Ubiquitin-2 like Rad60 SUMO-like family protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small ubiquitin protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H652_LEIDO

TriTrypDb:

LdBPK_080480.1 , LdCL_080009700 , LDHU3_08.0540

Length:

117

Annotations

Annotations by Jardim et al.

Protein modification, small ubiquitin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H652

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H652

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031386	protein tag	1	1
GO:0044389	ubiquitin-like protein ligase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.272
CLV_PCSK_KEX2_1	53	55	PF00082	0.353
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.350
CLV_PCSK_SKI1_1	77	81	PF00082	0.272
DEG_Nend_UBRbox_2	1	3	PF02207	0.610
DOC_CKS1_1	88	93	PF01111	0.299
DOC_USP7_MATH_1	29	33	PF00917	0.602
DOC_WW_Pin1_4	87	92	PF00397	0.272
LIG_BRCT_BRCA1_1	74	78	PF00533	0.274
LIG_CtBP_PxDLS_1	91	95	PF00389	0.350
LIG_FHA_2	88	94	PF00498	0.272
LIG_LIR_Nem_3	47	52	PF02991	0.272
LIG_Rb_pABgroove_1	74	82	PF01858	0.272
LIG_REV1ctd_RIR_1	47	58	PF16727	0.290
LIG_SH2_STAT5	65	68	PF00017	0.286
LIG_UBA3_1	48	53	PF00899	0.290
MOD_CK1_1	72	78	PF00069	0.272
MOD_GlcNHglycan	31	34	PF01048	0.551
MOD_N-GLC_1	14	19	PF02516	0.611
MOD_PIKK_1	53	59	PF00454	0.290
MOD_PKA_1	53	59	PF00069	0.350
MOD_PKA_2	53	59	PF00069	0.350
MOD_PKA_2	72	78	PF00069	0.272
MOD_ProDKin_1	87	93	PF00069	0.272
MOD_SUMO_for_1	23	26	PF00179	0.569
MOD_SUMO_rev_2	81	91	PF00179	0.272
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P930	Leptomonas seymouri	82%	94%
A0A0S4J6U7	Bodo saltans	87%	100%
A0A1X0NP22	Trypanosomatidae	80%	100%
A0A3R7N9J1	Trypanosoma rangeli	87%	100%
A4H5B4	Leishmania braziliensis	90%	100%
A4HTJ5	Leishmania infantum	100%	100%
A7WLH8	Sus scrofa	49%	100%
B3H5R8	Arabidopsis thaliana	40%	100%
C9ZPI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AMC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
G2XKQ0	Homo sapiens	43%	100%
O13351	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	100%
P55853	Caenorhabditis elegans	46%	100%
P55857	Oryza sativa subsp. japonica	49%	100%
P61955	Bos taurus	49%	100%
P61956	Homo sapiens	49%	100%
P61957	Mus musculus	49%	100%
P61958	Sus scrofa	49%	100%
P61959	Rattus norvegicus	49%	100%
P63165	Homo sapiens	49%	100%
P63166	Mus musculus	49%	100%
Q12306	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q17QV3	Bos taurus	54%	100%
Q28H04	Xenopus tropicalis	49%	100%
Q2EF74	Ictidomys tridecemlineatus	49%	100%
Q2PFW2	Macaca fascicularis	49%	100%
Q3E8A8	Arabidopsis thaliana	34%	100%
Q4QIC2	Leishmania major	97%	100%
Q5E9D1	Bos taurus	49%	100%
Q5I0H3	Rattus norvegicus	49%	100%
Q5R6J4	Pongo abelii	49%	100%
Q5XIF4	Rattus norvegicus	54%	100%
Q5ZJM9	Gallus gallus	49%	100%
Q6DHL4	Danio rerio	49%	100%
Q6DK72	Xenopus tropicalis	49%	100%
Q6GPW2	Xenopus laevis	49%	100%
Q6LDZ8	Cricetulus griseus	49%	100%
Q7SZ22	Xenopus laevis	49%	100%
Q7SZR5	Danio rerio	45%	100%
Q7ZTK7	Xenopus laevis	54%	100%
Q8QGH2	Gallus gallus	49%	100%
Q9FKC5	Arabidopsis thaliana	40%	100%
Q9FKC6	Arabidopsis thaliana	29%	100%
Q9FLP5	Arabidopsis thaliana	38%	100%
Q9MZD5	Cervus nippon	49%	100%
Q9PT08	Oncorhynchus mykiss	43%	100%
Q9Z172	Mus musculus	48%	100%