Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H654_LEIDO

TriTrypDb:

LdBPK_080510.1 , LdCL_080010000 , LDHU3_08.0570

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H654

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H654

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.785
CLV_NRD_NRD_1	164	166	PF00675	0.735
CLV_NRD_NRD_1	289	291	PF00675	0.704
CLV_NRD_NRD_1	319	321	PF00675	0.708
CLV_NRD_NRD_1	339	341	PF00675	0.407
CLV_NRD_NRD_1	354	356	PF00675	0.466
CLV_NRD_NRD_1	4	6	PF00675	0.756
CLV_NRD_NRD_1	63	65	PF00675	0.766
CLV_NRD_NRD_1	84	86	PF00675	0.606
CLV_PCSK_KEX2_1	164	166	PF00082	0.735
CLV_PCSK_KEX2_1	236	238	PF00082	0.841
CLV_PCSK_KEX2_1	289	291	PF00082	0.704
CLV_PCSK_KEX2_1	318	320	PF00082	0.724
CLV_PCSK_KEX2_1	339	341	PF00082	0.624
CLV_PCSK_KEX2_1	354	356	PF00082	0.466
CLV_PCSK_KEX2_1	84	86	PF00082	0.609
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.727
CLV_PCSK_PC7_1	315	321	PF00082	0.724
CLV_PCSK_SKI1_1	283	287	PF00082	0.717
DEG_APCC_DBOX_1	317	325	PF00400	0.738
DEG_APCC_DBOX_1	353	361	PF00400	0.562
DEG_APCC_DBOX_1	93	101	PF00400	0.706
DEG_SPOP_SBC_1	47	51	PF00917	0.701
DOC_MAPK_gen_1	354	362	PF00069	0.523
DOC_USP7_MATH_1	163	167	PF00917	0.727
DOC_USP7_MATH_1	345	349	PF00917	0.584
DOC_USP7_MATH_1	47	51	PF00917	0.701
DOC_USP7_MATH_1	89	93	PF00917	0.579
DOC_WW_Pin1_4	181	186	PF00397	0.698
DOC_WW_Pin1_4	216	221	PF00397	0.810
DOC_WW_Pin1_4	266	271	PF00397	0.791
DOC_WW_Pin1_4	31	36	PF00397	0.792
DOC_WW_Pin1_4	324	329	PF00397	0.673
DOC_WW_Pin1_4	73	78	PF00397	0.715
LIG_14-3-3_CanoR_1	153	162	PF00244	0.677
LIG_14-3-3_CanoR_1	300	307	PF00244	0.647
LIG_14-3-3_CanoR_1	339	346	PF00244	0.669
LIG_14-3-3_CanoR_1	354	363	PF00244	0.463
LIG_14-3-3_CanoR_1	70	78	PF00244	0.695
LIG_14-3-3_CanoR_1	84	93	PF00244	0.540
LIG_deltaCOP1_diTrp_1	281	286	PF00928	0.708
LIG_eIF4E_1	106	112	PF01652	0.702
LIG_FHA_1	185	191	PF00498	0.824
LIG_FHA_1	357	363	PF00498	0.609
LIG_FHA_2	329	335	PF00498	0.689
LIG_Integrin_RGD_1	246	248	PF01839	0.596
LIG_LIR_Nem_3	189	195	PF02991	0.761
LIG_LIR_Nem_3	197	202	PF02991	0.652
LIG_LIR_Nem_3	279	285	PF02991	0.706
LIG_PDZ_Class_3	361	366	PF00595	0.673
LIG_Pex14_1	282	286	PF04695	0.649
LIG_PTAP_UEV_1	172	177	PF05743	0.609
LIG_REV1ctd_RIR_1	283	294	PF16727	0.663
LIG_SH2_NCK_1	106	110	PF00017	0.696
LIG_SH2_NCK_1	341	345	PF00017	0.601
LIG_SH2_STAP1	168	172	PF00017	0.608
LIG_SH2_STAP1	341	345	PF00017	0.601
LIG_SH2_STAT5	106	109	PF00017	0.698
LIG_SH2_STAT5	341	344	PF00017	0.672
