Isochorismatase_family_putative/Pfam:PF00857

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isochorismatase family, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H641_LEIDO

TriTrypDb:

LdBPK_080310.1 , LdCL_080008000 , LDHU3_08.0370

Length:

252

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 17
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H641

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H641

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.260
CLV_NRD_NRD_1	180	182	PF00675	0.266
CLV_NRD_NRD_1	31	33	PF00675	0.463
CLV_NRD_NRD_1	38	40	PF00675	0.265
CLV_PCSK_KEX2_1	164	166	PF00082	0.260
CLV_PCSK_KEX2_1	180	182	PF00082	0.260
CLV_PCSK_KEX2_1	232	234	PF00082	0.496
CLV_PCSK_KEX2_1	30	32	PF00082	0.453
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.477
CLV_PCSK_SKI1_1	32	36	PF00082	0.530
CLV_PCSK_SKI1_1	39	43	PF00082	0.371
CLV_PCSK_SKI1_1	45	49	PF00082	0.292
CLV_Separin_Metazoa	161	165	PF03568	0.460
DEG_SIAH_1	108	116	PF03145	0.368
DOC_MAPK_gen_1	164	171	PF00069	0.456
DOC_MAPK_gen_1	180	188	PF00069	0.386
DOC_PP4_FxxP_1	231	234	PF00568	0.610
DOC_USP7_MATH_1	212	216	PF00917	0.238
DOC_USP7_UBL2_3	56	60	PF12436	0.460
LIG_14-3-3_CanoR_1	20	28	PF00244	0.439
LIG_14-3-3_CanoR_1	31	41	PF00244	0.504
LIG_14-3-3_CterR_2	250	252	PF00244	0.516
LIG_Actin_WH2_2	149	166	PF00022	0.460
LIG_APCC_ABBA_1	74	79	PF00400	0.460
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_FHA_1	198	204	PF00498	0.386
LIG_FHA_1	20	26	PF00498	0.466
LIG_FHA_1	205	211	PF00498	0.327
LIG_FHA_1	33	39	PF00498	0.359
LIG_FHA_1	65	71	PF00498	0.438
LIG_FHA_2	156	162	PF00498	0.482
LIG_FHA_2	7	13	PF00498	0.456
LIG_LIR_Gen_1	75	85	PF02991	0.401
LIG_LIR_Nem_3	192	197	PF02991	0.529
LIG_LIR_Nem_3	214	220	PF02991	0.351
LIG_LIR_Nem_3	84	88	PF02991	0.407
LIG_PTAP_UEV_1	108	113	PF05743	0.335
LIG_SH2_CRK	206	210	PF00017	0.356
LIG_SH2_CRK	85	89	PF00017	0.488
LIG_SH2_SRC	129	132	PF00017	0.455
LIG_SH2_STAP1	206	210	PF00017	0.356
LIG_SH2_STAT5	129	132	PF00017	0.465
LIG_SH2_STAT5	206	209	PF00017	0.337
LIG_SH2_STAT5	85	88	PF00017	0.431
LIG_SH3_3	106	112	PF00018	0.468
LIG_SH3_3	213	219	PF00018	0.461
LIG_SH3_3	22	28	PF00018	0.589
LIG_SH3_3	238	244	PF00018	0.668
LIG_SH3_3	89	95	PF00018	0.506
LIG_SH3_4	218	225	PF00018	0.396
LIG_SUMO_SIM_anti_2	185	190	PF11976	0.460
LIG_TRAF2_1	244	247	PF00917	0.461
LIG_UBA3_1	188	193	PF00899	0.457
MOD_CK1_1	23	29	PF00069	0.617
MOD_CK2_1	155	161	PF00069	0.465
MOD_CK2_1	189	195	PF00069	0.398
MOD_CK2_1	6	12	PF00069	0.422
MOD_GlcNHglycan	109	112	PF01048	0.135
MOD_GSK3_1	19	26	PF00069	0.609
MOD_GSK3_1	235	242	PF00069	0.536
MOD_GSK3_1	39	46	PF00069	0.284
MOD_GSK3_1	64	71	PF00069	0.471
MOD_N-GLC_1	64	69	PF02516	0.250
MOD_NEK2_1	1	6	PF00069	0.564
MOD_NEK2_1	189	194	PF00069	0.478
MOD_NEK2_1	197	202	PF00069	0.346
MOD_NEK2_1	64	69	PF00069	0.460
MOD_PIKK_1	32	38	PF00454	0.403
MOD_PKA_1	39	45	PF00069	0.263
MOD_PKA_2	19	25	PF00069	0.455
MOD_PKA_2	68	74	PF00069	0.386
MOD_PKB_1	30	38	PF00069	0.371
MOD_Plk_1	212	218	PF00069	0.275
MOD_Plk_1	23	29	PF00069	0.629
MOD_Plk_1	64	70	PF00069	0.368
MOD_Plk_1	72	78	PF00069	0.392
MOD_Plk_4	117	123	PF00069	0.440
MOD_Plk_4	204	210	PF00069	0.308
MOD_Plk_4	212	218	PF00069	0.419
MOD_Plk_4	72	78	PF00069	0.384
MOD_SUMO_for_1	115	118	PF00179	0.368
TRG_DiLeu_BaEn_1	118	123	PF01217	0.413
TRG_ENDOCYTIC_2	102	105	PF00928	0.419
TRG_ENDOCYTIC_2	206	209	PF00928	0.359
TRG_ENDOCYTIC_2	85	88	PF00928	0.488
TRG_ER_diArg_1	163	165	PF00400	0.460
TRG_ER_diArg_1	180	182	PF00400	0.460
TRG_ER_diArg_1	30	32	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.186

