Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H653_LEIDO

TriTrypDb:

LdBPK_080500.1 , LdCL_080009900 , LDHU3_08.0560

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H653

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H653

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.713
CLV_NRD_NRD_1	209	211	PF00675	0.841
CLV_PCSK_KEX2_1	211	213	PF00082	0.832
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.832
DEG_Nend_Nbox_1	1	3	PF02207	0.663
DOC_CYCLIN_RxL_1	269	279	PF00134	0.701
DOC_PP1_RVXF_1	270	277	PF00149	0.654
DOC_PP2B_LxvP_1	220	223	PF13499	0.745
DOC_PP2B_LxvP_1	337	340	PF13499	0.811
DOC_PP4_MxPP_1	17	20	PF00568	0.763
DOC_USP7_MATH_1	203	207	PF00917	0.779
DOC_USP7_MATH_1	21	25	PF00917	0.744
DOC_USP7_MATH_1	253	257	PF00917	0.738
DOC_USP7_MATH_1	264	268	PF00917	0.588
DOC_USP7_MATH_1	289	293	PF00917	0.735
DOC_USP7_MATH_1	350	354	PF00917	0.659
DOC_USP7_MATH_1	48	52	PF00917	0.758
DOC_USP7_MATH_1	69	73	PF00917	0.775
DOC_USP7_MATH_1	80	84	PF00917	0.715
DOC_WW_Pin1_4	131	136	PF00397	0.695
DOC_WW_Pin1_4	15	20	PF00397	0.728
DOC_WW_Pin1_4	169	174	PF00397	0.830
DOC_WW_Pin1_4	176	181	PF00397	0.708
DOC_WW_Pin1_4	199	204	PF00397	0.719
DOC_WW_Pin1_4	223	228	PF00397	0.815
DOC_WW_Pin1_4	292	297	PF00397	0.773
DOC_WW_Pin1_4	70	75	PF00397	0.785
LIG_14-3-3_CanoR_1	11	19	PF00244	0.610
LIG_14-3-3_CanoR_1	291	296	PF00244	0.778
LIG_14-3-3_CanoR_1	47	53	PF00244	0.788
LIG_14-3-3_CanoR_1	54	60	PF00244	0.715
LIG_14-3-3_CanoR_1	85	95	PF00244	0.654
LIG_APCC_ABBA_1	258	263	PF00400	0.650
LIG_BRCT_BRCA1_1	23	27	PF00533	0.748
LIG_BRCT_BRCA1_1	328	332	PF00533	0.797
LIG_FHA_1	148	154	PF00498	0.825
LIG_FHA_1	229	235	PF00498	0.801
LIG_FHA_1	263	269	PF00498	0.736
LIG_FHA_1	320	326	PF00498	0.712
LIG_FHA_1	349	355	PF00498	0.758
LIG_FHA_2	144	150	PF00498	0.720
LIG_FHA_2	244	250	PF00498	0.702
LIG_GSK3_LRP6_1	19	24	PF00069	0.713
LIG_LIR_Gen_1	186	195	PF02991	0.783
LIG_LIR_Gen_1	254	264	PF02991	0.700
LIG_LIR_Gen_1	329	340	PF02991	0.798
LIG_LIR_Nem_3	186	190	PF02991	0.776
LIG_LIR_Nem_3	254	260	PF02991	0.705
LIG_LIR_Nem_3	329	335	PF02991	0.790
LIG_NRBOX	91	97	PF00104	0.758
LIG_PDZ_Class_2	385	390	PF00595	0.758
LIG_Pex14_1	328	332	PF04695	0.797
LIG_SH2_NCK_1	124	128	PF00017	0.692
LIG_SH2_STAP1	124	128	PF00017	0.692
LIG_SH2_STAT5	187	190	PF00017	0.780
LIG_SH2_STAT5	277	280	PF00017	0.771
LIG_SH3_2	20	25	PF14604	0.793
LIG_SH3_3	167	173	PF00018	0.805
LIG_SH3_3	17	23	PF00018	0.778
LIG_SH3_3	192	198	PF00018	0.741
LIG_SUMO_SIM_anti_2	384	389	PF11976	0.751
LIG_SUMO_SIM_par_1	311	317	PF11976	0.750
LIG_ULM_U2AF65_1	210	216	PF00076	0.757
LIG_WRC_WIRS_1	84	89	PF05994	0.723
LIG_WW_3	141	145	PF00397	0.709
MOD_CDC14_SPxK_1	179	182	PF00782	0.689
MOD_CDC14_SPxK_1	22	25	PF00782	0.797
MOD_CDK_SPxK_1	176	182	PF00069	0.697
MOD_CDK_SPxK_1	19	25	PF00069	0.748
