Mycolic acid cyclopropane synthetase/Methyltransferase small domain/Methyltransferase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclopropane-fatty-acyl-phospholipid syntahse

Species:

Leishmania donovani

UniProt:

A0A3S5H657_LEIDO

TriTrypDb:

LdBPK_080560.1 , LdCL_080010500 , LDHU3_08.0620

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H657

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H657

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.477
CLV_NRD_NRD_1	128	130	PF00675	0.372
CLV_NRD_NRD_1	131	133	PF00675	0.422
CLV_NRD_NRD_1	196	198	PF00675	0.336
CLV_NRD_NRD_1	324	326	PF00675	0.254
CLV_NRD_NRD_1	352	354	PF00675	0.259
CLV_PCSK_KEX2_1	128	130	PF00082	0.372
CLV_PCSK_KEX2_1	160	162	PF00082	0.370
CLV_PCSK_KEX2_1	196	198	PF00082	0.277
CLV_PCSK_KEX2_1	352	354	PF00082	0.259
CLV_PCSK_KEX2_1	91	93	PF00082	0.347
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.356
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.347
CLV_PCSK_SKI1_1	160	164	PF00082	0.380
CLV_PCSK_SKI1_1	176	180	PF00082	0.484
CLV_PCSK_SKI1_1	211	215	PF00082	0.259
CLV_PCSK_SKI1_1	303	307	PF00082	0.283
CLV_PCSK_SKI1_1	319	323	PF00082	0.227
CLV_PCSK_SKI1_1	345	349	PF00082	0.282
CLV_PCSK_SKI1_1	352	356	PF00082	0.260
CLV_PCSK_SKI1_1	384	388	PF00082	0.259
CLV_PCSK_SKI1_1	92	96	PF00082	0.387
DEG_Nend_UBRbox_2	1	3	PF02207	0.625
DOC_CYCLIN_RxL_1	349	359	PF00134	0.459
DOC_MAPK_gen_1	128	138	PF00069	0.558
DOC_MAPK_gen_1	257	266	PF00069	0.459
DOC_MAPK_gen_1	303	313	PF00069	0.441
DOC_MAPK_gen_1	325	333	PF00069	0.435
DOC_MAPK_gen_1	91	99	PF00069	0.432
DOC_MAPK_MEF2A_6	306	313	PF00069	0.463
DOC_MAPK_MEF2A_6	326	335	PF00069	0.459
DOC_USP7_MATH_1	424	428	PF00917	0.477
DOC_USP7_UBL2_3	283	287	PF12436	0.539
DOC_USP7_UBL2_3	345	349	PF12436	0.446
DOC_USP7_UBL2_3	91	95	PF12436	0.394
DOC_WW_Pin1_4	472	477	PF00397	0.333
LIG_14-3-3_CanoR_1	217	225	PF00244	0.448
LIG_14-3-3_CanoR_1	329	334	PF00244	0.459
LIG_Actin_WH2_2	246	263	PF00022	0.448
LIG_deltaCOP1_diTrp_1	144	152	PF00928	0.351
LIG_deltaCOP1_diTrp_1	379	387	PF00928	0.459
LIG_FHA_1	61	67	PF00498	0.708
LIG_FHA_2	240	246	PF00498	0.459
LIG_FHA_2	290	296	PF00498	0.459
LIG_LIR_Apic_2	168	172	PF02991	0.504
LIG_LIR_Gen_1	114	125	PF02991	0.371
LIG_LIR_Gen_1	23	31	PF02991	0.557
LIG_LIR_Gen_1	324	335	PF02991	0.539
LIG_LIR_Gen_1	42	52	PF02991	0.393
LIG_LIR_Gen_1	479	488	PF02991	0.449
LIG_LIR_Gen_1	85	94	PF02991	0.407
LIG_LIR_Nem_3	114	120	PF02991	0.374
LIG_LIR_Nem_3	149	155	PF02991	0.350
LIG_LIR_Nem_3	156	162	PF02991	0.342
LIG_LIR_Nem_3	23	28	PF02991	0.546
LIG_LIR_Nem_3	324	330	PF02991	0.517
LIG_LIR_Nem_3	379	385	PF02991	0.462
LIG_LIR_Nem_3	42	48	PF02991	0.386
LIG_LIR_Nem_3	445	451	PF02991	0.461
LIG_LIR_Nem_3	479	485	PF02991	0.443
LIG_LIR_Nem_3	85	89	PF02991	0.414
LIG_LIR_Nem_3	93	99	PF02991	0.390
LIG_Pex14_1	381	385	PF04695	0.459
LIG_Pex14_1	425	429	PF04695	0.459
LIG_Pex14_2	323	327	PF04695	0.459
LIG_Pex14_2	429	433	PF04695	0.459
LIG_Pex14_2	447	451	PF04695	0.459
LIG_PTB_Apo_2	204	211	PF02174	0.459
LIG_PTB_Apo_2	312	319	PF02174	0.446
LIG_PTB_Apo_2	410	417	PF02174	0.459
LIG_PTB_Phospho_1	312	318	PF10480	0.446
LIG_REV1ctd_RIR_1	156	165	PF16727	0.322
LIG_REV1ctd_RIR_1	207	215	PF16727	0.459
LIG_REV1ctd_RIR_1	345	353	PF16727	0.459
LIG_REV1ctd_RIR_1	445	453	PF16727	0.539
LIG_SH2_CRK	117	121	PF00017	0.452
LIG_SH2_CRK	69	73	PF00017	0.509
LIG_SH2_NCK_1	220	224	PF00017	0.459
LIG_SH2_NCK_1	25	29	PF00017	0.553
LIG_SH2_NCK_1	45	49	PF00017	0.378
LIG_SH2_PTP2	385	388	PF00017	0.459
