Movement protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Movement protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H659_LEIDO

TriTrypDb:

LdBPK_080600.1 , LdCL_080010900 , LDHU3_08.0660

Length:

167

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S5H659

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H659

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.693
CLV_NRD_NRD_1	101	103	PF00675	0.558
CLV_NRD_NRD_1	110	112	PF00675	0.528
CLV_NRD_NRD_1	162	164	PF00675	0.445
CLV_NRD_NRD_1	69	71	PF00675	0.446
CLV_PCSK_FUR_1	99	103	PF00082	0.515
CLV_PCSK_KEX2_1	101	103	PF00082	0.557
CLV_PCSK_KEX2_1	110	112	PF00082	0.527
CLV_PCSK_KEX2_1	164	166	PF00082	0.448
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.437
CLV_PCSK_SKI1_1	31	35	PF00082	0.676
CLV_PCSK_SKI1_1	70	74	PF00082	0.419
DEG_MDM2_SWIB_1	34	42	PF02201	0.423
DOC_CKS1_1	1	6	PF01111	0.446
DOC_MAPK_RevD_3	150	165	PF00069	0.615
DOC_USP7_MATH_1	119	123	PF00917	0.732
DOC_USP7_MATH_1	15	19	PF00917	0.437
DOC_USP7_UBL2_3	73	77	PF12436	0.580
LIG_14-3-3_CanoR_1	110	115	PF00244	0.733
LIG_14-3-3_CterR_2	163	167	PF00244	0.672
LIG_EVH1_2	29	33	PF00568	0.434
LIG_FHA_1	38	44	PF00498	0.347
LIG_FHA_2	138	144	PF00498	0.672
LIG_FHA_2	8	14	PF00498	0.522
LIG_FHA_2	95	101	PF00498	0.642
LIG_GBD_Chelix_1	50	58	PF00786	0.256
LIG_LIR_Gen_1	144	155	PF02991	0.624
LIG_LIR_Gen_1	18	29	PF02991	0.460
LIG_LIR_Nem_3	144	150	PF02991	0.722
LIG_LIR_Nem_3	18	24	PF02991	0.472
LIG_LIR_Nem_3	82	88	PF02991	0.658
LIG_Pex14_2	34	38	PF04695	0.448
LIG_PTB_Apo_2	80	87	PF02174	0.600
LIG_SH2_CRK	21	25	PF00017	0.421
LIG_SH2_CRK	39	43	PF00017	0.235
LIG_SH2_PTP2	147	150	PF00017	0.638
LIG_SH2_PTP2	53	56	PF00017	0.451
LIG_SH2_STAT3	66	69	PF00017	0.648
LIG_SH2_STAT5	147	150	PF00017	0.638
LIG_SH2_STAT5	39	42	PF00017	0.396
LIG_SH2_STAT5	53	56	PF00017	0.296
LIG_SH2_STAT5	80	83	PF00017	0.722
LIG_SH3_3	151	157	PF00018	0.648
LIG_SH3_3	9	15	PF00018	0.473
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.300
LIG_TYR_ITIM	19	24	PF00017	0.395
MOD_CK1_1	103	109	PF00069	0.742
MOD_CK1_1	136	142	PF00069	0.743
MOD_CK2_1	103	109	PF00069	0.801
MOD_CK2_1	119	125	PF00069	0.637
MOD_CK2_1	137	143	PF00069	0.791
MOD_CK2_1	7	13	PF00069	0.426
MOD_GlcNHglycan	119	122	PF01048	0.517
MOD_GlcNHglycan	133	136	PF01048	0.469
MOD_GSK3_1	100	107	PF00069	0.755
MOD_GSK3_1	109	116	PF00069	0.719
MOD_GSK3_1	131	138	PF00069	0.722
MOD_GSK3_1	90	97	PF00069	0.697
MOD_PIKK_1	94	100	PF00454	0.754
MOD_PKA_1	101	107	PF00069	0.696
MOD_PKA_1	110	116	PF00069	0.684
MOD_PKA_2	100	106	PF00069	0.735
MOD_PKA_2	109	115	PF00069	0.744
MOD_PKB_1	99	107	PF00069	0.727
MOD_Plk_4	110	116	PF00069	0.646
MOD_Plk_4	15	21	PF00069	0.439
MOD_Plk_4	29	35	PF00069	0.370
TRG_ENDOCYTIC_2	147	150	PF00928	0.649
TRG_ENDOCYTIC_2	21	24	PF00928	0.553
TRG_ENDOCYTIC_2	39	42	PF00928	0.336
TRG_ENDOCYTIC_2	53	56	PF00928	0.415
TRG_ER_diArg_1	162	165	PF00400	0.667
TRG_NLS_MonoExtC_3	69	74	PF00514	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	43%	79%
A0A3S7WQ87	Leishmania donovani	31%	100%
A4H5C6	Leishmania braziliensis	39%	100%
A4H5C7	Leishmania braziliensis	58%	100%
A4HTK6	Leishmania infantum	31%	100%
A4HTK7	Leishmania infantum	96%	99%
E9AMD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	93%
E9AMD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QIB1	Leishmania major	86%	100%
Q4QIB2	Leishmania major	35%	100%