MOD_CDK_SPxxK_3	292	299	PF00069	0.773
MOD_CK1_1	123	129	PF00069	0.813
MOD_CK1_1	133	139	PF00069	0.663
MOD_CK1_1	172	178	PF00069	0.786
MOD_CK1_1	243	249	PF00069	0.731
MOD_CK1_1	256	262	PF00069	0.678
MOD_CK1_1	292	298	PF00069	0.844
MOD_CK1_1	319	325	PF00069	0.783
MOD_CK1_1	371	377	PF00069	0.710
MOD_CK1_1	6	12	PF00069	0.717
MOD_CK1_1	78	84	PF00069	0.752
MOD_CK1_1	86	92	PF00069	0.624
MOD_CK2_1	143	149	PF00069	0.730
MOD_CK2_1	161	167	PF00069	0.649
MOD_CK2_1	369	375	PF00069	0.742
MOD_CMANNOS	215	218	PF00535	0.830
MOD_GlcNHglycan	12	15	PF01048	0.615
MOD_GlcNHglycan	125	128	PF01048	0.750
MOD_GlcNHglycan	159	162	PF01048	0.751
MOD_GlcNHglycan	205	208	PF01048	0.826
MOD_GlcNHglycan	278	281	PF01048	0.770
MOD_GlcNHglycan	328	331	PF01048	0.797
MOD_GlcNHglycan	379	382	PF01048	0.711
MOD_GSK3_1	143	150	PF00069	0.782
MOD_GSK3_1	15	22	PF00069	0.754
MOD_GSK3_1	157	164	PF00069	0.628
MOD_GSK3_1	172	179	PF00069	0.586
MOD_GSK3_1	199	206	PF00069	0.722
MOD_GSK3_1	290	297	PF00069	0.826
MOD_GSK3_1	312	319	PF00069	0.778
MOD_GSK3_1	377	384	PF00069	0.707
MOD_GSK3_1	6	13	PF00069	0.681
MOD_GSK3_1	65	72	PF00069	0.651
MOD_GSK3_1	83	90	PF00069	0.538
MOD_N-GLC_1	6	11	PF02516	0.820
MOD_NEK2_1	130	135	PF00069	0.713
MOD_NEK2_1	148	153	PF00069	0.602
MOD_NEK2_1	188	193	PF00069	0.707
MOD_NEK2_1	276	281	PF00069	0.772
MOD_NEK2_1	326	331	PF00069	0.798
MOD_NEK2_1	377	382	PF00069	0.714
MOD_NEK2_1	65	70	PF00069	0.590
MOD_NEK2_1	87	92	PF00069	0.594
MOD_NEK2_2	161	166	PF00069	0.755
MOD_NEK2_2	264	269	PF00069	0.759
MOD_NEK2_2	80	85	PF00069	0.657
MOD_PIKK_1	133	139	PF00454	0.806
MOD_PIKK_1	369	375	PF00454	0.692
MOD_PIKK_1	78	84	PF00454	0.837
MOD_PIKK_1	90	96	PF00454	0.563
MOD_PKA_1	210	216	PF00069	0.757
MOD_PKA_2	10	16	PF00069	0.565
MOD_PKA_2	143	149	PF00069	0.755
MOD_PKA_2	157	163	PF00069	0.689
MOD_PKA_2	243	249	PF00069	0.768
MOD_PKA_2	290	296	PF00069	0.778
MOD_PKA_2	3	9	PF00069	0.724
MOD_Plk_1	148	154	PF00069	0.746
MOD_Plk_1	253	259	PF00069	0.779
MOD_Plk_4	253	259	PF00069	0.704
MOD_Plk_4	350	356	PF00069	0.660
MOD_Plk_4	55	61	PF00069	0.625
MOD_Plk_4	87	93	PF00069	0.642
MOD_ProDKin_1	131	137	PF00069	0.698
MOD_ProDKin_1	15	21	PF00069	0.728
MOD_ProDKin_1	169	175	PF00069	0.829
MOD_ProDKin_1	176	182	PF00069	0.708
MOD_ProDKin_1	199	205	PF00069	0.720
MOD_ProDKin_1	223	229	PF00069	0.817
MOD_ProDKin_1	292	298	PF00069	0.773
MOD_ProDKin_1	70	76	PF00069	0.788
TRG_ENDOCYTIC_2	187	190	PF00928	0.780
TRG_ER_diArg_1	209	212	PF00400	0.840
TRG_NES_CRM1_1	186	201	PF08389	0.730
TRG_NLS_MonoExtC_3	209	214	PF00514	0.760
TRG_NLS_MonoExtN_4	209	215	PF00514	0.835

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H5B6	Leishmania braziliensis	52%	100%
A4HTJ7	Leishmania infantum	99%	100%
E9AMC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QIC0	Leishmania major	84%	100%