LIG_SH3_2	16	21	PF14604	0.748
LIG_SH3_3	10	16	PF00018	0.764
LIG_SH3_3	137	143	PF00018	0.686
LIG_SH3_3	170	176	PF00018	0.607
LIG_TRAF2_1	101	104	PF00917	0.693
MOD_CK1_1	171	177	PF00069	0.698
MOD_CK1_1	184	190	PF00069	0.745
MOD_CK1_1	269	275	PF00069	0.705
MOD_CK1_1	276	282	PF00069	0.577
MOD_CK1_1	348	354	PF00069	0.499
MOD_CK1_1	45	51	PF00069	0.777
MOD_CK1_1	69	75	PF00069	0.788
MOD_CK1_1	88	94	PF00069	0.498
MOD_CK2_1	191	197	PF00069	0.737
MOD_CK2_1	328	334	PF00069	0.703
MOD_Cter_Amidation	234	237	PF01082	0.798
MOD_DYRK1A_RPxSP_1	33	37	PF00069	0.724
MOD_GlcNHglycan	165	168	PF01048	0.754
MOD_GlcNHglycan	169	173	PF01048	0.691
MOD_GlcNHglycan	241	244	PF01048	0.627
MOD_GlcNHglycan	291	294	PF01048	0.674
MOD_GlcNHglycan	350	353	PF01048	0.625
MOD_GlcNHglycan	45	48	PF01048	0.735
MOD_GlcNHglycan	87	90	PF01048	0.665
MOD_GSK3_1	177	184	PF00069	0.840
MOD_GSK3_1	186	193	PF00069	0.672
MOD_GSK3_1	219	226	PF00069	0.794
MOD_GSK3_1	269	276	PF00069	0.656
MOD_GSK3_1	289	296	PF00069	0.660
MOD_GSK3_1	324	331	PF00069	0.725
MOD_GSK3_1	42	49	PF00069	0.716
MOD_GSK3_1	64	71	PF00069	0.738
MOD_GSK3_1	85	92	PF00069	0.646
MOD_N-GLC_1	322	327	PF02516	0.612
MOD_NEK2_1	133	138	PF00069	0.735
MOD_NEK2_1	291	296	PF00069	0.581
MOD_NEK2_1	68	73	PF00069	0.624
MOD_NEK2_2	186	191	PF00069	0.595
MOD_PIKK_1	99	105	PF00454	0.686
MOD_PKA_1	289	295	PF00069	0.708
MOD_PKA_1	339	345	PF00069	0.607
MOD_PKA_1	64	70	PF00069	0.626
MOD_PKA_2	163	169	PF00069	0.728
MOD_PKA_2	289	295	PF00069	0.708
MOD_PKA_2	339	345	PF00069	0.607
MOD_PKA_2	69	75	PF00069	0.673
MOD_PKB_1	62	70	PF00069	0.625
MOD_Plk_1	272	278	PF00069	0.612
MOD_Plk_4	107	113	PF00069	0.622
MOD_Plk_4	273	279	PF00069	0.637
MOD_ProDKin_1	181	187	PF00069	0.698
MOD_ProDKin_1	216	222	PF00069	0.811
MOD_ProDKin_1	266	272	PF00069	0.789
MOD_ProDKin_1	31	37	PF00069	0.791
MOD_ProDKin_1	324	330	PF00069	0.666
MOD_ProDKin_1	73	79	PF00069	0.714
MOD_SUMO_rev_2	242	252	PF00179	0.663
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.726
TRG_ENDOCYTIC_2	195	198	PF00928	0.718
TRG_ER_diArg_1	289	291	PF00400	0.637
TRG_ER_diArg_1	318	320	PF00400	0.791
TRG_ER_diArg_1	338	340	PF00400	0.396
TRG_ER_diArg_1	353	355	PF00400	0.460
TRG_ER_diArg_1	61	64	PF00400	0.708
TRG_ER_diArg_1	83	85	PF00400	0.604
TRG_NLS_MonoExtN_4	2	9	PF00514	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H5B7	Leishmania braziliensis	50%	95%
A4HTJ8	Leishmania infantum	98%	99%
E9AMC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	89%
Q4QIB9	Leishmania major	81%	98%