Mitochondrial_associated_ribonuclease_putative/Ge neDB:LmjF.08.0320

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial associated ribonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H642_LEIDO

TriTrypDb:

LdBPK_080330.1 , LdCL_080008200 , LDHU3_08.0390

Length:

225

Annotations

Annotations by Jardim et al.

Nucleases, mitochondrial associated ribonuclease

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 25
NetGPI	no	yes: 0, no: 27

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H642

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H642

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.354
CLV_PCSK_SKI1_1	201	205	PF00082	0.537
CLV_PCSK_SKI1_1	24	28	PF00082	0.408
CLV_PCSK_SKI1_1	82	86	PF00082	0.389
DEG_APCC_DBOX_1	195	203	PF00400	0.389
DEG_SCF_FBW7_1	60	65	PF00400	0.605
DOC_MAPK_gen_1	144	152	PF00069	0.560
DOC_MAPK_gen_1	193	202	PF00069	0.616
DOC_MAPK_MEF2A_6	144	152	PF00069	0.596
DOC_USP7_MATH_1	208	212	PF00917	0.677
DOC_USP7_MATH_1	3	7	PF00917	0.733
DOC_USP7_MATH_1	62	66	PF00917	0.628
DOC_USP7_MATH_1	8	12	PF00917	0.643
DOC_WW_Pin1_4	58	63	PF00397	0.602
LIG_14-3-3_CanoR_1	7	17	PF00244	0.652
LIG_APCC_ABBA_1	105	110	PF00400	0.586
LIG_FHA_1	177	183	PF00498	0.537
LIG_FHA_1	64	70	PF00498	0.624
LIG_FHA_2	135	141	PF00498	0.601
LIG_FHA_2	83	89	PF00498	0.548
LIG_Integrin_RGD_1	190	192	PF01839	0.421
LIG_LIR_Nem_3	211	216	PF02991	0.752
LIG_SH2_SRC	108	111	PF00017	0.602
LIG_SH2_STAT5	108	111	PF00017	0.607
LIG_SH3_3	211	217	PF00018	0.582
LIG_SUMO_SIM_anti_2	179	186	PF11976	0.516
LIG_TRAF2_1	166	169	PF00917	0.505
LIG_UBA3_1	199	206	PF00899	0.648
MOD_CDK_SPK_2	58	63	PF00069	0.505
MOD_CK1_1	11	17	PF00069	0.619
MOD_CK1_1	22	28	PF00069	0.449
MOD_CK1_1	52	58	PF00069	0.491
MOD_CK2_1	134	140	PF00069	0.582
MOD_CK2_1	82	88	PF00069	0.615
MOD_GSK3_1	174	181	PF00069	0.442
MOD_GSK3_1	208	215	PF00069	0.674
MOD_GSK3_1	52	59	PF00069	0.586
MOD_GSK3_1	63	70	PF00069	0.566
MOD_N-GLC_1	174	179	PF02516	0.397
MOD_NEK2_1	176	181	PF00069	0.470
MOD_NEK2_1	195	200	PF00069	0.384
MOD_NEK2_1	9	14	PF00069	0.485
MOD_PIKK_1	154	160	PF00454	0.566
MOD_PKA_2	195	201	PF00069	0.552
MOD_Plk_1	174	180	PF00069	0.394
MOD_Plk_1	82	88	PF00069	0.626
MOD_Plk_4	195	201	PF00069	0.557
MOD_Plk_4	63	69	PF00069	0.525
MOD_Plk_4	96	102	PF00069	0.568
MOD_ProDKin_1	58	64	PF00069	0.602
TRG_ER_diArg_1	36	39	PF00400	0.505
TRG_NES_CRM1_1	140	153	PF08389	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	50%	94%
A0A0N1HWD2	Leptomonas seymouri	43%	100%
A0A0N1I400	Leptomonas seymouri	53%	94%
A0A0N1IAK4	Leptomonas seymouri	61%	100%
A0A0S4IL71	Bodo saltans	37%	100%
A0A0S4IVV9	Bodo saltans	41%	100%
A0A1X0NQH8	Trypanosomatidae	47%	100%
A0A3S5H641	Leishmania donovani	52%	100%
A0A3S5IQS6	Trypanosoma rangeli	45%	100%
A0A3S7WQ71	Leishmania donovani	46%	73%
A0JME6	Danio rerio	33%	100%
A4H5A0	Leishmania braziliensis	50%	100%
A4H5A1	Leishmania braziliensis	47%	100%
A4H5A2	Leishmania braziliensis	77%	100%
A4H6S1	Leishmania braziliensis	42%	100%
A4HTI1	Leishmania infantum	52%	100%
A4HTI2	Leishmania infantum	46%	73%
A4HTI3	Leishmania infantum	100%	100%
A4HV50	Leishmania infantum	38%	100%
A6QLY4	Bos taurus	37%	76%
B5X0W9	Salmo salar	36%	80%
D0VWV0	Leishmania donovani	38%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9ANT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
G4YEI5	Phytophthora sojae (strain P6497)	29%	100%
P85094	Mus musculus	36%	100%
Q08C33	Danio rerio	35%	80%
Q0IHU5	Xenopus tropicalis	34%	73%
Q32KX0	Bos taurus	35%	100%
Q4QGT7	Leishmania major	38%	100%
Q4QID7	Leishmania major	95%	100%
Q4QID8	Leishmania major	43%	100%
Q4QID9	Leishmania major	50%	100%
Q4R826	Macaca fascicularis	34%	100%
Q54NZ6	Dictyostelium discoideum	31%	100%
Q54NZ8	Dictyostelium discoideum	31%	100%
Q54RC7	Dictyostelium discoideum	28%	100%
Q5PQ71	Xenopus laevis	35%	100%
Q5PQA5	Xenopus laevis	35%	74%
Q5RC03	Pongo abelii	32%	100%
Q5U3Z3	Rattus norvegicus	32%	100%
Q6DF67	Xenopus tropicalis	34%	100%
Q6I7R3	Rattus norvegicus	36%	76%
Q91V64	Mus musculus	36%	76%
Q96AB3	Homo sapiens	32%	100%
Q96CN7	Homo sapiens	36%	76%
Q9DCC7	Mus musculus	34%	100%