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	71%	100%
A0A0N1HWD2	Leptomonas seymouri	32%	100%
A0A0N1I400	Leptomonas seymouri	40%	100%
A0A0N1IAK4	Leptomonas seymouri	48%	100%
A0A0S4IL71	Bodo saltans	32%	100%
A0A0S4IVV9	Bodo saltans	32%	100%
A0A1X0NQH8	Trypanosomatidae	39%	100%
A0A3S5H642	Leishmania donovani	52%	100%
A0A3S5IQS6	Trypanosoma rangeli	35%	100%
A0A3S7WQ71	Leishmania donovani	37%	82%
A0JME6	Danio rerio	29%	100%
A4H5A0	Leishmania braziliensis	75%	100%
A4H5A1	Leishmania braziliensis	37%	85%
A4H5A2	Leishmania braziliensis	55%	100%
A4H6S1	Leishmania braziliensis	30%	99%
A4HTI1	Leishmania infantum	100%	100%
A4HTI2	Leishmania infantum	37%	100%
A4HTI3	Leishmania infantum	52%	100%
A4HV50	Leishmania infantum	29%	99%
A6QLY4	Bos taurus	35%	85%
B5X0W9	Salmo salar	33%	89%
D0VWV0	Leishmania donovani	29%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ANT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	99%
G4YEI5	Phytophthora sojae (strain P6497)	24%	100%
P85094	Mus musculus	30%	100%
Q08C33	Danio rerio	32%	89%
Q0IHU5	Xenopus tropicalis	34%	82%
Q32KX0	Bos taurus	26%	100%
Q4QGT7	Leishmania major	28%	99%
Q4QID7	Leishmania major	51%	100%
Q4QID8	Leishmania major	38%	81%
Q4QID9	Leishmania major	88%	100%
Q4R826	Macaca fascicularis	27%	100%
Q54NZ8	Dictyostelium discoideum	26%	100%
Q54RC7	Dictyostelium discoideum	26%	100%
Q5PQ71	Xenopus laevis	30%	100%
Q5PQA5	Xenopus laevis	34%	82%
Q5RC03	Pongo abelii	26%	100%
Q5U3Z3	Rattus norvegicus	31%	100%
Q6DF67	Xenopus tropicalis	31%	100%
Q6I7R3	Rattus norvegicus	34%	85%
Q91V64	Mus musculus	35%	85%
Q96AB3	Homo sapiens	28%	100%
Q96CN7	Homo sapiens	35%	85%
Q9DCC7	Mus musculus	31%	100%