LIG_SH2_PTP2	482	485	PF00017	0.401
LIG_SH2_SRC	203	206	PF00017	0.539
LIG_SH2_STAP1	117	121	PF00017	0.464
LIG_SH2_STAP1	220	224	PF00017	0.459
LIG_SH2_STAP1	284	288	PF00017	0.446
LIG_SH2_STAP1	45	49	PF00017	0.509
LIG_SH2_STAT5	170	173	PF00017	0.503
LIG_SH2_STAT5	382	385	PF00017	0.459
LIG_SH2_STAT5	405	408	PF00017	0.473
LIG_SH2_STAT5	454	457	PF00017	0.459
LIG_SH2_STAT5	482	485	PF00017	0.401
LIG_SH2_STAT5	96	99	PF00017	0.540
LIG_SH3_3	118	124	PF00018	0.357
LIG_SH3_3	183	189	PF00018	0.562
LIG_SH3_3	470	476	PF00018	0.485
LIG_SH3_3	482	488	PF00018	0.443
LIG_SUMO_SIM_anti_2	361	368	PF11976	0.539
LIG_SUMO_SIM_par_1	361	368	PF11976	0.539
LIG_UBA3_1	178	185	PF00899	0.637
LIG_UBA3_1	365	372	PF00899	0.477
LIG_UBA3_1	78	83	PF00899	0.489
LIG_WRC_WIRS_1	344	349	PF05994	0.459
MOD_CDK_SPK_2	472	477	PF00069	0.446
MOD_CK1_1	21	27	PF00069	0.700
MOD_CK1_1	371	377	PF00069	0.465
MOD_CK1_1	394	400	PF00069	0.477
MOD_CK1_1	436	442	PF00069	0.459
MOD_CK1_1	77	83	PF00069	0.537
MOD_CK2_1	162	168	PF00069	0.397
MOD_CK2_1	239	245	PF00069	0.515
MOD_CK2_1	289	295	PF00069	0.459
MOD_CK2_1	79	85	PF00069	0.524
MOD_GlcNHglycan	104	107	PF01048	0.388
MOD_GlcNHglycan	164	167	PF01048	0.552
MOD_GlcNHglycan	230	233	PF01048	0.246
MOD_GlcNHglycan	376	379	PF01048	0.259
MOD_GlcNHglycan	457	460	PF01048	0.259
MOD_GSK3_1	188	195	PF00069	0.478
MOD_GSK3_1	278	285	PF00069	0.465
MOD_GSK3_1	29	36	PF00069	0.721
MOD_GSK3_1	370	377	PF00069	0.466
MOD_GSK3_1	433	440	PF00069	0.446
MOD_GSK3_1	472	479	PF00069	0.397
MOD_N-GLC_1	309	314	PF02516	0.339
MOD_N-GLC_1	433	438	PF02516	0.259
MOD_N-GLC_1	74	79	PF02516	0.475
MOD_NEK2_1	218	223	PF00069	0.459
MOD_NEK2_1	365	370	PF00069	0.486
MOD_NEK2_1	455	460	PF00069	0.465
MOD_NEK2_1	59	64	PF00069	0.581
MOD_NEK2_1	79	84	PF00069	0.501
MOD_NEK2_2	481	486	PF00069	0.452
MOD_NEK2_2	74	79	PF00069	0.588
MOD_PK_1	329	335	PF00069	0.459
MOD_PKA_1	132	138	PF00069	0.502
MOD_PKA_2	21	27	PF00069	0.624
MOD_PKA_2	29	35	PF00069	0.594
MOD_Plk_1	309	315	PF00069	0.539
MOD_Plk_1	319	325	PF00069	0.427
MOD_Plk_4	309	315	PF00069	0.465
MOD_Plk_4	343	349	PF00069	0.459
MOD_Plk_4	418	424	PF00069	0.459
MOD_Plk_4	481	487	PF00069	0.461
MOD_Plk_4	74	80	PF00069	0.597
MOD_ProDKin_1	472	478	PF00069	0.336
MOD_SUMO_for_1	87	90	PF00179	0.392
MOD_SUMO_rev_2	244	251	PF00179	0.459
MOD_SUMO_rev_2	320	327	PF00179	0.539
MOD_SUMO_rev_2	7	14	PF00179	0.569
MOD_SUMO_rev_2	90	97	PF00179	0.407
TRG_DiLeu_BaEn_1	361	366	PF01217	0.477
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.459
TRG_ENDOCYTIC_2	117	120	PF00928	0.449
TRG_ENDOCYTIC_2	25	28	PF00928	0.550
TRG_ENDOCYTIC_2	344	347	PF00928	0.459
TRG_ENDOCYTIC_2	405	408	PF00928	0.459
TRG_ENDOCYTIC_2	45	48	PF00928	0.375
TRG_ENDOCYTIC_2	452	455	PF00928	0.459
TRG_ENDOCYTIC_2	482	485	PF00928	0.420
TRG_ENDOCYTIC_2	86	89	PF00928	0.548
TRG_ENDOCYTIC_2	96	99	PF00928	0.398
TRG_ER_diArg_1	127	129	PF00400	0.360
TRG_ER_diArg_1	196	198	PF00400	0.477
TRG_ER_diArg_1	258	261	PF00400	0.539
TRG_ER_diArg_1	351	353	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P927	Leptomonas seymouri	74%	100%
A4H5C3	Leishmania braziliensis	82%	100%
A4HTK3	Leishmania infantum	99%	100%
E9AMD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O53732	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
O69687	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
P0A9H7	Escherichia coli (strain K12)	48%	100%
P0A9H8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	48%	100%
P31049	Pseudomonas putida	29%	100%