%	100%
A4H5E7	Leishmania braziliensis	59%	100%
A4HTK9	Leishmania infantum	99%	100%
E9AME0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIA9	Leishmania major	83%	100%